Journal
NATURAL PRODUCT REPORTS
Volume 33, Issue 2, Pages 141-149Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5np00092k
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Funding
- NIH [GM106112]
- Welch Foundation [F-1712]
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Most of the stereocenters of polyketide natural products are established during assembly line biosynthesis. The body of knowledge for how stereocenters are set is now large enough to begin constructing physical models of key reactions. Interactions between stereocenter-forming enzymes and polyketide intermediates are examined here at atomic resolution, drawing from the most current structural and functional information of ketosynthases (KSs), ketoreductases (KRs), dehydratases (DHs), enoylreductases (ERs), and related enzymes. While many details remain to be experimentally determined, our understanding of the chemical and physical mechanisms utilized by the chirality-molding enzymes of modular PKSs is rapidly advancing.
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