Journal
NATURAL PRODUCT RESEARCH
Volume 30, Issue 19, Pages 2149-2153Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1146886
Keywords
Syringa pinnatifolia; noralashinol A; anti-inflammatory activity
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Funding
- National Natural Science Foundation of China [81473426, 81303309]
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One new norlignan, namely noralashinol A (1), one known analogue (2), together with seven known lignans (3-9) were isolated from the stem barks of Syringa pinnatifolia. Their structures were elucidated extensively by spectroscopic methods, including mass spectrometry and 1D and 2D NMR spectroscopies. Compound 8 significantly inhibited NO production in LPS-induced BV-2 murine microglia cells with its IC50 value of 20.7M, compared to a positive control quercetin with its IC50 value of 15.3M. [GRAPHICS] .
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