4.8 Review

Levodopa-induced dyskinesia: interplay between the N-methyl-D-aspartic acid receptor and neuroinflammation

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Dopamine, Immunity, and Disease

Breana Channer et al.

Summary: Dopamine plays a crucial role in CNS function, regulating reward, movement, and cognition. It also regulates vital functions in peripheral organs and acts as an immunoregulatory factor. Despite inconsistent and poorly understood data, targeting dopaminergic pathways could be promising for inflammation and disease treatment. This review integrates current knowledge on the role of dopamine in immune cell function and inflammatory signaling across systems and highlights its importance in various diseases. Rating: 8/10.

PHARMACOLOGICAL REVIEWS (2023)

Article Pharmacology & Pharmacy

Impeding the combination of astrocytic ASCT2 and NLRP3 by talniflumate alleviates neuroinflammation in experimental models of Parkinson's disease

Yang Liu et al.

Summary: The study demonstrates the involvement of ASCT2 in the progression of Parkinson's disease, with high expression correlated with dyskinesia. It further shows that genetic ablation of astrocytic ASCT2 alleviates neuroinflammation and rescues dopaminergic neuron damage. The drug talniflumate, identified through virtual molecular screening, inhibits astrocytic inflammation and prevents degeneration of dopaminergic neurons in Parkinson's disease models.

ACTA PHARMACEUTICA SINICA B (2023)

Review Clinical Neurology

Impaired dopamine release in Parkinson's disease

Kaitlyn M. L. Cramb et al.

Summary: Cramb et al. provide a review of evidence suggesting dopamine release deficits occur prior to neurodegeneration in Parkinson's disease. They also highlight the need for further investigation in understanding the mechanisms behind these deficits.

BRAIN (2023)

Article Clinical Neurology

Physical Frailty, Genetic Predisposition, and Incident Parkinson Disease

Zekun Zheng et al.

Summary: This study examined the longitudinal association of frailty with the development of Parkinson's disease (PD) and found that physical prefrailty and frailty were associated with incident PD, with a higher risk observed in individuals with frailty and high genetic risk.

JAMA NEUROLOGY (2023)

Article Clinical Neurology

X-Chromosome Association Study in Latin American Cohorts Identifies New Loci in Parkinson's Disease

Thiago P. Leal et al.

Summary: This study conducted the first X-chromosome-wide association study for PD risk in a Latin American cohort, identifying eight linkage disequilibrium regions associated with PD. One of these regions (rs5525496) is associated with multiple expression quantitative trait loci in brain and non-brain tissues, but colocalization analysis suggests that it may not mediate risk through the expression of these genes. The study also replicated a previous finding from an X-chromosome-wide association study, showing an association between rs28602900 and PD in non-European populations.

MOVEMENT DISORDERS (2023)

Article Neurosciences

ONO-2506 Can Delay Levodopa-induced Dyskinesia in the Early Stage

Yuhao Yuan et al.

Summary: This study examined the effects of an astrocyte regulator (ONO-2506) on levodopa-induced dyskinesia (LID) in a rat model of Parkinson's disease. The results showed that ONO-2506 significantly delayed the development of LID in the early stage of L-DOPA treatment. However, it had no significant effect on motor function improvement. The study suggests that interventions targeting astrocytes and glutamate transporters may be potential therapeutic strategies to delay the development of LID.

NEUROSCIENCE (2023)

Review Cell Biology

Urgent needs of caregiving in ageing populations with Alzheimer's disease and other chronic conditions: Support our loved ones

John W. Culberson et al.

Summary: This article discusses the origins and effects of the ageing process, emphasizing the pressure age-related diseases put on caregivers and families. It also explores innovative approaches to improve the medical system, funding for caregiving, and the skills and efficiency of caregivers. Overall, there is an urgent need for caregiving and support for the elderly population.

AGEING RESEARCH REVIEWS (2023)

Article Immunology

Effects of hydrogen gas inhalation on L-DOPA-induced dyskinesia

Glauce C. Nascimento et al.

Summary: Hydrogen gas inhalation reduces L-DOPA-induced dyskinesia by reducing inflammation, which has important implications for the treatment of Parkinson's disease.

BRAIN, BEHAVIOR, & IMMUNITY - HEALTH (2023)

Review Biochemistry & Molecular Biology

Role of neuroinflammation in neurodegeneration development

Weifeng Zhang et al.

Summary: Studies have shown that inflammation plays a crucial role in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Amyotrophic lateral sclerosis. Protein aggregates, a common pathological phenomenon, induce neuroinflammation which worsens protein aggregation and neurodegeneration. Inflammation occurs even before protein aggregation. Genetic variations in CNS cells or peripheral immune cells can induce neuroinflammation and protein deposition. Blocking or enhancing inflammatory signaling pathways are considered promising strategies for the treatment of neurodegenerative diseases, and some have shown exciting results in animal models and clinical trials, with a few already approved by FDA for clinical usage.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2023)

Article Cell Biology

Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration

Jinbin Xu et al.

Summary: Zhao et al. discovered evolutionarily conserved astrocyte and microglia subpopulations shared across multiple brain regions, revealing similarities and differences in AD and PD glia and regional variance linked to AD pathology and neurodegeneration. Their analysis identified commonalities between AD and PD astrocytes and unique transcriptomic changes in microglia for each disorder. They also delineated undescribed subpopulations of medium spiny neurons (MSNs) and provided neuronal transcriptomic profiles suggesting disease-specific changes and selective vulnerability.

NATURE AGING (2023)

Article Clinical Neurology

Physical Frailty, Genetic Predisposition, and Incident Parkinson Disease

Zekun Zheng et al.

Summary: The study found a significant association between frailty and the development of PD, with a stronger impact of frailty in individuals with high genetic risk. These findings may have important implications for the assessment and management of frailty in PD prevention.

JAMA NEUROLOGY (2023)

Article Neurosciences

Astrocytes Render Memory Flexible by Releasing D-Serine and Regulating NMDA Receptor Tone in the Hippocampus

Wuhyun Koh et al.

Summary: This study found that hippocampal astrocytes regulate NMDAR tone by releasing D-serine and glutamate, with the process mediated by BEST1. Decreased NMDAR tone results in impaired cognitive flexibility, and NMDAR tone during initial learning is crucial for subsequent learning.

BIOLOGICAL PSYCHIATRY (2022)

Article Pharmacology & Pharmacy

CD44 deficiency represses neuroinflammation and rescues dopaminergic neurons in a mouse model of Parkinson's disease

Yuejun Wang et al.

Summary: CD44 plays a crucial role in neuroinflammation and may be involved in the progression of Parkinson's disease. This study reveals that CD44 deficiency can inhibit the expression of proinflammatory cytokines and improve behavioral defects in PD model mice. Neutralization of CD44 with antibodies produces similar effects.

PHARMACOLOGICAL RESEARCH (2022)

Article Psychiatry

N-Methyl-D-Aspartate receptor and inflammation in dorsolateral prefrontal cortex in schizophrenia

Tasnim Rahman et al.

Summary: Lower levels of N-methyl-D-aspartate receptor (NMDAR) GluN1 subunit and heightened neuroinflammation are found in the cortex in schizophrenia. Changes in NMDAR composition, specifically the ratios of GluN2A:GluN2B binding and GRIN2A:GRIN2B mRNA, are associated with inflammation in schizophrenia cases.

SCHIZOPHRENIA RESEARCH (2022)

Review Neurosciences

Excitotoxicity, calcium and mitochondria: a triad in synaptic neurodegeneration

Manish Verma et al.

Summary: Glutamate is a commonly used neurotransmitter in the central nervous system of mammals, but excessive levels can lead to excitotoxicity and neuronal cell death. Excitatory synaptic dysregulation also contributes to neurodegeneration. Optimizing mitochondrial calcium flux can prevent excitatory mitochondrial toxicity and provide neuroprotection in various diseases.

TRANSLATIONAL NEURODEGENERATION (2022)

Article Neurosciences

Striatal Synaptic Dysfunction in Dystonia and Levodopa-Induced Dyskinesia

Mariangela Scarduzio et al.

Summary: This review provides an overview of synaptic dysfunctions and neurochemical alterations in hyperkinetic movement disorders, including changes in synaptic plasticity and neuromodulation.

NEUROBIOLOGY OF DISEASE (2022)

Article Cell Biology

NMDA receptor-dependent prostaglandin-endoperoxide synthase 2 induction in neurons promotes glial proliferation during brain development and injury

Jia Zhou et al.

Summary: The study reveals that astrocyte proliferation is regulated by neuronal activity through NMDA receptor signaling, and the expression of Ptgs(2) induced by NMDAR activation in neurons plays a crucial role in activity-dependent astrocyte proliferation.

CELL REPORTS (2022)

Review Pharmacology & Pharmacy

Molecular Mechanisms and Therapeutic Strategies for Levodopa-Induced Dyskinesia in Parkinson's Disease: A Perspective Through Preclinical and Clinical Evidence

Ritam Bandopadhyay et al.

Summary: This study focuses on the recent updates in molecular mechanisms and therapeutic approaches for the effective management of levodopa-induced dyskinesia (LID) in Parkinson's disease patients.

FRONTIERS IN PHARMACOLOGY (2022)

Review Biochemistry & Molecular Biology

Cerebral Glutamate Regulation and Receptor Changes in Perioperative Neuroinflammation and Cognitive Dysfunction

Yan Zhang et al.

Summary: This article reviews how glutamate handling and glutamatergic function are affected by neuroinflammation and their contribution to cognitive impairment. The authors summarize the current data regarding glutamate in neurotransmission, including its receptors and regulation. They also examine the impact of inflammation on glutamate handling and neurotransmission, focusing on changes in glial cells and the effect of cytokines. Finally, they discuss the implications of these changes for perioperative neuroinflammation and perioperative neurocognitive disorders.

BIOMOLECULES (2022)

Review Oncology

Microglia and metastases to the central nervous system: victim, ravager, or something else?

Maria M. Caffarel et al.

Summary: This review summarizes the findings on microglia heterogeneity from classical studies to the new single-cell omics. It discusses the interaction between microglia and metastatic cancer cells in the unique brain tumor microenvironment, the limitations of the microglia classical M1-M2 binary concept, and the single-cell omic findings that help understand microglia heterogeneity and functions in CNS metastasis. The review also proposes ways to exploit microglia plasticity for brain metastasis treatment depending on the microenvironment profile.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2022)

Article Biochemistry & Molecular Biology

Gliotransmission of D-serine promotes thirst-directed behaviors in Drosophila

Annie Park et al.

Summary: Using single-cell sequencing, molecular and cellular adaptations in the brain of water-deprived Drosophila were identified. The study revealed that water deficiency primarily affected the glial transcriptome, with astrocytes playing a key role in regulating water consumption through the synthesis and release of the gliotransmitter D-serine. This finding suggests that thirst can elevate astrocytic D-serine release to enhance water procurement.

CURRENT BIOLOGY (2022)

Article Immunology

Transient neuroinflammation following surgery contributes to long-lasting cognitive decline in elderly rats via dysfunction of synaptic NMDA receptor

Bo Chen et al.

Summary: The transient neuroinflammation induced by surgery contributes to the development of PNDs in elderly rats through sustained downregulation and hypofunction of synaptic NR2A and NR2B subunits.

JOURNAL OF NEUROINFLAMMATION (2022)

Article Neurosciences

Selective Ablation of Sod2 in Astrocytes Induces Sex-Specific Effects on Cognitive Function, D-Serine Availability, and Astrogliosis

Matthew P. Baier et al.

Summary: This study investigates the impact of reduced mitochondrial antioxidant response in astrocytes on cognitive function and neuronal activity. The findings suggest that decreasing antioxidant stress in astrocytes replicates age-related cognitive deficits, decreased availability of D-serine, and enhanced astrogliosis, indicating that improving astrocyte mitochondrial homeostasis may be a therapeutic target for addressing cognitive impairment in aging.

JOURNAL OF NEUROSCIENCE (2022)

Article Neurosciences

Microglia states and nomenclature: A field at its crossroads

Rosa C. Paolicelli et al.

NEURON (2022)

Review Clinical Neurology

Microglia as Central Protagonists in the Chronic Stress Response

Eva Schramm et al.

Summary: Chronic stress is a major risk factor for psychiatric conditions, and it activates the immune system, alters the phenotype of microglia, and affects the CNS environment.

NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION (2022)

Review Pharmacology & Pharmacy

Dyskinesia and Parkinson's disease: animal model, drug targets, and agents in preclinical testing

Valentina Cesaroni et al.

Summary: LIDs are supported by complex molecular and neurobiological mechanisms that are still being studied today. This complexity suggests the need of developing personalized pharmacological approach to obtain an effective amelioration of LID condition and improve the quality of life of PD patients.

EXPERT OPINION ON THERAPEUTIC TARGETS (2022)

Article Neurosciences

α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss

Dorit Trudler et al.

Summary: In Parkinson's disease, synaptic and neuronal loss are prominent features. The study reveals that alpha Syn oligomers induce excessive glutamate release from astrocytes, activating NMDARs on neurons and leading to synaptic damage. However, the drug NitroSynapsin shows promise in protecting synapses from alpha Syn-induced damage.

JOURNAL OF NEUROSCIENCE (2021)

Article Pharmacology & Pharmacy

Contributive Role of TNF-α to L-DOPA-Induced Dyskinesia in a Unilateral 6-OHDA Lesion Model of Parkinson's Disease

Mauricio dos Santos Pereira et al.

Summary: The study aimed to characterize mechanisms regulating neuroinflammation in L-DOPA-induced dyskinesia in mice, finding that astrocytic and microglial responses, as well as increased pro-inflammatory cytokine levels, were associated with LID development. Treatment with cannabidiol and capsazepine reduced LID severity and TNF-alpha levels, suggesting a potential therapeutic approach. Glutamate-induced TNF-alpha release from astrocytes may contribute to LID by modulating corticostriatal glutamatergic inputs, with cannabidiol + capsazepine attenuating this effect.

FRONTIERS IN PHARMACOLOGY (2021)

Article Neurosciences

Evaluation of microglia in a rodent model of Parkinson's disease primed with L-DOPA after sub-anesthetic ketamine treatment

Ayumi E. Pottenger et al.

Summary: The study demonstrated that sub-anesthetic ketamine can alleviate motor dysfunction in Parkinson's disease patients caused by prolonged use of L-DOPA. The mechanism of ketamine's therapeutic effects may involve inflammation and microglia phagocytic functions.

NEUROSCIENCE LETTERS (2021)

Article Pharmacology & Pharmacy

The Negative Allosteric Modulator EU1794-4 Reduces Single-Channel Conductance and Ca2+ Permeability of GluN1/GluN2A N-Methyl-D-Aspartate Receptors

Riley E. Perszyk et al.

Summary: NMDA receptors play a crucial role in brain functions and are implicated in various neurological conditions. The negative allosteric modulator EU1794-4 reduces overall current flow after receptor activation and Ca2+ flux through the receptors, showing therapeutic potential for neurodegenerative diseases and acute injuries.

MOLECULAR PHARMACOLOGY (2021)

Article Biochemistry & Molecular Biology

The effect of aged microglia on synaptic impairment and its relevance in neurodegenerative diseases

Juan Jose Trivino et al.

Summary: Microglia play crucial roles in the CNS by regulating synapses and the neuronal network, responding to signals to protect the CNS, and influencing neuroinflammation and oxidative stress associated with aging and neurodegenerative diseases. Dysregulation of microglia function in aging may lead to cognitive dysfunction and increase susceptibility to neurodegeneration.

NEUROCHEMISTRY INTERNATIONAL (2021)

Article Clinical Neurology

Perivascular Spaces in the Basal Ganglia and Long-term Motor Prognosis in Newly Diagnosed Parkinson Disease

Seok Jong Chung et al.

Summary: Enlarged perivascular spaces (PVS) in the basal ganglia are associated with the progression of motor disability in Parkinson's disease (PD). Patients with a higher number of enlarged PVS require higher doses of dopaminergic medications for symptom control, and they are at higher risk for freezing of gait.

NEUROLOGY (2021)

Article Neurosciences

Interferon-γ Involvement in the Neuroinflammation Associated with Parkinson's Disease and L-DOPA-Induced Dyskinesia

D. P. Ferrari et al.

Summary: The absence of IFN-gamma intensifies the inflammatory reaction during L-DOPA treatment, but does not affect the degeneration of dopaminergic neurons or LID development.

NEUROTOXICITY RESEARCH (2021)

Article Geriatrics & Gerontology

Systemic Inflammation Increases the Susceptibility to Levodopa-Induced Dyskinesia in 6-OHDA Lesioned Rats by Targeting the NR2B-Medicated PKC/MEK/ERK Pathway

Aijuan Yan et al.

Summary: Systemic inflammation exacerbates levodopa-induced dyskinesia (LID) by increasing neuroinflammation and NR2B subunit activity. The use of clodronate-encapsulated liposomes can suppress the inflammatory response and improve behavioral dysfunction, reducing susceptibility to LID.

FRONTIERS IN AGING NEUROSCIENCE (2021)

Article Pharmacology & Pharmacy

Icariin ameliorates partial sciatic nerve ligation induced neuropathic pain in rats: an evidence of in silico and in vivo studies

Swapna Pokkula et al.

Summary: Icariin (ICA) shows promise in alleviating neuropathic pain by inhibiting NR2B, TRPV1 receptors, and Cav2.2 channels, reducing inflammation and apoptosis in the bodies of patients with neuropathic pain.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2021)

Article Cell Biology

TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

Kaspar Russ et al.

Summary: TNF-alpha and alpha-synuclein fibrils induce distinct immune reactive responses in astrocytes, accompanied by impaired mitochondrial respiration, with competition between the two stimuli. This study provides evidence for astrocytic involvement in Parkinson's disease pathology and highlights the complex immune reactive responses of astrocytes to exogenous stressors.

CELL REPORTS (2021)

Article Neurosciences

Astrocyte-selective STAT3 knockdown rescues methamphetamine withdrawal-disrupted spatial memory in mice via restoring the astrocytic capacity of glutamate clearance in dCA1

Pengbo Shi et al.

Summary: The study revealed that METH withdrawal disrupted spatial memory in mice, associated with increased Glu levels and postsynaptic neuronal activities at dCA1 synapses. METH withdrawal weakened the capacity of Glu clearance in astrocytes, while it did not affect the presynaptic Glu release from dCA3 within dCA1.
Article Multidisciplinary Sciences

A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis

Martina Absinta et al.

Summary: Through MRI-guided single-nucleus RNA sequencing, a diversity of glial and immune cells at the edge of demyelinated white matter lesions in multiple sclerosis (MS) have been identified, along with the definition of inflamed glial cell phenotypes in MS. The overlap of the transcriptional profile of microglia inflamed in MS with that in other neurodegenerative diseases suggests common mechanisms between primary and secondary neurodegeneration that could benefit from similar therapeutic approaches. The critical role of complement component 1q (C1q) in the activation of microglia inflamed in MS has been identified and potential therapeutic avenues, such as C1q inhibition, have been suggested for addressing chronic white matter inflammation.

NATURE (2021)

Review Neurosciences

Modulation of Glial Function in Health, Aging, and Neurodegenerative Disease

Kendra L. Hanslik et al.

Summary: Glial cells in the CNS play important roles in support and immune response, and their function can be affected by aging and neurodegenerative diseases. Glia may contribute to the pathogenesis of various neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease.

FRONTIERS IN CELLULAR NEUROSCIENCE (2021)

Review Immunology

Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy?

Yan-mei Qiu et al.

Summary: Blood-Brain Barrier (BBB) disruption is a crucial pathophysiological process in acute ischemic stroke, where the rapid activation of immune cells plays a critical role. Infiltrating immune cells increase BBB permeability, causing microvascular disorder, but also promote BBB repair and angiogenesis. Understanding the inflammatory mechanisms behind BBB disruption can lead to the development of more effective therapeutics for acute ischemic stroke.

FRONTIERS IN IMMUNOLOGY (2021)

Article Immunology

Resveratrol Alleviates Levodopa-Induced Dyskinesia in Rats

Chang-Qing Zheng et al.

Summary: Resveratrol (RES) has shown potential in alleviating dyskinesia associated with Parkinson's disease treatment, reducing the abnormal movements induced by L-DOPA while protecting DA neurons from long-term damage, and inhibiting neuroinflammatory reactions mediated by glial cells.

FRONTIERS IN IMMUNOLOGY (2021)

Article Neurosciences

Pivotal Role of Fyn Kinase in Parkinson's Disease and Levodopa-Induced Dyskinesia: a Novel Therapeutic Target?

Efthalia Angelopoulou et al.

Summary: The exact etiology of Parkinson's disease (PD) is still unknown, and there is no cure for PD. Fyn, a tyrosine phospho-transferase, may play a crucial role in the pathogenesis of PD and levodopa-induced dyskinesia (LID) by regulating key signaling pathways. Therapeutic targeting of Fyn or Fyn-related pathways could represent a novel approach in PD treatment.

MOLECULAR NEUROBIOLOGY (2021)

Article Neurosciences

Targeting the cannabinoid receptor CB2 in a mouse model of 1-dopa induced dyskinesia

Peggy Rentsch et al.

NEUROBIOLOGY OF DISEASE (2020)

Review Medicine, General & Internal

Diagnosis and Treatment of Parkinson Disease A Review

Melissa J. Armstrong et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

Article Pharmacology & Pharmacy

Subunit-specific effects of poricoic acid A on NMDA receptors

Jaeeun Lee et al.

PHARMACOLOGICAL REPORTS (2020)

Article Medicine, Research & Experimental

Striatal Kir2 K+ channel inhibition mediates the antidyskinetic effects of amantadine

Weixing Shen et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Article Neurosciences

ATP Signaling Controlling Dyskinesia Through P2X7 Receptors

Analu A. Fonteles et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2020)

Review Neurosciences

Neuromodulation of Glial Function During Neurodegeneration

Rebecca Stevenson et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

Review Neurosciences

Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes

Hyuk Sung Kwon et al.

TRANSLATIONAL NEURODEGENERATION (2020)

Letter Clinical Neurology

The Movement disorder associated with NMDAR antibody-encephalitis is complex and characteristic: an expert video-rating study

James A. Varley et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

Article Neurosciences

NMDA receptor G1uN2D subunit participates to levodopa-induced dyskinesia pathophysiology

Manuela Mellone et al.

NEUROBIOLOGY OF DISEASE (2019)

Review Chemistry, Medicinal

Significant roles of neuroinflammation in Parkinson's disease: therapeutic targets for PD prevention

Yujeong Lee et al.

ARCHIVES OF PHARMACAL RESEARCH (2019)

Article Clinical Neurology

Assessment of plasma creatine kinase as biomarker for levodopa-induced dyskinesia in Parkinson's disease

Anna Delamarre et al.

JOURNAL OF NEURAL TRANSMISSION (2019)

Article Endocrinology & Metabolism

Microglial-driven changes in synaptic plasticity: A possible role in major depressive disorder

Stuart Innes et al.

PSYCHONEUROENDOCRINOLOGY (2019)

Review Immunology

An update on reactive astrocytes in chronic pain

Ting Li et al.

JOURNAL OF NEUROINFLAMMATION (2019)

Article Medicine, General & Internal

Parkinson's Disease

Stephen G. Reich et al.

MEDICAL CLINICS OF NORTH AMERICA (2019)

Editorial Material Clinical Neurology

Neuroinflammation: Fanning the Fire of L-Dopa-Induced Dyskinesia

Christopher Bishop

MOVEMENT DISORDERS (2019)

Article Neurosciences

Synaptic plasticity may underlie L-DOPA induced dyskinesia

Anders Borgkvist et al.

CURRENT OPINION IN NEUROBIOLOGY (2018)

Review Clinical Neurology

Levodopa-induced dyskinesia: clinical features, incidence, and risk factors

Tai N. Tran et al.

JOURNAL OF NEURAL TRANSMISSION (2018)

Article Neurosciences

Diversity of Astroglial Effects on Aging- and Experience-Related Cortical Metaplasticity

Ulyana Lalo et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

Article Medicine, Research & Experimental

Modulation of CaMKIIa-GluN2B interaction in levodopa-induced dyskinesia in 6-OHDA-lesioned Parkinson's rats

Xin-Shi Wang et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Article Neurosciences

l-DOPA-induced dyskinesia and neuroinflammation: do microglia and astrocytes play a role?

Anna R. Carta et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2017)

Article Biochemistry & Molecular Biology

The noble gas xenon provides protection and trophic stimulation to midbrain dopamine neurons

Jeremie Lavaur et al.

JOURNAL OF NEUROCHEMISTRY (2017)

Review Biochemistry & Molecular Biology

Current disease modifying approaches to treat Parkinson's disease

Dan Lindholm et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Article Neurosciences

mGlu5, Dopamine D-2 and Adenosine A(2A) Receptors in L-DOPA-induced Dyskinesias

Nicolas Morin et al.

CURRENT NEUROPHARMACOLOGY (2016)

Review Neurosciences

Maladaptive Synaptic Plasticity in L-DOPA-Induced Dyskinesia

Qiang Wang et al.

FRONTIERS IN NEURAL CIRCUITS (2016)

Review Medicine, Research & Experimental

Regulating G protein activity by lipase-independent functions of phospholipase C

Irene Litosch

LIFE SCIENCES (2015)

Article Clinical Neurology

Ranitidine reduced levodopa-induced dyskinesia by remodeling neurochemical changes in hemiparkinsonian model of rats

Hongjuan Shi et al.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2015)

Review Clinical Neurology

Therapeutic potential of targeting glutamate receptors in Parkinson's disease

Clare Finlay et al.

JOURNAL OF NEURAL TRANSMISSION (2014)

Article Medicine, Research & Experimental

PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking

Gregory Porras et al.

JOURNAL OF CLINICAL INVESTIGATION (2012)

Article Biochemistry & Molecular Biology

Synaptic dysfunction in Parkinson's disease

Vincenza Bagetta et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2010)

Article Neurosciences

Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra

Vikas Kaushal et al.

JOURNAL OF NEUROSCIENCE (2008)

Review Biochemistry & Molecular Biology

Microglia, major player in the brain inflammation: their roles in the pathogenesis of Parkinson's disease

Yoon Seong Kim et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2006)

Article Biochemistry & Molecular Biology

Tumor necrosis factor-α induces neurotoxicity via glutamate release from hemichannels of activated microglia in an autocrine manner

Hideyuki Takeuchi et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Review Clinical Neurology

Natural history and syndromic associations of orthostatic tremor:: A review of 41 patients

W Gerschlager et al.

MOVEMENT DISORDERS (2004)

Article Neurosciences

Loss of bidirectional striatal synaptic plasticity in L-DOPA-induced dyskinesia

B Picconi et al.

NATURE NEUROSCIENCE (2003)