Journal
NATURAL PRODUCT RESEARCH
Volume 30, Issue 15, Pages 1690-1697Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2015.1135143
Keywords
Clausena excavata; carbazole alkaloids; Rutaceae; cytotoxic activity
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Funding
- Department of Chemistry, Faculty of Science, Prince of Songkla University
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A carbazole-pyranocoumarin conjugate, carbazomarin B (1), and two carbazole alkaloids, 6-methoxymukonidine (2) and 2-hydroxy-3-methoxycarbazole (3), together with 27 known compounds (4-30), were isolated from the stems of Clausena excavata. Their structures have been elucidated by spectroscopic analyses. Compound 2 showed moderate cytotoxicity to HuCCA-1, MOLT-3 and HepG2 cancer cell lines with IC50 values of 15.09-28.50 mu g/mL, but none to A549 cell line. Heptaphylline (6) and nordentatin (23) were found to show moderate cytotoxic activity against HepG2 cell line with IC50 values of 12.33 and 11.33, respectively, while clausine K (27) exhibited strong cytotoxicity with IC50 value of 1.05 mu g/mL, better than a standard drug (etoposide, IC50 13.40 mu g/mL). [GRAPHICS] .
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