4.6 Article

Gad1 knock-out rats exhibit abundant spike-wave discharges in EEG, exacerbated with valproate treatment

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Rats deficient in the GAD65 isoform exhibit epilepsy and premature lethality

Toshikazu Kakizaki et al.

Summary: GAD65 deficiency causes different phenotypes between rats and mice, with Gad2(-/-) rats being more severely affected and exhibiting more severe symptoms such as epilepsy and premature death. Considering the similarity of GAD65/GAD67 ratio in human brains to that in rat brains, Gad2(-/-) rats would be useful for further investigating the roles of GAD65 in vivo.

FASEB JOURNAL (2021)

Article Behavioral Sciences

Heterogeneous GAD65 Expression in Subtypes of GABAergic Neurons Across Layers of the Cerebral Cortex and Hippocampus

Yuki Kajita et al.

Summary: This study compared GAD65 expression among six GABAergic subtypes, revealing high-expression and low-expression groups in the cerebral cortex and hippocampus. Different GABAergic subtypes exhibit distinct GAD65 expression patterns in the layers of the cerebral cortex and hippocampus, with GAD65 expression in the soma serving as a proxy for cytoplasmic GAD65 levels.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2021)

Article Biochemistry & Molecular Biology

Impact of Dysfunctional Feed-Forward Inhibition on Glutamate Decarboxylase Isoforms and γ-Aminobutyric Acid Transporters

Sandesh Panthi et al.

Summary: Absence seizures are characterized by alterations in awareness associated with 2.5-4 Hz spike-wave discharges, with childhood absence epilepsy (CAE) being a common manifestation. Changes in GABA levels and receptors within the cortico-thalamocortical network are implicated in the pathophysiology of absence seizures, with upregulation of GAD65 in the somatosensory cortex potentially serving as a compensatory response to chronic seizures in epileptic stargazers.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Neurosciences

Spontaneous Recurrent Absence Seizure-like Events in Wild-Caught Rats

Jeremy A. Taylor et al.

JOURNAL OF NEUROSCIENCE (2019)

Review Neurosciences

GABA receptors and T-type Ca2+ channels crosstalk in thalamic networks

Nathalie Leresche et al.

NEUROPHARMACOLOGY (2018)

Article Multidisciplinary Sciences

Enhanced susceptibility to stress and seizures in GAD65 deficient mice

Jin Qi et al.

PLOS ONE (2018)

Article Multidisciplinary Sciences

The generation mechanism of spike-and-slow wave discharges appearing on thalamic relay nuclei

Bing Hu et al.

SCIENTIFIC REPORTS (2018)

Article Neurosciences

Voluntary Control of Epileptiform Spike-Wave Discharges in Awake Rats

Jeremy A. Taylor et al.

JOURNAL OF NEUROSCIENCE (2017)

Article Neurosciences

Lack of Intrinsic GABAergic Connections in the Thalamic Reticular Nucleus of the Mouse

Guoqiang Hou et al.

JOURNAL OF NEUROSCIENCE (2016)

Review Biology

Extrasynaptic release of GABA and dopamine by retinal dopaminergic neurons

Hajime Hirasawa et al.

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2015)

Article Neurosciences

GABAA, NMDA and mGlu2 receptors tonically regulate inhibition and excitation in the thalamic reticular nucleus

John W. Crabtree et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2013)

Article Neurosciences

The zona incerta modulates spontaneous spike-wave discharges in the rat

Fu-Zen Shaw et al.

JOURNAL OF NEUROPHYSIOLOGY (2013)

Article Behavioral Sciences

No response to acoustic stimuli: Absence or akinetic seizure?

Jan Remi et al.

EPILEPSY & BEHAVIOR (2011)

Article Endocrinology & Metabolism

Knockout of GAD65 has major impact on synaptic GABA synthesized from astrocyte-derived glutamine

Anne B. Walls et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2011)

Article Clinical Neurology

Epilepsy and the Consciousness System: Transient Vegetative State?

Hal Blumenfeld

NEUROLOGIC CLINICS (2011)

Article Pharmacology & Pharmacy

Effects of Antiepileptics on Behavioral and Electroencephalographic Seizure Induced by Pentetrazol in Mice

Yusuke Watanabe et al.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2010)

Article Veterinary Sciences

Optimized single electroencephalogram channel sleep staging in rats

Guangzhan Fang et al.

LABORATORY ANIMALS (2010)

Article Multidisciplinary Sciences

A gain in GABAA receptor synaptic strength in thalamus reduces oscillatory activity and absence seizures

Claude M. Schofield et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Clinical Neurology

Predictability analysis of absence seizures with permutation entropy

Xiaoli Li et al.

EPILEPSY RESEARCH (2007)

Review Neurosciences

The thalamic reticular nucleus: structure, function and concept

D Pinault

BRAIN RESEARCH REVIEWS (2004)

Review Behavioral Sciences

Genetic animal models for absence epilepsy: A review of the WAG/Rij strain of rats

AML Coenen et al.

BEHAVIOR GENETICS (2003)

Article Behavioral Sciences

Ictal stimulus processing during spike-wave discharges in genetic epileptic rats

WHIM Drinkenburg et al.

BEHAVIOURAL BRAIN RESEARCH (2003)

Article Neurosciences

Thalamcortical optimization of tactile processing according to behavioral state

MAL Nicolelis et al.

NATURE NEUROSCIENCE (2002)