4.6 Review

Neuroprotection in metabolic syndrome by environmental enrichment. A lifespan perspective

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Predicting childhood and adolescent attention-deficit/hyperactivity disorder onset: a nationwide deep learning approach

Miguel Garcia-Argibay et al.

Summary: This study examined the use of different machine learning techniques to assess the feasibility of using registry data for diagnosing ADHD in children and adolescents in Sweden. The findings showed that a DNN model achieved good predictive ability for ADHD and identified several important features for classification. If validated and proven to be cost-effective in external samples, this model could potentially serve as a useful tool in clinical practice to aid in ADHD screening and decision-making.

MOLECULAR PSYCHIATRY (2023)

Article Pediatrics

Endothelial dysfunction as a factor leading to arterial hypertension

Dorota Drozdz et al.

Summary: Hypertension is the main cause of cardiovascular complications and increased mortality. Endothelial dysfunction plays an important role in the development of arterial hypertension. Oxidative stress and inflammation damage the endothelium, shifting its function from vasoprotective to vasoconstrictive, prothrombotic, and pro-apoptotic. Reduced nitric oxide bioavailability is essential in the pathophysiology of ED-associated hypertension.

PEDIATRIC NEPHROLOGY (2023)

Article Cell Biology

An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation

Sol Diaz de Leon-Guerrero et al.

Summary: Obesity can cause chronic inflammation and disruptions in glucose and lipid metabolism, leading to degenerative diseases. Research shows that an enriched environment (EE), which enhances central nervous system activity, can improve metabolic abnormalities by reducing hepatic steatosis and inflammation, and promoting lipolysis and browning.

DISEASE MODELS & MECHANISMS (2022)

Review Neurosciences

The environmental enrichment model revisited: A translatable paradigm to study the stress of our modern lifestyle

Mijail Rojas-Carvajal et al.

Summary: The evidence suggests that environmental enrichment has positive effects on neurobehavior, while social isolation can lead to deficits that could be improved by exposure to environments resembling wild habitats. The stress of urban life can be alleviated by activities in green environments.

EUROPEAN JOURNAL OF NEUROSCIENCE (2022)

Review Pediatrics

Physical Exercise and Brain-Derived Neurotrophic Factor Concentration in Children and Adolescents: A Systematic Review With Meta-Analysis

Francisco Jose De Menezes-Junior et al.

Summary: This systematic review examined the relationship between physical activity, physical training, and brain-derived neurotrophic factor (BDNF) concentrations in children and adolescents. The findings suggest that adolescent athletes tend to have lower serum BDNF concentrations, but higher plasma BDNF concentrations compared to sedentary individuals. Physical training also appears to marginally increase serum BDNF concentrations in sedentary adolescents.

PEDIATRIC EXERCISE SCIENCE (2022)

Article Medicine, General & Internal

The Role of Brain-Derived Neurotrophic Factor in Obstructive Sleep Apnea and Endothelial Function in a Pediatric Population With Obesity

Sanae Makhout et al.

Summary: The study found that BDNF levels were comparable in children with obesity, both with and without OSA, and showed an interaction effect of OSA and endothelial function on BDNF levels. However, after one year of weight loss therapy, there was no change in BDNF levels.

FRONTIERS IN MEDICINE (2022)

Review Public, Environmental & Occupational Health

Barker Hypothesis and Hypertension

Felix Jebasingh et al.

Summary: Early onset hypertension is a major medical disorder that has emerged in both developing and developed countries in the current millennium. Low birth weight has been associated with hypertension, possibly due to foetal onset adult disease and the impact of low nephron mass.

FRONTIERS IN PUBLIC HEALTH (2022)

Review Biochemistry & Molecular Biology

Obesity and the Brain

Jacek Karczewski et al.

Summary: Innate and adaptive immunity play vital roles in neurodevelopment and CNS homeostasis. Overactivation of the immune system increases brain vulnerability and the risk of neuropsychiatric disorders. Obesity and gut dysbiosis are important factors affecting microglial function in later life.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Psychiatry

The role of ADHD genetic risk in mid-to-late life somatic health conditions

Miguel Garcia-Argibay et al.

Summary: Growing evidence suggests that ADHD is associated with poor somatic health in adulthood, but the mechanisms underlying these associations are poorly understood. This study found that ADHD polygenic risk scores (PRS) are associated with multiple somatic health problems in mid-to-late life, particularly in the cardiometabolic domain. These associations were observed in the general population and appear to be partially mediated by life-course risk factors.

TRANSLATIONAL PSYCHIATRY (2022)

Article Pediatrics

The Role of Brain-Derived Neurotrophic Factor (BDNF) in the Relation between Physical Activity and Executive Functioning in Children

Julie Latomme et al.

Summary: This study investigated the effects of acute and chronic physical activity on brain-derived neurotrophic factor (BDNF) levels and executive functioning (EF) in children. The results indicated that acute physical activity might increase BDNF levels and improve some aspects of EF, while chronic physical activity was not associated with EF or BDNF.

CHILDREN-BASEL (2022)

Review Endocrinology & Metabolism

Impact of glucose metabolism on the developing brain

Marta Cacciatore et al.

Summary: Glucose is crucial for proper brain functioning and its alterations can lead to developmental issues. Changes in glucose homeostasis can affect brain structure and cognition, such as intelligence deficits and learning abnormalities. Glycemic control is important in preventing diabetic ketoacidosis and protecting brain development in children. Neuroimaging techniques provide insights into the mechanisms underlying brain changes due to dysglycemia.

FRONTIERS IN ENDOCRINOLOGY (2022)

Review Biochemistry & Molecular Biology

Genetics of Cholesterol-Related Genes in Metabolic Syndrome: A Review of Current Evidence

Sok Kuan Wong et al.

Summary: Metabolic syndrome is a cluster of metabolic dysregulations, including insulin resistance, obesity, hypertension, and dyslipidemia. This review summarizes the genetic information of cholesterol-related genes in metabolic syndrome, which may potentially serve as biomarkers for early prevention and management of the syndrome.

BIOMEDICINES (2022)

Review Neurosciences

The role of enriched environment in neural development and repair

Yu Han et al.

Summary: In addition to genetic information, environmental factors play a crucial role in the structure and function of the nervous system and the development of nervous system diseases. Enriched environment promotes neural development and repair, enhances learning and memory capacity, but its effects may vary across different developmental stages.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

Review Nutrition & Dietetics

The Current Findings on the Impact of Prenatal BPA Exposure on Metabolic Parameters: In Vivo and Epidemiological Evidence

Hala F. S. Abulehia et al.

Summary: Prenatal exposure to low doses of bisphenol A (BPA) may increase the risk of obesity and type 2 diabetes mellitus (T2DM).

NUTRIENTS (2022)

Article Biochemistry & Molecular Biology

Does Childhood Obesity Trigger Neuroinflammation?

Valeria Domenica Zingale et al.

Summary: Childhood obesity is a major health issue worldwide. Our study suggests that obesity may trigger inflammation and neuroinflammation from an early age, accompanied by alterations in lipid metabolism and inflammatory response.

BIOMEDICINES (2022)

Article Pediatrics

Intake of Fruits, Vegetables, and Sugar-Sweetened Beverages among a Sample of Children in Rural Northern Ontario, Canada

Brenton L. G. Button et al.

Summary: There is evidence suggesting that the dietary intake of children in rural areas differs from those in urban areas, with rural children having a higher intake of fat and sugar-rich foods. This study aimed to investigate the intake of fruits and vegetables and the frequency of consuming sugar-sweetened beverages among rural children in Northern Ontario, Canada, during different seasons. The study found that the intake of fruits and vegetables was lower than recommended, and the consumption of sugar-sweetened beverages was high among rural children in this region. Moreover, the study also revealed that the intake of fruits and vegetables varied between seasons and among different ethnic groups.

CHILDREN-BASEL (2022)

Article Neurosciences

The Molecular Effects of Environmental Enrichment on Alzheimer's Disease

Anthony Kin Yip Liew et al.

Summary: This article summarizes the evidence for environmental enrichment (EE) as a neuroprotective strategy and discusses the potential molecular pathways that explain its effects from a biochemical perspective. It also explores the differences in early and late life EE exposure and its potential application in humans.

MOLECULAR NEUROBIOLOGY (2022)

Article Psychology, Biological

Voluntary physical activity improves spatial and recognition memory deficits induced by post-weaning chronic exposure to a high-fat diet

Susana Hernandez-Ramirez et al.

Summary: Childhood and adolescent exposure to obesogenic environments has been linked to various health disorders, including neurocognitive impairment. This study demonstrates that voluntary physical exercise can have a restorative effect on metabolic and cognitive dysfunctions associated with long-term exposure to a high-fat diet.

PHYSIOLOGY & BEHAVIOR (2022)

Article Medicine, General & Internal

Effects of an Exercise Program on Brain Health Outcomes for Children With Overweight or Obesity The ActiveBrains Randomized Clinical Trial

Francisco B. Ortega et al.

Summary: This study investigates the effects of an exercise program on brain health indicators among children with overweight or obesity. The results show that exercise positively affects intelligence and cognitive flexibility in these children, although the specific brain changes responsible for these improvements are not identified.

JAMA NETWORK OPEN (2022)

Review Geriatrics & Gerontology

A Conceptual View of Cognitive Intervention in Older Adults With and Without Cognitive Decline-A Systemic Review

Liliana Mendes et al.

Summary: This study aims to clarify the heterogeneity in the field of cognitive intervention for older adults and determine the main variables involved. By conducting a study analysis using previous literature, it was found that there are variations and overlapping information in methods, concepts, and procedures.

FRONTIERS IN AGING (2022)

Review Pediatrics

Obesity, metabolic syndrome, and primary hypertension

Mieczyslaw Litwin et al.

Summary: Primary hypertension is the main form of arterial hypertension in adolescents, closely related to metabolic syndrome and visceral obesity. Metabolic syndrome is also observed in adolescents with primary hypertension. Obesity and metabolic abnormalities can increase the risk of hypertension and target organ damage.

PEDIATRIC NEPHROLOGY (2021)

Review Physiology

Astroglial asthenia and loss of function, rather than reactivity, contribute to the ageing of the brain

Alexei Verkhratsky et al.

Summary: Astroglia undergo morphological and functional changes with aging, leading to a decline in various functions in the central nervous system. Lifestyle interventions can influence and improve the morphology and function of astroglia, playing a crucial role in cognitive longevity.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2021)

Article Gastroenterology & Hepatology

Childhood Development and the Microbiome-The Intestinal Microbiota in Maintenance of Health and Development of Disease During Childhood Development

Victoria Ronan et al.

Summary: The composition of the intestinal microbiome affects childhood development, influencing the brain, immune system, lungs, and body growth. Dysbiosis has been associated with diseases such as autism, attention deficit hyperactivity disorder, asthma, and allergies in children and adults.

GASTROENTEROLOGY (2021)

Review Nutrition & Dietetics

Genetic variants related to physical activity or sedentary behaviour: a systematic review

Lene Aasdahl et al.

Summary: Genetic factors play a role in explaining the variation in physical activity and sedentary behavior. High-quality GWAS and consistent replication studies are crucial for establishing robust genetic instruments for physical activity and sedentary behavior. Systematic review highlights the need for more research in this area to improve credibility of genetic variants.

INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY (2021)

Article Endocrinology & Metabolism

Does Lifestyle Intervention Improve Health of Adults with Overweight/Obesity and Type 2 Diabetes: Findings from the Look AHEAD Randomized Trial

Rena R. Wing

Summary: This paper reviews the findings of the Look AHEAD Trial, which tested the effects of intensive lifestyle interventions on health outcomes in individuals with overweight/obesity and type 2 diabetes. The study showed positive impacts of ILI on various health parameters, but also found that some outcomes did not significantly differ between the intervention and control groups. Post hoc analyses suggested potential subgroup differences, indicating that ILI may benefit some individuals while potentially harming others.

OBESITY (2021)

Article Multidisciplinary Sciences

Metabolic syndrome and cognitive performance across the adult lifespan

Lori Haase Alasantro et al.

Summary: Metabolic Syndrome (MetS) is associated with cognitive impairment, especially in middle-aged individuals, and the impact may be further influenced by excess weight. Future research should explore potential causal relationships between metabolic and vascular risk factors, disinhibited eating, and executive dysfunction.

PLOS ONE (2021)

Review Cell Biology

Western diet as a trigger of Alzheimer's disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

Angelika Wieckowska-Gacek et al.

Summary: The studies suggest that an excess of saturated fatty acids and simple sugars in the diet is a known environmental risk factor of Alzheimer's disease. The systemic alterations induced by a Western diet, including metabolic changes, obesity, inflammation, may drive impairment of the blood-brain barrier and neuroinflammation, leading to neurodegeneration and cognitive impairment.

AGEING RESEARCH REVIEWS (2021)

Review Behavioral Sciences

Molecular and cellular pathways contributing to brain aging

Aliabbas Zia et al.

Summary: Aging is the primary risk factor for age-related diseases such as neurodegenerative disorders, understanding the mechanisms behind aging is crucial for brain health. Brain aging is characterized by a decline in neurophysiological functions, impaired neuroplasticity, dysregulation of neuronal Ca2+ homeostasis, and other factors. Various pathways contribute to brain aging, including oxidative stress, inflammation, energy metabolism disturbances, and the involvement of key modulators in metabolic control.

BEHAVIORAL AND BRAIN FUNCTIONS (2021)

Review Biology

Lifestyle-dependent microglial plasticity: training the brain guardians

Marcus Augusto-Oliveira et al.

Summary: Lifestyle plays a crucial role in shaping neuroplasticity and cognitive longevity by affecting microglial cells, brain homoeostasis, and neural networks through factors such as nourishment, education, physical activity, and sleep quality. This ultimately enhances neuroprotection and cognitive longevity.

BIOLOGY DIRECT (2021)

Review Endocrinology & Metabolism

The metabolic syndrome in pediatrics: do we have a reliable definition? A systematic review

Angelo Tropeano et al.

Summary: There is currently no universally accepted definition of metabolic syndrome in pediatric populations, with the IDF definition being the most straightforward and easiest to use in clinical practice. Further research is needed to validate new versions of diagnostic criteria for metabolic syndrome.

EUROPEAN JOURNAL OF ENDOCRINOLOGY (2021)

Article Geriatrics & Gerontology

Association between metabolic syndrome and resting-state functional brain connectivity

Barnaly Rashid et al.

Summary: This study investigated the impact of metabolic syndrome on the resting-state functional connectivity of large-scale cortical brain networks. It was found that individuals with MetS show hyperconnectivity across core brain regions, loss of modularity, and disrupted between-network connections in both hemispheres.

NEUROBIOLOGY OF AGING (2021)

Review Nutrition & Dietetics

Recent Developments in Rodent Models of High-Fructose Diet-Induced Metabolic Syndrome: A Systematic Review

Alvin Man Lung Chan et al.

Summary: Metabolic syndrome is a cluster of physiological features, with chronic illnesses including obesity, cardiovascular system, renal operation, hepatic function, oncology, and mortality; rodents have been ideal models for mammalian studies for centuries.

NUTRIENTS (2021)

Article Psychiatry

Gray Matter Volume in the Developing Frontal Lobe and Its Relationship With Executive Function in Late Childhood and Adolescence: A Community-Based Study

Dajung Sung et al.

Summary: The study found that in late childhood, the GMV of certain regions in the frontal lobe was negatively correlated with attention scores, while in adolescents, it was positively correlated. The correlations between Stroop test scores and GMV were not significant in both age groups. Sub-regions of the frontal lobe involved in attention networks may significantly improve during late childhood and become stable in adolescence.

FRONTIERS IN PSYCHIATRY (2021)

Review Medicine, General & Internal

Energy metabolism in childhood neurodevelopmental disorders

A. Oyarzabal et al.

Summary: This review discusses the physiological brain energetics at prenatal, neonatal, and childhood stages, as well as the main groups of inborn errors of energy metabolism affecting the brain. The lack of basic neuroscience research in this field hinders the opportunity for these disorders to provide paradigms of energy utilization during neurodevelopment, but understanding the mechanisms of brain energy disturbance precisely can pave the way for metabolic modulation therapies.

EBIOMEDICINE (2021)

Article Gastroenterology & Hepatology

Akkermansia muciniphila and environmental enrichment reverse cognitive impairment associated with high-fat high-cholesterol consumption in rats

Sara G. Higarza et al.

Summary: This study explores the impact of environmental enrichment and the administration of Lacticaseibacillus rhamnosus GG (LGG) or Akkermansia muciniphila CIP107961 (AKK) on cognitive dysfunction related to nonalcoholic steatohepatitis (NASH). It was found that AKK and EE were effective in reversing cognitive impairment induced by a high-fat, high-cholesterol diet, with differences in their effects on brain metabolism. Furthermore, AKK and LGG did not significantly alter the intestinal microbiota composition, while EE led to an increase in certain microbial members.

GUT MICROBES (2021)

Review Gastroenterology & Hepatology

Novel aspects of enteric serotonergic signaling in health and brain-gut disease

Andrew Del Colle et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2020)

Review Biochemistry & Molecular Biology

Brain-Derived Neurotrophic Factor and Diabetes

Olga Rozanska et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Evolutionary Biology

Links be: peen metabolic syndrome and the microbiome

Theresa E. Gildner

EVOLUTION MEDICINE AND PUBLIC HEALTH (2020)

Article Multidisciplinary Sciences

Alterations in Amygdala Connectivity in Internet Addiction Disorder

Hewei Cheng et al.

SCIENTIFIC REPORTS (2020)

Article Immunology

Physical exercise promotes astrocyte coverage of microvessels in a model of chronic cerebral hypoperfusion

Marina Leardini-Tristao et al.

JOURNAL OF NEUROINFLAMMATION (2020)

Article Psychology, Multidisciplinary

Environmental and Cognitive Enrichment in Childhood as Protective Factors in the Adult and Aging Brain

Bertrand Schoentgen et al.

FRONTIERS IN PSYCHOLOGY (2020)

Article Geriatrics & Gerontology

Lifespan leisure physical activity profile, brain plasticity and cognitive function in old age

Tobias Engeroff et al.

AGING & MENTAL HEALTH (2019)

Review Clinical Neurology

Early environmental influences on the development of children's brain structure and function

Patricia M. Miguel et al.

DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY (2019)

Review Neurosciences

Environmental enrichment, new neurons and the neurobiology of individuality

Gerd Kempermann

NATURE REVIEWS NEUROSCIENCE (2019)

Article Neurosciences

Neurogenesis and brain aging

Nickolay K. Isaev et al.

REVIEWS IN THE NEUROSCIENCES (2019)

Article Public, Environmental & Occupational Health

Methodology of an exercise intervention program using social incentives and gamification for obese children

Yue Fang et al.

BMC PUBLIC HEALTH (2019)

Review Nutrition & Dietetics

Gut Microbiome: Profound Implications for Diet and Disease

Ronald D. Hills et al.

NUTRIENTS (2019)

Review Developmental Biology

Smoking and pregnancy: Epigenetics and developmental origins of the metabolic syndrome

John M. Rogers

BIRTH DEFECTS RESEARCH (2019)

Review Endocrinology & Metabolism

Prevention of Obesity and Metabolic Syndrome in Children

John W. Gregory

FRONTIERS IN ENDOCRINOLOGY (2019)

Review Neurosciences

Aging, lifestyle and dementia

Devin Wahl et al.

NEUROBIOLOGY OF DISEASE (2019)

Review Nutrition & Dietetics

Sugar-Sweetened Beverages and Cardiometabolic Health: An Update of the Evidence

Vasanti S. Malik et al.

NUTRIENTS (2019)

Article Endocrinology & Metabolism

Metabolic Syndrome in Children and Adolescents: Diagnostic Criteria, Therapeutic Options and Perspectives

Paul Weihe et al.

CURRENT OBESITY REPORTS (2019)

Article Psychiatry

Metabolic syndrome and psychiatric disorders: a population-based study

Fernanda Pedrotti Moreira et al.

BRAZILIAN JOURNAL OF PSYCHIATRY (2019)

Article Biochemistry & Molecular Biology

Chronic inflammation in the etiology of disease across the life span

David Furman et al.

NATURE MEDICINE (2019)

Review Geriatrics & Gerontology

Metabolic Syndrome, Mild Cognitive Impairment, and Dementia: A Meta-Analysis of Longitudinal Studies

Anna Rita Atti et al.

AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY (2019)

Article Neurosciences

Neurotransmitter modulation by the gut microbiota

Philip Strandwitz

BRAIN RESEARCH (2018)

Review Physiology

Resistance exercise and episodic memory function: asystematic review

Paul D. Loprinzi et al.

CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING (2018)

Article Public, Environmental & Occupational Health

Physical activity and trajectories in cognitive function: English Longitudinal Study of Ageing

Mark Hamer et al.

JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH (2018)

Review Endocrinology & Metabolism

White matter microstructure and cognitive decline in metabolic syndrome: a review of diffusion tensor imaging

Freddy J. Alfaro et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2018)

Article Multidisciplinary Sciences

Early impoverished environment delays the maturation of cerebral cortex

Roberta Narducci et al.

SCIENTIFIC REPORTS (2018)

Review Neurosciences

Metabolic Syndrome and Neuroprotection

Melisa Etchegoyen et al.

FRONTIERS IN NEUROSCIENCE (2018)

Article Neuroimaging

Differential associations of metabolic risk factors on cortical thickness in metabolic syndrome

Nicolette F. Schwarz et al.

NEUROIMAGE-CLINICAL (2018)

Review Endocrinology & Metabolism

Poor Sleep and Obesity: Concurrent Epidemics in Adolescent Youth

Anisha Gohil et al.

FRONTIERS IN ENDOCRINOLOGY (2018)

Review Neurosciences

Metabolic Syndrome and Its Effect on the Brain: Possible Mechanism

Nurul Ain Arshad et al.

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS (2018)

Review Behavioral Sciences

Environmental Enrichment and Successful Aging

Michael Leon et al.

FRONTIERS IN BEHAVIORAL NEUROSCIENCE (2018)

Article Neurosciences

Midlife Physical Activity, Psychological Distress, and Dementia Risk: The HUNT Study

Ekaterina Zotcheva et al.

JOURNAL OF ALZHEIMERS DISEASE (2018)

Review Medicine, General & Internal

Does Obesity Increase the Risk of Dementia: A Literature Review

Ibrar Anjum et al.

CUREUS JOURNAL OF MEDICAL SCIENCE (2018)

Review Endocrinology & Metabolism

Non-alcoholic fatty liver disease and associated dietary and lifestyle risk factors

Hana'a Mahmoud Al-Dayyat et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2018)

Article Clinical Neurology

Tai Chi Improves Cognition and Plasma BDNF in Older Adults With Mild Cognitive Impairment: A Randomized Controlled Trial

Somporn Sungkarat et al.

NEUROREHABILITATION AND NEURAL REPAIR (2018)

Article Physiology

PHYSICAL ACTIVITY, CARDIORESPIRATORY FITNESS AND METABOLIC SYNDROME IN ADOLESCENTS

Raphael Goncalves de Oliveira et al.

REVISTA BRASILEIRA DE MEDICINA DO ESPORTE (2018)

Article Endocrinology & Metabolism

Hippocampal atrophy and altered brain responses to pleasant tastes among obese compared with healthy weight children

Z. L. Mestre et al.

INTERNATIONAL JOURNAL OF OBESITY (2017)

Review Medicine, Research & Experimental

Hypothalamic inflammation in obesity and metabolic disease

Alexander Jais et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Psychiatry

Increased incidence of psychiatric disorders in immune-mediated inflammatory disease

Ruth Ann Marrie et al.

JOURNAL OF PSYCHOSOMATIC RESEARCH (2017)

Review Neurosciences

Is Metabolic Syndrome Associated with the Risk of Recurrent Stroke: A Meta-Analysis of Cohort Studies

Xuelong Li et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2017)

Review Clinical Neurology

Neurological consequences of obesity

Phillipe D. O'Brien et al.

LANCET NEUROLOGY (2017)

Review Neurosciences

The Persistence and Transience of Memory

Blake A. Richards et al.

NEURON (2017)

Article Nutrition & Dietetics

Adverse effects of consuming high fat-sugar diets on cognition: implications for understanding obesity

Martin R. Yeomans

PROCEEDINGS OF THE NUTRITION SOCIETY (2017)

Review Psychology

Mental Health of Extremely Low Birth Weight Survivors: A Systematic Review and Meta-Analysis

Karen J. Mathewson et al.

PSYCHOLOGICAL BULLETIN (2017)

Review Neurosciences

Obesity-Induced Neuroinflammation: Beyond the Hypothalamus

Owein Guillemot-Legris et al.

TRENDS IN NEUROSCIENCES (2017)

Review Neurosciences

Is Metabolic Syndrome Associated with the Risk of Recurrent Stroke: A Meta-Analysis of Cohort Studies

Xuelong Li et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2017)

Review Neurosciences

Environmental Enrichment as a Positive Behavioral Intervention Across the Lifespan

P. Sampedro-Piquero et al.

CURRENT NEUROPHARMACOLOGY (2017)

Review Biochemistry & Molecular Biology

Introduction to the human gut microbiota

Elizabeth Thursby et al.

BIOCHEMICAL JOURNAL (2017)

Review Developmental Biology

Neural tube closure: cellular, molecular and biomechanical mechanisms

Evanthia Nikolopoulou et al.

DEVELOPMENT (2017)

Editorial Material Critical Care Medicine

Obstructive Sleep Apnea, Obesity, and Endothelial Dysfunction in Children

Sherri Lynne Katz et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)

Article Developmental Biology

Environmental enrichment attenuates the blood brain barrier dysfunction induced by the neonatal hypoxia-ischemia

Ramiro Diaz et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2016)

Article Medicine, Research & Experimental

Environmental enrichment reverses cognitive impairments provoked by Western diet in rats: Role of corticosteroid receptors

Hasan Serdar Gergerlioglu et al.

LIFE SCIENCES (2016)

Review Biochemistry & Molecular Biology

The role of Gut Microbiota in the development of obesity and Diabetes

Othman A. Baothman et al.

LIPIDS IN HEALTH AND DISEASE (2016)

Review Behavioral Sciences

Stress and the adolescent brain Amygdala-prefrontal cortex circuitry and ventral striatum as developmental targets

Nim Tottenham et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2016)

Article Behavioral Sciences

Mechanisms contributing to prefrontal cortex maturation during adolescence

Adriana Caballero et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2016)

Article Endocrinology & Metabolism

Sleep quality and obesity in young subjects: a meta-analysis

Y. Fatima et al.

OBESITY REVIEWS (2016)

Review Pediatrics

Neurocognitive and Behavioural Outcomes Following Intervention for Obstructive Sleep Apnoea Syndrome in Children

Sofia Konstantinopoulou et al.

PAEDIATRIC RESPIRATORY REVIEWS (2016)

Article Neuroimaging

Disrupted functional connectivity in adolescent obesity

Laura Moreno-Lopez et al.

NEUROIMAGE-CLINICAL (2016)

Review Endocrinology & Metabolism

Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood

Seung-Hwan Lee et al.

MOLECULAR METABOLISM (2016)

Review Endocrinology & Metabolism

Gut microbiome and metabolic syndrome

Mohsen Mazidi et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2016)

Review Cell Biology

Slowing the progression of Alzheimer's disease; what works?

Lucy Nelson et al.

AGEING RESEARCH REVIEWS (2015)

Article Medicine, General & Internal

Brain-derived neurotrophic factor and its clinical implications

Siresha Bathina et al.

ARCHIVES OF MEDICAL SCIENCE (2015)

Review Neuroimaging

Meta-analyses of structural regional cerebral effects in type 1 and type 2 diabetes

Calum D. Moulton et al.

BRAIN IMAGING AND BEHAVIOR (2015)

Article Psychology, Clinical

Cognitive Control in Preadolescent Children With Risk Factors for Metabolic Syndrome

Mark R. Scudder et al.

HEALTH PSYCHOLOGY (2015)

Review Clinical Neurology

Protective Effects of Physical Exercise in Alzheimer's Disease and Parkinson's Disease: A Narrative Review

Thierry Paillard et al.

JOURNAL OF CLINICAL NEUROLOGY (2015)

Review Endocrinology & Metabolism

Sex differences in metabolic homeostasis, diabetes, and obesity

Franck Mauvais-Jarvis

BIOLOGY OF SEX DIFFERENCES (2015)

Article Peripheral Vascular Disease

Essential Hypertension vs. Secondary Hypertension Among Children

Monesha Gupta-Malhotra et al.

AMERICAN JOURNAL OF HYPERTENSION (2015)

Review Neurosciences

Cognitive Reserve and Alzheimer's Disease

Wei Xu et al.

MOLECULAR NEUROBIOLOGY (2015)

Review Biochemistry & Molecular Biology

Insulin resistance as a key link for the increased risk of cognitive impairment in the metabolic syndrome

Bhumsoo Kim et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2015)

Article Psychology, Clinical

Executive Functioning and the Metabolic Syndrome: A Project FRONTIER Study

Jed Falkowski et al.

ARCHIVES OF CLINICAL NEUROPSYCHOLOGY (2014)

Article Cardiac & Cardiovascular Systems

Microvascular dysfunction in the course of metabolic syndrome induced by high-fat diet

Cristiane Aoqui et al.

CARDIOVASCULAR DIABETOLOGY (2014)

Article Endocrinology & Metabolism

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

Andre Kleinridders et al.

DIABETES (2014)

Article Neurosciences

Midlife and Late-Life Body Mass Index and Late-Life Dementia: Results from a Prospective Population-Based Cohort

Anna-Maija Tolppanen et al.

JOURNAL OF ALZHEIMERS DISEASE (2014)

Review Chemistry, Medicinal

The Gut Microbiome and the Brain

Leo Galland

JOURNAL OF MEDICINAL FOOD (2014)

Article Clinical Neurology

Enriched environment induces angiogenesis and improves neural function outcomes in rat stroke model

Kewei Yu et al.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2014)

Review Medicine, General & Internal

Ectopic Fat in Insulin Resistance, Dyslipidemia, and Cardiometabolic Disease

Gerald I. Shulman

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Review Neurosciences

Damaging effects of a high-fat diet to the brain and cognition: A review of proposed mechanisms

Linnea R. Freeman et al.

NUTRITIONAL NEUROSCIENCE (2014)

Article Geriatrics & Gerontology

Not only cardiovascular, but also coordinative exercise increases hippocarnpal volume in older adults

Claudia Niemann et al.

FRONTIERS IN AGING NEUROSCIENCE (2014)

Review Behavioral Sciences

The amygdala: An agent of change in adolescent neural networks

K. Suzanne Scherf et al.

HORMONES AND BEHAVIOR (2013)

Article Behavioral Sciences

Long-term social isolation in the adulthood results in CM shrinkage and cognitive impairment

Inmaculada Pereda-Perez et al.

NEUROBIOLOGY OF LEARNING AND MEMORY (2013)

Article Endocrinology & Metabolism

Brain-derived neurotrophic factor and its relation to leptin in obese children before and after weight loss

Christian L. Roth et al.

METABOLISM-CLINICAL AND EXPERIMENTAL (2013)

Review Behavioral Sciences

Effects of diabetes on hippocampal neurogenesis: Links to cognition and depression

Nancy Ho et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2013)

Review Obstetrics & Gynecology

Current Thoughts on Maternal Nutrition and Fetal Programming of the Metabolic Syndrome

Bonnie Brenseke et al.

JOURNAL OF PREGNANCY (2013)

Review Hematology

Impact of Metabolic Syndrome on Cognition and Brain A Selected Review of the Literature

Kathy F. Yates et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2012)

Review Medicine, General & Internal

Effects of lifestyle modification on metabolic syndrome: a systematic review and meta-analysis

Kazue Yamaoka et al.

BMC MEDICINE (2012)

Review Pharmacology & Pharmacy

Metabolic syndrome: a brain disease

Ram B. Singh et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2012)

Article Endocrinology & Metabolism

Resting-State Brain Functional Connectivity Is Altered in Type 2 Diabetes

Gail Musen et al.

DIABETES (2012)

Article Medicine, General & Internal

Association Between Urinary Bisphenol A Concentration and Obesity Prevalence in Children and Adolescents

Leonardo Trasande et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2012)

Review Clinical Neurology

Association between brain-derived neurotrophic factor Val66Met and obesity in children and adolescents

Marijana Skledar et al.

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY (2012)

Article Geriatrics & Gerontology

Histories of Social Engagement and Adult Cognition: Midlife in the U.S. Study

Teresa E. Seeman et al.

JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES (2011)

Article Multidisciplinary Sciences

Extraordinary neoteny of synaptic spines in the human prefrontal cortex

Zdravko Petanjek et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Biochemistry & Molecular Biology

Understanding the role of gut microbiome-host metabolic signal disruption in health and disease

Elaine Holmes et al.

TRENDS IN MICROBIOLOGY (2011)

Article Neurosciences

White Matter Development in Adolescence: A DTI Study

M. R. Asato et al.

CEREBRAL CORTEX (2010)

Review Psychology, Clinical

The Basics of Brain Development

Joan Stiles et al.

NEUROPSYCHOLOGY REVIEW (2010)

Review Physiology

Pathophysiology of Sleep Apnea

Jerome A. Dempsey et al.

PHYSIOLOGICAL REVIEWS (2010)

Review Biochemistry & Molecular Biology

Human cerebral neuropathology of Type 2 diabetes mellitus

Peter T. Nelson et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)

Article Neurosciences

Mental slowness and executive dysfunctions in patients with metabolic syndrome

Barbara Segura et al.

NEUROSCIENCE LETTERS (2009)

Article Substance Abuse

Environmental enrichment alters neurotrophin levels after fetal alcohol exposure in rats

Elizabeth A. Parks et al.

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2008)

Review Biochemistry & Molecular Biology

Inflammatory mechanisms in the regulation of insulin resistance

Herbert Tilg et al.

MOLECULAR MEDICINE (2008)

Review Endocrinology & Metabolism

The metabolic syndrome in children and adolescents - an IDF consensus report

Paul Zimmet et al.

PEDIATRIC DIABETES (2007)

Review Clinical Neurology

Neurogenesis in the adult brain

O. Arias-Carrion et al.

REVISTA DE NEUROLOGIA (2007)

Review Endocrinology & Metabolism

Physiology of BDNF: focus on hypothalamic function

L Tapia-Arancibia et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2004)

Article Medicine, General & Internal

The metabolic syndrome, inflammation, and risk of cognitive decline

K Yaffe et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2004)

Article Neurosciences

Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition

S Vaynman et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2004)

Article Multidisciplinary Sciences

Dynamic mapping of human cortical development during childhood through early adulthood

N Gogtay et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Neurosciences

Mapping cortical change across the human life span

ER Sowell et al.

NATURE NEUROSCIENCE (2003)

Article Medicine, General & Internal

The thrifty phenotype hypothesis

CN Hales et al.

BRITISH MEDICAL BULLETIN (2001)

Review Neurosciences

Neural consequences of environmental enrichment

H van Praag et al.

NATURE REVIEWS NEUROSCIENCE (2000)