Clinical severity classes in COVID-19 pneumonia have distinct immunological profiles, facilitating risk stratification by machine learning

Review Oncology

The state of the art for artificial intelligence in lung digital pathology

Vidya Sankar Viswanathan et al.

Summary: The development of digital pathology and artificial intelligence has provided new opportunities for the diagnosis and treatment of lung diseases. Research has explored the application of AI methods and tools in lung diseases, including image analysis and the use of biomarkers. AI tools also have the potential to play a role in areas such as multimodal data analysis, 3D pathology, and transplant rejection in lung diseases.

JOURNAL OF PATHOLOGY (2022)

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Article Immunology

Understanding COVID-19-associated coagulopathy

Edward M. Conway et al.

Summary: In this article, the authors discuss the emerging understanding of COVID-19-associated coagulopathy and the need to comprehend its cellular and molecular mechanisms. They categorize the current understanding into three main pathological mechanisms and address key questions and research gaps in order to improve diagnosis and treatment. The suitability of animal models for studying this condition is also considered.

NATURE REVIEWS IMMUNOLOGY (2022)

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Review Respiratory System

COVID-19 pneumonia: pathophysiology and management

Luciano Gattinoni et al.

Summary: COVID-19 pneumonia is a developing disease with evolving clinical features over time. In the acute phase, altered lung perfusion is the primary mechanism, while in the progression phase, patients may experience self-inflicted lung injury. As the disease advances, there is a shift towards irreversible lung fibrosis, leading to significant impairment in respiratory mechanics.

EUROPEAN RESPIRATORY REVIEW (2021)

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Article Medicine, General & Internal

Risk of acute myocardial infarction and ischaemic stroke following COVID-19 in Sweden: a self-controlled case series and matched cohort study

Ioannis Katsoularis et al.

Summary: This study in Sweden quantified the risk of acute myocardial infarction and ischaemic stroke associated with COVID-19, finding a significant correlation.

LANCET (2021)

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Article Medicine, General & Internal