Journal
ADVANCED SCIENCE
Volume -, Issue -, Pages -Publisher
WILEY
DOI: 10.1002/advs.202302918
Keywords
atherosclerosis; drug; nanodelivery; nanoparticles; therapeutic strategy
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Atherosclerosis, the leading cause of death worldwide, results in 17.6 million deaths globally each year. Diversified nanomaterials are crucial for improving drug properties and developing better treatment strategies for atherosclerosis. This study summarizes the pathological mechanisms of atherosclerosis, designs nanoparticle-mediated therapeutic strategies, and explores potential therapeutic targets for nanodelivery, highlighting the potential and challenges of nanoparticle use in treating atherosclerosis and suggesting new design ideas.
Atherosclerosis, the leading cause of death worldwide, is responsible for & AP;17.6 million deaths globally each year. Most therapeutic drugs for atherosclerosis have low delivery efficiencies and significant side effects, and this has hampered the development of effective treatment strategies. Diversified nanomaterials can improve drug properties and are considered to be key for the development of improved treatment strategies for atherosclerosis. The pathological mechanisms underlying atherosclerosis is summarized, rationally designed nanoparticle-mediated therapeutic strategies, and potential future therapeutic targets for nanodelivery. The content of this study reveals the potential and challenges of nanoparticle use for the treatment of atherosclerosis and highlights new effective design ideas. Atherosclerosis, the leading cause of death worldwide, is responsible for & AP;17.6 million deaths globally each year. Diversified nanomaterials can improve drug properties and are considered to be key for the development of improved treatment strategies for atherosclerosis. The pathological mechanisms underlying atherosclerosis is summarized, rationally designed nanoparticle-mediated therapeutic strategies, and potential future therapeutic targets for nanodelivery.image
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