Journal
NATURAL PRODUCT RESEARCH
Volume 31, Issue 5, Pages 523-528Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1198348
Keywords
Diterpenoid alkaloid; pubesine; Aconitum soongaricum var. pubescens; cytotoxic activity
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Funding
- National Natural Science Foundation of China [81402803]
- Science and Technology Support Programs of Sichuan Province [2013SZ0083]
- Research Foundation for Educational Commission of Sichuan Province [15TD0048, 15ZB0140]
- Fundamental Research Funds for Central Universities
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A new denudatine-type C-20-diterpenoid alkaloid, pubesine (1), along with seven known diterpenoid alkaloids, altaconitine (2), 14-benzoylaconine (3), spicatine A (4), 14-benzoylaconine-8-palmitate (5), 14-O-acetylsenbusine A (6), senbusine A (7) and 14-acetylneoline (8) were isolated from the whole plant of Aconitum soongaricum var. pubescens. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and HR-ESI-MS) and comparison with data reported in the literature. All compounds were evaluated for their cytotoxicity against H460, MCF-7 and Hep G2 human cancer cell lines.
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