Journal
NATURAL PRODUCT RESEARCH
Volume 30, Issue 21, Pages 2460-2467Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1201668
Keywords
Streptomycete; secondary metabolites; dipeptide; streptomyceamide C; piperidinedione
Categories
Funding
- Natural Science Foundation of China [81383320]
- Foundation of Guangdong Natural Sciences Committee, China [2015A030312002]
- Fundamental Research Funds for the Central Universities in Jinan University [21612114]
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A new secondary metabolite, (2S,3R)-l-threonine, N-[3-(formylamino)-2-hydroxybenzoyl]-ethyl ester (streptomyceamide C, 1), together with four known compounds 1, 4-dimethyl-3-isopropyl-2,5-piperidinedione (2), cyclo-((S)-Pro-8- hydroxy-(R)-Ile (3), cyclo-((S)-Pro-(R)-Leu (4), and seco-((S)-Pro-(R)-Val) (5), were isolated from the EtOH extract of the fermented mycelium of the marine-derived streptomycete strain H74-21, which was isolated from sea sediment in a mangrove site. The structure of the new compound was established on the basis of its spectroscopic data, including 1D and 2D NMR, HR-TOF-MS. Their antifungal activities against Candida albicans and cytotoxicities against human breast adenocarcinoma cell line MCF-7, human glioblastoma cell line SF-268 and human lung cancer cell line NCI-H460 were tested. Compounds 1 only displayed cytotoxicity against human breast adenocarcinoma cell line MCF-7 with the IC50 value of 27.0g/mL. However, compounds 1-5 do not show antifungal activities at the test concentration of 1mg/mL, and 2-5 have no cytotoxicities at the test concentration of 50g/mL. angustata
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