☆ 4.8 Review

Nanomedicine for Diagnosis and Treatment of Atherosclerosis

ADVANCED SCIENCE (2023)

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A ROS-Responsive Simvastatin Nano-Prodrug and its Fibronectin-Targeted Co-Delivery System for Atherosclerosis Treatment

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Summary: This review provides updated evidence on the cardiovascular disease (CVD) risk associated with consumption of specific food items for atherosclerosis prevention. The evidence shows that low consumption of salt and animal-based foods, along with increased intake of plant-based foods and unsaturated-fat-rich oils, are linked with reduced atherosclerosis risk in healthy adults.

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Carrier-Free Trehalose-Based Nanomotors Targeting Macrophages in Inflammatory Plaque for Treatment of Atherosclerosis

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A nitric oxide-eluting and REDV peptide-conjugated coating promotes vascular healing

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Magnetic resonance imaging contrast-enhancement with superparamagnetic iron oxide nanoparticles amplifies macrophage foam cell apoptosis in human and murine atherosclerosis

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Regulation of the macrophage-related inflammatory micro-environment for atherosclerosis treatment and angiogenesis via anti-cytokine agents

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Summary: In this study, mesoporous silica nanoparticles (MSNs) were used as carriers to regulate the inflammatory microenvironment of macrophage-mediated atherosclerosis (AS) by controlling the release of anti-interleukin-1 beta (anti-IL-1 beta). In vitro and in vivo experiments demonstrated that MSNs@anti-IL-1 beta can reduce the proliferation and phenotypic switching of vascular smooth muscle cells, promote the viability of vascular endothelial cells, and impede the progression of AS by maintaining endothelial integrity.

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Targeted Therapy of Atherosclerosis Vulnerable Plaque by ROS-Scavenging Nanoparticles and MR/Fluorescence Dual-Modality Imaging Tracing

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Self-Assembled CuCo2S4 Nanoparticles for Efficient Chemo-Photothermal Therapy of Arterial Inflammation

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Macrophage-Targeted Sonodynamic/Photothermal Synergistic Therapy for Preventing Atherosclerotic Plaque Progression Using CuS/TiO2 Heterostructured Nanosheets

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ACS NANO (2022)

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Turning Hot into Cold: Immune Microenvironment Reshaping for Atherosclerosis Attenuation Based on pH-Responsive shSiglec-1 Delivery System

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ACS NANO (2022)

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Review Pharmacology & Pharmacy

Biodistribution, pharmacokinetics and excretion studies of intravenously injected nanoparticles and extracellular vesicles: Possibilities and challenges

Tore Skotland et al.

Summary: The paper discusses the development and application of nanoparticles and extracellular vesicles for therapeutic delivery or imaging. It explores the methods and challenges involved in studying their biodistribution, metabolism, and excretion, often through the use of radioactive isotopes or fluorescent molecules. The importance of evaluating the behavior of labeled and unlabeled products in the body and considering the association of labels with the products during analysis is emphasized. Additionally, the advantages and disadvantages of different imaging modalities for whole-body biodistribution are compared, and methods for estimating the amount of labeled product in harvested organs and tissue are described.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Review Biochemistry & Molecular Biology

The landscape of mRNA nanomedicine

Xiangang Huang et al.

Summary: mRNA is an emerging therapeutic agent with great potential for revolutionizing life science and medical research. Recent progress in mRNA engineering and delivery has addressed the challenges related to stability, immunogenicity, and in vivo delivery. The success of mRNA vaccines against COVID-19 has transformed the field and opened up possibilities for treating other diseases.

NATURE MEDICINE (2022)

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Article Engineering, Biomedical

ROS responsive nanoparticles loaded with lipid-specific AIEgen for atherosclerosis-targeted diagnosis and bifunctional therapy

Hong Xu et al.

Summary: Atherosclerosis, a common cardiovascular disease, can benefit from drug delivery systems for accurate diagnosis and treatment, but improvements are needed to overcome current limitations like stability and targeting issues.

BIOMATERIALS (2022)

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Article Multidisciplinary Sciences

Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects

Kang Chen et al.

Summary: This study demonstrates that targeted delivery of thyroid hormone to adipose tissue with liposomes is a safe and efficient strategy for treating obesity and its related complications.

NATURE COMMUNICATIONS (2022)

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Article Biotechnology & Applied Microbiology

Pro-efferocytic macrophage membrane biomimetic nanoparticles for the synergistic treatment of atherosclerosis via competition effect

Xuan Sha et al.

Summary: The design of macrophage membrane biomimetic nanoparticles can effectively treat atherosclerosis by reducing lipid uptake by macrophages, decreasing foam cell formation, and inhibiting the expression of inflammatory cytokines.

JOURNAL OF NANOBIOTECHNOLOGY (2022)

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Article Pharmacology & Pharmacy

Hyaluronic Acid-Functionalized Mesoporous Silica Nanoparticles Loading Simvastatin for Targeted Therapy of Atherosclerosis

Kechen Song et al.

Summary: In this study, an enzyme-responsive and macrophage-targeting drug delivery system was constructed for precise treatment of atherosclerosis. The results showed that the system had high drug loading efficiency and enzyme-responsive release, as well as robust targeting, anti-inflammatory, and anti-foaming effects, with low cytotoxicity and excellent hemocompatibility.

PHARMACEUTICS (2022)

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Article Medicine, General & Internal

Prevalence and Vascular Distribution of Multiterritorial Atherosclerosis Among Community-Dwelling Adults in Southeast China

Yuesong Pan et al.

Summary: This study investigated the prevalence and vascular distribution of multiterritorial atherosclerotic plaque and stenosis in older community-dwelling populations in China. The study found that atherosclerotic plaque was highly prevalent and a substantial proportion of individuals had stenosis of 50% or greater.

JAMA NETWORK OPEN (2022)

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Article Chemistry, Multidisciplinary

Living Macrophage-Delivered Tetrapod PdH Nanoenzyme for Targeted Atherosclerosis Management by ROS Scavenging, Hydrogen Anti-inflammation, and Autophagy Activation

Li Ding et al.

Summary: A distinct tetrapod needle-like PdH nanozyme was designed and engineered for efficient atherosclerosis treatment. This nanozyme scavenges reactive oxygen species (ROS), reduces inflammation, and activates autophagy. Both in vitro and in vivo results demonstrated the synergistic effects of antioxidation, anti-inflammatory response, and autophagy activation in alleviating atherosclerosis development. This study highlights the importance of engineering nanomedicines with multiple therapeutic functions and topology-induced biological effects for effective atherosclerosis management and therapy.

ACS NANO (2022)

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Article Cardiac & Cardiovascular Systems

Targeting of Scavenger Receptors Stabilin-1 and Stabilin-2 Ameliorates Atherosclerosis by a Plasma Proteome Switch Mediating Monocyte/Macrophage Suppression

Calin-Petru Manta et al.

Summary: This study shows that inhibiting Stabilin-1 and Stabilin-2 can reduce the occurrence of atherosclerosis. By affecting the plasma proteome and the function of monocytes, this inhibition can suppress patrolling and inflammatory monocytes, providing systemic protection against atherosclerosis.

CIRCULATION (2022)

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Article Chemistry, Multidisciplinary

Inhibition of IL-1β release from macrophages targeted with necrosulfonamide-loaded porous nanoparticles

Bart Boersma et al.

Summary: Inflammation is essential for protective responses, but excessive inflammation can lead to diseases. Porous nanoparticles have been found to effectively deliver anti-inflammatory drugs to macrophages, suppressing inflammatory responses.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Chemistry, Multidisciplinary

Cyclodextrin-mediated conjugation of macrophage and liposomes for treatment of atherosclerosis

Cheng Gao et al.

Summary: This article introduces a method of targeted anti-atherosclerosis therapy using macrophage-liposome conjugate, which can lyse plaques, alleviate inflammation, and promote cholesterol efflux, effectively regressing atherosclerotic plaques.

JOURNAL OF CONTROLLED RELEASE (2022)

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Article Endocrinology & Metabolism

VCAM-1-binding peptide targeted cationic liposomes containing NLRP3 siRNA to modulate LDL transcytosis as a novel therapy for experimental atherosclerosis

Xiong Jia et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2022)

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Article Multidisciplinary Sciences

Scavenger receptor-targeted plaque delivery of microRNA-coated nanoparticles for alleviating atherosclerosis

Qianqian Bai et al.

Summary: This study demonstrates the use of a three-dimensional nanostructure for delivering therapeutic oligonucleotides to atherosclerotic plaques. The nanoparticles target specific cells in the plaques and modulate genes related to plaque formation and inflammation, resulting in reduced and stabilized plaques without severe toxicity.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

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Article Multidisciplinary Sciences

Small molecule-assisted assembly of multifunctional ceria nanozymes for synergistic treatment of atherosclerosis

Xiaoxue Fu et al.

Summary: The authors developed a novel approach for the treatment of atherosclerosis by creating a cell membrane coated ceria nanocomposite loaded with probucol. This nanoplatform specifically accumulates at inflammatory atherosclerotic lesions and synergistically regulates reactive oxygen species and inflammation, leading to efficient inhibition of foam cell formation. The assembly method used in this study could also be applied to the treatment of other diseases associated with oxidative stress and inflammation.

NATURE COMMUNICATIONS (2022)

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Article Engineering, Biomedical

LIFU-responsive nanomedicine enables acoustic droplet vaporization-induced apoptosis of macrophages for stabilizing vulnerable atherosclerotic plaques

Jingxin Hou et al.

Summary: The engineered FPD@CD nanomedicine efficiently treats vulnerable plaques by loading phase transition agent PFH and attaching targeting molecule DS onto biocompatible PPP NPs. The nanomedicine also has optical and magnetic resonance imaging capabilities. In in vivo and in vitro evaluation, it shows a significant therapeutic effect.

BIOACTIVE MATERIALS (2022)

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Article Cardiac & Cardiovascular Systems

CSL112 (Apolipoprotein A-I [Human]) Strongly Enhances Plasma Apoa-I and Cholesterol Efflux Capacity in Post-Acute Myocardial Infarction Patients: A PK/PD Substudy of the AEGIS-I Trial

C. Michael Gibson et al.

Summary: CSL112 is effective in improving cholesterol efflux capacity in patients with acute myocardial infarction, and may provide atheroprotective benefits.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS (2022)

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Article Medicine, Research & Experimental

Inflammatory endothelium-targeted and cathepsin responsive nanoparticles are effective against atherosclerosis

Fei Fang et al.

Summary: Targeted and responsive nanoparticles can control the release of drugs and effectively treat atherosclerosis. In vitro experiments showed that these nanoparticles can rapidly release drugs in response to stimulation and effectively inhibit inflammatory responses. In vivo experiments showed that these nanoparticles can slow down the progression of atherosclerosis and reduce inflammation.

THERANOSTICS (2022)

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Article Chemistry, Multidisciplinary

Targeted therapy of atherosclerosis by pH-sensitive hyaluronic acid nanoparticles co-delivering all-trans retinal and rapamycin

Nihad Cheraga et al.

Summary: This study developed pH-sensitive nanoparticles (HRRAP NPs) for targeted combination therapy of atherosclerosis. The nanoparticles effectively reduced reactive oxygen species levels and inflammation through the release of an antioxidant and an anti-inflammatory drug. In vitro and in vivo experiments demonstrated the potential of HRRAP NPs in inhibiting atherosclerosis progression and reducing adverse effects.

NANOSCALE (2022)

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Review Chemistry, Multidisciplinary

Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

Jiang Ouyang et al.

Summary: Traditional treatments like chemotherapy and surgery often have severe side effects and cause pain. The emergence of nanomedicines and minimally invasive therapies has brought hope to patients with malignant diseases. Minimally invasive nanomedicines combine the advantages of nanomedicines and minimally invasive therapies, effectively targeting pathological cells and minimizing side effects. This review provides a comprehensive overview of the research status and challenges of minimally invasive nanomedicines and their applications in various fields.

CHEMICAL SOCIETY REVIEWS (2022)

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Review Chemistry, Multidisciplinary

Emerging biomimetic nanotechnology in orthopedic diseases: progress, challenges, and opportunities

Zhongyang Zhang et al.

Summary: Biomimetic nanotechnology plays an important role in the treatment of orthopedic diseases by restoring the structure and function of bone tissue and improving therapeutic efficacy. Understanding the pathogenesis can optimize treatment strategies. However, there are still challenges and unmet needs that hinder the clinical implementation of biomimetic nanotechnology.

TRENDS IN CHEMISTRY (2022)

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Article Medicine, Research & Experimental

Plaque-targeted, proteolysis-resistant, activatable and MRI-visible nano-GLP-1 receptor agonist targets smooth muscle cell differentiation in atherosclerosis

Andrei Maiseyeu et al.

Summary: GLP-1R agonists have been shown to lower cardiovascular events and mortality, but their specific effects on atherosclerosis have been unclear. This study demonstrates that targeted agonists of GLP-1R may alleviate vascular inflammation and plaque burden in atherosclerosis, even at low doses. The engineered nanoparticles carrying GLP-1R agonist showed promising results in reducing atherosclerosis, cholesterol, and triglyceride-rich lipoproteins in Apoe(-/-) mice.

THERANOSTICS (2022)

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Article Cardiac & Cardiovascular Systems

Evaluation of the safety and efficacy of the CobraPzF NanoCoatedcoronary stent in routine, consecutive, prospective, and high-risk patients: Thee-Cobrastudy

Luc Maillard et al.

Summary: The study demonstrates that the Cobra PzF stent is safe and effective in routine PCI patients, especially suitable for those in need of short-term dual antiplatelet therapy. Satisfactory clinical outcomes were associated with one-year follow-up and validate previously reported data.

CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS (2021)

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Article Engineering, Environmental

Biomimetic liposomes hybrid with platelet membranes for targeted therapy of atherosclerosis

Yanan Song et al.

Summary: Atherosclerosis is a major cause of cardiovascular events and deaths worldwide, with platelets playing a role in the disease process. Biomimetic nanoparticles, such as P-Lipo, have been designed to target atherosclerosis by mimicking the natural homing of platelets. P-Lipo showed increased accumulation and efficacy in inhibiting atherosclerosis development, making it a promising platform for treating atherosclerosis and other platelet-related diseases.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Nanoscience & Nanotechnology

Dynamic Protein Corona of Gold Nanoparticles with an Evolving Morphology

Aparna Nandakumar et al.

Summary: This study investigated the protein coronae associated with gold nanoparticles of different shapes and found distinct differences in protein composition, shedding light on the implications for future nanomedicine research.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Biotechnology & Applied Microbiology

Sonodynamic therapy reduces iron retention of hemorrhagic plaque

Bicheng Li et al.

Summary: The study demonstrates that sonodynamic therapy can treat hemorrhagic atherosclerotic plaques by regulating iron retention and reducing plaque burden. It also shows therapeutic effects on mouse plaques with high susceptibility to hemorrhage, indicating its potential translational value in clinical practice for advanced atherosclerosis patients.

BIOENGINEERING & TRANSLATIONAL MEDICINE (2021)

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Article Nanoscience & Nanotechnology

Hyaluronan-Conjugated Carbon Quantum Dots for Bioimaging Use

Bedia Begum Karakocak et al.

Summary: This study demonstrates the use of hyaluronan-conjugated nitrogen-doped carbon quantum dots (HA-nCQDs) for imaging of tumor cells and potential as carriers for targeted drug delivery. By grafting hyaluronic acid onto nCQDs, targeted internalization by cancer cells was achieved. Results show that HA-nCQDs can be used for imaging CD44-specific tumors and hold promise for targeted drug delivery into CD44-rich cells.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Hematology

Analysis of 18F-Sodium Fluoride Positron Emission Tomography Signal Sources in Atherosclerotic Minipigs Shows Specific Binding of 18F-Sodium Fluoride to Plaque Calcifications

Paula Nogales et al.

Summary: In a study on atherosclerotic minipigs, it was confirmed that F-18-NaF accumulated specifically in plaque calcifications in vivo, but was less accurate than computed tomography in detecting small calcifications.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

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Article Pharmacology & Pharmacy

Pharmacometric analyses to characterize the effect of CSL112 on apolipoprotein A-I and cholesterol efflux capacity in acute myocardial infarction patients

Bo Zheng et al.

Summary: The pharmacometric analysis of CSL112 administration in patients with acute myocardial infarction (AMI) showed that a fixed 6 g dose can significantly increase cholesterol efflux capacity (CEC), potentially reducing the risk of early recurrent cardiovascular events in AMI patients.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2021)

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Article Cell Biology

Efferocytosis induces macrophage proliferation to help resolve tissue injury

Brennan D. Gerlach et al.

Summary: This study demonstrates that nucleotides derived from apoptotic cell DNA hydrolysis by phagolysosomal DNase2a activate a pathway promoting non-inflammatory macrophage proliferation. The findings suggest that these nucleotides can amplify the resolution benefit by increasing the number of efferocytosing macrophages, thus enhancing tissue resolution in various experimental models including peritonitis, thymocyte apoptosis, and atherosclerosis regression.

CELL METABOLISM (2021)

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Review Biochemistry & Molecular Biology

Safe Nanoparticles: Are We There Yet?

Wided Najahi-Missaoui et al.

Summary: The field of nanotechnology has rapidly grown over the past two decades, leading to the emergence of nanoparticles as promising tools in various applications. However, questions about the toxicity and safety of nanoparticles remain unanswered, despite efforts to understand them. Several approaches to minimize and prevent nanoparticle toxicity have been identified through research.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Biochemistry & Molecular Biology

Harnessing nanotechnology to expand the toolbox of chemical biology

Ryan M. Williams et al.

Summary: Although nanotechnology is often utilized in the biomedical field, it can also aid in broad biological discoveries. There is currently opportunity for collaboration between chemical biologists and nanotechnologists, with nanotechnology expanding the utility of chemical tools and chemical biologists working with nanotechnologists to tackle challenging biological questions.

NATURE CHEMICAL BIOLOGY (2021)

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Article Multidisciplinary Sciences

Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions

Mano R. Maurya et al.

Summary: The study found that the responses of HAECs and HUVECs are qualitatively similar for endothelial function-relevant genes and several important pathways, with HAECs exhibiting faster kinetics compared to HUVECs in some aspects. The comparative analysis offers insights into the mechanisms of common and disparate shear stress responses across these two major endothelial cell types.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Review Cardiac & Cardiovascular Systems

Altered Vascular Extracellular Matrix in the Pathogenesis of Atherosclerosis

Rohit Mohindra et al.

Summary: The pathogenesis of atherosclerosis leads to changes in the blood vessel and its extracellular matrix (ECM), which significantly affects the inflammatory response, proliferation and migration of vascular smooth muscle cells, neointimal formation, and vascular fibrosis. Understanding these effects of ECM alterations provides numerous therapeutic options to reduce the impact of atherosclerosis on global health.

JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2021)

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Article Chemistry, Medicinal

Imaging of Dysfunctional Elastogenesis in Atherosclerosis Using an Improved Gadolinium-Based Tetrameric MRI Probe Targeted to Tropoelastin

Federico Capuana et al.

Summary: The use of Gd-4-TESMA, a tetrameric probe specifically designed for molecular imaging of tropoelastin within atherosclerotic plaques, shows great promise in enhancing the characterization of plaque progression compared to monomeric counterparts.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Chemistry, Multidisciplinary

The Protein Corona Leads to Deformation of Spherical Micelles

Cheng Cao et al.

Summary: The formation of a non-specific protein corona around nanoparticles has been identified as a factor in the failure of nanomedicine. When proteins adsorb onto nanoparticles, they can cause deformation, affecting blood circulation and cell uptake.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2021)

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Article Nanoscience & Nanotechnology

Anti-inflammatory potential of simvastatin loaded nanoliposomes in 2D and 3D foam cell models

Moumita Rakshit et al.

Summary: Atherosclerosis is a multifactorial disease triggered by risk factors such as high cholesterol, high blood pressure, and unhealthy lifestyle. In this study, a simvastatin-loaded nanoliposomal formulation (LIPOSTAT) was developed to deliver the drug into atherosclerotic plaque, reducing inflammation and promoting cholesterol efflux.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2021)

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Review Nanoscience & Nanotechnology

The ancillary effects of nanoparticles and their implications for nanomedicine

Evan P. Stater et al.

Summary: Nanoparticles, beyond their engineered functions, can induce specific biological effects, which may have implications for the development and clinical application of nanomedicine.

NATURE NANOTECHNOLOGY (2021)

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Editorial Material Cardiac & Cardiovascular Systems

Midlife Cardiovascular Risk Factors, Subclinical Atherosclerosis, and Cerebral Hypometabolism

Neal S. Parikh et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2021)

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Article Medicine, Research & Experimental

CC Chemokine Receptor 5 Targeted Nanoparticles Imaging the Progression and Regression of Atherosclerosis Using Positron Emission Tomography/Computed Tomography

Lisa Detering et al.

Summary: Chemokine receptor 5 (CCR5) plays a crucial role in the development of atherosclerosis, with CCR5 antagonists showing potential for inhibiting disease progression. Targeted nanoparticles for CCR5 can sensitively detect atherosclerotic lesions, making them promising for atherosclerosis imaging applications.

MOLECULAR PHARMACEUTICS (2021)

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Article Multidisciplinary Sciences

Stiffness of targeted layer-by-layer nanoparticles impacts elimination half-life, tumor accumulation, and tumor penetration

Stephanie M. Kong et al.

Summary: The stiffness of nanoparticles plays a crucial role in drug delivery, affecting circulation time, tumor accumulation, and penetration. Layer-by-layer nanoparticles can modulate stiffness by adjusting the mechanical properties of the core, leading to improved tumor targeting and therapeutic outcomes.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Nanoscience & Nanotechnology

Magnetic mesoporous silica nanoparticles-aided dual MR/NIRF imaging to identify macrophage enrichment in atherosclerotic plaques

Menglin Wu et al.

Summary: The enrichment of active foamy macrophages plays a crucial role in atherosclerotic plaque formation and evolution, and is a key target for identifying vulnerable plaque. However, current magnetic resonance (MR) imaging of plaque using iron oxide nanoparticles is often limited by issues such as insufficient perfusion and nonspecific accumulation. By developing a novel magnetic mesoporous silica nanoparticle (PIMI) loaded with near-infrared fluorescence dye (IR820) and targeting macrophage enrichment in atherosclerotic plaque, this study lays the foundation for a next-generation contrast agent for recognizing macrophage-rich plaque in the future.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2021)

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Review Immunology

NLRP3 inflammasome in cancer and metabolic diseases

Bhesh Raj Sharma et al.

Summary: The NLRP3 inflammasome plays diverse roles in cancer and metabolic diseases, being involved in the release of inflammatory cytokines and inflammatory cell death upon activation. While inflammatory cytokines contribute to chronic inflammation and disease pathogenesis, fine tuning NLRP3 activity is crucial for maintaining cellular health.

NATURE IMMUNOLOGY (2021)

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Article Cell Biology

Detection of Vascular Reactive Oxygen Species in Experimental Atherosclerosis by High-Resolution Near-Infrared Fluorescence Imaging Using VCAM-1-Targeted Liposomes Entrapping a Fluorogenic Redox-Sensitive Probe

Simona-Adriana Manea et al.

Summary: Excessive production of reactive oxygen species (ROS) plays a key role in atherosclerosis. This study aimed to develop an imaging procedure to monitor ROS overproduction in atherosclerosis. Encapsulation of the ROS BriteTM 700 probe into VCAM-1-targeted liposomes allowed for the quantitative detection of ROS signals in cells and mouse models, providing a novel approach for studying atherosclerosis.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

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Article Chemistry, Multidisciplinary

Platelet-Mimicking Therapeutic System for Noninvasive Mitigation of the Progression of Atherosclerotic Plaques

Yi Ma et al.

Summary: Atherosclerotic plaque is the primary cause of cardiovascular disorders, and traditional clinical strategies are often limited. Researchers have designed a biomimic photodynamic therapeutic system that can target foam cells in early atherosclerotic plaques using platelet membrane-coated upconversion nanoparticle cores loaded with photosensitizer, which shows promising results in alleviating plaque progression.

ADVANCED SCIENCE (2021)

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Article Chemistry, Physical

The emerging role of nanotechnology in skincare

Lucia Salvioni et al.

Summary: The role of cosmetic products in society is evolving rapidly, with the importance of personal wellness contributing to their increasing use. This necessitates a detailed explanation of the use of nanoparticles in cosmetics. Nanotechnology has been shown to improve the performance of cosmetics in various ways, particularly in skincare, and despite concerns about nanoparticle toxicity, there are detailed examples of nanocosmetic products with investigated safety.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2021)

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Article Engineering, Biomedical

The protein corona hampers the transcytosis of transferrin-modified nanoparticles through blood-brain barrier and attenuates their targeting ability to brain tumor

Wei Xiao et al.

Summary: The modification of targeting ligands on nanoparticles is expected to enhance therapeutic delivery to diseased tissues, but the protein corona formed when exposed to the blood stream can hinder this process. Research shows that the protein corona has different impacts on receptor targeting, lysosomal escape, and protein transcytosis in BBB. After crossing the BBB, transferrin retains its targeting specificity towards brain tumor cells.

BIOMATERIALS (2021)

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Article Chemistry, Medicinal

Highly Efficient Activatable MRI Probe to Sense Myeloperoxidase Activity

Cuihua Wang et al.

Summary: heMAMP is a highly efficient MPO-activatable MRI probe with improved stability and increased affinity to the active site of MPO. It shows significantly higher contrast-to-noise ratios in animal models of inflammation and unstable atherosclerotic plaques compared to conventional probes, making it a promising candidate for translation to clinical settings.

JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Article Engineering, Biomedical

Durable endothelium-mimicking coating for surface bioengineering cardiovascular stents

Qing Ma et al.

Summary: Research has shown that mimicking the functions of native endothelium on cardiovascular stent surfaces by releasing nitric oxide and mimicking glycocalyx can effectively reduce restenosis. A mussel-inspired amine-bearing adhesive coating has been developed to tether the NO-generating species and glycocalyx-like component, creating a durable endothelium-mimicking surface with high bioactivity retention and sustained NO generation. This strategy demonstrates long-term physiological effects on inhibiting thrombosis, inflammation, and intimal hyperplasia, enhancing re-endothelialization, and efficiently reducing restenosis.

BIOACTIVE MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Ratiometric Semiconducting Polymer Nanoparticle for Reliable Photoacoustic Imaging of Pneumonia-Induced Vulnerable Atherosclerotic Plaque in Vivo

Yuan Ma et al.

Summary: The developed RSPN nanoparticles in this study can accurately assess the rupture risk of vulnerable plaque caused by acute pneumonia and successfully reflect the oxidative stress level in vulnerable plaque, providing a promising approach to reduce the mortality of atherosclerotic-induced cardiovascular disease.

NANO LETTERS (2021)

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Article Nanoscience & Nanotechnology

Fe3O4@M nanoparticles for MRI-targeted detection in the early lesions of atherosclerosis

Xin Huang et al.

Summary: This study prepared Fe3O4 biomimetic nanoparticles coated with a macrophage membrane for imaging early lesions of atherosclerosis. The nanoparticles showed promising potential as a contrast agent for the diagnosis of early stage atherosclerosis.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2021)

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Review Multidisciplinary Sciences

The changing landscape of atherosclerosis

Peter Libby

Summary: Emerging evidence has led to a significant evolution of concepts related to atherosclerosis, with a shifting risk profile that is no longer limited to specific regions or demographics. Recent research has highlighted new risk factors and mechanisms underlying atherosclerosis, opening doors to potential therapeutic interventions for this widespread disease.

NATURE (2021)

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Article Nutrition & Dietetics

Relationship Between Dietary Patterns and Carotid Atherosclerosis Among People Aged 50 Years or Older: A Population-Based Study in China

Yunyun Liu et al.

Summary: This study aimed to investigate the relationship between dietary patterns and carotid atherosclerosis. The results showed that greater adherence to sweets dietary patterns was positively related to a higher prevalence of carotid atherosclerosis in women, while no relationship was found between any dietary pattern and carotid atherosclerosis in men.

FRONTIERS IN NUTRITION (2021)

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Article Nanoscience & Nanotechnology

cRGD Peptide-Modified Nanocarriers for Targeted Delivery of Angiogenesis Inhibitors to Attenuate Advanced Atherosclerosis

Zhaojun Li et al.

Summary: This study developed a targeting nanodelivery system, cRGD peptide-modified RNPs, for delivering the antiangiogenesis drug PEDF to inhibit neovascularization in plaque. In vitro and in vivo experiments demonstrated the effectiveness of PEDF RNPs in reducing plaque area and thickness, suggesting their potential for future clinical applications in atherosclerosis treatment.

ACS APPLIED NANO MATERIALS (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

In Vivo Molecular K-Edge Imaging of Atherosclerotic Plaque Using Photon-counting CT

Salim A. Si-Mohamed et al.

Summary: This study successfully detected and quantified macrophage burden within atherosclerotic plaques in rabbits using gold nanoparticles in combination with k-edge imaging technology. The results were consistent with findings from histologic examination and other methods.

RADIOLOGY (2021)

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Article Multidisciplinary Sciences

2D vanadium carbide MXenzyme to alleviate ROS-mediated inflammatory and neurodegenerative diseases

Wei Feng et al.

Summary: Materials with enzymatic-like activities, such as 2D vanadium carbide MXene nanozymes, show promise in treating inflammatory and neurodegenerative diseases mediated by reactive oxygen species.

NATURE COMMUNICATIONS (2021)

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Article Chemistry, Multidisciplinary

Modulation of Macrophage Polarization by Carbon Nanodots and Elucidation of Carbon Nanodot Uptake Routes in Macrophages

Andrew Dunphy et al.

Summary: This research demonstrates that CNDs cause functional changes in macrophages by increasing expression of key receptors and pro-inflammatory cytokines. Additionally, the study explores potential entrance routes of CNDs into macrophages, showing inhibition in uptake with certain inhibitors.

NANOMATERIALS (2021)

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Article Nanoscience & Nanotechnology

Near-Infrared Light-Driven Multifunctional Tubular Micromotors for Treatment of Atherosclerosis

Xiaoyun Li et al.

Summary: This near-infrared light-driven multifunctional micromotor can rapidly target damaged blood vessels and release different drugs, promoting penetration into plaque sites through motion effects and achieving photothermal ablation of inflammatory macrophages through heat effects. In vivo experiments have demonstrated that these micromotors can provide good therapeutic effects for atherosclerosis.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

SR-A-Targeted Nanoplatform for Sequential Photothermal/Photodynamic Ablation of Activated Macrophages to Alleviate Atherosclerosis

Jingjing Liu et al.

Summary: The study utilized a multifunctional therapeutic nanoplatform, CS-CNCs@Ce6/DS, for selective targeting of activated macrophages in arterial plaques. The photothermal conversion capability of CS-CNCs facilitated efficient therapeutic delivery during photothermal therapy, while near-infrared-accelerated drug release enhanced the concentration of Ce6 in atherosclerotic plaque areas and the efficiency of photodynamic therapy.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Nanoscience & Nanotechnology

HAP-Multitag, a PET and Positive MRI Contrast Nanotracer for the Longitudinal Characterization of Vascular Calcifications in Atherosclerosis

Juan Pellico et al.

Summary: Vascular microcalcifications are associated with atherosclerosis plaque instability and increased mortality, with imaging probes such as [F-18]FNa playing a key role in their in vivo identification. The development of HAP-multitag shows promise in early characterization of atherosclerosis, with potential for identifying lesion progression and calcification stages using PET/(T-1)MRI imaging.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Review Pharmacology & Pharmacy

Liposome composition in drug delivery design, synthesis, characterization, and clinical application

Danielle E. Large et al.

Summary: Liposomal drug delivery is a highly adaptable therapeutic platform for treating a wide range of diseases. The molecular diversity in liposome composition enables drug delivery with unique physiological functions, such as pH response and reduced systemic toxicity.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Article Chemistry, Multidisciplinary

Ultraselective Carbon Nanotubes for Photoacoustic Imaging of Inflamed Atherosclerotic Plaques

Mahsa Gifani et al.

Summary: Targeting inflammatory immune cells in atherosclerotic plaques may provide clinically relevant diagnostic information about cardiovascular disease, and a new method combining ultraselective nanoparticle targeting and clinically-viable photoacoustic imaging has shown promise in accurately identifying and diagnosing inflamed plaques.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Article Chemistry, Multidisciplinary

Palladium Hydride Nanopocket Cubes and Their H2-Therapy Function in Amplifying Inhibition of Foam Cells to Attenuate Atherosclerosis

Min Xu et al.

Summary: In this study, a coupling hardness with softness strategy utilizing palladium hydride nanopocket cubes was developed for the first time to regulate lipid uptake and efflux, resulting in the inhibition of foam cell formation and reduction of atherosclerosis. This approach shows promise as a high efficacy and low toxicity method for treating atherosclerosis.

ADVANCED FUNCTIONAL MATERIALS (2021)

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Review Chemistry, Physical

Advances in amphiphilic polylactide/vinyl polymer based nano-assemblies for drug delivery

Didier Gigmes et al.

Summary: Amphiphilic copolymer micelles are key candidates in drug delivery, with PLA-based micelles and controlled radical polymerizations offering new opportunities for advanced drug delivery systems. Key properties such as stealth character, cell targeting and stimuli-responsiveness have been advanced in the past decade for PLA/vinyl polymer based nano-carriers.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2021)

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Article Hematology

Near-Infrared Autofluorescence in Atherosclerosis Associates With Ceroid and Is Generated by Oxidized Lipid-Induced Oxidative Stress

Mazen S. Albaghdadi et al.

Summary: The study shows that NIRAF is associated with lipid and oxidative stress, generated through oxidized lipid-driven oxidative stress, and supports ceroid as a source of NIRAF in human atherosclerosis.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2021)

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Article Public, Environmental & Occupational Health

Systemic inflammation markers and cancer incidence in the UK Biobank

Therese Haugdahl Nost et al.

Summary: Systemic inflammation markers are associated with increased cancer risk and mortality. This study found associations between pre-diagnostic systemic inflammation markers and cancer risk, with SII showing the strongest impact on colorectal and lung cancer risk.

EUROPEAN JOURNAL OF EPIDEMIOLOGY (2021)

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Article Chemistry, Multidisciplinary

Macrophage-biomimetic anti-inflammatory liposomes for homing and treating of aortic dissection

Jingxuan Liu et al.

Summary: The study suggests that utilizing nanotherapy, such as PM/TN-CCLP, can significantly prevent and treat aortic dissection by reducing the rupture rate, preventing loss of elastic fibers, and decreasing inflammation at the lesion site.

JOURNAL OF CONTROLLED RELEASE (2021)

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Article Engineering, Environmental

Porous Co3O4 nanodisks as robust peroxidase mimetics in an ultrasensitive colorimetric sensor for the rapid detection of multiple heavy metal residues in environmental water samples

Wenying Zou et al.

Summary: A porous Co3O4 nanodisks with robust peroxidase-mimicking activity was prepared for ultrasensitive and rapid detection of multiple heavy metals in environmental water. The heavy metals inhibit the catalytic activity of the sensor, with an average recovery range of up to 98.3% in actual water samples.

JOURNAL OF HAZARDOUS MATERIALS (2021)

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Article Nanoscience & Nanotechnology

Liposome interaction with macrophages and foam cells for atherosclerosis treatment: effects of size, surface charge and lipid composition

Jinkai Tang et al.

Summary: The study showed that the size, charge, and lipid composition of liposomes affect the uptake by macrophages and foam cells, with cationic and DSPC liposomes being internalized more. Phagocytosis and clathrin-mediated endocytosis were identified as dominant mechanisms of uptake, and anionic and DSPC liposomes induced more cholesterol efflux capacity in foam cells.

NANOTECHNOLOGY (2021)

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Article Multidisciplinary Sciences

A model of atherosclerosis using nicotine with balloon overdilation in a porcine

Munki Kim et al.

Summary: A porcine coronary artery atherosclerosis model was successfully developed using nicotine injection with a balloon overdilation, inducing atherosclerotic lesions within one month. This model can serve as an alternative pig animal model for the development of coronary stents.

SCIENTIFIC REPORTS (2021)

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Article Biotechnology & Applied Microbiology

Theranostic nanoplatform to target macrophages enables the inhibition of atherosclerosis progression and fluorescence imaging of plaque in ApoE(-/-) mice

Qi Wang et al.

Summary: The study presented the development of composite mesoporous silica nanoparticle-based nanomedicines for accurate diagnosis and treatment of atherosclerosis. The designed CMSN@SRT@Anti showed excellent biocompatibility, high-performance, and superior atherosclerosis-targeting ability. Animal experimental results demonstrated significant improvements in aortic plaque status and area after treatment with CMSN@SRT@Anti.

JOURNAL OF NANOBIOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Low-Intensity Focused Ultrasound-Responsive Ferrite-Encapsulated Nanoparticles for Atherosclerotic Plaque Neovascularization Theranostics

Jianting Yao et al.

Summary: Pathological angiogenesis is a crucial factor in atherosclerotic plaque rupture, and a new nanoplatform called PHPMR NPs has been developed for multimodality imaging-guided therapy targeting plaque neovascularization, showing promising results in stabilizing plaques and reducing neovessel density.

ADVANCED SCIENCE (2021)

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Article Chemistry, Multidisciplinary

A ROS and shear stress dual-sensitive bionic system with cross-linked dendrimers for atherosclerosis therapy

Meili Shen et al.

Summary: The study developed a dual-response drug delivery system for the treatment of atherosclerosis, which could release drugs in response to the special microenvironment of plaques and detach under shear stress stimulus. The system showed better therapeutic effects and excellent safety in vivo compared to free drugs, demonstrating its promising potential for atherosclerosis treatment.

NANOSCALE (2021)

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Article Materials Science, Multidisciplinary

Biomimetic immunomodulation by crosstalk with nanoparticulate regulatory T cells

Shuang Li et al.

Summary: This study presents a biomimetic manipulation strategy for immunosuppression using regulatory T cell membrane-coated nanoparticles. The coated nanoparticles interact with overactive immune cells, inhibiting immune responses effectively in murine and canine models of periodontitis. This approach shows promise in treating immuno-inflammatory diseases by modulating dysregulated immune responses.

MATTER (2021)

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Article Biochemistry & Molecular Biology

The pro-angiogenesis effect of miR33a-5p/Ets-1/DKK1 signaling in ox-LDL induced HUVECs

Mingxue Di et al.

Summary: The study revealed that the MiR33a-5p/Ets-1/DKK1 signaling pathway is involved in ox-LDL-induced angiogenesis of HUVECs. These new findings provide a rationale and notable method for tumor therapy and cardiovascular protection.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2021)

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Article Chemistry, Applied

Cardio-protective and Anti-atherosclerosis Effect of Crocetin on Vitamin D3 and HFD-induced Atherosclerosis in Rats

Laizeng Yu et al.

Summary: The study demonstrated that Crocetin has cardioprotective effects in rats with atherosclerosis induced by vitamin D3 and high fat diets, by reducing lipid levels, decreasing vascular inflammation, and attenuating aortic membrane thickness through anti-inflammatory and antioxidant mechanisms.

JOURNAL OF OLEO SCIENCE (2021)

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Article Medicine, Research & Experimental

Macrophage targeted theranostic strategy for accurate detection and rapid stabilization of the inflamed high-risk plaque

Joon Woo Song et al.

Summary: A theranostic nanodrug targeting macrophage mannose receptor was developed to deliver specific medication to high-risk plaques with high inflammatory activity, rapidly stabilizing inflamed plaques in coronary arteries, providing a promising therapeutic strategy for high-risk coronary plaques.

THERANOSTICS (2021)

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Article Medicine, Research & Experimental

High Pathological Reproducibility of Diet-induced Atherosclerosis in Microminipigs via Cloning Technology

Masayoshi Otake et al.

Summary: The study found that F1 offspring and F1 clones fed with HcD showed similar results in serum lipid levels and systemic atherosclerosis to HcD-fed non-cloned microminipigs, indicating high reproducibility in atherogenesis.

IN VIVO (2021)

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Article Chemistry, Analytical

A nano-detection system based on a chemical probe for early diagnosis of atherosclerosis in situ

Qiaolei Wang et al.

Summary: This study utilized a fluorescent probe to detect cellular reactive oxygen species and prepared a nano-detection system for early detection of AS. Experimental results showed effective targeting in early AS rats and no acute biological toxicity, indicating promising application potential for early AS detection.

ANALYST (2021)

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Article Medicine, Research & Experimental

Imaging atherosclerotic plaques by targeting Galectin-3 and activated macrophages using (89Zr)-DFO-Galectin3-F(ab')2 mAb

Zohreh Varasteh et al.

Summary: The study found that targeting Gal3 through PET/CT imaging can effectively track atherosclerotic plaques in mice. The results suggest that Gal3 is mainly expressed in macrophages within plaques, and exhibits similar expression patterns in human plaques.

THERANOSTICS (2021)

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Article Medicine, Research & Experimental

Highly sensitive magnetic particle imaging of vulnerable atherosclerotic plaque with active myeloperoxidase-targeted nanoparticles

Wei Tong et al.

Summary: The novel multimodal imaging platform targeting active myeloperoxidase showed promising results in sensitively differentiating and accurately localizing vulnerable atherosclerotic plaques in vivo. This approach may serve as a method for detecting vulnerable plaques and monitoring inflammation activity related to atherosclerosis.

THERANOSTICS (2021)

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Article Medicine, Research & Experimental

Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications

Yi Wang et al.

Summary: This study aimed to develop an ideal biomimetic nanoparticle for targeted atherosclerosis (AS) therapy. The results showed that the advanced MM/RAPNPs demonstrated good biocompatibility, effectively inhibited the progression of AS, and displayed favorable safety performance in AS mouse models. These biomimetic nanoparticles may be potential drug delivery systems for safe and effective anti-AS applications.

THERANOSTICS (2021)

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Article Biochemical Research Methods

Multimodal Positron Emission Tomography Imaging to Quantify Uptake of 89Zr-Labeled Liposomes in the Atherosclerotic Vessel Wall

Mark E. Lobatto et al.

BIOCONJUGATE CHEMISTRY (2020)

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Article Nanoscience & Nanotechnology

Dual-Targeted Synthetic Nanoparticles for Cardiovascular Diseases

Bhabatosh Banik et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

Platelet Membrane Biomimetic Magnetic Nanocarriers for Targeted Delivery and in Situ Generation of Nitric Oxide in Early Ischemic Stroke

Mingxi Li et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Semiconducting Polymer Nanoparticles as Theranostic System for Near-Infrared-II Fluorescence Imaging and Photothermal Therapy under Safe Laser Fluence

Yanqing Yang et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Molecularly Engineered Macrophage-Derived Exosomes with Inflammation Tropism and Intrinsic Heme Biosynthesis for Atherosclerosis Treatment

Guanghao Wu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Chemistry, Applied

Novel dual ROS-sensitive and CD44 receptor targeting nanomicelles based on oligomeric hyaluronic acid for the efficient therapy of atherosclerosis

Xiaoya Hou et al.

CARBOHYDRATE POLYMERS (2020)

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Article Pharmacology & Pharmacy

Sonodynamic therapy in atherosclerosis by curcumin nanosuspensions: Preparation design, efficacy evaluation, and mechanisms analysis

Lei Jiang et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

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Article Materials Science, Biomaterials

Covalent immobilization of biomolecules on stent materials through mussel adhesive protein coating to form biofunctional films

Yi Wang et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Nanoscience & Nanotechnology

Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis

Alyssa M. Flores et al.

NATURE NANOTECHNOLOGY (2020)

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Review Pharmacology & Pharmacy

Brothers in Arms: ABCA1-and ABCG1-Mediated Cholesterol Efflux as Promising Targets in Cardiovascular Disease Treatment

Sanne J. C. M. Frambach et al.

PHARMACOLOGICAL REVIEWS (2020)

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Article Multidisciplinary Sciences

Photosynthesis-inspired H2 generation using a chlorophyll-loaded liposomal nanoplatform to detect and scavenge excess ROS

Wei-Lin Wan et al.

NATURE COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

Reactive Oxygen Species Responsive Theranostic Nanoplatform for Two-Photon Aggregation-Induced Emission Imaging and Therapy of Acute and Chronic Inflammation

Boxuan Ma et al.

ACS NANO (2020)

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Article Multidisciplinary Sciences

Ferumoxytol-enhanced three-dimensional magnetic resonance imaging of carotid atheroma- a feasibility and temporal dependence study

Ammara Usman et al.

SCIENTIFIC REPORTS (2020)

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Review Chemistry, Physical

Dendrimers as efficient nanocarriers for the protection and delivery of bioactive phytochemicals

Mohammad Yousefi et al.

ADVANCES IN COLLOID AND INTERFACE SCIENCE (2020)

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Article Chemistry, Multidisciplinary

Fine-Tuning the Homometallic Interface of Au-on-Au Nanorods and Their Photothermal Therapy in the NIR-II Window

Jia Jia et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)

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Article Pharmacology & Pharmacy

Stent coating by electrospinning with chitosan/poly-cyclodextrin based nanofibers loaded with simvastatin for restenosis prevention

Dyhia Kersani et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2020)

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Review Biochemistry & Molecular Biology

Current Advances in the Diagnostic Imaging of Atherosclerosis: Insights into the Pathophysiology of Vulnerable Plaque

Nataliya V. Mushenkova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Article Multidisciplinary Sciences

Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines

Cheng Gao et al.

NATURE COMMUNICATIONS (2020)

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Article Chemistry, Multidisciplinary

Biodegradable Gold Nanoclusters with Improved Excretion Due to pH-Triggered Hydrophobic-to-Hydrophilic Transition

Elizabeth M. Higbee-Dempsey et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Engineering, Biomedical

Complement Receptor Targeted Liposomes Encapsulating the Liver X Receptor Agonist GW3965 Accumulate in and Stabilize Atherosclerotic Plaques

Naomi Benne et al.

ADVANCED HEALTHCARE MATERIALS (2020)

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Article Materials Science, Biomaterials

Enhancing biocompatibility and corrosion resistance of biodegradable Mg-Zn-Y-Nd alloy by preparing PDA/HA coating for potential application of cardiovascular biomaterials

Jing-an Li et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Nanoscience & Nanotechnology

Probing myeloid cell dynamics in ischaemic heart disease by nanotracer hot-spot imaging

Max L. Senders et al.

NATURE NANOTECHNOLOGY (2020)

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Article Chemistry, Analytical

In Vivo Imaging of Senescent Vascular Cells in Atherosclerotic Mice Using a β-Galactosidase-Activatable Nanoprobe

Ji-An Chen et al.

ANALYTICAL CHEMISTRY (2020)

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Article Cardiac & Cardiovascular Systems

Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate Complex SMC Phenotypic Changes Critical in Late-Stage Atherosclerotic Lesion Pathogenesis

Gabriel F. Alencar et al.

CIRCULATION (2020)

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Article Nanoscience & Nanotechnology

ORIGINAL RESEARCH Molecular Imaging of Inflammation in a Mouse Model of Atherosclerosis Using a Zirconium-89-Labeled Probe

Mona Ahmed et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2020)

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Editorial Material Medicine, General & Internal

Lipids and Lipoproteins in 2020

Brian A. Ference et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2020)

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Article Nanoscience & Nanotechnology

Protein Nanoparticle Charge and Hydrophobicity Govern Protein Corona and Macrophage Uptake

Samantha M. Pustulka et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Article Chemistry, Multidisciplinary

RNA Nanoparticles as Rubber for Compelling Vessel Extravasation to Enhance Tumor Targeting and for Fast Renal Excretion to Reduce Toxicity

Chiran Ghimire et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

A Non-Invasive Nanoprobe for In Vivo Photoacoustic Imaging of Vulnerable Atherosclerotic Plaque

Xiaoxiao Ge et al.

ADVANCED MATERIALS (2020)

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Article Materials Science, Biomaterials

Immobilisation of an anti-platelet adhesion and anti-thrombotic drug (EP224283) on polydopamine coated vascular stent promoting anti-thrombogenic properties

Nicolas Bricout et al.

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Article Cardiac & Cardiovascular Systems

Single-Cell Genomics Reveals a Novel Cell State During Smooth Muscle Cell Phenotypic Switching and Potential Therapeutic Targets for Atherosclerosis in Mouse and Human

Huize Pan et al.

CIRCULATION (2020)

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Article Cell Biology

siRNA nanoparticles targeting CaMKIIγ in lesional macrophages improve atherosclerotic plaque stability in mice

Wei Tao et al.

SCIENCE TRANSLATIONAL MEDICINE (2020)

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Article Materials Science, Biomaterials

Synthesis and characterization of Gd-DTPA/fucoidan/peptide complex nanoparticle and in vitro magnetic resonance imaging of inflamed endothelial cells

Tsai-Mu Cheng et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2020)

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Review Chemistry, Multidisciplinary

Ultrasound mediated therapy: Recent progress and challenges in nanoscience

Jiang Ouyang et al.

NANO TODAY (2020)

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Article Cardiac & Cardiovascular Systems

Label-Free Visualization and Quantification of Biochemical Markers of Atherosclerotic Plaque Progression Using Intravascular Fluorescence Lifetime

Julien Bec et al.

JACC-CARDIOVASCULAR IMAGING (2020)

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Article Cardiac & Cardiovascular Systems

Sonodynamic Therapy Suppresses Neovascularization in Atherosclerotic Plaques via Macrophage Apoptosis-Induced Endothelial Cell Apoptosis

Jianting Yao et al.

JACC-BASIC TO TRANSLATIONAL SCIENCE (2020)

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Article Multidisciplinary Sciences

In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment

Jiang Ouyang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

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Article Materials Science, Multidisciplinary

Nitric Oxide Releasing Polyamide Dendrimer with Anti-inflammatory Activity

Ana M. Garzon-Porras et al.

ACS APPLIED POLYMER MATERIALS (2020)

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Article Chemistry, Multidisciplinary

IL-6-targeted ultrasmall superparamagnetic iron oxide nanoparticles for optimized MRI detection of atherosclerotic vulnerable plaques in rabbits

Huaqiang Mo et al.

RSC ADVANCES (2020)

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Article Materials Science, Biomaterials

Platelet-derived nanomotor coated balloon for atherosclerosis combination therapy

Yangyang Huang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2020)

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Article Chemistry, Multidisciplinary

AgFeS2 nanoparticles as a novel photothermal platform for effective artery stenosis therapy

Xuan Peng et al.

NANOSCALE (2020)

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Article Medicine, Research & Experimental

In vivo assessment of inflammation in carotid atherosclerosis by noninvasive photoacoustic imaging

Zhihua Xie et al.

THERANOSTICS (2020)

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Article Chemistry, Medicinal

Peptide-Based Soft Hydrogels Modified with Gadolinium Complexes as MRI Contrast Agents

Enrico Gallo et al.

PHARMACEUTICALS (2020)

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Article Chemistry, Multidisciplinary

Imaging endogenous HClO in atherosclerosis using a novel fast-response fluorescence probe

Beibei Wang et al.

CHEMICAL COMMUNICATIONS (2020)

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Article Medicine, Research & Experimental

Immunization with the Gly1127-Cys1140 amino acid sequence of the LRP1 receptor reduces atherosclerosis in rabbits. Molecular, immunohistochemical and nuclear imaging studies

Olga Bornachea et al.

THERANOSTICS (2020)

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Article Cardiac & Cardiovascular Systems

Rapid inhibition of atherosclerotic plaque progression by sonodynamic therapy

Xin Sun et al.

CARDIOVASCULAR RESEARCH (2019)

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Article Nanoscience & Nanotechnology

Platelet membrane-coated nanoparticle-mediated targeting delivery of Rapamycin blocks atherosclerotic plaque development and stabilizes plaque in apolipoprotein E-deficient (ApoE(-/-)) mice

Yanan Song et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

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Article Engineering, Biomedical

Stimulus-activatable echogenic maltodextrin nanoparticles as nanotheranostic agents for peripheral arterial disease

Eunkyeong Jung et al.

BIOMATERIALS (2019)

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Article Chemistry, Multidisciplinary

Macrophage-targeted, enzyme-triggered fluorescence switch-on system for detection of embolism-vulnerable atherosclerotic plaques

Yudai Narita et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Materials Science, Biomaterials

Innovative coating based on graphene and their decorated nanoparticles for medical stent applications

Amr M. ElSawy et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Article Chemistry, Analytical

A novel lipid droplets-targeting ratiometric fluorescence probe for hypochlorous acid in living cells

Wen-Li Wu et al.

TALANTA (2019)

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Article Cardiac & Cardiovascular Systems

Paclitaxel-Coated Balloon Angioplasty Versus Drug-Eluting Stent in Acute Myocardial Infarction The REVELATION Randomized Trial

Nicola S. Vos et al.

JACC-CARDIOVASCULAR INTERVENTIONS (2019)

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Article Chemistry, Multidisciplinary

Biomimetic Nanotherapies: Red Blood Cell Based Core-Shell Structured Nanocomplexes for Atherosclerosis Management

Yi Wang et al.

ADVANCED SCIENCE (2019)

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Review Pharmacology & Pharmacy

Subchronic and chronic toxicity evaluation of inorganic nanoparticles for delivery applications

Raziye Mohammadpour et al.

ADVANCED DRUG DELIVERY REVIEWS (2019)

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Article Chemistry, Multidisciplinary

Subchronic toxicity of silica nanoparticles as a function of size and porosity

Raziye Mohammadpour et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Cardiac & Cardiovascular Systems

Vascular smooth muscle cells in atherosclerosis

Gemma L. Basatemur et al.

NATURE REVIEWS CARDIOLOGY (2019)

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Letter Cardiac & Cardiovascular Systems

Plaque Permeability Assessed With DCE-MRI Associates With USPIO Uptake in Patients With Peripheral Artery Disease

Kang H. Zheng et al.

JACC-CARDIOVASCULAR IMAGING (2019)

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Article Engineering, Biomedical

Surface-Engineered Monocyte Inhibits Atherosclerotic Plaque Destabilization via Graphene Quantum Dot-Mediated MicroRNA Delivery

Feila Liu et al.

ADVANCED HEALTHCARE MATERIALS (2019)

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Meeting Abstract Cardiac & Cardiovascular Systems

PLASMONIC PHOTOTHERMAL THERAPY OF ATHEROSCLEROSIS AND PREPARATION OF TARGET LESION IN PATIENTS WITH ARTERIAL REMODELING: SUBANALYSIS OF NANOM-FIM TRIAL

A. Kharlamov

ATHEROSCLEROSIS (2019)

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Article Nanoscience & Nanotechnology

Nanofibrous vildagliptin-eluting stents enhance re-endothelialization and reduce neointimal formation in diabetes: in vitro and in vivo

Chen-Hung Lee et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Cell Biology

Imaging-assisted nanoimmunotherapy for atherosclerosis in multiple species

Tina Binderup et al.

SCIENCE TRANSLATIONAL MEDICINE (2019)

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Article Medicine, General & Internal

Atherosclerosis

Peter Libby et al.

NATURE REVIEWS DISEASE PRIMERS (2019)

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Article Nanoscience & Nanotechnology

Differential Phagocytosis-Based Photothermal Ablation of Inflammatory Macrophages in Atherosclerotic Disease

Xin Wang et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Engineering, Biomedical

Mitigation of monocyte driven thrombosis on cobalt chrome surfaces in contact with whole blood by thin film polar/hydrophobic/ionic polyurethane coatings

Audrey Gossart et al.

BIOMATERIALS (2019)

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Article Cardiac & Cardiovascular Systems

A population-based study of cardiovascular diseasemortality risk in US cancer patients

Kathleen M. Sturgeon et al.

EUROPEAN HEART JOURNAL (2019)

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Article Surgery

Editor's Choice - Follow-up of Patients After Revascularisation for Peripheral Arterial Diseases: A Consensus Document From the European Society of Cardiology Working Group on Aorta and Peripheral Vascular Diseases and the European Society for Vascular Surgery

Maarit Venermo et al.

EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY (2019)

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Article Chemistry, Multidisciplinary

In vitro and in vivo evaluation of degradation, toxicity, biodistribution, and clearance of silica nanoparticles as a function of size, porosity, density, and composition

Seyyed Pouya Hadipour Moghaddam et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Article Nanoscience & Nanotechnology

Multimodal molecular imaging of atherosclerosis: Nanoparticles functionalized with scFv fragments of an anti-αIIbβ3 antibody

Melusine Lariviere et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2019)

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Article Multidisciplinary Sciences

Brain-targeted drug delivery by manipulating protein corona functions

Zui Zhang et al.

NATURE COMMUNICATIONS (2019)

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Article Multidisciplinary Sciences

Renal clearable nanochelators for iron overload therapy

Homan Kang et al.

NATURE COMMUNICATIONS (2019)

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Review Immunology

The Platelet Napoleon Complex-Small Cells, but Big Immune Regulatory Functions

Craig N. Morrell et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 37, 2019 (2019)

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Article Hematology

Statin Safety and Associated Adverse Events: A Scientific Statement From the American Heart Association

Connie B. Newman et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

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Article Hematology

Ultrasound Molecular Imaging of Atherosclerosis With Nanobodies Translatable Microbubble Targeting Murine and Human VCAM (Vascular Cell Adhesion Molecule) 1

Mukesh Punjabi et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Endothelial NOD1 directs myeloid cell recruitment in atherosclerosis through VCAM-1

Silvia Gonzalez-Ramos et al.

FASEB JOURNAL (2019)

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Article Cardiac & Cardiovascular Systems

Coronary restenosis

R. J. Zotz et al.

HERZ (2019)

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Article Nanoscience & Nanotechnology

Nanotubular TiO2 regulates macrophage M2 polarization and increases macrophage secretion of VEGF to accelerate endothelialization via the ERK1/2 and PI3K/AKT pathways

Wei-Chang Xu et al.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2019)

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Article Chemistry, Multidisciplinary

An apoptotic body-biomimic liposome in situ upregulates anti-inflammatory macrophages for stabilization of atherosclerotic plaques

Yue Wu et al.

JOURNAL OF CONTROLLED RELEASE (2019)

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Review Oncology

Nanotechnology in cancer diagnosis: progress, challenges and opportunities

Ye Zhang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

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Review Pathology

Apolipoprotein E in lipoprotein metabolism, health and cardiovascular disease

A. David Marais

PATHOLOGY (2019)

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Review Pharmacology & Pharmacy

Targeting epigenetics and non-coding RNAs in atherosclerosis: from mechanisms to therapeutics

Suowen Xu et al.

PHARMACOLOGY & THERAPEUTICS (2019)

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Article Cardiac & Cardiovascular Systems

Nanobody-Facilitated Multiparametric PET/MRI Phenotyping of Atherosclerosis

Max L. Senders et al.

JACC-CARDIOVASCULAR IMAGING (2019)

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Article Nanoscience & Nanotechnology

SR-A-Targeted Phase-Transition Nanoparticles for the Detection and Treatment of Atherosclerotic Vulnerable Plaques

Man Ye et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Cardiac & Cardiovascular Systems

The CSL112-2001 trial: Safety and tolerability of multiple doses of CSL112 (apolipoprotein A-I [human]), an intravenous formulation of plasma-derived apolipoprotein A-I, among subjects with moderate renal impairment after acute myocardial infarction

C. Michael Gibson et al.

AMERICAN HEART JOURNAL (2019)

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Review Chemistry, Multidisciplinary

Emerging two-dimensional monoelemental materials (Xenes) for biomedical applications

Wei Tao et al.

CHEMICAL SOCIETY REVIEWS (2019)

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Article Chemistry, Multidisciplinary

Reductively dissociable biomimetic nanoparticles for control of integrin-coupled inflammatory signaling to retard atherogenesis

Wen Gao et al.

CHEMICAL COMMUNICATIONS (2019)

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Article Chemistry, Multidisciplinary

CuCo2S4 nanocrystals as a nanoplatform for photothermal therapy of arterial inflammation

Xing Zhang et al.

NANOSCALE (2019)

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Article Medicine, Research & Experimental

A Theranostic Cathepsin Activity-Based Probe for Noninvasive Intervention in Cardiovascular Diseases

Tommy Weiss-Sadan et al.

THERANOSTICS (2019)

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Review Chemistry, Multidisciplinary

Anisotropic nanomaterials for shape-dependent physicochemical and biomedical applications

Lijiao Yang et al.

CHEMICAL SOCIETY REVIEWS (2019)

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Article Chemistry, Physical

Gold nanoshells: Contrast agents for cell imaging by cardiovascular optical coherence tomography

Jie Hu et al.

NANO RESEARCH (2018)

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Article Nanoscience & Nanotechnology

Effects of Nanoprobe Morphology on Cellular Binding and Inflammatory Responses: Hyaluronan-Conjugated Magnetic Nanoworms for Magnetic Resonance Imaging of Atherosclerotic Plaques

Seyedmehdi Hossaini Nasr et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Article Nanoscience & Nanotechnology

Nitric Oxide-Delivering High-Density Lipoprotein-like Nanoparticles as a Biomimetic Nanotherapy for Vascular Diseases

Jonathan S. Rink et al.

ACS APPLIED MATERIALS & INTERFACES (2018)

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Review Chemistry, Multidisciplinary

Big Potential from Small Agents: Nanoparticles for Imaging-Based Companion Diagnostics

Emily B. Ehlerding et al.

ACS NANO (2018)

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Article Cardiac & Cardiovascular Systems

Hyperlipidemia induces typical atherosclerosis development in Ldlr and Apoe deficient rats

Yongliang Zhao et al.

ATHEROSCLEROSIS (2018)

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Article Cardiac & Cardiovascular Systems

Activatable fluorescence imaging of macrophages in atherosclerotic plaques using iron oxide nanoparticles conjugated with indocyanine green

Hiroyuki Ikeda et al.

ATHEROSCLEROSIS (2018)

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Review Cell Biology

The role of monocytosis and neutrophilia in atherosclerosis

Dimitry A. Chistiakov et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

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Article Chemistry, Physical

Gold core/ceria shell-based redox active nanozyme mimicking the biological multienzyme complex phenomenon

Stuti Bhagat et al.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2018)

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Efferocytosis in atherosclerotic lesions: Malfunctioning regulatory pathways and control mechanisms

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Guía ESC 2017 sobre el diagnóstico y tratamiento de la enfermedad arterial periférica, desarrollada en colaboración con la European Society for Vascular Surgery (ESVS)

Autores/Miembros del Grupo de Trabajo: Victor Aboyans et al.

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Peripheral vascular atherosclerosis in a novel PCSK9 gain-of-function mutant Ossabaw miniature pig model

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Linear Micro-patterned Drug Eluting Balloon (LMDEB) for Enhanced Endovascular Drug Delivery

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Diet-Induced Abdominal Obesity, Metabolic Changes, and Atherosclerosis in Hypercholesterolemic Minipigs

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Efficacy and safety assessment of a TRAF6-targeted nanoimmunotherapy in atherosclerotic mice and non-human primates

Marnix Lameijer et al.

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Bioengineered H-Ferritin Nanocages for Quantitative Imaging of Vulnerable Plaques in Atherosclerosis

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Oral Nanoparticles Exhibit Specific High-Efficiency Intestinal Uptake and Lymphatic Transport

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Overcoming the Blood-Brain Barrier: The Role of Nanomaterials in Treating Neurological Diseases

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Toxicological status of nanoparticles: What we know and what we don't know

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Targeting ability of self-assembled nanomedicines in rat acute limb ischemia model is affected by size

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Influence of particle size and shape on their margination and wall-adhesion: implications in drug delivery vehicle design across nano-to-micro scale

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Effect of Serial Infusions of CER-001, a Pre-β High-Density Lipoprotein Mimetic, on Coronary Atherosclerosis in Patients Following Acute Coronary Syndromes in the CER-001 Atherosclerosis Regression Acute Coronary Syndrome Trial A Randomized Clinical Trial

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JAMA CARDIOLOGY (2018)

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Effect of Infusion of High-Density Lipoprotein Mimetic Containing Recombinant Apolipoprotein A-I Milano on Coronary Disease in Patients With an Acute Coronary Syndrome in the MILANO-PILOT Trial A Randomized Clinical Trial

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The Yin and Yang of carbon nanomaterials in atherosclerosis

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Promoting vascular healing using nanofibrous ticagrelor-eluting scents

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Anionic 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG) liposomes induce antigen-specific regulatory T cells and prevent atherosclerosis in mice

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Sonodynamic therapy-induced foam cells apoptosis activates the phagocytic PPARγ-LXRα-ABCA1/ABCG1 pathway and promotes cholesterol efflux in advanced plaque

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Identifying macrophage enrichment in atherosclerotic plaques by targeting dual-modal US imaging/MRI based on biodegradable Fe-doped hollow silica nanospheres conjugated with anti-CD68 antibody

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Dynamic single gold nanoparticle visualization by clinical intracoronary optical coherence tomography

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Imaging the Cytokine Receptor CXCR4 in Atherosclerotic Plaques with the Radiotracer 68Ga-Pentixafor for PET

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In Vivo Ischemia Detection by Luminescent Nanothermometers

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Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

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Estimation of Basis Line-Integrals in a Spectral Distortion-Modeled Photon Counting Detector Using Low-Rank Approximation-Based X-Ray Transmittance Modeling: K-Edge Imaging Application

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Surface modification of endovascular stents with rosuvastatin and heparin-loaded biodegradable nanofibers by electrospinning

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ROS-Dependent Activation of Autophagy through the PI3K/Akt/mTOR Pathway Is Induced by Hydroxysafflor Yellow A-Sonodynamic Therapy in THP-1 Macrophages

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Near-infrared autofluorescence induced by intraplaque hemorrhage and heme degradation as marker for high-risk atherosclerotic plaques

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Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease

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Immediate and 1-year follow-up with the novel nanosurface modified COBRA PzF stent

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Plasmonic photothermal therapy of atherosclerosis with nanoparticles: long-term outcomes and safety in NANOM-FIM trial

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MRI/optical dual-modality imaging of vulnerable atherosclerotic plaque with an osteopontin-targeted probe based on Fe3O4 nanoparticles

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Quantum Dots Emitting in the Third Biological Window as Bimodal Contrast Agents for Cardiovascular Imaging

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Association Between Circulating Oxidized LDL and Atherosclerotic Cardiovascular Disease: A Meta-analysis of Observational Studies

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Spectral analysis assisted photoacoustic imaging for lipid composition differentiation

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A Redox Modulatory Mn3O4 Nanozyme with Multi-Enzyme Activity Provides Efficient Cytoprotection to Human Cells in a Parkinson's Disease Model

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Evaluation of ultrasmall superparamagnetic iron-oxide (USPIO) enhanced MRI with ferumoxytol to quantify arterial wall inflammation

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Hyaluronan Nanoparticles Selectively Target Plaque-Associated Macrophages and Improve Plaque Stability in Atherosclerosis

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Direct Plasmon-Accelerated Electrochemical Reaction on Gold Nanoparticles

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Atherogenesis and metabolic dysregulation in LDL receptorknockout rats

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Development of a new bioactivatable fluorescent probe for quantification of apolipoprotein A-I proteolytic degradation in vitro and in vivo

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Molecular Imaging of Vulnerable Atherosclerotic Plaques in Vivo with Osteopontin-Specific Upconversion Nanoprobes

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The Role of Efferocytosis in Atherosclerosis

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Reversible and Dynamic Fluorescence Imaging of Cellular Redox Self-Regulation Using Fast-Responsive Near-Infrared Ge-Pyronines

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Enhanced Cellular Uptake of Bowl-like Microcapsules

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Tailoring Nanostructure Morphology for Enhanced Targeting of Dendritic Cells in Atherosclerosis

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Labeling monocytes with gold nanoparticles to track their recruitment in atherosclerosis with computed tomography

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Safety and Tolerability of CSL112, a Reconstituted, Infusible, Plasma-Derived Apolipoprotein A-I, After Acute Myocardial Infarction The AEGIS-I Trial (ApoA-I Event Reducing in Ischemic Syndromes I)

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Epidemiology of Atherosclerosis and the Potential to Reduce the Global Burden of Atherothrombotic Disease

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Imaging Atherosclerosis

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Polyethylene glycol (PEG): a versatile polymer for pharmaceutical applications

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High-performance dendritic contrast agents for X-ray computed tomography imaging using potent tetraiodobenzene derivatives

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Nanoparticle-liver interactions: Cellular uptake and hepatobiliary elimination

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Novel PET Imaging of Atherosclerosis with 68Ga-Labeled NOTA-Neomannosylated Human Serum Albumin

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Adequately-Sized Nanocarriers Allow Sustained Targeted Drug Delivery to Neointimal Lesions in Rat Arteries

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In Vivo Targeting and Imaging of Atherosclerosis Using Multifunctional Virus-Like Particles of Simian Virus 40

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Oncogenic mutations in the FBXW7 gene of adult T-cell leukemia patients

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RNAi targeting multiple cell adhesion molecules reduces immune cell recruitment and vascular inflammation after myocardial infarction

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Near Infrared Fluorescence (NIRF) Molecular Imaging of Oxidized LDL with an Autoantibody in Experimental Atherosclerosis

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Engineered atherosclerosis-specific zinc ferrite nanocomplex-based MRI contrast agents

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A single infusion of MDCO-216 (ApoA-1 Milano/POPC) increases ABCA1-mediated cholesterol efflux and pre-beta 1 HDL in healthy volunteers and patients with stable coronary artery disease

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Treatment of patients with aortic atherosclerotic disease with paclitaxel-associated lipid nanoparticles

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Ferumoxytol-enhanced magnetic resonance imaging methodology and normal values at 1.5 and 3T

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Enhanced Bioactivity of Mg-Nd-Zn-Zr Alloy Achieved with Nanoscale MgF2 Surface for Vascular Stent Application

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Parallel Comparative Studies on Mouse Toxicity of Oxide Nanoparticle- and Gadolinium-Based T1 MRI Contrast Agents

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Ferumoxytol-Enhanced Magnetic Resonance Angiography is a Feasible Method for the Clinical Evaluation of Lower Extremity Arterial Disease

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Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability

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Development of Man-rGO for Targeted Eradication of Macrophage Ablation

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Prednisolone-containing liposomes accumulate in human atherosclerotic macrophages upon intravenous administration

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Gold nanorods as a theranostic platform for in vitro and in vivo imaging and photothermal therapy of inflammatory macrophages

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Silica-gold nanoparticles for atheroprotective management of plaques: results of the NANOM-FIM trial

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Rabbit models for the study of human atherosclerosis: From pathophysiological mechanisms to translational medicine

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Rapid stabilisation of atherosclerotic plaque with 5-aminolevulinic acid-mediated sonodynamic therapy

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Direct Imaging of Cerebral Thromboemboli Using Computed Tomography and Fibrin-targeted Gold Nanoparticles

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Infusion of Reconstituted High-Density Lipoprotein, CSL112, in Patients With Atherosclerosis: Safety and Pharmacokinetic Results From a Phase 2a Randomized Clinical Trial

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Shaping bio-inspired nanotechnologies to target thrombosis for dual optical-magnetic resonance imaging

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Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos

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Endothelial overexpression of LOX-1 increases plaque formation and promotes atherosclerosis in vivo

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Effects of the high-density lipoprotein mimetic agent CER-001 on coronary atherosclerosis in patients with acute coronary syndromes: a randomized trial

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A Multiple Ascending Dose Study of CSL112, an Infused Formulation of ApoA-I

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Selective uptake of single-walled carbon nanotubes by circulating monocytes for enhanced tumour delivery

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Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes

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PET/CT Imaging of Integrin αvβ3 Expression in Human Carotid Atherosclerosis

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CD36, a scavenger receptor implicated in atherosclerosis

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High-Resolution Cellular MRI: Gadolinium and Iron Oxide Nanoparticles for in-Depth Dual-Cell Imaging of Engineered Tissue Constructs

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The margination propensity of ellipsoidal micro/nanoparticles to the endothelium in human blood flow

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Imaging of myocardial infarction using ultrasmall superparamagnetic iron oxide nanoparticles: a human study using a multi-parametric cardiovascular magnetic resonance imaging approach

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Understanding the correlation between in vitro and in vivo immunotoxicity tests for nanomedicines

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Poly(iohexol) Nanoparticles As Contrast Agents for in Vivo X-ray Computed Tomography Imaging

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Polyprodrug Amphiphiles: Hierarchical Assemblies for Shape-Regulated Cellular Internalization, Trafficking, and Drug Delivery

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Local proliferation dominates lesional macrophage accumulation in atherosclerosis

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Macrophage Accumulation in Atherosclerosis

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The Sonodynamic Effect of Curcumin on THP-1 Cell-Derived Macrophages

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Porcine Models of Accelerated Coronary Atherosclerosis: Role of Diabetes Mellitus and Hypercholesterolemia

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Endogenous Renovascular Hypertension Combined With Low Shear Stress Induces Plaque Rupture in Apolipoprotein E-Deficient Mice

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Lack of Neutrophil-Derived CRAMP Reduces Atherosclerosis in Mice

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Intravenous Delivery of Hydrophobin-Functionalized Porous Silicon Nanoparticles: Stability, Plasma Protein Adsorption and Biodistribution

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Noninvasive Assessment of Atherosclerotic Plaque Progression in ApoE-/- Mice Using Susceptibility Gradient Mapping

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Novel geometry type of nanocarriers mitigated the phagocytosis for drug delivery

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Multi-slice computed tomography with N1177 identifies ruptured atherosclerotic plaques in rabbits

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Block-copolymer-stabilized iodinated emulsions for use as CT contrast agents

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Flow and adhesion of drug carriers in blood vessels depend on their shape: A study using model synthetic microvascular networks

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Polymer particle shape independently influences binding and internalization by macrophages

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Multimodal Clinical Imaging To Longitudinally Assess a Nanomedical Anti-Inflammatory Treatment in Experimental Atherosclerosis

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Berberine promotes the development of atherosclerosis and foam cell formation by inducing scavenger receptor A expression in macrophage

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Impaired Fibrillin-1 Function Promotes Features of Plaque Instability in Apolipoprotein E-Deficient Mice

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Utility of USPIO-enhanced MR imaging to identify inflammation and the fibrous cap: A comparison of symptomatic and asymptomatic individuals

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VLDL best predicts aortic root atherosclerosis in LDL receptor deficient mice

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Quantification of Inflammation Within Rabbit Atherosclerotic Plaques Using the Macrophage-Specific CT Contrast Agent N1177: A Comparison with 18F-FDG PET/CT and Histology

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An iodinated liposomal computed tomographic contrast agent prepared from a diiodophosphatidylcholine lipid

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Chronic apoptosis of vascular smooth muscle cells accelerates atherosclerosis and promotes calcification and medial degeneration

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Comparison of the inflammatory burden of truly asymptomatic carotid atheroma with atherosclerotic plaques in patients with asymptomatic carotid stenosis undergoing coronary artery bypass grafting: An Ultrasmall Superparamagnetic Iron Oxide enhanced Magnetic Resonance study

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Nanoparticulate carrier containing water-insoluble iodinated oil as a multifunctional contrast agent for computed tomography imaging

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Subendothelial lipoprotein retention as the initiating process in atherosclerosis -: Update and therapeutic implications

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Renal clearance of quantum dots

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Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography

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Effects of reconstituted high-density lipoprotein infusions on coronary atherosclerosis -: A randomized controlled trial

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A simple method of plaque rupture induction in apolipoprotein E-deficient mice

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Macrophage metalloelastase accelerates the progression of atherosclerosis in transgenic rabbits

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Diagnostic precision of nanoparticle-enhanced MRI for lymph-node metastases: a meta-analysis

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Chemokines in the pathogenesis of vascular disease

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Effect of recombinant ApoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes - A randomized controlled trial

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Induction of atherosclerosis by low-fat, semisynthetic diets in LDL receptor-deficient C57BL/6J and FVB/NJ mice - Comparison of lesions of the aortic root, brachiocephalic artery, and whole aorta (en face measurement)

D Teupser et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2003)

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Article Hematology

Human macrophage-induced vascular smooth muscle cell apoptosis requires NO enhancement of Fas/Fas-L interactions

JJ Boyle et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2002)

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Article Hematology

Apolipoprotein E inhibition of vascular smooth muscle cell proliferation but not the inhibition of migration is mediated through activation of inducible nitric oxide synthase

M Ishigami et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2000)

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