Journal
NATURAL PRODUCT RESEARCH
Volume 31, Issue 3, Pages 261-267Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1230115
Keywords
Halogenated monoterpenes; human lung cancers; human colon cancers; human leukaemia; Plocamium cartilagineum
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Funding
- National Institute of Health [GM 63554, CA52955]
- NATIONAL CANCER INSTITUTE [U19CA052955, R01CA047135] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM063554] Funding Source: NIH RePORTER
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As a result of our efforts to identify bioactive agents from marine algae, we have isolated and identified one new halogenated monoterpene 1 [(-)-(5E,7Z)-348-trichloro-7-dichloromethyl-3-methyl-157-octatriene] in addition to three known compounds (2, 3 and 4) from the red alga Plocamium cartilagineum collected by hand from the eastern coast of South Africa. Compound 1 was found to be active as a cytotoxic agent in human lung cancer (NCI-H460) and mouse neuro-2a cell lines (IC50 4g/mL). Two of these compounds (3 and 4) were found to have cytotoxic activity in other cell line assays, especially against human leukaemia and human colon cancers (IC50 1.3g/mL). None of these metabolites were active as sodium channel blockers or activators. All structures were determined by spectroscopic methods (UV, IR, LRMS, HRMS, 1D NMR and 2D NMR). 1D and 2D NOE experiments were carried out on these compounds to confirm the geometry of the double bonds. [GRAPHICS] .
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