4.8 Article

Deubiquitinase OTUD5 as a Novel Protector against 4-HNE-Triggered Ferroptosis in Myocardial Ischemia/Reperfusion Injury

Related references

Note: Only part of the references are listed.
Review Cardiac & Cardiovascular Systems

The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease

Xuexian Fang et al.

Summary: Iron homeostasis is crucial for proper cardiac function, and iron imbalance is a common factor in various cardiovascular diseases. Ferroptosis, an iron-dependent regulated cell death, has been increasingly recognized as an important process underlying the pathogenesis and progression of cardiovascular diseases. Understanding the mechanisms of iron metabolism and ferroptosis regulation in cardiomyocytes may lead to improvements in disease management.

NATURE REVIEWS CARDIOLOGY (2023)

Article Cardiac & Cardiovascular Systems

Heart Disease and Stroke Statistics-2022 Update: A Report From the American Heart Association

Connie W. Tsao et al.

Summary: This article introduces the latest statistics on heart disease, stroke, and cardiovascular risk factors published by the American Heart Association in conjunction with the National Institutes of Health. The Statistical Update includes data on a range of clinical heart and circulatory disease conditions and their associated outcomes. It serves as a critical resource for the general public, policymakers, healthcare professionals, researchers, and others seeking the best available data.

CIRCULATION (2022)

Article Biochemistry & Molecular Biology

Bufotalin induces ferroptosis in non-small cell lung cancer cells by facilitating the ubiquitination and degradation of GPX4

Wen Zhang et al.

Summary: In this study, we reported for the first time that Bufotalin (BT), a natural small molecule, is a glutathione peroxidase 4 (GPX4) inhibitor that can trigger ferroptosis in non-small cell lung cancer cells. BT induces ferroptosis and lipid peroxidation by accelerating GPX4 degradation and increasing intracellular Fe2+.

FREE RADICAL BIOLOGY AND MEDICINE (2022)

Article Plant Sciences

Britanin relieves ferroptosis-mediated myocardial ischaemia/reperfusion damage by upregulating GPX4 through activation of AMPK/GSK3β/Nrf2 signalling

Haoyang Lu et al.

Summary: This study investigated the effect and mechanism of Bri on MIR damage. The results showed that Bri significantly reduced infarct area, myocardial apoptosis, creatine phosphokinase, and lactate dehydrogenase levels, concomitant with alleviation of ferroptosis. Bri protected against ferroptosis-mediated MIR damage by upregulating GPX4 through activation of the AMPK/GSK3 beta/Nrf2 signaling.

PHARMACEUTICAL BIOLOGY (2022)

Article Chemistry, Multidisciplinary

Mitochondrial aldehyde dehydrogenase (ALDH2) rescues cardiac contractile dysfunction in an APP/PS1 murine model of Alzheimer's disease via inhibition of ACSL4-dependent ferroptosis

Zhi-yun Zhu et al.

Summary: The study demonstrated that ALDH2 overexpression significantly improved cognitive function, cardiac function, and morphological properties in an Alzheimer's disease mouse model, attenuating oxidative stress, apoptosis, and inflammation in the myocardium. ALDH2 played a crucial role in protecting against cardiac anomalies induced by Alzheimer's disease through regulation of lipid peroxidation and ferroptosis.

ACTA PHARMACOLOGICA SINICA (2022)

Article Biochemistry & Molecular Biology

The lipid peroxidation product 4-hydroxynonenal inhibits NLRP3 inflammasome activation and macrophage pyroptosis

Chia George Hsu et al.

Summary: Pyroptosis is a form of cell death triggered by the innate immune system that is associated with the pathogenesis of sepsis and acute lung injury. A study found that the endogenous lipid 4-hydroxynonenal (HNE) can inhibit pyroptosis and inflammasome activation.

CELL DEATH AND DIFFERENTIATION (2022)

Article Gastroenterology & Hepatology

The Deubiquitinating Enzyme OTUD5 Sustains Inflammatory Cytokine Response in Inflammatory Bowel Disease

Vincenzo Dinallo et al.

Summary: The study found that OTUD5 is overexpressed in both Crohn's disease and ulcerative colitis, suggesting its involvement in amplifying the aberrant cytokine response in inflammatory bowel disease.

JOURNAL OF CROHNS & COLITIS (2022)

Review Biochemistry & Molecular Biology

Post-Translational Modification of GPX4 is a Promising Target for Treating Ferroptosis-Related Diseases

Can Cui et al.

Summary: The article summarizes the importance of GPX4 as an antioxidant enzyme and its role in regulating ferroptosis. It also highlights the potential of targeting the post-translational modifications of GPX4 for the treatment of ferroptosis-related diseases.

FRONTIERS IN MOLECULAR BIOSCIENCES (2022)

Review Biochemistry & Molecular Biology

Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications

Brent R. Stockwell

Summary: This review describes the key regulators of ferroptosis and provides an overview of metabolism, ROS biology, and iron biology. Additionally, it highlights the important concepts and unanswered questions in the field of ferroptosis. The future holds promise for further breakthroughs in understanding the mechanisms of ferroptosis and utilizing it for therapeutic purposes.
Article Multidisciplinary Sciences

HOIP modulates the stability of GPx4 by linear ubiquitination

Kangyun Dong et al.

Summary: LUBAC-mediated linear ubiquitination plays a crucial role in regulating cell death and inflammatory pathways. Deficiency in LUBAC components increases susceptibility to ferroptosis by promoting GPx4 degradation and lipid peroxidation. Additionally, LUBAC stabilizes GPx4 by modulating its linear ubiquitination.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2022)

Article Cell Biology

Deubiquitinase OTUD5 modulates mTORC1 signaling to promote bladder cancer progression

Tao Hou et al.

Summary: This study reveals that the deubiquitinating enzyme OTUD5 activates the mTOR signaling pathway to promote bladder cancer progression. OTUD5 stabilizes the function of RNF186, a RING-type E3 ligase, leading to the degradation of sestrin2, an inhibitor of the mTOR signaling pathway.

CELL DEATH & DISEASE (2022)

Article Multidisciplinary Sciences

A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis

Xin Chen et al.

Summary: The authors discovered that the translation initiation factor eIF4E can increase lipid peroxidation levels and promote ferroptosis by repressing ALDH1B1 independent of translation. This finding provides insights into the mechanisms of ferroptosis and establishes a foundation for utilizing ferroptosis as a cancer therapeutic strategy.

NATURE COMMUNICATIONS (2022)

Article Immunology

OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING

Yunyun Guo et al.

Summary: STING is a critical adaptor protein for innate antiviral and antitumor immunity, regulated by protein ubiquitination, with OTUD5 identified as a key deubiquitinase that interacts with STING to maintain its stability. Knockout of OTUD5 resulted in impaired immune responses and increased susceptibility to viral infection and tumor development.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Review Biochemistry & Molecular Biology

Cellular degradation systems in ferroptosis

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent oxidative cell death driven by lipid peroxidation. Various antioxidant systems play a significant role in preventing ferroptotic death. The cellular degradation systems play a dual role in regulating the ferroptotic response.

CELL DEATH AND DIFFERENTIATION (2021)

Article Oncology

Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells

Yahui Ding et al.

Summary: This study identified a novel approach to treat TNBC by inducing ferroptosis through ubiquitination of GPX4 with the compound DMOCPTL, and revealed the role of GPX4 in regulating mitochondria-mediated apoptosis through up-regulation of EGR1 in TNBC cells. Furthermore, the prodrug Compound 13 showed promising anti-tumor effects in vivo with no apparent toxicity, suggesting its potential as a lead compound for developing effective anti-TNBC drugs.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2021)

Review Cell Biology

Ferroptosis: mechanisms, biology and role in disease

Xuejun Jiang et al.

Summary: Ferroptosis, as a form of regulated cell death driven by iron-dependent phospholipid peroxidation, has seen significant growth in research in recent years. Studies have focused on molecular mechanisms, regulation, and functions of ferroptosis, linking this cell death modality to various pathologies and proposing its roles in normal physiology and potential therapeutic targeting.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2021)

Article Gastroenterology & Hepatology

X Chromosome Contribution to the Genetic Architecture of Primary Biliary Cholangitis

Rosanna Asselta et al.

Summary: This study is the first comprehensive investigation of the chrX contribution to the genetics of an autoimmune liver disease, revealing a novel genome-wide significant locus related to PBC.

GASTROENTEROLOGY (2021)

Article Biotechnology & Applied Microbiology

Naringenin alleviates myocardial ischemia/reperfusion injury by regulating the nuclear factor-erythroid factor 2-related factor 2 (Nrf2)/System xc-/glutathione peroxidase 4 (GPX4) axis to inhibit ferroptosis

Shujun Xu et al.

Summary: Naringenin (NAR) has shown significant benefits in improving myocardial ischemia-reperfusion injury (MIRI) by regulating the Nrf2/System xc-/GPX4 axis to inhibit ferroptosis, demonstrating its potential as a therapeutic agent for heart injury.

BIOENGINEERED (2021)

Article Cell Biology

4-Hydroxy-2-Nonenal Promotes Cardiomyocyte Necroptosis via Stabilizing Receptor-Interacting Serine/Threonine-Protein Kinase 1

Xiaoxuan Zhai et al.

Summary: This study demonstrated that 4-HNE contributes to cardiomyocyte necroptosis by regulating RIP1 protein degradation, while ALDH2-Tg mice showed significantly reduced necroptosis. Perfusion of 4-HNE enhanced cardiomyocyte necroptosis in a time- and concentration-dependent manner, and knockdown of RIP1 prevented 4-HNE-induced necroptosis.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Biochemistry & Molecular Biology

Participation of Mind Bomb-2 in Sevoflurane Anesthesia Induces Cognitive Impairment in Aged Mice via Modulating Ferroptosis

Lili Zhao et al.

Summary: The study showed that MIB2 plays a role in regulating the effects of sevoflurane anesthesia on mouse hippocampal neurons and function, and downregulation of MIB2 can alleviate cognitive dysfunction and neuron injury induced by sevoflurane.

ACS CHEMICAL NEUROSCIENCE (2021)

Review Cell Biology

Insight into Crosstalk between Ferroptosis and Necroptosis: Novel Therapeutics in Ischemic Stroke

Yue Zhou et al.

Summary: Ferroptosis and necroptosis play crucial roles in ischemic stroke, with crosstalk between the two pathways. Iron overload and HSP90 are important factors associated with the occurrence of necroptosis and ferroptosis.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Review Medicine, Research & Experimental

Ferroptosis as a novel therapeutic target for cardiovascular disease

Xiaoguang Wu et al.

Summary: Cell death is a significant factor in cardiovascular disease pathophysiology. Ferroptosis, a regulated cell death form characterized by iron overload and lipid hydroperoxide accumulation, is closely associated with various diseases and plays critical roles in cardiomyopathy, myocardial infarction, ischemia/reperfusion injury, and heart failure. Targeting ferroptosis may offer potential novel therapeutic strategies for cardiovascular diseases.

THERANOSTICS (2021)

Review Biochemistry & Molecular Biology

Regulated Necrosis in Pulmonary Disease A Focus on Necroptosis and Ferroptosis

Shunsuke Minagawa et al.

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Mitochondrial 4-HNE derived from MAO-A promotes mitoCa2+ overload in chronic postischemic cardiac remodeling

Yohan Santin et al.

CELL DEATH AND DIFFERENTIATION (2020)

Article Immunology

Redox homeostasis maintained by GPX4 facilitates STING activation

Mutian Jia et al.

NATURE IMMUNOLOGY (2020)

Review Cardiac & Cardiovascular Systems

Myocardial ischaemia-reperfusion injury and cardioprotection in perspective

Gerd Heusch

NATURE REVIEWS CARDIOLOGY (2020)

Review Biochemistry & Molecular Biology

Ferroptosis and Necroptosis in the Kidney

Alexia Belavgeni et al.

CELL CHEMICAL BIOLOGY (2020)

Article Multidisciplinary Sciences

Ferroptosis as a target for protection against cardiomyopathy

Xuexian Fang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemistry & Molecular Biology

The deubiquitinase OTUD5 regulates Ku80 stability and non-homologous end joining

Fangzhou Li et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

Review Physiology

FUNDAMENTAL MECHANISMS OF REGULATED CELL DEATH AND IMPLICATIONS FOR HEART DISEASE

Dominic P. Del Re et al.

PHYSIOLOGICAL REVIEWS (2019)

Review Cell Biology

4-Hydroxy-Trans-2-Nonenal in the Regulation of Anti-Oxidative and Pro-Inflammatory Signaling Pathways

Himangshu Sonowal et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

Article Biochemistry & Molecular Biology

The OTUD5-UBR5 complex regulates FACT-mediated transcription at damaged chromatin

Angelo de Vivo et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Cell Biology

Aldehyde dehydrogenase 2 Glu504Lys variant predicts a worse prognosis of acute coronary syndrome patients

Chang Pan et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2018)

Article Biochemistry & Molecular Biology

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

Michael M. Gaschler et al.

NATURE CHEMICAL BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Proatherogenic effects of 4-hydroxynonenal

Anne Negre-Salvayre et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Article Cardiac & Cardiovascular Systems

Evolving Therapies for Myocardial Ischemia/Reperfusion Injury

Borja Ibáñez et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2015)

Review Physiology

TARGETING ALDEHYDE DEHYDROGENASE 2: NEW THERAPEUTIC OPPORTUNITIES

Che-Hong Chen et al.

PHYSIOLOGICAL REVIEWS (2014)

Review Medicine, General & Internal

The Glu504Lys Polymorphism of Aldehyde Dehydrogenase 2 Contributes to Development of Coronary Artery Disease

Feng Xu et al.

TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE (2014)

Review Biochemistry & Molecular Biology

Cell death and diseases related to oxidative stress: 4-hydroxynonenal (HNE) in the balance

S. Dalleau et al.

CELL DEATH AND DIFFERENTIATION (2013)

Review Medicine, Research & Experimental

Myocardial ischemia-reperfusion injury: a neglected therapeutic target

Derek J. Hausenloy et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Cell Biology

Role of aldehyde dehydrogenase 2 Glu504lys polymorphism in acute coronary syndrome

Feng Xu et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2011)

Article Multidisciplinary Sciences

Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart

Che-Hong Chen et al.

SCIENCE (2008)

Article Multidisciplinary Sciences

DUBA: A deubiquitinase that regulates type I interferon production

Nobuhiko Kayagaki et al.

SCIENCE (2007)