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Standardization for natural product synthetic biology

Journal

NATURAL PRODUCT REPORTS
Volume 33, Issue 8, Pages 920-924

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c6np00030d

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Funding

  1. VENI grant from Netherlands Organization for Scientific Research (NWO) [863.15.002]
  2. U.S. National Institutes of Health [GM077596]

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Standardization is one of the foundational features of modern-day engineering, and the use of standardized parts and processes is a key element that distinguishes bona fide synthetic biology from traditional genetic engineering. Here, we discuss the role of standardization in natural product synthetic biology, focusing on standardization of data on biosynthetic pathways and gene clusters, as well as the role of standardization in the process of biosynthetic gene cluster engineering.

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