Journal
NATURAL PRODUCT RESEARCH
Volume 31, Issue 11, Pages 1339-1342Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1244193
Keywords
Oroxylin A; PC12 cells; ROS
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Funding
- National Natural Science Foundation [31201908]
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Oroxylin A, a natural flavonoid isolated from Scutellaria baicalensis, has been reported to have anti-inflammatory and antioxidant effects. However, suppression of oxidative stress and neuroapoptosis by oroxylin A is largely uninvestigated. To investigate the protective effects of oroxylin A, PC12 cells were exposed to oroxylin A and hydrogen peroxide solutions and measured. Oroxylin A significantly reduced the levels of intracellular calcium and reactive oxygen species and increased the levels of CAT and Mn/SOD. Oroxylin A also inhibited the activation of caspase-3. These results suggest that treatment of PC12 cells with oroxylin A inhibits H2O2-induced oxidative stress. [GRAPHICS]
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