m7G-related genes predict prognosis and affect the immune microenvironment and drug sensitivity in osteosarcoma

Editorial Material Cell Biology

N7-methylguanosine (m7G) tRNA modification: a novel autophagy modulator in cancer

Hui Han et al.

Summary: METTL1 and WDR4 act as negative regulators of autophagy in esophageal squamous cell carcinoma (ESCC) by modulating the MTORC1-mediated autophagy signaling pathway, leading to cell death and poor prognosis in ESCC.

AUTOPHAGY (2023)

Add to Collection

Article Gastroenterology & Hepatology

Eliminating METTL1-mediated accumulation of PMN-MDSCs prevents hepatocellular carcinoma recurrence after radiofrequency ablation

Xuezhen Zeng et al.

Summary: METTL1 plays a role in shaping the immunosuppressive tumor microenvironment after insufficient RFA, influencing tumor recurrence and treatment efficacy.

HEPATOLOGY (2023)

Add to Collection

Article Biochemistry & Molecular Biology

eIF4A1-dependent mRNAs employ purine-rich 5'UTR sequences to activate localised eIF4A1-unwinding through eIF4A1-multimerisation to facilitate translation

Tobias Schmidt et al.

Summary: This study shows that single-stranded RNA sequence motifs can activate eIF4A1, leading to structural rearrangement and translation of highly structured oncogene mRNAs. These eIF4A1-dependent mRNAs contain AG-rich motifs within their 5'UTR, which specifically activate eIF4A1 unwinding and make them sensitive to eIF4A1-inhibition.

NUCLEIC ACIDS RESEARCH (2023)

Add to Collection

Article Oncology

Aberrant translation regulated by METTL1/WDR4-mediated tRNA N7-methylguanosine modification drives head and neck squamous cell carcinoma progression

Jie Chen et al.

Summary: The study revealed that tRNA m(7)G methyltransferase METTL1 promotes the development and malignancy of head and neck squamous cell carcinoma (HNSCC) by regulating global mRNA translation, including the PI3K/AKT/mTOR signaling pathway, and alters the immune landscape.

CANCER COMMUNICATIONS (2022)

Add to Collection

Review Oncology

The potential role of N-7-methylguanosine (m7G) in cancer

Yuejun Luo et al.

Summary: N-7-methylguanosine (m7G) is a prevalent RNA modification that actively participates in biological and pathological functions. It plays a critical role in cancer development and is closely associated with tumorigenesis and progression. The underlying molecular mechanisms of m7G in cancer are not fully understood.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Epigenetic regulation of EIF4A1 through DNA methylation and an oncogenic role of eIF4A1 through BRD2 signaling in prostate cancer

Chao Wang et al.

Summary: In prostate cancer, high expression of eIF4A1 is regulated by DNA methylation and it plays an oncogenic role through the BRD2 signaling pathway.

ONCOGENE (2022)

Add to Collection

Article Multidisciplinary Sciences

N7-methylguanosine tRNA modification promotes esophageal squamous cell carcinoma tumorigenesis via the RPTOR/ULK1/autophagy axis

Hui Han et al.

Summary: This study reveals the oncogenic function of mis-regulated tRNA modification in esophageal squamous cell carcinoma (ESCC) and suggests that targeting METTL1 and its downstream signaling could be a promising therapeutic strategy for ESCC treatment.

NATURE COMMUNICATIONS (2022)

Add to Collection

Article Immunology

Identification and Verification of m7G Modification Patterns and Characterization of Tumor Microenvironment Infiltration via Multi-Omics Analysis in Clear Cell Renal Cell Carcinoma

Kai Dong et al.

Summary: The study demonstrated the importance of N7-methylguanosine (m(7)G) modification in clear cell renal cell carcinoma (ccRCC). Three distinct m(7)G modification patterns were identified and characterized, and a scoring tool called m7Sig was developed to predict patient prognosis. Understanding m(7)G modification landscape can help improve the characterization and clinical decision making in ccRCC.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Immunology

A Comprehensive Analysis of METTL1 to Immunity and Stemness in Pan-Cancer

Zijie Gao et al.

Summary: This study reveals the correlation of METTL1 with tumor immune infiltration and stemness in pan-cancer, highlighting the significance of METTL1 in cancer progression and guiding more effective and generalized therapy strategies.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Biotechnology & Applied Microbiology

m7G Methylation-Related Genes as Biomarkers for Predicting Overall Survival Outcomes for Hepatocellular Carcinoma

Xin-Yu Li et al.

Summary: The study aimed to search for prognostic biomarkers for hepatocellular carcinoma (HCC) and construct a prognostic risk model based on N7-methyladenosine (m7G) methylation regulators. The results showed that the developed model had good predictive power, and a high-risk score was found to be an independent risk factor for the prognosis of HCC patients.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2022)

Add to Collection

Article Oncology

A bioinformatic analysis study of m7G regulator-mediated methylation modification patterns and tumor microenvironment infiltration in glioblastoma

Xinrui Wu et al.

Summary: This study establishes a prognostic signature for glioblastoma patients based on m7G-related genes and demonstrates its association with immune-related processes.

BMC CANCER (2022)

Add to Collection

Review Immunology

Modulation of immunosuppressive cells and noncoding RNAs as immunotherapy in osteosarcoma

Yidan Xia et al.

Summary: Osteosarcoma is the most common bone cancer affecting children and teenagers. Immune escape in the tumor microenvironment is a major cause of poor prognosis in osteosarcoma and a primary target of immunotherapy, with immunosuppressive cells playing a key role in regulating tumor progression and immune suppression.

FRONTIERS IN IMMUNOLOGY (2022)

Add to Collection

Article Medicine, General & Internal

Comprehensive multi-omits analysis of the m7G in pan-cancer from the perspective of predictive, preventive, and personalized medicine

Xiaoliang Huang et al.

Summary: This study comprehensively explored m7G in pan-cancer for the first time, identifying it as an innovative marker for predicting clinical outcomes and immunotherapeutic efficacy, with potential for deeper integration with PPPM.

EPMA JOURNAL (2022)

Add to Collection

Editorial Material Cell Biology

Role of N7-methylguanosine (m7G) in cancer

Yongping Chen et al.

Summary: This article summarizes the importance of m(7)G in cancer suppression and explores potential valuable targets for improving cancer therapy and prognoses based on research on this modification.

TRENDS IN CELL BIOLOGY (2022)

Add to Collection

Article Genetics & Heredity

N7-Methylguanosine Genes Related Prognostic Biomarker in Hepatocellular Carcinoma

Parbatraj Regmi et al.

Summary: This study identified several genes related to N7-methylguanosine that can serve as prognostic biomarkers for hepatocellular carcinoma (HCC). These genes are also associated with immune infiltration and chemotherapy response in HCC. The findings provide new insights and guidance for the treatment of HCC.

FRONTIERS IN GENETICS (2022)

Add to Collection

Article Genetics & Heredity

Molecular characterization, clinical relevance and immune feature of m7G regulator genes across 33 cancer types

Zhanzhan Li et al.

Summary: This study uncovered the profile of m7G RNA modification across different cancers and identified the connection between m7G modification levels and therapeutic outcomes, providing potential better options for cancer treatment.

FRONTIERS IN GENETICS (2022)

Add to Collection

Article Genetics & Heredity

Combining bulk RNA-sequencing and single-cell RNA-sequencing data to reveal the immune microenvironment and metabolic pattern of osteosarcoma

Ruichao Huang et al.

Summary: This study used RNA-seq to reveal two molecular subtypes of osteosarcoma (OS) with prognosis, metabolic pattern, and tumor microenvironment (TME). The composition and metabolic heterogeneity of immune cells in OS tumors were also determined using bulk RNA-seq and single-cell RNA-seq analysis.

FRONTIERS IN GENETICS (2022)

Add to Collection

Article Medicine, Research & Experimental

Single-cell transcriptomics reveals the regulative roles of cancer associated fibroblasts in tumor immune microenvironment of recurrent osteosarcoma

Xin Huang et al.

Summary: This study investigated the tumor microenvironment (TME) and gene expression pattern of primary and recurrent osteosarcoma (OS) at the single-cell level. Cancer-associated fibroblasts (CAFs) were found to have a higher infiltrating level in recurrent OS, and enrichment in the epithelial-mesenchymal transition (EMT) pathway. CAFs showed increased expression of LOX, which might lead to EMT and poor prognosis of OS. LOX was found to regulate the function of CAFs and macrophage polarization to remodel the tumor immune microenvironment. Targeting LOX of CAFs showed promising efficacy in remodeling TME and treating recurrent OS.

THERANOSTICS (2022)

Add to Collection

Review Pharmacology & Pharmacy

Bone sarcomas in the immunotherapy era

Marie-Francoise Heymann et al.

Summary: Bone sarcomas primarily occur in children and adolescents, with recent developments focusing on understanding the immune system's role in the oncologic process. Immunotherapies have not shown significant improvements, highlighting the need to improve tumor micro-environment characterization to enhance immune therapeutic responses.

BRITISH JOURNAL OF PHARMACOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Combined bezafibrate, medroxyprogesterone acetate and valproic acid treatment inhibits osteosarcoma cell growth without adversely affecting normal mesenchymal stem cells

Jonathan J. Sheard et al.

Summary: The drug combination V-BAP effectively inhibits the growth and survival of human osteosarcoma cells while minimally affecting normal cells. Additionally, it hinders cell migration and modulates lipid metabolism in osteosarcoma cells. V-BAP may serve as a promising therapeutic strategy for osteosarcoma.

BIOSCIENCE REPORTS (2021)

Add to Collection

Article Oncology

Prognostic role of METTL1 in glioma

Lun Li et al.

Summary: This study revealed that high expression of METTL1 in glioma is significantly associated with poor prognosis and may serve as an independent risk factor. Additionally, elevated METTL1 expression promotes glioma cell proliferation and is potentially involved in regulating the MAPK signaling pathway. These findings suggest that METTL1 could be a valuable biomarker for glioma and merit further exploration for clinical utility.

CANCER CELL INTERNATIONAL (2021)

Add to Collection

Review Pharmacology & Pharmacy

Safety and Efficacy of Bromodomain and Extra-Terminal Inhibitors for the Treatment of Hematological Malignancies and Solid Tumors: A Systematic Study of Clinical Trials

Yanli Sun et al.

Summary: The upregulated expression of BET proteins is closely related to hematological malignancies and solid tumors. Ten BET inhibitors currently in clinical trials showed exposure-dependent thrombocytopenia, and further efforts are needed to explore optimal dosing schemes for maximizing their efficacy.META_DESCRIPTION

FRONTIERS IN PHARMACOLOGY (2021)

Add to Collection

Review Medicine, General & Internal

New Horizons in the Treatment of Osteosarcoma

Paul S. Meltzer et al.

Summary: Osteosarcoma is a common malignant tumor that primarily affects individuals aged 10 to 30, and is usually treated with surgery and chemotherapy. While whole-genome sequencing can detect genetic alterations, it has not yet resulted in improved treatment outcomes.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Add to Collection

Article Oncology

Noncoding RNAs in osteosarcoma: Implications for drug resistance

Zhengjun Lin et al.

Summary: Osteosarcoma is the most frequent bone malignancy in children and adolescents, with the development of multi-drug resistance posing a major obstacle in improving chemotherapy efficacy. Research has shown that noncoding RNAs play significant roles in osteosarcoma progression and chemosensitivity, highlighting their potential as biomarkers and therapeutic targets for improving patient prognosis.

CANCER LETTERS (2021)

Add to Collection

Article Oncology

METTL1 promotes hepatocarcinogenesis via m7G tRNA modification-dependent translation control

Zhihang Chen et al.

Summary: The N-7-methylguanosine (m(7)G) modification is a common transfer RNA (tRNA) modification in humans. Elevated levels of METTL1 and WDR4 in hepatocellular carcinoma (HCC) are associated with advanced tumor stages and poor patient survival. Mechanistically, METTL1-mediated tRNA m(7)G modification promotes the translation of target mRNAs with higher frequencies of m(7)G-related codons, providing new insights into the role of misregulated tRNA modifications in liver cancer.

CLINICAL AND TRANSLATIONAL MEDICINE (2021)

Add to Collection

Article Oncology

Dual mTORC1/2 inhibitor AZD2014 diminishes myeloid-derived suppressor cells accumulation in ovarian cancer and delays tumor growth

Ruyu Pi et al.

Summary: High mTORC2 expression level in EOC is associated with poor prognosis, while AZD2014 inhibits tumor growth, reduces peritoneal ascites, and prolongs survival in tumor-bearing mice. In addition, AZD2014 also reduces MDSC accumulation and delays tumor recurrence in EOC models.

CANCER LETTERS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression

Zihao Dai et al.

Summary: Intrahepatic cholangiocarcinoma (ICC) shows upregulation of N-7-methylguanosine (m(7)G) tRNA modification and its methyltransferase complex components, METTL1 and WDR4, which are associated with poor prognosis. METTL/WDR4 play a critical role in promoting ICC cell survival and progression by selectively regulating the translation of oncogenic transcripts through m(7)G-tRNA-decoded codon-frequency-dependent mechanisms. Studies with overexpression and knockout mouse models demonstrate the crucial oncogenic function of Mettl1-mediated m(7)G tRNA modification in promoting ICC tumorigenesis and progression in vivo.

MOLECULAR CELL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation

Esteban A. Orellana et al.

Summary: The study revealed that METTL1 is frequently overexpressed in cancer, affecting tRNA modification and the cell cycle, promoting oncogenesis. Additionally, it was found that overexpression of a specific tRNA can induce oncogenic transformation.

MOLECULAR CELL (2021)

Add to Collection

Review Oncology

Advancing therapy for osteosarcoma

Jonathan Gill et al.

Summary: Osteosarcoma, the most common primary bone cancer in children and young adults, presents challenges in treatment due to its rarity and molecular heterogeneity. Collaborative efforts in biological discoveries, technologies, and therapeutic approaches are expected to advance osteosarcoma treatment and improve patient outcomes. The increasing feasibility of molecular profiling, along with the creation of robust model systems and large tissue banks, has enhanced understanding of osteosarcoma biology.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology