Journal
NANOMATERIALS
Volume 13, Issue 17, Pages -Publisher
MDPI
DOI: 10.3390/nano13172488
Keywords
FETAX test; nanoparticles; transmission electron microscopy; gene expression
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This study found that both gold and silver nanoparticles can induce morphological anomalies and modify gene expression in Xenopus laevis, suggesting their toxicity and the need for further research on their activity in animals and humans.
Exposure to metal nanoparticles is potentially harmful, particularly when occurring during embryogenesis. In this study, we tested the effects of commercial AuNPs and AgNPs, widely used in many fields for their features, on the early development of Xenopus laevis, an anuran amphibian key model species in toxicity testing. Through the Frog Embryo Teratogenesis Assay-Xenopus test (FETAX), we ascertained that both nanoparticles did not influence the survival rate but induced morphological anomalies like modifications of head and branchial arch cartilages, depigmentation of the dorsal area, damage to the intestinal brush border, and heart rate alteration. The expression of genes involved in the early pathways of embryo development was also modified. This study suggests that both types of nanoparticles are toxic though nonlethal, thus indicating that their use requires attention and further study to better clarify their activity in animals and, more importantly, in humans.
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