Journal
NANOTECHNOLOGY
Volume 27, Issue 28, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/0957-4484/27/28/285102
Keywords
targeted photothermal therapy; near-infrared light; hybrid nanoparticles; phospholipids; polyaniline; photoacoustic imaging
Funding
- National Natural Science Foundation of China [81503016]
- Application Foundation and Cutting-Edge Technologies Research Project of Tianjin [15JCQNJC13800]
- National Basic Research Project (973 Program) of China [2014CB932200]
- King's College London-KC Wong Postdoctoral Fellowships
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Designing a targeted and versatile photothermal agent for the integration of precise diagnosis and effective photothermal treatment of tumors is desirable but remains a great challenge. In this study, folic acid ligand conjugated lipid-coated polyaniline hybrid nanoparticles (FA-Lipid-PANI NPs) were successfully fabricated by a distinctive technology. The obtained hybrid FA-Lipid-PANI NPs with small size exhibited not only significant photoacoustic (PA) imaging signals, but also a remarkable photothermal effect for tumor treatment. With PA imaging and photothermal therapy (PTT), the tumor could be accurately positioned and thoroughly eradicated in vivo after intravenous injection of FA-Lipid-PANI NPs. These multifunctional nanoparticles could play an important role in simultaneously facilitating imaging and PTT to achieve better therapeutic efficacy.
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