4.6 Article

CAR-T cells dual-target CD123 and NKG2DLs to eradicate AML cells and selectively target immunosuppressive cells

Related references

Note: Only part of the references are listed.
Review Oncology

The Black Hole: CAR T Cell Therapy in AML

Erden Atilla et al.

Summary: Despite limited progress in adoptive cellular therapies for relapsed/refractory AML compared to B cell malignancies, CAR T cell Phase I trials targeting single antigens have been established worldwide with around 100 patients recruited. The high heterogeneity in AML patients at genetic and molecular levels poses unique therapeutic challenges. This review discusses the need for new perspectives and presents promising novel strategies, including advanced CAR T, TCR-T, and CAR NK therapies, tailored microenvironment and neoantigen targeting, as well as allogeneic approaches.

CANCERS (2023)

Review Oncology

Biomarkers as targets for CAR-T/NK cell therapy in AML

Ruonan Shao et al.

Summary: Acute myeloid leukemia (AML), the most common form of acute leukemia in adults, is typically treated with induction chemotherapy followed by consolidation or stem cell transplantation. However, some patients experience relapsed or refractory AML (R/R-AML), requiring novel therapies. Chimeric antigen receptor (CAR)-engineered T cells and natural killer (NK) cells targeting AML-associated antigens have shown promise in both pre-clinical and clinical trials. This review provides an overview of CAR-T/NK treatments for AML.

BIOMARKER RESEARCH (2023)

Article Oncology

Clinical Pharmacology and Determinants of Response to UCART19, an Allogeneic Anti-CD19 CAR-T Cell Product, in Adult B-cell Acute Lymphoblastic Leukemia

Sandra Dupouy et al.

Summary: UCART19 expansion is a driver of response in adult patients with R/R B-ALL. The impact of alemtuzumab on IL7 and host T lymphocyte population plays a crucial role in sustaining UCART19 expansion and persistence.

CANCER RESEARCH COMMUNICATIONS (2022)

Article Hematology

CLEC12A and CD33 coexpression as a preferential target for pediatric AML combinatorial immunotherapy

Semjon Willier et al.

Summary: Emerging immunotherapies like chimeric antigen receptor T cells have shown progress in treating acute lymphoblastic leukemia, but controlling acute myeloid leukemia poses challenges due to differences in clinical and biological characteristics across age groups.

BLOOD (2021)

Article Oncology

CRISPR/Cas9-Engineered Universal CD19/CD22 Dual-Targeted CAR-T Cell Therapy for Relapsed/Refractory B-cell Acute Lymphoblastic Leukemia

Yongxian Hu et al.

Summary: The study successfully developed CRISPR-edited universal CAR-T cells as a novel therapy for r/r ALL. Results showed that this therapy has a manageable safety profile and prominent antileukemia activity, providing an alternative treatment option for patients.

CLINICAL CANCER RESEARCH (2021)

Article Biotechnology & Applied Microbiology

A novel and efficient tandem CD19- and CD22-directed CAR for B-cell ALL

Samanta Romina Zanetti et al.

MOLECULAR THERAPY (2021)

Article Hematology

How I treat acute myeloid leukemia in the era of new drugs

Courtney D. DiNardo et al.

BLOOD (2020)

Review Chemistry, Multidisciplinary

Current challenges and emerging opportunities of CAR-T cell therapies

Teresa R. Abreu et al.

JOURNAL OF CONTROLLED RELEASE (2020)

Review Oncology

Engineering strategies to overcome the current roadblocks in CAR T cell therapy

Sarwish Rafiq et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2020)

Review Biotechnology & Applied Microbiology

'Off-the-shelf' allogeneic CAR T cells: development and challenges

S. Depil et al.

NATURE REVIEWS DRUG DISCOVERY (2020)

Article Oncology

Rapidly Switchable Universal CAR-T Cells for Treatment of CD123-Positive Leukemia

Simon Loff et al.

MOLECULAR THERAPY-ONCOLYTICS (2020)

Article Oncology

41BB-based and CD28-based CD123-redirected T-cells ablate human normal hematopoiesis in vivo

Matteo Libero Baroni et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2020)

Review Hematology

Will CAR T cell therapy have a role in AML? Promises and pitfalls

Katherine D. Cummins et al.

SEMINARS IN HEMATOLOGY (2019)

Article Hematology

Novel monoclonal antibody-based therapies for acute myeloid leukemia

Linde M. Morsink et al.

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2019)

Review Oncology

The Intersection between Tumor Angiogenesis and Immune Suppression

Osama E. Rahma et al.

CLINICAL CANCER RESEARCH (2019)

Article Hematology

How close are we to CAR T-cell therapy for AML?

Saar Gill

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY (2019)

Review Oncology

Allogeneic Hematopoietic Stem Cell Transplantation for Older Patients With Acute Myeloid Leukemia

Rebecca Levin-Epstein et al.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2018)

Article Cell Biology

Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells

Waseem Qasim et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Genetics & Heredity

Methylation of NKG2D ligands contributes to immune system evasion in acute myeloid leukemia

A. Baragano Raneros et al.

GENES AND IMMUNITY (2015)

Article Education, Scientific Disciplines

Allogeneic hematopoietic cell transplantation for acute myeloid leukemia in older adults

Mohamed L. Sorror et al.

HEMATOLOGY-AMERICAN SOCIETY OF HEMATOLOGY EDUCATION PROGRAM (2014)

Article Medicine, Research & Experimental

TanCAR: A Novel Bispecific Chimeric Antigen Receptor for Cancer Immunotherapy

Zakaria Grada et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2013)

Review Biochemistry & Molecular Biology

Dual Roles of Immune Cells and Their Factors in Cancer Development and Progression

Brian F. Zamarron et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2011)