Economic and social values in the brain: evidence from lesions to the human ventromedial prefrontal cortex

Making good economic and social decisions is essential for individual and social welfare. Decades of research have provided compelling evidence that damage to the ventromedial prefrontal cortex (vmPFC) is associated with dramatic personality changes and impairments in economic and social decision-making. However, whether the vmPFC subserves a unified mechanism in the social and non-social domains remains unclear. When choosing between economic options, the vmPFC is thought to guide decision by encoding value signals that reflect the motivational relevance of the options on a common scale. A recent framework, the extended common neural currency hypothesis, suggests that the vmPFC may also assign values to social factors and principles, thereby guiding social decision-making. Although neural value signals have been observed in the vmPFC in both social and non-social studies, it is yet to be determined whether they have a causal influence on behavior or merely correlate with decision-making. In this review, we assess whether lesion studies of patients with vmPFC damage offer evidence for such a causal role of the vmPFC in shaping economic and social behavior.

Automated summary

Damage to the vmPFC is associated with personality changes and impairments in decision-making. The vmPFC may play a unified role in guiding decisions in both social and non-social domains, but the exact mechanism is unclear. Assessing the effects of vmPFC damage in patients can help determine its causal role in shaping economic and social behavior.