Journal
NATURAL PRODUCT RESEARCH
Volume 31, Issue 6, Pages 639-644Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786419.2016.1217203
Keywords
Secondary metabolites; Streptomyces; nactins; Lake Baikal
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Funding
- Federal Agency for Scientific Organizations (FASO Russia) [0345-2014-0004 (VI.55.1.3), 0345-2014-0006 (VI.61.1)]
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The potential antibacterial activity of secondary metabolites produced by Streptomyces sp. 156A isolated from Lake Baikal was investigated. The selective liquid-liquid extraction method was applied to obtain a mixture of nactins (polynactin) produced by the strain. The polynactin consisted of nonactin (3%), monactin (18%), dinactin (36%), trinactin (31%) and tetranactin (12%). The compounds were identified by MS/MS, H-1 and C-13 NMR methods. The loss of neutral 184 and 198 Da fragments from a sodiated molecular ion, [M + Na](+), of nactins was observed in the MS/MS spectrum. The polynactin was shown to possess the antibiotic activity against Gram-positive strains including opportunistic strains and strains isolated from various ecosystems of Lake Baikal. [GRAPHICS] .
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