☆ 4.6 Review

Building blocks of microphysiological system to model physiology and pathophysiology of human heart

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Directional Growth of Human Neuronal Axons in a Microfluidic Device with Nanotopography on Azobenzene-Based Material

Mervi Ristola et al.

Summary: Engineered microfluidic chips combined with human pluripotent stem cell-derived neurons offer valuable tools for in vitro research on axons related to CNS diseases and traumas. A microfluidic chip integrated with a light patterned substrate allows isolated and unidirectional axonal growth, achieved through optimized cross-sectional area and length of microtunnels for axonal compartmentalization. Integration of nanotopographic patterns with compartmentalized microfluidic chip provides a human neuron-based model supporting superior axonal alignment in an isolated microenvironment, demonstrating practical utility in studying axonal damage.

ADVANCED MATERIALS INTERFACES (2021)

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Article Pharmacology & Pharmacy

Comparison of the Simulated Response of Three in Silico Human Stem Cell-Derived Cardiomyocytes Models and in Vitro Data Under 15 Drug Actions

Michelangelo Paci et al.

Summary: This study evaluated the response of three in silico models of hSC-CM to simulated drug action and compared the simulation results with in vitro data for 15 drugs. The results showed qualitative consistency between the observed CTD90 changes in silico and in vitro data, but differences in drug responses across the hSC-CM models were also noted.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Cell & Tissue Engineering

Stem cell-based vascularization of microphysiological systems

Shane Browne et al.

Summary: This review discusses the importance and development trends of the vascular system in microphysiological systems based on microfluidics and 3D cell culture. The growing library of pluripotent stem cell-derived endothelial cell and perivascular cell protocols has the potential to improve the physiological relevance of vasculature within MPS design.

STEM CELL REPORTS (2021)

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Article Physiology

Substrate Stiffness Influences Structural and Functional Remodeling in Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Arlene Koerner et al.

Summary: The stiffness of the cell environment plays a crucial role in influencing the structural and functional properties of iPSC-CMs, with substrates in the physiological range promoting maturation and improving intercellular coupling in these cells.

FRONTIERS IN PHYSIOLOGY (2021)

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Editorial Material Materials Science, Biomaterials

Beyond PDMS and Membranes: New Materials for Organ-on-a-Chip Devices

Milica Radisic et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Review Materials Science, Biomaterials

In-Line Analysis of Organ-on-Chip Systems with Sensors: Integration, Fabrication, Challenges, and Potential

Stefanie Fuchs et al.

Summary: Organ-on-chip systems are promising new tools for in vitro research in medical, pharmaceutical, and biological fields, offering improved resemblance to in vivo cell culture environments. Integration of in situ analysis methods on-chip allows for better time resolution and continuous measurements, with sensor technology playing a growing role in enhancing these systems.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2021)

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Review Cardiac & Cardiovascular Systems

The use of electrical stimulation to induce cardiac differentiation of stem cells for the treatment of myocardial infarction

Yue Dai et al.

Summary: Studies have shown that electrical stimulation can promote the cardiac differentiation of stem cells, but these induced cardiomyocytes have low rates of differentiation and are immature, potentially increasing the risk of arrhythmias.

REVIEWS IN CARDIOVASCULAR MEDICINE (2021)

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Article Biochemical Research Methods

Bridging the academic-industrial gap: application of an oxygen and pH sensor-integrated lab-on-a-chip in nanotoxicology

Helene Zirath et al.

Summary: The article discusses the limitations in the translation of advanced cell-based assays due to the lack of industrial-relevant prototypes, focusing on the development of a dual-sensor integrated microfluidic cell analysis platform for risk assessment studies of engineered nanoparticles. By utilizing optical sensor spots in a COC-based microfluidic platform, the platform allows for non-invasive and time-resolved monitoring of cellular oxygen uptake and metabolic activity, enabling rapid detection of cytotoxicities in nanotoxicological studies. Results show the platform's suitability as a pre-screening tool in nanomaterial risk assessment and as a quality control measure in medium to high-throughput settings.

LAB ON A CHIP (2021)

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Article Multidisciplinary Sciences

Self-assembling human heart organoids for the modeling of cardiac development and congenital heart disease

Yonatan R. Lewis-Israeli et al.

Summary: The study presents a method to generate human heart organoids using pluripotent stem cells, which are comparable to fetal cardiac tissues at transcriptomic, structural, and cellular levels. These organoids exhibit sophisticated internal chambers, well-organized cardiac cell types, heart field formation, atrioventricular specification, and a complex vasculature, with robust functional activity. Additionally, the organoid platform can reproduce metabolic disorders associated with congenital heart defects, such as pregestational diabetes-induced congenital heart defects.

NATURE COMMUNICATIONS (2021)

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Review Biochemistry & Molecular Biology

The Role of Neuro-Cardiac Junctions in Sympathetic Regulation of the Heart

Y. G. Odnoshivkina et al.

Summary: One of the key mechanisms of cardiac regulation is achieved through sympathetic innervation of cardiac myocytes. Neuro-cardiac junctions play a crucial role in mediating the effects of neurotransmission on heart function and cardiomyocyte size.

JOURNAL OF EVOLUTIONARY BIOCHEMISTRY AND PHYSIOLOGY (2021)

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Article Multidisciplinary Sciences

Tissue-engineered vascular microphysiological platform to study immune modulation of xenograft rejection

Tae Hee Kim et al.

Summary: The study introduced a tissue-engineered vascular microphysiological platform (TEVMP) with a three-dimensional vascular structure similar to an artery for evaluating vascular-related responses. This platform was utilized to investigate the effects of human CD200 overexpression in porcine endothelial cells on vascular xenogeneic immune responses, showing promising results.

SCIENCE ADVANCES (2021)

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Article Medicine, Research & Experimental

Progressive stretch enhances growth and maturation of 3D stem-cell-derived myocardium

Kun Lu et al.

Summary: Bio-engineered myocardium has the potential for myocardial physiology studies, but current protocols fall short of simulating postnatal myocardial growth conditions. A new approach using progressive stretch has been developed to improve the maturation of engineered heart tissue.

THERANOSTICS (2021)

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Article Biochemical Research Methods

Compartmentalized microfluidic chambers enable long-term maintenance and communication between human pluripotent stem cell-derived forebrain and midbrain neurons

Ziqiu Tong et al.

Summary: Compartmentalized microfluidic devices are valuable tools for studying neurobiological functions, and the integration of Matrigel as a 3D cell culture scaffold enables high cell seeding density over a small fraction of the culture surface. This approach allows for neuron-to-neuron communication networks and essentially one-way communication between separate populations of human neuron cultures.

LAB ON A CHIP (2021)

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Article Biochemistry & Molecular Biology

Human pluripotent stem cell-derived cardiomyocytes for studying energy metabolism

Barbel M. Ulmer et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2020)

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Review Biotechnology & Applied Microbiology

Integrating Organs-on-Chips: Multiplexing, Scaling, Vascularization, and Innervation

DoYeun Park et al.

TRENDS IN BIOTECHNOLOGY (2020)

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Article Biophysics

Pneumatic unidirectional cell stretching device for mechanobiological studies of cardiomyocytes

Joose Kreutzer et al.

BIOMECHANICS AND MODELING IN MECHANOBIOLOGY (2020)

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Article Materials Science, Multidisciplinary

Printed 3D Electrode Arrays with Micrometer-Scale Lateral Resolution for Extracellular Recording of Action Potentials

Leroy Grob et al.

ADVANCED MATERIALS TECHNOLOGIES (2020)

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Article Engineering, Biomedical

Enhanced structural maturation of human induced pluripotent stem cell-derived cardiomyocytes under a controlled microenvironment in a microfluidic system

Tomasz Jan Kolanowski et al.

ACTA BIOMATERIALIA (2020)

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Article Engineering, Biomedical

A heart-on-a-chip platform for online monitoring of contractile behavior via digital image processing and piezoelectric sensing technique

Mutsuhito Sakamiya et al.

MEDICAL ENGINEERING & PHYSICS (2020)

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Article Engineering, Biomedical

Co-culture of human induced pluripotent stem cell-derived retinal pigment epithelial cells and endothelial cells on double collagen-coated honeycomb films

Maria Teresa Calejo et al.

ACTA BIOMATERIALIA (2020)

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Article Chemistry, Analytical

Non-Invasive Plasmonic-Based Real-Time Characterization of Cardiac Drugs on Cardiomyocytes Functional Behavior

Maedeh Mozneb et al.

ANALYTICAL CHEMISTRY (2020)

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Article Engineering, Biomedical

Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug testing

Olya Mastikhina et al.

BIOMATERIALS (2020)

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Article Chemistry, Multidisciplinary

Heart-on-a-Chip Model with Integrated Extra- and Intracellular Bioelectronics for Monitoring Cardiac Electrophysiology under Acute Hypoxia

Haitao Liu et al.

NANO LETTERS (2020)

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Review Cardiac & Cardiovascular Systems

Cardiomyocyte maturation: advances in knowledge and implications for regenerative medicine

Elaheh Karbassi et al.

NATURE REVIEWS CARDIOLOGY (2020)

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Article Cell & Tissue Engineering

Human Induced Pluripotent Stem Cell-Derived Non-Cardiomyocytes Modulate Cardiac Electrophysiological Maturation Through Connexin 43-Mediated Cell-Cell Interactions

Sherri M. Biendarra-Tiegs et al.

STEM CELLS AND DEVELOPMENT (2020)

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Article Engineering, Biomedical

Monitoring matrix remodeling in the cellular microenvironment using microrheology for complex cellular systems

Johanna Hafner et al.

ACTA BIOMATERIALIA (2020)

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Article Biophysics

All-Optical Electrophysiology Refines Populations of In Silico Human iPSC-CMs for Drug Evaluation

Michelangelo Paci et al.

BIOPHYSICAL JOURNAL (2020)

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Article Cell & Tissue Engineering

Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease

Elisa Giacomelli et al.

CELL STEM CELL (2020)

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Review Cardiac & Cardiovascular Systems

Cardiomyocyte Maturation New Phase in Development

Yuxuan Guo et al.

CIRCULATION RESEARCH (2020)

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Article Nanoscience & Nanotechnology

Marker-Free Automatic Quantification of Drug-Treated Cardiomyocytes with Digital Holographic Imaging

Keyvan Jaferzadeh et al.

ACS PHOTONICS (2020)

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Article Pharmacology & Pharmacy

Improved Computational Identification of Drug Response Using Optical Measurements of Human Stem Cell Derived Cardiomyocytes in Microphysiological Systems

Karoline Horgmo Jaeger et al.

FRONTIERS IN PHARMACOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

A cardiomyocyte show of force: A fluorescent alpha-actinin reporter line sheds light on human cardiomyocyte contractility versus substrate stiffness

Marcelo C. Ribeiro et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

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Review Cell Biology

A Brief Review of Current Maturation Methods for Human Induced Pluripotent Stem Cells-Derived Cardiomyocytes

Razan Elfadil Ahmed et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Review Cell Biology

When Stiffness Matters: Mechanosensing in Heart Development and Disease

Roberto Gaetani et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

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Article Engineering, Biomedical

Covalent immobilization of luminescent oxygen indicators reduces cytotoxicity

Hannu Valimaki et al.

BIOMEDICAL MICRODEVICES (2020)

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Article Chemistry, Multidisciplinary

Bright and High-Performance Genetically Encoded Ca2+ Indicator Based on mNeonGreen Fluorescent Protein

Landon Zarowny et al.

ACS SENSORS (2020)

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Review Cell & Tissue Engineering

Innervation: the missing link for biofabricated tissues and organs

Suradip Das et al.

NPJ REGENERATIVE MEDICINE (2020)

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Article Multidisciplinary Sciences

Functional Characterization of Three-Dimensional Cortical Cultures for In Vitro Modeling of Brain Networks

Yu-Ting L. Dingle et al.

ISCIENCE (2020)

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Article Biophysics

Electrical impedance-based contractile stress measurement of human iPSC-Cardiomyocytes

Xian Wang et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Article Biochemistry & Molecular Biology

Cardiac optical mapping - State-of-the-art and future challenges

Christopher O'Shea et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2020)

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Article Multidisciplinary Sciences

Cells of the adult human heart

Monika Litvinukova et al.

NATURE (2020)

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Review Chemistry, Analytical

Integrating Biosensors in Organs-on-Chip Devices: A Perspective on Current Strategies to Monitor Microphysiological Systems

Erika Ferrari et al.

BIOSENSORS-BASEL (2020)

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Article Pharmacology & Pharmacy

Human in vitro vascularized micro-organ and micro-tumor models are reproducible organ-on-a-chip platforms for studies of anticancer drugs

Yizhong Liu et al.

TOXICOLOGY (2020)

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Article Multidisciplinary Sciences

Modeling early stage atherosclerosis in a primary human vascular microphysiological system

Xu Zhang et al.

NATURE COMMUNICATIONS (2020)

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Article Biochemical Research Methods

Integrated human organ-on-a-chip model for predictive studies of anti-tumor drug efficacy and cardiac safety

Alan Chramiec et al.

LAB ON A CHIP (2020)

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Article Multidisciplinary Sciences

Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function

Mosha Abulaiti et al.

SCIENTIFIC REPORTS (2020)

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Article Cardiac & Cardiovascular Systems

Functional coculture of sympathetic neurons and cardiomyocytes derived from human-induced pluripotent stem cells

Annika Winbo et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

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Article Biophysics

A modular brain-on-a-chip for modelling epileptic seizures with functionally connected human neuronal networks

Anssi Pelkonen et al.

BIOSENSORS & BIOELECTRONICS (2020)

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Article Materials Science, Biomaterials

Reconfigurable Microphysiological Systems for Modeling Innervation and Multitissue Interactions

Jonathan R. Soucy et al.

ADVANCED BIOSYSTEMS (2020)

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Article Biochemistry & Molecular Biology

3D Co-culture of hiPSC-Derived Cardiomyocytes With Cardiac Fibroblasts Improves Tissue-Like Features of Cardiac Spheroids

Philippe Beauchamp et al.

FRONTIERS IN MOLECULAR BIOSCIENCES (2020)

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Article Nanoscience & Nanotechnology

Mechanically Biomimetic Gelatin-Gellan Gum Hydrogels for 3D Culture of Beating Human Cardiomyocytes

Janne T. Koivisto et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Engineering, Biomedical

Engineered heart tissue models from hiPSC-derived cardiomyocytes and cardiac ECM for disease modeling and drug testing applications

Idit Goldfracht et al.

ACTA BIOMATERIALIA (2019)

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Article Cell & Tissue Engineering

User-Friendly and Parallelized Generation of Human Induced Pluripotent Stem Cell-Derived Microtissues in a Centrifugal Heart-on-a-Chip

Oliver Schneider et al.

TISSUE ENGINEERING PART A (2019)

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Review Chemistry, Multidisciplinary

Monitoring of Microphysiological Systems: Integrating Sensors and Real-Time Data Analysis toward Autonomous Decision-Making

Ashlyn T. Young et al.

ACS SENSORS (2019)

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Article Chemistry, Multidisciplinary

Microphysiological Engineering of Self-Assembled and Perfusable Microvascular Beds for the Production of Vascularized Three-Dimensional Human Microtissues

Jungwook Paek et al.

ACS NANO (2019)

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Article Neurosciences

A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources

Divya C. Kernik et al.

JOURNAL OF PHYSIOLOGY-LONDON (2019)

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Article Multidisciplinary Sciences

Maturation of three-dimensional, hiPSC-derived cardiomyocyte spheroids utilizing cyclic, uniaxial stretch and electrical stimulation

Wesley LaBarge et al.

PLOS ONE (2019)

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Article Biochemistry & Molecular Biology

Optical Investigation of Action Potential and Calcium Handling Maturation of hiPSC-Cardiomyocytes on Biomimetic Substrates

Jose Manuel Pioner et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Chemistry, Multidisciplinary

Intracellular Recording of Cardiomyocyte Action Potentials with Nanopatterned Volcano-Shaped Microelectrode Arrays

B. X. E. Desbiolles et al.

NANO LETTERS (2019)

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Article Biochemical Research Methods

Engineering of human cardiac muscle electromechanically matured to an adult-like phenotype

Kacey Ronaldson-Bouchard et al.

NATURE PROTOCOLS (2019)

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Article Cell Biology

Fatty Acid-Treated Induced Pluripotent Stem Cell-Derived Human Cardiomyocytes Exhibit Adult Cardiomyocyte-Like Energy Metabolism Phenotypes

Yuichi Horikoshi et al.

CELLS (2019)

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Article Cardiac & Cardiovascular Systems

Workshop Report FDA Workshop on Improving Cardiotoxicity Assessment With Human-Relevant Platforms

Li Pang et al.

CIRCULATION RESEARCH (2019)

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Article Medicine, Research & Experimental

Disease modeling of a mutation in α-actinin 2 guides clinical therapy in hypertrophic cardiomyopathy

Maksymilian Prondzynski et al.

EMBO MOLECULAR MEDICINE (2019)

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Review Cell Biology

hiPSCs Derived Cardiac Cells for Drug and Toxicity Screening and Disease Modeling: What Micro- Electrode-Array Analyses Can Tell Us

Sophie Kussauer et al.

CELLS (2019)

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Article Materials Science, Biomaterials

Characterization of the microstructure of hydrazone crosslinked polysaccharide-based hydrogels through rheological and diffusion studies

Jennika Karvinen et al.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2019)

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Review Cardiac & Cardiovascular Systems

Computational models in cardiology

Steven A. Niederer et al.

NATURE REVIEWS CARDIOLOGY (2019)

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Review Physiology

DEFINING PHYSIOLOGICAL NORMOXIA FOR IMPROVED TRANSLATION OF CELL PHYSIOLOGY TO ANIMAL MODELS AND HUMANS

Thomas P. Keeley et al.

PHYSIOLOGICAL REVIEWS (2019)

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Article Toxicology

Resolving the Reversed Rate Effect of Calcium Channel Blockers on Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes and the Impact on In Vitro Cardiac Safety Evaluation

Haoyu Zeng et al.

TOXICOLOGICAL SCIENCES (2019)

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Review Chemistry, Analytical

Latest Trends in Biosensing for Microphysiological Organs-on-a-Chip and Body-on-a-Chip Systems

Sebastian Rudi Adam Kratz et al.

BIOSENSORS-BASEL (2019)

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Review Chemistry, Analytical

Measuring and regulating oxygen levels in microphysiological systems: design, material, and sensor considerations

Kristina R. Rivera et al.

ANALYST (2019)

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Review Biochemistry & Molecular Biology

Smart Cell Culture Systems: Integration of Sensors and Actuators into Microphysiological Systems

Mario M. Modena et al.

ACS CHEMICAL BIOLOGY (2018)

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Article Engineering, Biomedical

3D bioprinted functional and contractile cardiac tissue constructs

Zhan Wang et al.

ACTA BIOMATERIALIA (2018)

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Article Biochemistry & Molecular Biology

Electrical Stimulation Enhances Cardiac Differentiation of Human Induced Pluripotent Stem Cells for Myocardial Infarction Therapy

Ruilian Ma et al.

ANTIOXIDANTS & REDOX SIGNALING (2018)

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Article Cardiac & Cardiovascular Systems

Human Induced Pluripotent Stem Cell-Derived Engineered Heart Tissue as a Sensitive Test System for QT Prolongation and Arrhythmic Triggers

Marc D. Lemoine et al.

CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

Afterload promotes maturation of human induced pluripotent stem cell derived cardiomyocytes in engineered heart tissues

Andrea Leonard et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2018)

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Article Cell & Tissue Engineering

Assessing glucose and oxygen diffusion in hydrogels for the rational design of 3D stem cell scaffolds in regenerative medicine

L. Figueiredo et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2018)

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Article Biochemical Research Methods

A compartmentalized microfluidic chip with crisscross microgrooves and electrophysiological electrodes for modeling the blood-retinal barrier

Jose Yeste et al.

LAB ON A CHIP (2018)

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Article Multidisciplinary Sciences

Advanced maturation of human cardiac tissue grown from pluripotent stem cells

Kacey Ronaldson-Bouchard et al.

NATURE (2018)

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Article Multidisciplinary Sciences

Investigation of human iPSC-derived cardiac myocyte functional maturation by single cell traction force microscopy

Matthew Wheelwright et al.

PLOS ONE (2018)

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Article Cell & Tissue Engineering

Antiarrhythmic Effects of Carvedilol and Flecainide in Cardiomyocytes Derived from Catecholaminergic Polymorphic Ventricular Tachycardia Patients

R. P. Polonen et al.

STEM CELLS INTERNATIONAL (2018)

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Article Physiology

Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities

Michelangelo Paci et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Article Physiology

Every Breath You Take: Non-invasive Real-Time Oxygen Biosensing in Two- and Three-Dimensional Microfluidic Cell Models

Helene Zirath et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Article Physiology

Structural Immaturity of Human iPSC-Derived Cardiomyocytes: In Silico Investigation of Effects on Function and Disease Modeling

Jussi T. Koivumaki et al.

FRONTIERS IN PHYSIOLOGY (2018)

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Article Cardiac & Cardiovascular Systems

MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo

Luca Sala et al.

CIRCULATION RESEARCH (2018)

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Article Biotechnology & Applied Microbiology

Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes by Soluble Factors from Human Mesenchymal Stem Cells

Shohei Yoshida et al.

MOLECULAR THERAPY (2018)

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Article Multidisciplinary Sciences

Human iPS cell-derived cardiac tissue sheets for functional restoration of infarcted porcine hearts

Masanosuke Ishigami et al.

PLOS ONE (2018)

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Article Cardiac & Cardiovascular Systems

Metabolic Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocytes by Inhibition of HIF1 alpha and LDHA

Dongjian Hu et al.

CIRCULATION RESEARCH (2018)

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Article Multidisciplinary Sciences

Inversion and computational maturation of drug response using human stem cell derived cardiomyocytes in microphysiological systems

Aslak Tveito et al.

SCIENTIFIC REPORTS (2018)

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Review Cardiac & Cardiovascular Systems

Genetic and Tissue Engineering Approaches to Modeling the Mechanics of Human Heart Failure for Drug Discovery

Michael J. Greenberg et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)

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Article Mathematical & Computational Biology

Population-based mechanistic modeling allows for quantitative predictions of drug responses across cell types

Jingqi Q. X. Gong et al.

NPJ SYSTEMS BIOLOGY AND APPLICATIONS (2018)

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Review Cardiac & Cardiovascular Systems

Cardiomyocyte-Endothelial Cell Interactions in Cardiac Remodeling and Regeneration

Virpi Talman et al.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)

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Review Biochemistry & Molecular Biology

Limitations of oxygen delivery to cells in culture: An underappreciated problem in basic and translational research

Trenton L. Place et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

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Article Cell Biology

Live Cell Imaging: Assessing the Phototoxicity of 488 and 546 nm Light and Methods to Alleviate it

Stephen Douthwright et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2017)

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Article Biochemical Research Methods

Organs-on-Chips with combined multi-electrode array and transepithelial electrical resistance measurement capabilities

Ben M. Maoz et al.

LAB ON A CHIP (2017)

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Article Multidisciplinary Sciences

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

Yu Shrike Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

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Review Biochemistry & Molecular Biology

Electro-mechanical conditioning of human iPSC-derived cardiomyocytes for translational research

Katharina Kroll et al.

PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY (2017)

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Article Cell & Tissue Engineering

Substrate and mechanotransduction influence SERCA2a localization in human pluripotent stem cell-derived cardiomyocytes affecting functional performance

Sebastian Martewicz et al.

STEM CELL RESEARCH (2017)

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Article Cell Biology

Dorsal root ganglion neurons regulate the transcriptional and translational programs of osteoblast differentiation in a microfluidic platform

Diana Isabel Silva et al.

CELL DEATH & DISEASE (2017)

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Review Biotechnology & Applied Microbiology

Artificial Cardiac Muscle with or without the Use of Scaffolds

Yifei Li et al.

BIOMED RESEARCH INTERNATIONAL (2017)

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Article Biology

Capillary pericytes mediate coronary no-reflow after myocardial ischaemia

Fergus M. O'Farrell et al.

ELIFE (2017)

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Article Physiology

Evaluation of Optogenetic Electrophysiology Tools in Human Stem Cell-Derived Cardiomyocytes

Susann Bjork et al.

FRONTIERS IN PHYSIOLOGY (2017)

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Article Physiology

Human In Silico Drug Trials Demonstrate Higher Accuracy than Animal Models in Predicting Clinical Pro-Arrhythmic Cardiotoxicity

Elisa Passini et al.

FRONTIERS IN PHYSIOLOGY (2017)

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Article Multidisciplinary Sciences

Geometry-dependent functional changes in iPSC-derived cardiomyocytes probed by functional imaging and RNA sequencing

Christopher A. Werley et al.

PLOS ONE (2017)

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Article Multidisciplinary Sciences

Developmental stage-dependent effects of cardiac fibroblasts on function of stem cell-derived engineered cardiac tissues

Brian Liau et al.

SCIENTIFIC REPORTS (2017)

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Article Multidisciplinary Sciences

Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform

Aleksander Skardal et al.

SCIENTIFIC REPORTS (2017)

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Review Cell Biology

Naturally Engineered Maturation of Cardiomyocytes

Gaetano J. Scuderi et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2017)

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Article Biochemistry & Molecular Biology

Functional innervation of human induced pluripotent stem cell-derived cardiomyocytes by co-culture with sympathetic neurons developed using a microtunnel technique

Koji Sakai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Article Cardiac & Cardiovascular Systems

Gq-activated fibroblasts induce cardiomyocyte action potential prolongation and automaticity in a three-dimensional microtissue environment

C. M. Kofron et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2017)

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Article Biotechnology & Applied Microbiology

Maturation of human pluripotent stem cell derived cardiomyocytes is improved in cardiovascular construct

Hanna Vuorenpaa et al.

CYTOTECHNOLOGY (2017)

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Article Engineering, Biomedical

Contractile force generation by 3D hiPSC-derived cardiac tissues is enhanced by rapid establishment of cellular interconnection in matrix with muscle-mimicking stiffness

Soah Lee et al.

BIOMATERIALS (2017)

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Article Cardiac & Cardiovascular Systems

Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair

Malte Tiburcy et al.

CIRCULATION (2017)

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Review Cardiac & Cardiovascular Systems

Engineering Cardiac Muscle Tissue A Maturating Field of Research

Florian Weinberger et al.

CIRCULATION RESEARCH (2017)

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Article Biochemical Research Methods

Human iPSC-derived myocardium-on-chip with capillary-like flow for personalized medicine

Bradley W. Ellis et al.

BIOMICROFLUIDICS (2017)

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Article Chemistry, Analytical

Aptamer-Based Microfluidic Electrochemical Biosensor for Monitoring Cell-Secreted Trace Cardiac Biomarkers

Su Ryon Shin et al.

ANALYTICAL CHEMISTRY (2016)

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Review Neurosciences

The sympathetic innervation of the heart: Important new insights

J. H. Coote et al.

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL (2016)

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Article Cardiac & Cardiovascular Systems

Human iPS cell model of type 3 long QT syndrome recapitulates drug-based phenotype correction

Daniela Malan et al.

BASIC RESEARCH IN CARDIOLOGY (2016)

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Article Engineering, Biomedical

Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip

Yu Shrike Zhang et al.

BIOMATERIALS (2016)

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Article Cardiac & Cardiovascular Systems

Mechanical Stress Conditioning and Electrical Stimulation Promote Contractility and Force Maturation of Induced Pluripotent Stem Cell-Derived Human Cardiac Tissue

Jia-Ling Ruan et al.

CIRCULATION (2016)

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Article Cell Biology

A device for co-culturing autonomic neurons and cardiomyocytes using micro-fabrication techniques

Kosuke Oiwa et al.

INTEGRATIVE BIOLOGY (2016)

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Article Biophysics

Sample-specific adaption of an improved electro-mechanical model of in vitro cardiac tissue

Ralf Frotscher et al.

JOURNAL OF BIOMECHANICS (2016)

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Article Neurosciences

Compartmentalized Microfluidic Platforms: The Unrivaled Breakthrough of In Vitro Tools for Neurobiological Research

Estrela Neto et al.

JOURNAL OF NEUROSCIENCE (2016)

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Article Neurosciences

Molecular and cellular neurocardiology: development, and cellular and molecular adaptations to heart disease

Beth A. Habecker et al.

JOURNAL OF PHYSIOLOGY-LONDON (2016)

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Review Biochemical Research Methods

Implementing oxygen control in chip-based cell and tissue culture systems

Pieter E. Oomen et al.

LAB ON A CHIP (2016)

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Article Chemistry, Multidisciplinary

Optical Projection Tomography Technique for Image Texture and Mass Transport Studies in Hydrogels Based on Gellan Gum

Ana M. Soto et al.

LANGMUIR (2016)

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Article Multidisciplinary Sciences

In Vitro Reconstruction of Neuronal Networks Derived from Human iPS Cells Using Microfabricated Devices

Yuzo Takayama et al.

PLOS ONE (2016)

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Article Pharmacology & Pharmacy

The Comprehensive in Vitro Proarrhythmia Assay (CiPA) initiative Update on progress

Thomas Colatsky et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2016)

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Review Nanoscience & Nanotechnology

Designing hydrogels for controlled drug delivery

Jianyu Li et al.

NATURE REVIEWS MATERIALS (2016)

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Article Multidisciplinary Sciences

Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs

Carlota Oleaga et al.

SCIENTIFIC REPORTS (2016)

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Article Multidisciplinary Sciences

Human Vascular Microphysiological System for in vitro Drug Screening

C. E. Fernandez et al.

SCIENTIFIC REPORTS (2016)

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Article Multidisciplinary Sciences

The myocardial regenerative potential of three-dimensional engineered cardiac tissues composed of multiple human iPS cell-derived cardiovascular cell lineages

Hidetoshi Masumoto et al.

SCIENTIFIC REPORTS (2016)

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Article Biochemistry & Molecular Biology

Luminescent sensing and imaging of oxygen: Fierce competition to the Clark electrode

Otto S. Wolfbeis

BIOESSAYS (2015)

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Article Pharmacology & Pharmacy

Human induced pluripotent stem cell-derived versus adult cardiomyocytes: an in silico electrophysiological study on effects of ionic current block

M. Paci et al.

BRITISH JOURNAL OF PHARMACOLOGY (2015)

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Article Cardiac & Cardiovascular Systems

Matrigel Mattress A Method for the Generation of Single Contracting Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes

Tromondae K. Feaster et al.

CIRCULATION RESEARCH (2015)

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Review Cardiac & Cardiovascular Systems

Cardiac endothelium-myocyte interaction: clinical opportunities for new heart failure therapies regardless of ejection fraction

Shir Lynn Lim et al.

EUROPEAN HEART JOURNAL (2015)

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Article Medicine, Research & Experimental

Fluorescent protein biosensors applied to microphysiological systems

Nina Senutovitch et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2015)

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Article Cardiac & Cardiovascular Systems

Mechanism of automaticity in cardiomyocytes derived from human induced pluripotent stem cells

Jong J. Kim et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

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Article Biochemical Research Methods

Stem cell derived in vivo-like human cardiac bodies in a microfluidic device for toxicity testing by beating frequency imaging

Gunnar Bergstrom et al.

LAB ON A CHIP (2015)

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Article Multidisciplinary Sciences

Contractility of single cardiomyocytes differentiated from pluripotent stem cells depends on physiological shape and substrate stiffness

Alexandre J. S. Ribeiro et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

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Article Chemistry, Analytical

A capillary-endothelium-mimetic microfluidic chip for the study of immune responses

Wen-Hao Wu et al.

SENSORS AND ACTUATORS B-CHEMICAL (2015)

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Article Cell & Tissue Engineering

Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales

Nathaniel Huebsch et al.

TISSUE ENGINEERING PART C-METHODS (2015)

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Article Cell & Tissue Engineering

Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and Voltage Fluorescent Reporters

Rami Shinnawi et al.

STEM CELL REPORTS (2015)

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Editorial Material Cardiac & Cardiovascular Systems

The Autonomic Nervous System and Cardiovascular Health and Disease A Complex Balancing Act

C. Noel Bairey Merz et al.

JACC-HEART FAILURE (2015)

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Article Multidisciplinary Sciences

Human iPSC-based Cardiac Microphysiological System For Drug Screening Applications

Anurag Mathur et al.

SCIENTIFIC REPORTS (2015)

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Article Physiology

Ion Channels in the Heart

Daniel C. Bartos et al.

COMPREHENSIVE PHYSIOLOGY (2015)

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Proceedings Paper Engineering, Mechanical

Simulation of Cardiac Cell-Seeded Membranes Using the Edge-Based Smoothed FEM

Ralf Frotscher et al.

SHELL AND MEMBRANE THEORIES IN MECHANICS AND BIOLOGY: FROM MACRO- TO NANOSCALE STRUCTURES (2015)

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Review Biochemistry & Molecular Biology

Mechanotransduction in the Endothelium: Role of Membrane Proteins and Reactive Oxygen Species in Sensing, Transduction, and Transmission of the Signal with Altered Blood Flow

Shampa Chatterjee et al.

ANTIOXIDANTS & REDOX SIGNALING (2014)

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Article Engineering, Biomedical

Video image-based analysis of single human induced pluripotent stem cell derived cardiomyocyte beating dynamics using digital image correlation

Antti Ahola et al.

BIOMEDICAL ENGINEERING ONLINE (2014)

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Review Chemistry, Multidisciplinary

Optical methods for sensing and imaging oxygen: materials, spectroscopies and applications

Xu-dong Wang et al.

CHEMICAL SOCIETY REVIEWS (2014)

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Article Cell Biology

Novel in vitro cardiovascular constructs composed of vascular-like networks and cardiomyocytes

Hanna Vuorenpaa et al.

IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL (2014)

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Review Cardiac & Cardiovascular Systems

Dynamic cell-cell and cell-ECM interactions in the heart

Catherine M. Howard et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2014)

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Article Cardiac & Cardiovascular Systems

Functional improvement and maturation of rat and human engineered heart tissue by chronic electrical stimulation

Marc N. Hirt et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2014)

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Article Toxicology

The Concordance between Nonclinical and Phase I Clinical Cardiovascular Assessment from a Cross-Company Data Sharing Initiative

Lorna Ewart et al.

TOXICOLOGICAL SCIENCES (2014)

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Article Physiology

Simultaneous mapping of membrane voltage and calcium in zebrafish heart in vivo reveals chamber-specific developmental transitions in ionic currents

Jennifer H. Hou et al.

FRONTIERS IN PHYSIOLOGY (2014)

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Article Cell & Tissue Engineering

Rapid Cellular Phenotyping of Human Pluripotent Stem Cell-Derived Cardiomyocytes using a Genetically Encoded Fluorescent Voltage Sensor

Jordan S. Leyton-Mange et al.

STEM CELL REPORTS (2014)

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Article Engineering, Biomedical

Computational Models of Ventricular- and Atrial-Like Human Induced Pluripotent Stem Cell Derived Cardiomyocytes

Michelangelo Paci et al.

ANNALS OF BIOMEDICAL ENGINEERING (2013)

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Article Engineering, Biomedical

Three-dimensional neuron-muscle constructs with neuromuscular junctions

Yuya Morimoto et al.

BIOMATERIALS (2013)

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Article Cell & Tissue Engineering

Distinct Metabolic Flow Enables Large-Scale Purification of Mouse and Human Pluripotent Stem Cell-Derived Cardiomyocytes

Shugo Tohyama et al.

CELL STEM CELL (2013)

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Article Biochemical Research Methods

Engineering of functional, perfusable 3D microvascular networks on a chip

Sudong Kim et al.

LAB ON A CHIP (2013)

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Article Biochemical Research Methods

Biowire: a platform for maturation of human pluripotent stem cell-derived cardiomyocytes

Sara S. Nunes et al.

NATURE METHODS (2013)

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Review Cardiac & Cardiovascular Systems

Myofibroblast-mediated mechanisms of pathological remodelling of the heart

Karl T. Weber et al.

NATURE REVIEWS CARDIOLOGY (2013)

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Article Multidisciplinary Sciences

Cardiomyocyte MEA Data Analysis (CardioMDA) - A Novel Field Potential Data Analysis Software for Pluripotent Stem Cell Derived Cardiomyocytes

Paruthi Pradhapan et al.

PLOS ONE (2013)

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Review Cardiac & Cardiovascular Systems

Cross talk between cardiac myocytes and fibroblasts: from multiscale investigative approaches to mechanisms and functional consequences

P. Zhang et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2012)

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Article Chemistry, Analytical

Inflammatory mimetic microfluidic chip by immobilization of cell adhesion molecules for T cell adhesion

Sung Kyu Kim et al.

ANALYST (2012)

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Article Anatomy & Morphology

Adipose Stromal Cell Tubule Network Model Provides a Versatile Tool for Vascular Research and Tissue Engineering

Jertta-Riina Sarkanen et al.

CELLS TISSUES ORGANS (2012)

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Editorial Material Cardiac & Cardiovascular Systems

Three-Dimensional Architecture of Cardiomyocytes and Connective Tissues in Hypertrophic Cardiomyopathy A Scanning Electron Microscopic Observation

Yumiko Kanzaki et al.

CIRCULATION (2012)

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Review Cardiac & Cardiovascular Systems

Development, Maturation, and Transdifferentiation of Cardiac Sympathetic Nerves

Kensuke Kimura et al.

CIRCULATION RESEARCH (2012)

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Article Cell Biology

Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture

Anna L. Lahti et al.

DISEASE MODELS & MECHANISMS (2012)

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Review Cardiac & Cardiovascular Systems

Intracellular Energetic Units regulate metabolism in cardiac cells

Valdur Saks et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2012)

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Article Multidisciplinary Sciences

Modulation of hERG potassium channel gating normalizes action potential duration prolonged by dysfunctional KCNQ1 potassium channel

Hongkang Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

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Article Medicine, Research & Experimental

Coronary vein infusion of multipotent stromal cells from bone marrow preserves cardiac function in swine ischemic cardiomyopathy via enhanced neovascularization

Takatoshi Sato et al.

LABORATORY INVESTIGATION (2011)

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Article Biochemical Research Methods

Impact of Sarcoplasmic Reticulum Calcium Release on Calcium Dynamics and Action Potential Morphology in Human Atrial Myocytes: A Computational Study

Jussi T. Koivumaki et al.

PLOS COMPUTATIONAL BIOLOGY (2011)

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Article Biochemical Research Methods

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

Thomas O'Hara et al.

PLOS COMPUTATIONAL BIOLOGY (2011)

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Article Cardiac & Cardiovascular Systems

Histologically Measured Cardiomyocyte Hypertrophy Correlates with Body Height as Strongly as with Body Mass Index

Richard E. Tracy et al.

CARDIOLOGY RESEARCH AND PRACTICE (2011)

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Article Cardiac & Cardiovascular Systems

A novel computational model of the human ventricular action potential and Ca transient

Eleonora Grandi et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2010)

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Article Neurosciences

Local Ca2+releases enable rapid heart rates in developing cardiomyocytes

Topi Korhonen et al.

JOURNAL OF PHYSIOLOGY-LONDON (2010)

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Article Cell & Tissue Engineering

Non-Cardiomyocytes Influence the Electrophysiological Maturation of Human Embryonic Stem Cell-Derived Cardiomyocytes During Differentiation

Changsung Kim et al.

STEM CELLS AND DEVELOPMENT (2010)

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Article Cell Biology

Cardiac Fibroblasts Regulate Myocardial Proliferation through β1 Integrin Signaling

Masaki Leda et al.

DEVELOPMENTAL CELL (2009)

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Article Biochemical Research Methods

Imaging neural activity in worms, flies and mice with improved GCaMP calcium indicators

Lin Tian et al.

NATURE METHODS (2009)

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Article Multidisciplinary Sciences

Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue

K. R. Stevens et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

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Editorial Material Cardiac & Cardiovascular Systems

Quantifying the role of oxygen pressure in tissue function

David F. Wilson

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2008)

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Article Biochemistry & Molecular Biology

Adaptive changes in cardiac fibroblast morphology and collagen organization as a result of mechanical environment

Sarah C. Baxter et al.

CELL BIOCHEMISTRY AND BIOPHYSICS (2008)

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Article Cardiac & Cardiovascular Systems

Endothelial cell coculture within tissue-engineered cardiomyocyte sheets enhances neovascularization and improves cardiac function of ischemic hearts

Hidekazu Sekine et al.

CIRCULATION (2008)

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Article Materials Science, Multidisciplinary

Cell patterning: Interaction of cardiac myocytes and fibroblasts in three-dimensional culture

Troy A. Baudino et al.

MICROSCOPY AND MICROANALYSIS (2008)

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Review Cardiac & Cardiovascular Systems

Sarcomeric dysfunction in heart failure

Nazha Hamdani et al.

CARDIOVASCULAR RESEARCH (2008)

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Review Medicine, General & Internal

Mechanisms of disease - The failing heart - An engine out of fuel

Stefan Neubauer

NEW ENGLAND JOURNAL OF MEDICINE (2007)

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Article Cell Biology

Organization of β-adrenoceptor signaling compartments by sympathetic innervation of cardiac myocytes

Olga G. Shcherbakova et al.

JOURNAL OF CELL BIOLOGY (2007)

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Article Cardiac & Cardiovascular Systems

Tissue engineering of vascularized cardiac muscle from human embryonic stem cells

Oren Caspi et al.

CIRCULATION RESEARCH (2007)

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Review Cell Biology

VEGF receptor signalling - in control of vascular function

AK Olsson et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

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Article Cardiac & Cardiovascular Systems

Altered fibroblast function following myocardial infarction

CE Squires et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2005)

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Article Cardiac & Cardiovascular Systems

Molecular profiling of heart endothelial cells

LL Zhang et al.

CIRCULATION (2005)

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Article Cardiac & Cardiovascular Systems

Electrical interaction of mechanosensitive fibroblasts and myocytes in the heart

A Kamkin et al.

BASIC RESEARCH IN CARDIOLOGY (2005)

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Article Cardiac & Cardiovascular Systems

A model for human ventricular tissue

KHWJ ten Tusscher et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2004)

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Article Cardiac & Cardiovascular Systems

Endothelial cells promote cardiac myocyte survival and spatial reorganization - Implications for cardiac regeneration

DA Narmoneva et al.

CIRCULATION (2004)

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Article Cardiac & Cardiovascular Systems

Isolation and expansion of adult cardiac stem cells from human and murine heart

E Messina et al.

CIRCULATION RESEARCH (2004)

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Article Biochemistry & Molecular Biology

Adult cardiac stem cells are multipotent and support myocardial regeneration

AP Beltrami et al.

CELL (2003)

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Review Physiology

Cardiac endothelial-myocardial signaling: Its role in cardiac growth, contractile performance, and rhythmicity

DL Brutsaert

PHYSIOLOGICAL REVIEWS (2003)

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Article Medicine, Research & Experimental

Human embryonic stem cells can differentiate into myocytes with structural and functional properties of cardiomyocytes

I Kehat et al.

JOURNAL OF CLINICAL INVESTIGATION (2001)

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