Journal
GENES
Volume 14, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/genes14101853
Keywords
ancient DNA; pre-Hispanic; mtDNA HVS-I; native American founding lineages; native American genetic history; native American ancestries; Colombia
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Analysis of mitochondrial DNA data from ancient human remains reveals high population heterogeneity among pre-Hispanic populations in Colombia.
The analysis of mitochondrial DNA (mtDNA) hypervariable region (HVR) sequence data from ancient human remains provides valuable insights into the genetic structure and population dynamics of ancient populations. mtDNA is particularly useful in studying ancient populations, because it is maternally inherited and has a higher mutation rate compared to nuclear DNA. To determine the genetic structure of three Colombian pre-Hispanic populations and compare them with current populations, we determined the haplotypes from human bone remains by sequencing several mitochondrial DNA segments. A wide variety of mitochondrial polymorphisms were obtained from 33 samples. Our results support a high population heterogeneity among pre-Hispanic populations in Colombia.
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