Journal
NATURAL PRODUCT RESEARCH
Volume 30, Issue 21, Pages 2448-2452Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1198352
Keywords
Marine sediment; Pleosporales sp; azaphilone derivative; antifungal activity
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Funding
- Science and Technology Support Project of Baoding [15ZN020]
- Scientific Research Foundation of Hebei Educational committee [QN2016177]
- Hebei University
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A fungal strain, Pleosporales sp. CF09-1, was isolated from marine sediment collected from the Bohai Sea. A novel azaphilone derivative, named pleosporalone A (1), along with two known analogues, cohaerins A and B (2 and 3), were obtained and identified from the culture extract of Pleosporales sp. CF09-1. Their planar structures were elucidated by detailed analysis of spectroscopic data and by comparison with related known compounds. Pleosporalone A (1) represents the first azaphilone derivative characterised with A-ring aromatisation. Compound 1 showed strong antifungal activity against three plant pathogenic fungi Botrytis cinerea, Rhizopus oryzae and Phytophthora capsici with the MIC values of 0.39, 0.78 and 0.78M, respectively. [GRAPHICS] .
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