The Q-Tube-Assisted Green Sustainable Synthesis of Fused Azines: New Synthetic Opportunities via Innovative Green Technology

An efficient, economical, and green, sustainable synthesis of fused azines using Mg-Al hydrotalcite under a high-pressure Q-Tube reactor has been developed. This reaction proceeds through the aza-Michael addition of alpha,beta-unsaturated ketone with different aminoazoles. This method offered excellent yields in a short reaction time that economically saved energy in addition to the protocol showing the reuse of the catalyst seven times without losing its catalytic activity.

Automated summary

An efficient, economical, and green synthesis method for fused azines has been developed using Mg-Al hydrotalcite under a high-pressure Q-Tube reactor. This method offers short reaction time, excellent yields, and the ability to reuse the catalyst without losing its catalytic activity for multiple cycles.