☆ 4.8 Review

Emerging role of METTL3 in inflammatory diseases: mechanisms and therapeutic applications

FRONTIERS IN IMMUNOLOGY (2023)

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Article Cell Biology

METTL3/N6-methyladenosine/ miR-21-5p promotes obstructive renal fibrosis by regulating inflammation through SPRY1/ERK/NF-κB pathway activation

Erpeng Liu et al.

Summary: Our research demonstrates that miR-21-5p and m(6)A modification are significantly increased in obstructive renal fibrosis, with miR-21-5p playing a crucial role in enhancing inflammation through activation of the SPRY1/ERK/NF-kB pathway. Additionally, METTL3 promotes obstructive renal fibrosis by driving maturation of miR-21-5p, thus providing a deeper understanding of the mechanism underlying renal fibrosis.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

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Article Medicine, Research & Experimental

METTL3 involves the progression of osteoarthritis probably by affecting ECM degradation and regulating the inflammatory response

Weilin Sang et al.

Summary: The study identified decreased expression of the m6A methylation gene METTL3 in osteoarthritis, suggesting its involvement in regulating the inflammatory response in OA. Overexpression of METTL3 may impact extracellular matrix degradation in OA through modulation of the balance between TIMPs and MMPs.

LIFE SCIENCES (2021)

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Article Multidisciplinary Sciences

METTL3-mediated m6A RNA methylation promotes the anti-tumour immunity of natural killer cells

Hao Song et al.

Summary: The m(6)A methylation protects the homeostasis and tumor immunosurveillance function of NK cells.

NATURE COMMUNICATIONS (2021)

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Article Pharmacology & Pharmacy

Total Flavones of Abelmoschus manihot Ameliorates Podocyte Pyroptosis and Injury in High Glucose Conditions by Targeting METTL3-Dependent m6A Modification-Mediated NLRP3-Inflammasome Activation and PTEN/PI3K/Akt Signaling

Bu-Hui Liu et al.

Summary: The study showed that TFA protected podocytes from pyroptosis and injury induced by high glucose by regulating m(6)A modification, NLRP3 inflammasome activation, and PTEN/PI3K/Akt signaling.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Cell Biology

N6-Methyladenosine RNA Modification in Inflammation: Roles, Mechanisms, and Applications

Jiahui Luo et al.

Summary: m6A modification plays a crucial role in regulating post-transcriptional expression of target genes and is associated with various inflammatory states, including autoimmunity, infection, metabolic disease, cancer, neurodegenerative diseases, heart diseases, and bone diseases. Despite the significant potential of m6A as a biomarker and therapeutic target for inflammatory diseases, systematic knowledge of the relationship between m6A modification and inflammation in human diseases remains unclear.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Medicine, General & Internal

METTL3 Promotes Activation and Inflammation of FLSs Through the NF-κB Signaling Pathway in Rheumatoid Arthritis

Wen Shi et al.

Summary: METTL3 plays a crucial role in rheumatoid arthritis by promoting FLS activation and inflammatory response via the NF-kappa B signaling pathway.

FRONTIERS IN MEDICINE (2021)

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Article Oncology

Histone demethylase JMJD1C promotes the polarization of M1 macrophages to prevent glioma by upregulating miR-302a

Chuanhong Zhong et al.

Summary: JMJD1C is found to be poorly expressed in glioma tissues, and it increases miR-302a expression by promoting H3K9me1 demethylation, thereby inhibiting the growth of glioma. JMJD1C promotes M1 macrophage polarization through the miR-302a/METTL3/SOCS2 axis, potentially serving as a novel targeted therapeutic approach for glioma.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

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Letter Medicine, General & Internal

Pathophysiology of Inflammatory Bowel Diseases

Chung-Jen Chen et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Biochemistry & Molecular Biology

Treatment with cinnamaldehyde reduces the visceral adiposity and regulates lipid metabolism, autophagy and endoplasmic reticulum stress in the liver of a rat model of early obesity

Jessika Geisebel Oliveira Neto et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2020)

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Article Genetics & Heredity

Dendritic cells with METTL3 gene knockdown exhibit immature properties and prolong allograft survival

Hongbing Wu et al.

GENES AND IMMUNITY (2020)

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Article Immunology

IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome

Min Guo et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Review Biochemistry & Molecular Biology

Pathophysiology of Type 2 Diabetes Mellitus

Unai Galicia-Garcia et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Pharmacology & Pharmacy

Resveratrol Attenuates High-Fat Diet Induced Hepatic Lipid Homeostasis Disorder and Decreases m6A RNA Methylation

Jiamin Wu et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Genetics & Heredity

Implication of m6A mRNA Methylation in Susceptibility to Inflammatory Bowel Disease

Maialen Sebastian-delaCruz et al.

EPIGENOMES (2020)

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Review Urology & Nephrology

Epigenetics and epigenomics in diabetic kidney disease and metabolic memory

Mitsuo Kato et al.

NATURE REVIEWS NEPHROLOGY (2019)

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Review Pharmacology & Pharmacy

Hyperuricemia and Cardiovascular Disease

Shuangshuang Zhang et al.

CURRENT PHARMACEUTICAL DESIGN (2019)

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Review Physiology

THE NEUTROPHIL'S ROLE DURING HEALTH AND DISEASE

Pei Xiong Liew et al.

PHYSIOLOGICAL REVIEWS (2019)

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Review Immunology

The pathogenicity of Th17 cells in autoimmune diseases

Keiko Yasuda et al.

SEMINARS IN IMMUNOPATHOLOGY (2019)

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Article Multidisciplinary Sciences

Mettl3-mediated mRNA m6A methylation promotes dendritic cell activation

Huamin Wang et al.

NATURE COMMUNICATIONS (2019)

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Article Cell Biology

The N6-methyladenosine (m6A)-forming enzyme METTL3 facilitates M1 macrophage polarization through the methylation of STAT1 mRNA

Yihan Liu et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2019)

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Article Pathology

Diversity, Mechanisms, and Significance of Macrophage Plasticity

Massimo Locati et al.

Annual Review of Pathology-Mechanisms of Disease (2019)

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Article Biochemistry & Molecular Biology

METTL3 promotes experimental osteoarthritis development by regulating inflammatory response and apoptosis in chondrocyte

Qingbai Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

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Review Cell Biology

Reading, writing and erasing mRNA methylation

Sara Zaccara et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Article Cell Biology

METTL3 Attenuates LPS-Induced Inflammatory Response in Macrophages via NF-κB Signaling Pathway

Jinghua Wang et al.

MEDIATORS OF INFLAMMATION (2019)

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Article Biochemistry & Molecular Biology

Chronic inflammation in the etiology of disease across the life span

David Furman et al.

NATURE MEDICINE (2019)

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Review Cell Biology

Reading, writing and erasing mRNA methylation

Sara Zaccara et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

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Review Immunology

Monocyte and macrophage immunometabolism in atherosclerosis

Laszlo Groh et al.

SEMINARS IN IMMUNOPATHOLOGY (2018)

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Article Cell Biology

METTL3 regulates alternative splicing of MyD88 upon the lipopolysaccharide-induced inflammatory response in human dental pulp cells

Zhihui Feng et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

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Review Cell Biology

Macrophage plasticity, polarization, and function in health and disease

Abbas Shapouri-Moghaddam et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

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Review Medicine, General & Internal

Sepsis and septic shock

Maurizio Cecconi et al.

LANCET (2018)

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Article Biochemistry & Molecular Biology

Osteoarthritis as a disease of the cartilage pericellular matrix

Farshid Guilak et al.

MATRIX BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal

Jing Wen et al.

MOLECULAR CELL (2018)

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Article Cell Biology

Recognition of RNA N6- methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Huilin Huang et al.

NATURE CELL BIOLOGY (2018)

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Article Biochemistry & Molecular Biology

Interactions, localization, and phosphorylation of the m6A generating METTL3-METTL14-WTAP complex

Eva Schoeller et al.

RNA (2018)

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Article Multidisciplinary Sciences

Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1

Baixing Wu et al.

NATURE COMMUNICATIONS (2018)

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Article Medicine, General & Internal

Rheumatoid arthritis

Nature Reviews Disease Primers (2018)

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Article Medicine, General & Internal

Relationship between oxidative stress and inflammation in hyperuricemia Analysis based on asymptomatic young patients with primary hyperuricemia

You Zhou et al.

MEDICINE (2018)

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Article Oncology

A comparative study of anti-aging properties and mechanism: resveratrol and caloric restriction

Juan Li et al.

ONCOTARGET (2017)

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Article Cell Biology

Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesis

Phillip J. Hsu et al.

CELL RESEARCH (2017)

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Article Immunology

A guiding map for inflammation

Mihai G. Netea et al.

NATURE IMMUNOLOGY (2017)

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Review Biochemistry & Molecular Biology

Dynamic RNA Modifications in Gene Expression Regulation

Ian A. Roundtree et al.

CELL (2017)

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Article Biochemistry & Molecular Biology

The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron Retention

Kathryn E. Pendleton et al.

CELL (2017)

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Article Immunology

Homeostasis-altering molecular processes as mechanisms of inflammasome activation

Adrian Liston et al.

NATURE REVIEWS IMMUNOLOGY (2017)

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Review Cell Biology

Macrophage polarization: the link between inflammation and related diseases

Samina Bashir et al.

INFLAMMATION RESEARCH (2016)

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Article Cardiac & Cardiovascular Systems

Regulation of uric acid metabolism and excretion

Jessica Maiuolo et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2016)

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Article Medicine, General & Internal

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

Mervyn Singer et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

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Article Biochemistry & Molecular Biology

Nuclear m6A Reader YTHDC1 Regulates mRNA Splicing

Wen Xiao et al.

MOLECULAR CELL (2016)

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Article Multidisciplinary Sciences

Structural basis of N6-adenosine methylation by the METTL3-METTL14 complex

Xiang Wang et al.

NATURE (2016)

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Article Multidisciplinary Sciences

m6A RNA methylation promotes XIST-mediated transcriptional repression

Deepak P. Patil et al.

NATURE (2016)

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Review Chemistry, Medicinal

Emodin: A Review of its Pharmacology, Toxicity and Pharmacokinetics

Xiaoxv Dong et al.

PHYTOTHERAPY RESEARCH (2016)

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Review Immunology

Resolution of inflammation: what Controls its Onset?

Michelle A. Sugimoto et al.

FRONTIERS IN IMMUNOLOGY (2016)

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Article Biochemistry & Molecular Biology

N6-methyladenosine Modulates Messenger RNA Translation Efficiency

Xiao Wang et al.

CELL (2015)

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Review Biochemistry & Molecular Biology

Homeostasis, Inflammation, and Disease Susceptibility

Maya E. Kotas et al.

CELL (2015)

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Review Rheumatology

Epigenetics in rheumatoid arthritis

Kerstin Klein et al.

CURRENT OPINION IN RHEUMATOLOGY (2015)

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Article Medicine, General & Internal

Psoriasis

Wolf-Henning Boehncke et al.

LANCET (2015)

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Article Multidisciplinary Sciences

N6-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions

Nian Liu et al.

NATURE (2015)

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Review Immunology

The resolution of inflammation: Principles and challenges

Sarah E. Headland et al.

SEMINARS IN IMMUNOLOGY (2015)

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Article Peripheral Vascular Disease

Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo

Nadine Jetten et al.

ANGIOGENESIS (2014)

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Review Immunology

Microglia Development and Function

Debasis Nayak et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 32 (2014)

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Article Cell Biology

Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase

Xiao-Li Ping et al.

CELL RESEARCH (2014)

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Review Immunology

Origin and Functions of Tissue Macrophages

Slava Epelman et al.

IMMUNITY (2014)

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Article Multidisciplinary Sciences

N6-methyladenosine-dependent regulation of messenger RNA stability

Xiao Wang et al.

NATURE (2014)

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Article Biochemistry & Molecular Biology

A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

Jianzhao Liu et al.

NATURE CHEMICAL BIOLOGY (2014)

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Review Rheumatology

Role of cytokines in intervertebral disc degeneration: pain and disc content

Makarand V. Risbud et al.

NATURE REVIEWS RHEUMATOLOGY (2014)

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Article Cell Biology

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

Schraga Schwartz et al.

CELL REPORTS (2014)

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Article Biochemistry & Molecular Biology

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

Guanqun Zheng et al.

MOLECULAR CELL (2013)

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Article Biochemistry & Molecular Biology

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

Kate D. Meyer et al.

CELL (2012)

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Review Cell Biology

Novel regulatory mechanisms in inflammatory arthritis: a role for microRNA

Derek Baxter et al.

IMMUNOLOGY AND CELL BIOLOGY (2012)

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Article Multidisciplinary Sciences

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

Dan Dominissini et al.

NATURE (2012)

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Article Urology & Nephrology

Relationship between Uric Acid and Subtle Cognitive Dysfunction in Chronic Kidney Disease

Baris Afsar et al.

AMERICAN JOURNAL OF NEPHROLOGY (2011)

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Article Biochemistry & Molecular Biology

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

Guifang Jia et al.

NATURE CHEMICAL BIOLOGY (2011)

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Review Medicine, General & Internal

MECHANISMS OF DISEASE The Pathogenesis of Rheumatoid Arthritis

Iain B. McInnes et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

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Review Environmental Sciences

Macrophage Polarization in Health and Disease

Luca Cassetta et al.

THESCIENTIFICWORLDJOURNAL (2011)

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Review Biochemistry & Molecular Biology

Pattern Recognition Receptors and Inflammation

Osamu Takeuchi et al.

CELL (2010)

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Editorial Material Biochemistry & Molecular Biology

Inflammation 2010: New Adventures of an Old Flame

Ruslan Medzhitov

CELL (2010)

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Article Dermatology

Circulating Th17, Th22, and Th1 Cells Are Increased in Psoriasis

Shinji Kagami et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2010)

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Editorial Material Multidisciplinary Sciences

Inflammation

Ursula Weiss

NATURE (2008)

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Review Multidisciplinary Sciences

Origin and physiological roles of inflammation

Ruslan Medzhitov

NATURE (2008)

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Review Immunology

Functions of natural killer cells

Eric Vivier et al.

NATURE IMMUNOLOGY (2008)

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Review Medicine, Research & Experimental

APC-derived cytokines and T cell polarization in autoimmune inflammation

Ilona Gutcher et al.

JOURNAL OF CLINICAL INVESTIGATION (2007)

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Article Critical Care Medicine

Incidence, treatment, and outcome of severe sepsis in ICU-treated adults in Finland: the Finnsepsis study

Sari Karlsson et al.

INTENSIVE CARE MEDICINE (2007)

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Article Cardiac & Cardiovascular Systems

Pathogenesis of atherosclerosis

E Falk

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2006)

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Article Immunology

A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

H Park et al.

NATURE IMMUNOLOGY (2005)

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Article Immunology

Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

LE Harrington et al.

NATURE IMMUNOLOGY (2005)

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Article Biochemistry & Molecular Biology

Impact of FASL-induced apoptosis in the elimination of tumor cells by NK cells

V Screpanti et al.

MOLECULAR IMMUNOLOGY (2005)

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Review Medicine, General & Internal

Medical progress: The pathophysiology and treatment of sepsis.

RS Hotchkiss et al.

NEW ENGLAND JOURNAL OF MEDICINE (2003)

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