4.6 Article

Hyaluronic acid modified mesoporous carbon nanoparticles for targeted drug delivery to CD44-overexpressing cancer cells

Journal

NANOTECHNOLOGY
Volume 27, Issue 13, Pages -

Publisher

IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/27/13/135102

Keywords

mesoporous carbon nanoparticles; hyaluronic acid; controlled release; co-delivery

Funding

  1. National Basic Research Program of China (973 Program) [2015CB932100]
  2. National Natural Science Foundation of China [81273449]

Ask authors/readers for more resources

In this paper, hyaluronic acid (HA) functionalized uniform mesoporous carbon spheres (UMCS) were synthesized for targeted enzyme responsive drug delivery using a facile electrostatic attraction. strategy. This HA. modification ensured. stable drug encapsulation in mesoporous carbon nanoparticles in an. extracellular environment while increasing. colloidal stability, biocompatibility, cell-targeting ability, and controlled cargo release. The cellular uptake experiments of fluorescently. labeled mesoporous carbon nanoparticles, with or without HA functionalization, demonstrated that HA-UMCS are able to specifically target cancer cells overexpressing CD44 receptors. Moreover, the. cargo. loaded. doxorubicin (DOX) and verapamil (VER) exhibited. a dual pH and hyaluronidase-1 responsive release in the tumor microenvironment. In addition,. VER/DOX/HA-UMCS exhibited a superior therapeutic effect on an. in vivo HCT-116 tumor in BALB/c nude mice. In summary, it is expected that HA-UMCS will offer a new method. for targeted co-delivery of drugs to tumors overexpressing CD44 receptors.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.6
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available