☆ 4.8 Article

T cells, more than antibodies, may prevent symptoms developing from respiratory syncytial virus infections in older adults

FRONTIERS IN IMMUNOLOGY (2023)

Related references

Note: Only part of the references are listed.

Review Infectious Diseases

Respiratory syncytial virus disease burden in adults aged 60 years and older in high-income countries: A systematic literature review and meta-analysis

Miloje Savic et al.

Summary: This study conducted a systematic literature review and meta-analysis to estimate the disease burden of respiratory syncytial virus (RSV)-associated acute respiratory infection (ARI) in adults aged >= 60 years in high-income countries. The results showed that the RSV-ARI attack rate was 1.62%, the hospitalization attack rate was 0.15%, and the in-hospital case fatality rate was 7.13% in this population. In 2019, this would translate into approximately 5.2 million cases, 470,000 hospitalizations, and 33,000 in-hospital deaths in >= 60-year-old adults in high-income countries. The study highlights the need for RSV prophylaxis in this age group.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2023)

Add to Collection

Article Immunology

Safety and Immunogenicity of a Respiratory Syncytial Virus Prefusion F (RSVPreF3) Candidate Vaccine in Older Adults: Phase 1/2 Randomized Clinical Trial

Isabel Leroux-Roels et al.

Summary: The safety and immunogenicity of vaccine formulations containing the stabilized prefusion conformation of RSV fusion protein (RSVPreF3) against respiratory syncytial virus (RSV) were investigated. The results showed that these vaccines effectively boosted humoral immune responses and increased the frequencies of polyfunctional CD4(+) T cells. Most adverse events were mild to moderate, and the safety of the vaccines was confirmed. Based on safety and immunogenicity profiles, the AS01(E)-adjuvanted vaccine containing 120 μg of RSVPreF3 was selected for further clinical development.

JOURNAL OF INFECTIOUS DISEASES (2023)

Add to Collection

Article Immunology

Baseline innate and T cell populations are correlates of protection against symptomatic influenza virus infection independent of serology

Robert J. Mettelman et al.

Summary: This study shows that cellular and humoral immune responses play important roles in the resistance and protection against influenza virus after vaccination. The diversity and functionality of specific cell subsets are associated with protection, while nonspecific inflammatory subsets are associated with increased susceptibility. The study also demonstrates that cellular subsets, in combination with humoral immunity, improve the prediction of symptomatic influenza susceptibility.

NATURE IMMUNOLOGY (2023)

Add to Collection

Article Microbiology

Upper and lower respiratory tract correlates of protection against respiratory syncytial virus following vaccination of nonhuman primates

Tomer Zohar et al.

Summary: Through studying a nonhuman primate-challenge model, we found that immune protection against RSV infection is associated with antibody levels, neutralization, complement activity, and Fc-mediated effector mechanisms. These findings provide important insights for the development of future vaccines.

CELL HOST & MICROBE (2022)

Add to Collection

Article Immunology

World Health Organization Influenza-Like Illness Underestimates the Burden of Respiratory Syncytial Virus Infection in Community-Dwelling Older Adults

Koos Korsten et al.

Summary: The accuracy of the influenza-like illness (ILI) case definition from the World Health Organization (WHO) in identifying acute respiratory tract infections (ARTI) caused by respiratory syncytial virus (RSV) in older adults is uncertain. The ILI definition, which includes fever, underestimates the occurrence of RSV-ARTI. There is a need for a better approach to measure RSV disease occurrence and the impact of future RSV vaccine introduction.

JOURNAL OF INFECTIOUS DISEASES (2022)

Add to Collection

Article Infectious Diseases

Change in functional status associated with respiratory syncytial virus infection in hospitalized older adults

Angela R. Branche et al.

Summary: RSV-associated hospitalization in older adults leads to acute functional decline and may be prolonged. Pre-hospitalization living situation can predict patient outcomes.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2022)

Add to Collection

Article Immunology

Harmonization and qualification of intracellular cytokine staining to measure influenza-specific CD4+ T cell immunity within the FLUCOP consortium

Sarah Begue et al.

Summary: This study describes the development of a consensus protocol to reduce inter-laboratory variability in measuring influenza-specific T cell responses. The protocol allows for quantitative and qualitative evaluation of vaccine-induced T cell responses, facilitating comparisons of different influenza vaccines and potential assessments of protection correlates.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Antibody effector functions are associated with protection from respiratory syncytial virus

Yannic C. Bartsch et al.

Summary: RSV infection is a major cause of severe respiratory tract infection and death in infants and the elderly. This study found that protection against RSV infection is linked to opsonophagocytic functions driven by IgA and differentially glycosylated RSV-specific IgG profiles, indicating the importance of functional humoral immune response in preventing RSV.

CELL (2022)

Add to Collection

Article Respiratory System

Burden of respiratory syncytial virus infection in community-dwelling older adults in Europe (RESCEU): an international prospective cohort study

Koos Korsten et al.

Summary: This European study found that RSV infection is prevalent among community-dwelling older adults, but rarely causes severe disease. Patients with PCR-confirmed RSV ARTI had an average symptom duration of 19 days, with a doctor visit rate of 31%.

EUROPEAN RESPIRATORY JOURNAL (2021)

Add to Collection

Article Medicine, Research & Experimental

Selective induction of antibody effector functional responses using MF59-adjuvanted vaccination

Carolyn M. Boudreau et al.

JOURNAL OF CLINICAL INVESTIGATION (2020)

Add to Collection

Article Immunology

Immunological and Inflammatory Biomarkers of Susceptibility and Severity in Adult Respiratory Syncytial Virus Infections

Dexter J. Wiseman et al.

JOURNAL OF INFECTIOUS DISEASES (2020)

Add to Collection

Article Cell Biology

Mapping functional humoral correlates of protection against malaria challenge following RTS,S/AS01 vaccination

Todd J. Suscovich et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

Add to Collection

Article Multidisciplinary Sciences

Neutrophilic inflammation in the respiratory mucosa predisposes to RSV infection

Maximillian S. Habibi et al.

SCIENCE (2020)

Add to Collection

Review Immunology

Vaccines against human respiratory syncytial virus in clinical trials, where are we now?

Iebe Rossey et al.

EXPERT REVIEW OF VACCINES (2019)

Add to Collection

Article Immunology

CD40L expression by CD4+ but not CD8+ T cells regulates antiviral immune responses in acute LCMV infection in mice

Sibel Durlanik et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2016)

Add to Collection

Article Critical Care Medicine

Impaired Antibody-mediated Protection and Defective IgA B-Cell Memory in Experimental Infection of Adults with Respiratory Syncytial Virus

Maximillian S. Habibi et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2015)

Add to Collection

Article Infectious Diseases

Estimates of mortality attributable to influenza and RSV in the United States during 1997-2009 by influenza type or subtype, age, cause of death, and risk status

Goncalo Matias et al.

INFLUENZA AND OTHER RESPIRATORY VIRUSES (2014)

Add to Collection

Article Immunology

Respiratory Syncytial Virus and Other Respiratory Viral Infections in Older Adults With Moderate to Severe Influenza-like Illness

Ann R. Falsey et al.

JOURNAL OF INFECTIOUS DISEASES (2014)

Add to Collection

Article Immunology

Adults 65 Years Old and Older Have Reduced Numbers of Functional Memory T Cells to Respiratory Syncytial Virus Fusion Protein

Anu Cherukuri et al.

CLINICAL AND VACCINE IMMUNOLOGY (2013)

Add to Collection

Article Medicine, General & Internal

Mortality associated with influenza and respiratory syncytial virus in the United States

WW Thompson et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2003)

Add to Collection

© Peeref 2019-2024. All rights reserved.