Journal
NATURAL PRODUCT RESEARCH
Volume 30, Issue 23, Pages 2682-2687Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1146883
Keywords
Pyrrolidine alkaloid; Punigratane; Punica granatum; pomegranate rind; RND efflux pump inhibitor; multidrug resistance; Klebsiella pneumoniae
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A new pyrrolidine alkaloid named Punigratane was isolated from the rind of Punica granatum. This is the first report of a pyrrolidine-like structure from the rind. The activity of this compound was tested in a representative MDR Klebsiella pneumoniae strain which exhibited high efflux pump activity. At a concentration of 6mg, this compound Punigratane was found to have efflux inhibition activity. [GRAPHICS] .
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