4.8 Review

Progress of PD-1/PD-L1 signaling in immune response to liver transplantation for hepatocellular carcinoma

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Prognostic implication of early posttransplant hypercholesterolemia in liver transplantation for patients with hepatocellular carcinoma

Rong-Li Wei et al.

Summary: This study aimed to evaluate the predictive ability of early posttransplant dyslipidemia on the prognosis of hepatocellular carcinoma (HCC) patients after liver transplantation (LT). Through retrospective analysis of 806 HCC patients from the China Liver Transplant Registry database, it was found that early posttransplant hypercholesterolemia was negatively correlated with the risk of recurrence, and borderline hypercholesterolemia indicated a better prognosis, especially in patients beyond Milan criteria but within Hangzhou criteria.

HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL (2023)

Review Immunology

Immune Checkpoint Inhibitors in Solid Organ Transplant Recipients With Advanced Skin Cancers-Emerging Strategies for Clinical Management

Carla Ferrandiz-Pulido et al.

Summary: The use of ICIs in solid organ transplant recipients with advanced skin cancers is a clinical challenge. While kidney transplant recipients can benefit from ICIs as a first-line treatment, for other transplant recipients the use of ICIs should be carefully considered on a case-by-case basis, weighing the benefits against the risk of allograft rejection.

TRANSPLANTATION (2023)

Review Gastroenterology & Hepatology

Liver transplantation immunology: Immunosuppression, rejection, and immunomodulation

Aldo J. Montano-Loza et al.

Summary: The outcomes of liver transplantation have improved over the years, but long-term survival rates are still lower than the general population. The liver has unique immunological functions and can modulate the recipient's immune system to promote tolerance. Immunosuppressive drugs should be individualized to control alloreactivity while minimizing toxicities.

JOURNAL OF HEPATOLOGY (2023)

Review Immunology

Mechanisms of drug resistance to immune checkpoint inhibitors in non-small cell lung cancer

Kexun Zhou et al.

Summary: Immune checkpoint inhibitors (ICIs) have shown great promise in prolonging the survival of patients with advanced non-small cell lung cancer (NSCLC). However, resistance to ICIs remains a challenge, with different mechanisms and tumor microenvironment playing a critical role.

FRONTIERS IN IMMUNOLOGY (2023)

Article Oncology

Real-world 10-year retrospective study of the guidelines for diagnosis and treatment of primary liver cancer in China

Yun-Wei Yan et al.

Summary: This study analyzed the current situation and problems associated with the Guidelines for Diagnosis and Treatment of Primary Liver Cancer in China. The study found that early diagnosis and treatment can be achieved by screening high-risk groups, but real-world compliance is poor.

WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY (2023)

Review Oncology

The Liver-Immunity Nexus and Cancer Immunotherapy

James C. Lee et al.

Summary: Liver metastases have a significant impact on the effectiveness of immune checkpoint inhibitors in patients with solid-tumor malignancies. Multiple clinical and translational studies have shown that liver metastasis leads to systemic immune suppression through the generation of suppressive macrophages and activation of regulatory T-cells. Various interventions, such as radiation therapy and combination checkpoint blockade, have been reported to address liver immune suppression.

CLINICAL CANCER RESEARCH (2022)

Review Oncology

Resident Immune Cells of the Liver in the Tumor Microenvironment

Yunjie Lu et al.

Summary: The liver plays a crucial role in maintaining a balance between protection and immunotolerance, and the deregulation of the immunological network in hepatocellular carcinoma (HCC) is a hallmark of its pathogenesis. The immune response in the liver involves various immune cells and is modulated by continuous exposure to toxic molecules and microorganisms. Understanding the roles of different resident immune cell subsets and their interaction in HCC pathogenesis may lead to the identification of new biomarkers and therapy options.

FRONTIERS IN ONCOLOGY (2022)

Review Chemistry, Analytical

Dostarlimab as a Miracle Drug: Rising Hope against Cancer Treatment

Vanshikha Singh et al.

Summary: Immunotherapy, especially the use of anti-PD-1 monoclonal antibody Dostarlimab, has shown promising results in various cancer treatments, with complete cure observed in colorectal cancer patients. This review emphasizes the mechanism of action of immunotherapy and discusses the ongoing clinical trials and combination therapies involving Dostarlimab to provide insights for future clinicians and researchers.

BIOSENSORS-BASEL (2022)

Article Biochemistry & Molecular Biology

Impact of nitric oxide in liver cancer microenvironment

Sandra Dios-Barbeito et al.

Summary: The regulation of nitric oxide generation in the tumor microenvironment plays a crucial role in hepatocellular carcinoma. The increased expression of NOS2 is associated with poor prognosis, yet the functional relevance seems to be influenced by different etiologies.

NITRIC OXIDE-BIOLOGY AND CHEMISTRY (2022)

Review Microbiology

Advances in multi-omics research on viral hepatitis

Ze Xiang et al.

Summary: Viral hepatitis is a significant global public health problem that affects millions of people and has high morbidity and mortality. Multi-omics analysis has been widely used in studying the origin, diagnosis, and treatment targets of viral hepatitis.

FRONTIERS IN MICROBIOLOGY (2022)

Article Biochemistry & Molecular Biology

PD-L1-Mediated Immunosuppression in Hepatocellular Carcinoma: Relationship with Macrophages Infiltration and Inflammatory Response Activity

Shuang Guo et al.

Summary: Immune dysfunction and pro-oncogenic inflammation play critical roles in malignant progression and non-response to immunotherapy for hepatocellular carcinoma (HCC). In this study, the intercommunication between PD-L1 and the immunosuppressive tumor microenvironment (TME) and inflammatory response activity in HCC was investigated. Additionally, potential therapeutic drugs were predicted to improve the current therapeutic strategy for specific HCC patients.

BIOMOLECULES (2022)

Article Medicine, General & Internal

Predicting survival for hepatic arterial infusion chemotherapy of unresectable colorectal liver metastases: Radiomics analysis of pretreatment computed tomography

Peng Liu et al.

Summary: This study demonstrates that a radiomics approach based on pretreatment CT texture analysis has the ability to predict the outcome of HAIC in patients with advanced unresectable colorectal cancer with a high degree of accuracy and feasibility.

JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE (2022)

Article Medicine, General & Internal

Dysregulation of miR-144-5p/RNF187 axis contributes to the progression of colorectal cancer

Zhuo Gao et al.

Summary: This study reveals the upregulation of RNF187 in colorectal cancer (CRC) and its association with poor prognosis. Inhibition of RNF187 expression suppresses the proliferation, migration, and invasion while promoting apoptosis of CRC cells. miR-144-5p is identified as a direct target of RNF187, and its downregulation in CRC tissues is negatively correlated with RNF187 expression. Restoration of miR-144-5p significantly inhibits CRC cell progression, which can be abolished by overexpression of RNF187.

JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE (2022)

Article Gastroenterology & Hepatology

Gut microbiota dysbiosis in Chinese children with type 1 diabetes mellitus: An observational study

Xia Liu et al.

Summary: The study revealed significant increase in bacterial diversity and changes in microbial composition in gut microbiota of children with T1DM. Certain taxa were found to be positively correlated with fasting blood glucose while others were negatively correlated, suggesting their potential use as diagnostic biomarkers. Additionally, functional changes in the gut microbiota were associated with altered metabolic activities, possibly playing crucial roles in the development of T1DM.

WORLD JOURNAL OF GASTROENTEROLOGY (2021)

Review Immunology

Downstaging treatment for patients with hepatocelluar carcinoma before transplantation

Guangjiang Jiang et al.

Summary: Liver transplantation is a radical method for treating unresectable liver cancer, with favorable prognosis for eligible patients but less satisfactory outcomes for those exceeding criteria. Downstaging treatment shows promise in reducing tumor burden to within transplant criteria, although issues such as inclusion criteria, treatment method choice, and endpoint of downstaging need further discussion.

TRANSPLANTATION REVIEWS (2021)

Review Infectious Diseases

Extrahepatic manifestations related to hepatitis E virus infection and their triggering mechanisms

Jian Wu et al.

Summary: Hepatitis E virus (HEV) infection has various extrahepatic manifestations affecting multiple organ systems, indicating it should be considered as a systemic disease. Different genotypes of HEV can induce different extrahepatic manifestations, and the severity of these diseases does not necessarily correlate with the severity of HEV infection. Antiviral therapy may alleviate or improve the extrahepatic manifestations related to HEV infection.

JOURNAL OF INFECTION (2021)

Review Gastroenterology & Hepatology

Gastrointestinal adverse events associated with immune checkpoint inhibitor therapy

Eva Rajha et al.

GASTROENTEROLOGY REPORT (2020)

Review Biochemistry & Molecular Biology

Role of the tumor microenvironment in PD-L1/PD-1-mediated tumor immune escape

Xianjie Jiang et al.

MOLECULAR CANCER (2019)

Review Medicine, Research & Experimental

The immunoregulation of mesenchymal stem cells plays a critical role in improving the prognosis of liver transplantation

Chenxia Hu et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2019)

Editorial Material Gastroenterology & Hepatology

Pembrolizumab for metastatic hepatocellular carcinoma following live donor liver transplantation: The silver bullet?

Ashwin Rammohan et al.

HEPATOLOGY (2018)

Review Immunology

The function and dysfunction of memory CD8+ T cells in tumor immunity

James L. Reading et al.

IMMUNOLOGICAL REVIEWS (2018)

Review Gastroenterology & Hepatology

Use of checkpoint inhibitors in liver transplant recipients

Stefan Munker et al.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2018)

Article Oncology

Distinct predictive biomarker candidates for response to anti-CTLA-4 and anti-PD-1 immunotherapy in melanoma patients

Priyanka B. Subrahmanyam et al.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2018)

Article Surgery

OPTN/SRTR 2015 Annual Data Report: Liver

W. R. Kim et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2017)

Letter Gastroenterology & Hepatology

Preserved Liver Transplant After PD-1 Pathway Inhibitor for Hepatocellular Carcinoma

Andreas Varkaris et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2017)

Article Gastroenterology & Hepatology

Counter-regulation of rejection activity against human liver grafts by donor PD-L1 and recipient PD-1 interaction

Xiao-Lei Shi et al.

JOURNAL OF HEPATOLOGY (2016)

Article Gastroenterology & Hepatology

Global patterns of hepatocellular carcinoma management from diagnosis to death: the BRIDGE Study

Joong-Won Park et al.

LIVER INTERNATIONAL (2015)

Review Medicine, General & Internal

Recent advances in the field of anti-cancer immunotherapy

Henrique Neves et al.

BBA CLINICAL (2015)

Review Oncology

PD-1 as an Immune Modulatory Receptor

Sheng Yao et al.

CANCER JOURNAL (2014)

Article Surgery

PD-1/B7-H1 Interaction Contribute to the Spontaneous Acceptance of Mouse Liver Allograft

M. Morita et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2010)

Review Immunology

Immune tolerance: What is unique about the liver

Gisa Tiegs et al.

JOURNAL OF AUTOIMMUNITY (2010)

Review Immunology

Multiple roles for CD4(+) T cells in anti-tumor immune responses

Richard Kennedy et al.

IMMUNOLOGICAL REVIEWS (2008)

Review Rheumatology

Apoptosis: Programmed cell death at a molecular level

DR Schultz et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2003)

Review Pharmacology & Pharmacy

T-helper type 2 cell-directed therapy for asthma

L Cohn et al.

PHARMACOLOGY & THERAPEUTICS (2000)