4.5 Article

Controversies in Allergy: Are Biologic Treatment Responses in Severe Asthma the Same in Adults and Children?

Related references

Note: Only part of the references are listed.
Article Allergy

Biologics in the treatment of asthma in children and adolescents

Leonard B. Bacharier et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2023)

Article Allergy

Baseline FeNO Independently Predicts the Dupilumab Response in Patients With Moderate-to- Severe Asthma

Ian D. Pavord et al.

Summary: Baseline FeNO levels can serve as a predictive biomarker for treatment response to dupilumab in patients with uncontrolled moderate-to-severe asthma, independent of blood eosinophil levels. Higher baseline FeNO is associated with greater clinical effects of dupilumab, regardless of eosinophil levels.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2023)

Article Allergy

Determinants of lung function across childhood in the Severe Asthma Research Program (SARP) 3

Jonathan M. Gaffin et al.

Summary: This study aimed to identify phenotypic factors associated with FEV1 in children with asthma. The results showed that baseline FENO, response to triamcinolone acetonide, and bronchodilator reversibility were associated with FEV1. Additionally, age, obesity, and exacerbation frequency predicted FEV1 over time. There was also a significant interaction between age and sex, with boys experiencing more significant effects of exacerbation frequency on FEV1 compared to girls.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2023)

Review Allergy

TH17 cells and corticosteroid insensitivity in severe asthma

Yan Xie et al.

Summary: Asthma can be classified into T2 and non-T2 types, with non-T2 asthma being more severe and often unresponsive to treatment. Recent studies suggest that non-T2 asthma is associated with T(H)17 cell immune responses, which may contribute to corticosteroid insensitivity in asthma.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2022)

Review Medicine, General & Internal

Biologic Therapies for Severe Asthma

Guy G. Brusselle et al.

Summary: Biologic therapies may be necessary to reduce the disease burden and risks for severe asthma patients. This review discusses the mechanisms, efficacy, and safety of biologics for severe asthma.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

Article Allergy

Controversies in Allergy: Choosing a Biologic for Patients with Severe Asthma

Ian D. Pavord et al.

Summary: The availability of various biological treatments targeting type-2 inflammation has opened up new possibilities for more severe asthma patients. However, the lack of direct comparative data makes it challenging to select the right biologic for each patient.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

Review Allergy

Difficult-to-Treat Asthma Management in School-Age Children

Andy Bush et al.

Summary: The World Health Organization categorizes severe asthma into three types and estimates the frequency of severe asthma in children. It is essential to carefully evaluate the diagnosis of asthma and utilize objective biomarkers to assess the pathophysiologic phenotypes of severe asthma. Children with difficult-to-treat asthma may require alternative treatment approaches, including asthma biologics. In addition to introducing new medications, advancements in digital health offer the opportunity for closer monitoring to improve treatment response and prevent severe asthma.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2022)

Article Allergy

The Prevalence of Subtypes of Type 2 Inflammation in an Unselected Population of Patients with Severe Asthma

Laurits Frossing et al.

Summary: This study examined the expression levels of T2 inflammatory markers in patients with severe asthma and their relationship with clinical characteristics and comorbidities. The majority of patients exhibited at least one T2 inflammatory trait, and the coexpression of T2 biomarkers showed high heterogeneity with distinct clinical characteristics.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

Article Allergy

Long-Term Therapy Response to Anti-IL-5 Biologics in Severe Asthma-A Real-Life Evaluation

Katrien Eger et al.

Summary: The study found that after 2 years of anti-IL-5 treatment, a favorable response was observed in the majority of severe asthma patients, including partial and super responders. Most partial responders showed impaired lung function or uncontrolled sinonasal disease.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2021)

Article Medicine, General & Internal

Dupilumab in Children with Uncontrolled Moderate-to-Severe Asthma

Leonard B. Bacharier et al.

Summary: This study showed that among children aged 6 to 11 with uncontrolled moderate-to-severe asthma, those who received add-on dupilumab had fewer asthma exacerbations, better lung function and asthma control compared to those who received placebo.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Review Medicine, General & Internal

Atopic Dermatitis

Sonja Staender

Summary: Atopic dermatitis is a chronic condition that typically begins in childhood and can persist into adulthood, with treatment options including both topical and systemic approaches targeting the underlying immune condition.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Tezepelumab in Adults and Adolescents with Severe, Uncontrolled Asthma

Andrew Menzies-Gow et al.

Summary: Tezepelumab, a monoclonal antibody targeting thymic stromal lymphopoietin, effectively reduces asthma exacerbations in patients with severe, uncontrolled asthma, leading to improved lung function, asthma control, and quality of life.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Critical Care Medicine

Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial

Joseph K. Han et al.

Summary: The study aimed to evaluate the efficacy and safety of mepolizumab in adults with recurrent, refractory severe bilateral chronic rhinosinusitis with nasal polyps. Results showed that mepolizumab treatment significantly improved nasal polyp size and nasal obstruction symptoms, with fewer adverse events.

LANCET RESPIRATORY MEDICINE (2021)

Article Allergy

Investigation of the relationship between IL-6 and type 2 biomarkers in patients with severe asthma

Xingnan Li et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Article Allergy

Serum IL-6: A biomarker in childhood asthma?

Daniel J. Jackson et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Article Allergy

Efficacy and safety of omalizumab in nasal polyposis: 2 randomized phase 3 trials

Philippe Gevaert et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2020)

Letter Allergy

Children with severe persistent asthma have disparate peripheral blood and lower airway eosinophil levels

Victoria Ribeiro et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2019)

Letter Allergy

Efficacy of add-on mepolizumab in adolescents with severe eosinophilic asthma

Steven W. Yancey et al.

ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY (2019)

Article Medicine, General & Internal

Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma

Klaus F. Rabe et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

M. Castro et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Respiratory System

Baseline patient factors impact on the clinical efficacy of benralizumab for severe asthma

Eugene R. Bleecker et al.

EUROPEAN RESPIRATORY JOURNAL (2018)

Review Allergy

Omalizumab in children with uncontrolled allergic asthma: Review of clinical trial and real-world experience

Bradley E. Chipps et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2017)

Article Medicine, General & Internal

Oral Glucocorticoid-Sparing Effect of Benralizumab in Severe Asthma

Parameswaran Nair et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Critical Care Medicine

A Distinct Low Lung Function Trajectory from Childhood to the Fourth Decade of Life

Cristine E. Berry et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)

Article Allergy

Assessment of corticosteroid response in pediatric patients with severe asthma by using a multidomain approach

Cara J. Bossley et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Letter Allergy

Anaphylactic reactions associated with omalizumab administration: Analysis of a case-control study

Phillip L. Lieberman et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Article Allergy

Asthma phenotypes in inner-city children

Edward M. Zoratti et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

Article Allergy

Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations

Stephen J. Teach et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2015)

Article Medicine, General & Internal

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

Elisabeth H. Bel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Medicine, General & Internal

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

Hector G. Ortega et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Critical Care Medicine

Exploring the Effects of Omalizumab in Allergic Asthma An Analysis of Biomarkers in the EXTRA Study

Nicola A. Hanania et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2013)

Article Allergy

Reassessment of Omalizumab-Dosing Strategies and Pharmacodynamics in Inner-City Children and Adolescents

Christine A. Sorkness et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE (2013)

Article Medicine, General & Internal

Omalizumab in Severe Allergic Asthma Inadequately Controlled With Standard Therapy A Randomized Trial

Nicola A. Hanania et al.

ANNALS OF INTERNAL MEDICINE (2011)

Article Medicine, General & Internal

Randomized Trial of Omalizumab (Anti-IgE) for Asthma in Inner-City Children

William W. Busse et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Article Critical Care Medicine

Identification of Asthma Phenotypes Using Cluster Analysis in the Severe Asthma Research Program

Wendy C. Moore et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)