Journal
NATURAL PRODUCT RESEARCH
Volume 31, Issue 10, Pages 1214-1218Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1226832
Keywords
Diospyros lotus; Ebenaceae; di-naphthodiospyrol M; urease inhibitory activity; molecular docking
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Funding
- Higher Education Commission of Pakistan [21:619/SRGP/RD/HEC/2014]
- Deanship of Scientific Research at king Saud University [RG-007-2016]
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The dimeric napthoquione 5,8,4-trihydroxy-1-methoxy-6, 6-dimethyl-7,3-binaphtyl-1,4,5,8-tetraone (1) was isolated from the chloroform fraction of Diospyros lotus extract. Compound 1 was screened for its inhibitory effects against four enzymes: urease, phosphodiesterase-I, carbonic anhydrase-II and -chymotrypsin, and showed selective activity against urease enzyme with an IC50 value of 254.1 +/- 3.82M as compared to the standard thiourea (IC50=21 +/- 0.11M). Furthermore, in silico docking study was carried out to explain the molecular mechanism of compound 1 against the target receptor.
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