Journal
NATURAL PRODUCT RESEARCH
Volume 31, Issue 7, Pages 758-764Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1242002
Keywords
Engyodontium album; phenylacetate derivative; benzoate derivative; antibacterial
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Funding
- Scientific Research Foundation of Third Institute of Oceanography, SOA [2014007]
- Special Financial Fund of Innovative Development of Marine Economic Demonstration Project [GD2012-D01-001]
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Two new benzoate derivatives, ethyl 3,5-dimethoxy-2-propionylbenzoate (1) and ethyl 3,5-dihydroxy-2-propionylbenzoate (2), and one new phenylacetate derivative, ethyl 3,5-dimethoxy-2-propionylphenylacetate (3), together with 9 known compounds, were isolated from the fermentation of Engyodontium album derived from deep sea sediment. Their structures were elucidated by spectroscopic techniques, such as NMR, IR and HRESIMS. Compound 3 exhibited inhibitory activities against methicillin-resistant Staphylococcus aureus ATCC 43300 (MRSA) and Vibrio vulnificus, with MIC values of 7.8 and 15.6g/mL, respectively.
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