Journal
NATURAL PRODUCT RESEARCH
Volume 31, Issue 8, Pages 951-958Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1258556
Keywords
Quinoline; 5-hydroxy-8-methoxy-4-phenylisoquinolin-1(2H)-one; Penicillium sp; Nerium indicum
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Funding
- Specialized Research Fund for the Natural Science Basic Research Plan in Shaanxi Province of China [2014JZ003]
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A new isoquinolone alkaloid named 5-hydroxy-8-methoxy-4-phenylisoquinolin-1(2H)-one (3), together with two known quinolinone alkaloids 3-O-methylviridicatin (1) and viridicatol (2) were isolated from the fermentation of an endophytic fungus Penicillium sp. R22 in Nerium indicum. Their structures were elucidated by NMR, IR and MS data, and were also confirmed by comparing with the reported data in the literature. Meanwhile, the antibacterial and antifungal activities of all compounds were tested, and the results showed that three compounds had strong antifungal activity. Among them, compound 2 revealed potent antibacterial activity against Staphylococcus aureus with MIC value of 15.6g/mL.
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