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Pharmacological intervention of curcumin via the NLRP3 inflammasome in ischemic stroke

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Article Immunology

TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats

Hui Liang et al.

Summary: Activation of TGR5 mitigates brain injury by inhibiting neuroinflammation after MCAO, potentially mediated by Pellino3 inhibition of caspase-8/NLRP3.

JOURNAL OF NEUROINFLAMMATION (2021)

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Review Pharmacology & Pharmacy

Neurodegenerative Disease and the NLRP3 Inflammasome

Jonathan A. Holbrook et al.

Summary: The prevalence of neurodegenerative diseases is increasing, characterized by progressive neuronal loss, protein aggregation, metabolic abnormalities, and immune dysregulation. Research has shown that low-grade systemic inflammation may impact the development and progression of these diseases, and inflammation may also be a causative factor.

FRONTIERS IN PHARMACOLOGY (2021)

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Review Chemistry, Medicinal

Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures

Ying Peng et al.

Summary: Curcumin, a natural compound, shows great potential in disease treatment with its significant anti-inflammatory effect. It has been proven to effectively improve symptoms of inflammatory diseases, making it a promising candidate for related disease treatments.

DRUG DESIGN DEVELOPMENT AND THERAPY (2021)

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Review Biochemistry & Molecular Biology

Curcumin as Scaffold for Drug Discovery against Neurodegenerative Diseases

Filippa Lo Cascio et al.

Summary: This review highlights recent research on modifying the structure of curcumin to search for new effective therapeutic agents against neurodegenerative diseases, with a particular focus on Alzheimer's disease.

BIOMEDICINES (2021)

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Article Neurosciences

Dexmedetomidine exerts a protective effect on ischemic brain injury by inhibiting the P2X7R/NLRP3/Caspase-1 signaling pathway

Ke Sun et al.

Summary: The study demonstrated that Dex exerts a protective role against ischemic brain injury by inhibiting microglial pyroptosis through the P2X7R/NLRP3/Caspase-1 pathway. Dex treatment alleviated neurological deficits, reduced brain water content and infarct size in p-MCAO rats. Furthermore, in vitro and in vivo experiments indicated that Dex could enhance cell activity and reduce LDH activity by suppressing the P2X7R/NLRP3/Caspase-1 pathway.

BRAIN RESEARCH BULLETIN (2021)

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Review Immunology

Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson's Disease

Yunna Li et al.

Summary: Recent studies have shown that the excessive activation of microglia and release of pro-inflammatory cytokines play crucial roles in the pathogenesis and progression of Parkinson's disease (PD). The elevated level of NLRP3 inflammasome in activated microglia in the substantia nigra of PD patients exacerbates the pathology and accelerates disease progression. Current therapeutic drugs for PD primarily focus on relieving clinical symptoms, as there are no established strategies to stop or reverse the disease.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Nanoscience & Nanotechnology

Triblock Copolymer Nanomicelles Loaded with Curcumin Attenuates Inflammation via Inhibiting the NF-κB Pathway in the Rat Model of Cerebral Ischemia

Fengguang Li et al.

Summary: The study demonstrated the therapeutic effect of NC in a rat model of cerebral ischemia/reperfusion injury by reducing NF-kappa B-p65 protein and inflammatory cytokines.

INTERNATIONAL JOURNAL OF NANOMEDICINE (2021)

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Article Oncology

Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-ΚB signaling pathway

Jie Liu et al.

Summary: Salidroside can inhibit NLRP3 inflammasome activation and reduce inflammatory injury by suppressing the TLR4/NF-κB signaling pathway, showing potential as a therapeutic drug for ischemic stroke.

ANNALS OF TRANSLATIONAL MEDICINE (2021)

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Article Cell Biology

Inflammaging and neurodegenerative diseases: Role of NLRP3 inflammasome activation in brain atherosclerotic vascular disease

Stefania Cicolari et al.

Summary: The activation of the NLRP3 inflammasome-IL-1β pathway is crucial in the onset of acute cerebral atherosclerotic vascular disease and subsequent neurodegeneration. Further studies and clinical trials are needed to evaluate the potential dual role of this pathway in stroke prevention and treatment.

MECHANISMS OF AGEING AND DEVELOPMENT (2021)

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Article Biochemistry & Molecular Biology

Gastrodin Alleviates Cerebral Ischaemia/Reperfusion Injury by Inhibiting Pyroptosis by Regulating the lncRNA NEAT1/miR-22-3p Axis

Heng-Sheng Zhang et al.

Summary: The study revealed that Gastrodin (GAS) significantly improved neurological scores and reduced cerebral infarction area in rats by modulating the lncRNA NEAT1/miR-22-3p axis. GAS inhibited pyroptosis by downregulating NLRP3, inflammatory factors (IL-1 beta, IL-18), and cleaved caspase-1. Furthermore, GAS attenuated I/R-induced inflammation in neuronal cells through the modulation of the lncRNA NEAT1/miR-22-3p axis.

NEUROCHEMICAL RESEARCH (2021)

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Article Medicine, Research & Experimental

Curcumin ameliorates ischemic stroke injury in rats by protecting the integrity of the blood-brain barrier

Shuguang Wu et al.

Summary: The study demonstrates that curcumin pretreatment can ameliorate ischemic stroke injury by protecting BBB integrity and synaptic remodeling, as well as inhibiting inflammatory responses.

EXPERIMENTAL AND THERAPEUTIC MEDICINE (2021)

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Article Clinical Neurology

Curcumin Alleviates Chronic Pain and Improves Cognitive Impairment via Enhancing Hippocampal Neurogenesis in Sciatic Nerve Constriction Rats

Jingyi Du et al.

Summary: The study showed that curcumin can improve cognitive deficits and pain behaviors in rats with chronic neuropathic pain, which may be associated with improvements in hippocampal neurogenesis and synaptic plasticity.

JOURNAL OF PAIN RESEARCH (2021)

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Review Integrative & Complementary Medicine

Natural antioxidants in the management of Parkinson's disease: Review of evidence from cell line and animal models

Reem Abdul-Latif et al.

Summary: Parkinson's disease is a chronic progressive neurodegenerative disease caused by the death of dopaminergic neurons. Natural antioxidants may provide an alternative therapy that prevents oxidative stress and reduces disease progression in Parkinson's disease.

JOURNAL OF INTEGRATIVE MEDICINE-JIM (2021)

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Review Biochemistry & Molecular Biology

Neuroprotective Effects of Curcumin in Cerebral Ischemia: Cellular and Molecular Mechanisms

Lalita Subedi et al.

Summary: Curcumin, a polyphenol abundant in turmeric, has shown promising neuroprotective effects in animal models of neurodegenerative diseases, including cerebral ischemia. Its pleiotropic effects in the postischemic brain, such as antioxidant and anti-inflammatory properties, make it a potential therapeutic strategy for treating cerebral ischemia. Studies have validated its neuroprotective effects in both ischemic and hemorrhagic stroke, demonstrating its broad-spectrum efficacy in protecting the brain.

ACS CHEMICAL NEUROSCIENCE (2021)

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Article Medicine, Research & Experimental

Pien-Tze-Huang, a Chinese patent formula, attenuates NLRP3 inflammasome-related neuroinflammation by enhancing autophagy via the AMPK/mTOR/ULK1 signaling pathway

Zhenwei Huang et al.

Summary: The study demonstrated that the traditional Chinese medicine Pien-Tze-Huang (PTH) can inhibit NLRP3 inflammasome-mediated neuroinflammation through enhancing autophagy and the AMPK/mTOR/ULK1 pathway both in vitro and in vivo, which was validated in experiments with cell cultures and rat models.

BIOMEDICINE & PHARMACOTHERAPY (2021)

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Article Neurosciences

Bone marrow mesenchymal stem cell-derived exosomes attenuate cerebral ischemia-reperfusion injury-induced neuroinflammation and pyroptosis by modulating microglia M1/M2 phenotypes

Xiaoli Liu et al.

Summary: The study demonstrated that BMSC-Exos attenuated cerebral I/R injury by suppressing NLRP3 inflammasome-mediated inflammation and pyroptosis, and also by modulating microglial polarization, ultimately providing neuroprotective effects.

EXPERIMENTAL NEUROLOGY (2021)

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Article Cell Biology

ATN-161 Ameliorates Ischemia/Reperfusion-induced Oxidative Stress, Fibro-inflammation, Mitochondrial damage, and Apoptosis-mediated Tight Junction Disruption in bEnd.3 Cells

Narayanappa Amruta et al.

Summary: This study demonstrates the significance of α5β1 integrin in ischemic stroke and the therapeutic potential of α5β1 inhibitor ATN-161 in reducing stroke injury through various mechanisms such as decreasing infarct volume, edema, stabilizing BBB, reducing inflammation, and inhibiting immune cell infiltration. ATN-161 effectively attenuates OGD/R-induced damage in mouse brain endothelial cells by inhibiting ECM deposition, oxidative stress, inflammation, tight junction loss, mitochondrial damage, and apoptosis. These findings further support the therapeutic targeting of α5 integrin with ATN-161 in ischemic stroke.

INFLAMMATION (2021)

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Article Medicine, Research & Experimental

Selenium attenuates ischemia/reperfusion injury-induced damage to the blood-brain barrier in hyperglycemia through PI3K/AKT/mTOR pathway-mediated autophagy inhibition

Biao Yang et al.

Summary: The study found that selenium can inhibit autophagy by regulating the PI3K/AKT/mTOR signaling pathway, significantly preventing BBB damage following cerebral I/R injury in hyperglycemic conditions.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2021)

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Article Immunology

NLRP3 inhibition attenuates early brain injury and delayed cerebral vasospasm after subarachnoid hemorrhage

William S. Dodd et al.

Summary: The study identified the role of NLRP3 in different phases following SAH, demonstrating that NLRP3 inhibition can improve neuroinflammation and cerebrovascular dysfunction caused by SAH. Furthermore, the research suggests that NLRP3 inhibitors could be promising tools in the treatment of EBI and DCI.

JOURNAL OF NEUROINFLAMMATION (2021)

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Review Geriatrics & Gerontology

Research Progress on the Mechanism of Mitochondrial Autophagy in Cerebral Stroke

Li Lei et al.

Summary: Mitochondrial autophagy plays an important role in selectively clearing dysfunctional or excessive mitochondria through a distinctive mechanism, particularly during ischemic stroke. Understanding the mechanism of mitochondrial autophagy helps to better comprehend the pathogenesis of stroke.

FRONTIERS IN AGING NEUROSCIENCE (2021)

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Review Cell Biology

Novel Insights and Current Evidence for Mechanisms of Atherosclerosis: Mitochondrial Dynamics as a Potential Therapeutic Target

Dan Li et al.

Summary: Cardiovascular disease (CVD) is the leading cause of death globally, with atherosclerosis as its underlying pathological basis. Mitochondrial dynamics play a crucial role in CVD progression, impacting processes such as ROS production, oxidative stress, and inflammatory responses.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Article Biochemistry & Molecular Biology

Prophylactic treatment of curcumin in a rat model of depression by attenuating hippocampal synaptic loss

Cuiqin Fan et al.

Summary: The study demonstrates that curcumin can alleviate depressive behaviors in a rat model by suppressing oxidative stress, neural inflammation, and synaptic dysregulation, potentially through the miR-146a-5p/ERK signaling pathway. This suggests a neuroprotective and antidepressant role of curcumin as a potential therapeutic strategy for depression.

FOOD & FUNCTION (2021)

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Review Neurosciences

The Role of NLRP3 Inflammasome in Cerebrovascular Diseases Pathology and Possible Therapeutic Targets

Rongrong Bai et al.

Summary: The NLRP3 inflammasome plays a key role in cerebrovascular diseases, with various signaling pathways influencing its activation and impact on disease progression.

ASN NEURO (2021)

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Review Food Science & Technology

Cellular and molecular mechanisms of curcumin in prevention and treatment of disease

Sita Sharan Patel et al.

CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION (2020)

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Article Biochemistry & Molecular Biology

Curcumin ameliorates oxidative stress-induced intestinal barrier injury and mitochondrial damage by promoting Parkin dependent mitophagy through AMPK-TFEB signal pathway

Shuting Cao et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

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Article Biochemistry & Molecular Biology

A Curcumin Derivative Activates TFEB and Protects Against Parkinsonian Neurotoxicity in Vitro

Ziying Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

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Review Biochemistry & Molecular Biology

Neuroprotective effects of curcumin through autophagy modulation

Fatemeh Forouzanfar et al.

IUBMB LIFE (2020)

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Review Pharmacology & Pharmacy

The Role of Inflammasomes in Atherosclerosis and Stroke Pathogenesis

Deepaneeta Sarmah et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

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Article Medicine, Research & Experimental

Inhibition of double-strand DNA-sensing cGAS ameliorates brain injury after ischemic stroke

Qian Li et al.

EMBO MOLECULAR MEDICINE (2020)

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Review Plant Sciences

Renshen Shouwu extract enhances neurogenesis and angiogenesis via inhibition of TLR4/NF-κB/NLRP3 signaling pathway following ischemic stroke in rats

Yuping Li et al.

JOURNAL OF ETHNOPHARMACOLOGY (2020)

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Review Immunology

The NLRP3 inflammasome in traumatic brain injury: potential as a biomarker and therapeutic target

William T. O'Brien et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Review Pharmacology & Pharmacy

Curcumin: an inflammasome silencer

Shima Hasanzadeh et al.

PHARMACOLOGICAL RESEARCH (2020)

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Review Pharmacology & Pharmacy

Pathophysiology of Ischemic Stroke: Role of Oxidative Stress

Sofia Orellana-Urzua et al.

CURRENT PHARMACEUTICAL DESIGN (2020)

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Article Biochemistry & Molecular Biology

TREM-1-targeting LP17 attenuates cerebral ischemia-induced neuronal injury by inhibiting oxidative stress and pyroptosis

Yu-Bin Liang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

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Article Immunology

Geniposide inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen-glucose deprivation/reoxygenation

Chen Fu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2020)

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Article Biochemistry & Molecular Biology

Premature synaptic mitochondrial dysfunction in the hippocampus during aging contributes to memory loss

Margrethe A. Olesen et al.

REDOX BIOLOGY (2020)

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Article Biochemistry & Molecular Biology

Idebenone attenuates cerebral inflammatory injury in ischemia and reperfusion via dampening NLRP3 inflammasome activity

Jialing Peng et al.

MOLECULAR IMMUNOLOGY (2020)

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Review Pharmacology & Pharmacy

Therapeutic targets of oxidative/nitrosative stress and neuroinflammation in ischemic stroke: Applications for natural product efficacy with omics and systemic biology

Hansen Chen et al.

PHARMACOLOGICAL RESEARCH (2020)

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Review Neurosciences

Inhibition of NLRP3 Inflammasome: A Prospective Target for the Treatment of Ischemic Stroke

Ya-Shuo Feng et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

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Article Cell Biology

Inhibition of microglial receptor-interacting protein kinase 1 ameliorates neuroinflammation following cerebral ischaemic stroke

Yang Jiao et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

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Article Immunology

MicroRNA-195 prevents hippocampal microglial/macrophage polarization towards the M1 phenotype induced by chronic brain hypoperfusion through regulating CX3CL1/CX3CR1 signaling

Meng Mao et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Article Neurosciences

MiR-139 protects against oxygen-glucose deprivation/reoxygenation (OGD/R)-induced nerve injury through targeting c-Jun to inhibit NLRP3 inflammasome activation

Qiao-Sheng Wang et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2020)

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Review Immunology

Interplay Between NLRP3 Inflammasome and Autophagy

Monika Biasizzo et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Cardiac & Cardiovascular Systems

Curcumin suppresses doxorubicin-induced cardiomyocyte pyroptosis via a PI3K/Akt/mTOR-dependent manner

Wei Yu et al.

CARDIOVASCULAR DIAGNOSIS AND THERAPY (2020)

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Article Medicine, Research & Experimental

D-Carvone inhibit cerebral ischemia/reperfusion induced inflammatory response TLR4/NLRP3 signaling pathway

Mengyuan Dai et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Clinical Neurology

Curcumin Prevents Neuroinflammation by Inducing Microglia to Transform into the M2-phenotype via CaMKKβ-dependent Activation of the AMP-Activated Protein Kinase Signal Pathway

Peifeng Qiao et al.

CURRENT ALZHEIMER RESEARCH (2020)

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Review Psychiatry

Curcumin in Depression: Potential Mechanisms of Action and Current Evidence-A Narrative Review

Tahiana Ramaholimihaso et al.

FRONTIERS IN PSYCHIATRY (2020)

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Article Immunology

Low-density lipoprotein receptor (LDLR) regulates NLRP3-mediated neuronal pyroptosis following cerebral ischemia/reperfusion injury

Rui Sun et al.

JOURNAL OF NEUROINFLAMMATION (2020)

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Article Neurosciences

Hypoxia Inducible Factor-1α (HIF-1α) Mediates NLRP3 Inflammasome-Dependent-Pyroptotic and Apoptotic Cell Death Following Ischemic Stroke

Qian Jiang et al.

NEUROSCIENCE (2020)

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Article Neurosciences

miR-668 inhibitor attenuates mitochondrial membrane potential and protects against neuronal apoptosis in cerebral ischemic stroke

Junna He et al.

FOLIA NEUROPATHOLOGICA (2020)

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Article Biochemistry & Molecular Biology

MPTP-driven NLRP3 inflammasome activation in microglia plays a central role in dopaminergic neurodegeneration

Eunju Lee et al.

CELL DEATH AND DIFFERENTIATION (2019)

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Article Neurosciences

Baicalin mitigates cognitive impairment and protects neurons from microglia-mediated neuroinflammation via suppressing NLRP3 inflammasomes and TLR4/NF-κB signaling pathway

Xin Jin et al.

CNS NEUROSCIENCE & THERAPEUTICS (2019)

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Article Immunology

Inhibition of GSK-3β alleviates cerebral ischemia/reperfusion injury in rats by suppressing NLRP3 inflammasome activation through autophagy

Yueting Wang et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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Article Biochemistry & Molecular Biology

Curcumin and Resveratrol Regulate Intestinal Bacteria and Alleviate Intestinal Inflammation in Weaned Piglets

Zhending Gan et al.

MOLECULES (2019)

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Review Cell Biology

Recent advances in the mechanisms of NLRP3 inflammasome activation and its inhibitors

Yang Yang et al.

CELL DEATH & DISEASE (2019)

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Review Biochemistry & Molecular Biology

Curcumin and Heme Oxygenase: Neuroprotection and Beyond

Emanuela Mhillaj et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Review Neurosciences

Antioxidant effects of curcumin in models of neurodegeneration, aging, oxidative and nitrosative stress: A review

Shameemah Abrahams et al.

NEUROSCIENCE (2019)

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Article Pharmacology & Pharmacy

NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia

Rebecca Ward et al.

PHARMACOLOGICAL RESEARCH (2019)

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Review Neurosciences

Dual Functions of Microglia in Ischemic Stroke

Chuan Qin et al.

NEUROSCIENCE BULLETIN (2019)

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Review Biochemistry & Molecular Biology

Benefits of curcumin in brain disorders

Abid Bhat et al.

BIOFACTORS (2019)

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Article Immunology

Ciprofloxacin and levofloxacin attenuate microglia inflammatory response via TLR4/NF-kB pathway

Morena Zusso et al.

JOURNAL OF NEUROINFLAMMATION (2019)

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Article Clinical Neurology

Persistence of Gut Microbiota Dysbiosis and Chronic Systemic Inflammation After Cerebral Infarction in Cynomolgus Monkeys

Yonghong Chen et al.

FRONTIERS IN NEUROLOGY (2019)

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Article Neurosciences

Mild hypothermia alleviates diabetes aggravated cerebral ischemic injury via activating autophagy and inhibiting pyroptosis

Yanling Tu et al.

BRAIN RESEARCH BULLETIN (2019)

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Article Clinical Neurology

Curcumin Prevents Brain Damage and Cognitive Dysfunction During Ischemic-reperfusion Through the Regulation of miR-7-5p

Hui Xu et al.

CURRENT NEUROVASCULAR RESEARCH (2019)

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Article Pharmacology & Pharmacy

Transplantation of fecal microbiota rich in short chain fatty acids and butyric acid treat cerebral ischemic stroke by regulating gut microbiota

Runzhi Chen et al.

PHARMACOLOGICAL RESEARCH (2019)

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Review Nutrition & Dietetics

Curcumin, Gut Microbiota, and Neuroprotection

Francesco Di Meo et al.

NUTRIENTS (2019)

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Article Neurosciences

Curcumin Mitigates Neuro-Inflammation by Modulating Microglia Polarization Through Inhibiting TLR4 Axis Signaling Pathway Following Experimental Subarachnoid Hemorrhage

YongYue Gao et al.

FRONTIERS IN NEUROSCIENCE (2019)

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Review Immunology

Pharmacological Inhibitors of the NLRP3 Inflammasome

Ayesha Zahid et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Biochemistry & Molecular Biology

The regulatory role of Toll-like receptors after ischemic stroke: neurosteroids as TLR modulators with the focus on TLR2/4

Saeedeh Tajalli-Nezhad et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2019)

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Article Biochemistry & Molecular Biology

Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells

Jiawei Zhang et al.

MOLECULAR IMMUNOLOGY (2019)

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Article Neurosciences

Meisoindigo Protects Against Focal Cerebral Ischemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Regulating Microglia/Macrophage Polarization via TLR4/NF-κB Signaling Pathway

Yingze Ye et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

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Article Geriatrics & Gerontology

Transplantation of Lymphocytes Co-Cultured with Human Cord Blood-Derived Multipotent Stem Cells Attenuates Inflammasome Activity in Ischemic Stroke

Yanxin Zhao et al.

CLINICAL INTERVENTIONS IN AGING (2019)

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Article Rheumatology

Curcumin attenuates MSU crystal-induced inflammation by inhibiting the degradation of IκBα and blocking mitochondrial damage

Baofeng Chen et al.

ARTHRITIS RESEARCH & THERAPY (2019)

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Article Geriatrics & Gerontology

Necrostatin-1 Prevents Necroptosis in Brains after Ischemic Stroke via Inhibition of RIPK1-Mediated RIPK3/MLKL Signaling

Xu-Xu Deng et al.

AGING AND DISEASE (2019)

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Article Cell Biology

Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation

Yufang Wang et al.

JOURNAL OF MOLECULAR CELL BIOLOGY (2019)

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Article Biochemistry & Molecular Biology

Neuroprotective Effect of Curcumin Against Cerebral Ischemia-Reperfusion Via Mediating Autophagy and Inflammation

Lifa Huang et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2018)

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Article Cardiac & Cardiovascular Systems

Curcumin prevents strokes in stroke-prone spontaneously hypertensive rats by improving vascular endothelial function

Cong Lan et al.

BMC CARDIOVASCULAR DISORDERS (2018)

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Article Immunology

Curcumin Suppresses IL-1β Secretion and Prevents Inflammation through Inhibition of the NLRP3 Inflammasome

Haipeng Yin et al.

JOURNAL OF IMMUNOLOGY (2018)

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Article Neurosciences

Transplantation of Human Umbilical Cord Blood Mononuclear Cells Attenuated Ischemic Injury in MCAO Rats via Inhibition of NF-κB and NLRP3 Inflammasome

Lu Liu et al.

NEUROSCIENCE (2018)

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Article Neurosciences

Ketogenic Diet Improves Brain Ischemic Tolerance and Inhibits NLRP3 Inflammasome Activation by Preventing Drp1-Mediated Mitochondrial Fission and Endoplasmic Reticulum Stress

Min Guo et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

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Review Biochemistry & Molecular Biology

Diverse roles of mitochondria in ischemic stroke

Jenq-Lin Yang et al.

REDOX BIOLOGY (2018)

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Article Immunology

Targeting Peroxiredoxin 1 by a Curcumin Analogue, AI-44, Inhibits NLRP3 Inflammasome Activation and Attenuates Lipopolysaccharide-Induced Sepsis in Mice

Wen Liu et al.

JOURNAL OF IMMUNOLOGY (2018)

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Article Immunology

Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury

Zhe Gong et al.

JOURNAL OF NEUROINFLAMMATION (2018)

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Article Clinical Neurology

Curcumin Reduces Neuronal Loss and Inhibits the NLRP3 Inflammasome Activation in an Epileptic Rat Model

Qianchao He et al.

CURRENT NEUROVASCULAR RESEARCH (2018)

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Article Immunology

Resveratrol alleviates cerebral ischemia/reperfusion injury in rats by inhibiting NLRP3 inflammasome activation through Sirt1-dependent autophagy induction

Qi He et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2017)

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Review Neurosciences

The Gut Microbiota and Alzheimer's Disease

Chunmei Jiang et al.

JOURNAL OF ALZHEIMERS DISEASE (2017)

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Article Geriatrics & Gerontology

Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization

Zongjian Liu et al.

FRONTIERS IN AGING NEUROSCIENCE (2017)

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Article Biochemistry & Molecular Biology

Arctigenin attenuates ischemic stroke via SIRT1-dependent inhibition of NLRP3 inflammasome

Shimeng Zhang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

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Article Immunology

The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling

Jing Qiu et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2016)

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Article Allergy

Regulation of inflammasomes by autophagy

Tatsuya Saitoh et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

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Review Cell Biology

ROS-Mediated NLRP3 Inflammasome Activation in Brain, Heart, Kidney, and Testis Ischemia/Reperfusion Injury

Letteria Minutoli et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2016)

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Review Medicine, General & Internal

NOD-Like Receptors in Infection, Immunity, and Diseases

Young Keun Kim et al.

YONSEI MEDICAL JOURNAL (2016)

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Review Biochemistry & Molecular Biology

Recent developments in curcumin and curcumin based polymeric materials for biomedical applications: A review

Kashif Mahmood et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2015)

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Article Cell Biology

Curcumin improves synaptic plasticity impairment induced by HIV-1gp120 V3 loop

Ling-ling Shen et al.

NEURAL REGENERATION RESEARCH (2015)

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Article Pharmacology & Pharmacy

Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK

Ying Li et al.

TOXICOLOGY AND APPLIED PHARMACOLOGY (2015)

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Article Cardiac & Cardiovascular Systems

Dysbiosis of Gut Microbiota With Reduced Trimethylamine-N-Oxide Level in Patients With Large-Artery Atherosclerotic Stroke or Transient Ischemic Attack

Jia Yin et al.

JOURNAL OF THE AMERICAN HEART ASSOCIATION (2015)

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Article Immunology

CX3CR1 deficiency suppresses activation and neurotoxicity of microglia/macrophage in experimental ischemic stroke

Zhiwei Tang et al.

JOURNAL OF NEUROINFLAMMATION (2014)

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Article Biochemistry & Molecular Biology

Curcumin Ameliorates the Permeability of the Blood-Brain Barrier During Hypoxia by Upregulating Heme Oxygenase-1 Expression in Brain Microvascular Endothelial Cells

Yan-feng Wang et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2013)

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Article Biochemistry & Molecular Biology

The Parkinson's disease-associated gene PINK1 protects neurons from ischemic damage by decreasing mitochondrial translocation of the fission promoter Drp1

Yanxin Zhao et al.

JOURNAL OF NEUROCHEMISTRY (2013)

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Article Multidisciplinary Sciences

Neuroprotection by Curcumin in Ischemic Brain Injury Involves the Akt/Nrf2 Pathway

Jingxian Wu et al.

PLOS ONE (2013)

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Article Toxicology

Curcumin protects organotypic hippocampal slice cultures from Aβ1-42-induced synaptic toxicity

Juliana Bender Hoppe et al.

TOXICOLOGY IN VITRO (2013)

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Article Agriculture, Multidisciplinary

PLGA Nanoparticles Improve the Oral Bioavailability of Curcumin in Rats: Characterizations and Mechanisms

Xiaoxia Xie et al.

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY (2011)

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Article Immunology

Systemic inflammatory challenges compromise survival after experimental stroke via augmenting brain inflammation, blood- brain barrier damage and brain oedema independently of infarct size

Adam Denes et al.

JOURNAL OF NEUROINFLAMMATION (2011)

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Article Biochemical Research Methods

Quantitative Neuroproteomics of an In Vivo Rodent Model of Focal Cerebral Ischemia/Reperfusion Injury Reveals a Temporal Regulation of Novel Pathophysiological Molecular Markers

Arnab Datta et al.

JOURNAL OF PROTEOME RESEARCH (2011)

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Review Biochemistry & Molecular Biology

Inhibitors of Microglial Neurotoxicity: Focus on Natural Products

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MOLECULES (2011)

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