4.6 Review

Transcriptional control of embryonic and adult neural progenitor activity

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Differential vulnerability of adult neurogenic niches to dosage of the neurodevelopmental-disorder linked gene Foxg1

Iris Schaeffner et al.

Summary: The transcription factor FOXG1 plays important roles in brain development, and its dosage is crucial for proper neuronal development. High levels of FOXG1 disrupt the survival and fate acquisition of glutamatergic neurons in the hippocampus, but do not affect neurogenesis of GABAergic neurons in the subependymal zone/olfactory bulb system. Interfering with the function of the apoptosis-linked nuclear receptor Nr4a1 rescues FOXG1-dependent death of hippocampal progenitors.

MOLECULAR PSYCHIATRY (2023)

Article Neurosciences

Inhibition of Foxp4 Disrupts Cadherin-based Adhesion of Radial Glial Cells, Leading to Abnormal Differentiation and Migration of Cortical Neurons in Mice

Xue Li et al.

Summary: Heterozygous loss-of-function variants of FOXP4 are associated with neurodevelopmental disorders (NDDs) characterized by delayed speech development, intellectual disability, and congenital abnormalities. FOXP4 plays a critical role in the development of the cerebral cortex during early gestation by regulating N-cadherin. Inhibition of Foxp4 disrupts the apical condensation of N-cadherin in radial glial cells (RGCs) and leads to abnormal differentiation and migration of cortical neurons from the proliferating ventricular zone (VZ). These findings uncover the possible mechanism underlying FOXP4 variant-associated NDDs through impaired adherens junctions and cerebral cortex malformation.

NEUROSCIENCE BULLETIN (2023)

Article Developmental Biology

Notch signaling in development and homeostasis

Oren Gozlan et al.

Summary: Notch signaling is a highly conserved pathway that plays a crucial role in the development and homeostasis of various organisms. It is activated by direct cell-cell contact and mechanical pulling of receptors. Notch signaling coordinates the differentiation into distinct cell fates of neighboring cells during development, and its activation is regulated at multiple levels. This article provides an overview of the activation mechanism and regulation of the Notch pathway, as well as its importance in various developmental processes.

DEVELOPMENT (2023)

Article Cell Biology

Differential cell-cycle control by oscillatory versus sustained Hes1 expression via p21

Yuki Maeda et al.

Summary: Oscillatory Hes1 expression activates cell proliferation by down-regulating the expression of p21, while sustained Hes1 overexpression inhibits cell proliferation by up-regulating p21 expression indirectly. This suggests that Hes1 differentially controls neural stem cell proliferation depending on its expression dynamics.

CELL REPORTS (2023)

Review Neurosciences

Genetic Regulation of Vertebrate Forebrain Development by Homeobox Genes

Ryan F. Leung et al.

Summary: This review summarizes the crucial role of transcription factors encoded by the homeobox, bHLH and forkhead gene families in forebrain development in vertebrates, with a focus on the telencephalon. It also discusses the links between these transcription factors and human diseases, such as neurodevelopmental disorders and brain tumors.

FRONTIERS IN NEUROSCIENCE (2022)

Article Biochemistry & Molecular Biology

FOXG1 Contributes Adult Hippocampal Neurogenesis in Mice

Jia Wang et al.

Summary: The role of FOXG1 in adult hippocampal neurogenesis is explored in this study. FOXG1 overexpression promotes neuronal lineage progression and contributes to the growth of the precursor cell population. Furthermore, FOXG1 induces the differentiation of radial-glia like neural progenitor cells into neuroblasts and promotes the exit of lineage-committed cells from the cell cycle.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2022)

Article Cell & Tissue Engineering

Coordinated changes in cellular behavior ensure the lifelong maintenance of the hippocampal stem cell population

Lachlan Harris et al.

Summary: The stabilization of neural stem cell numbers in young adults is a result of coordinated changes in stem cell behavior, with resting cells having a higher activation rate and greater contribution to neurogenesis. This change is associated with a progressive reduction in expression of the pro-activation protein ASCL1 due to increased post-translational degradation, providing insights into hippocampal NSC dynamics and neurogenesis rates in different mammalian species, including humans.

CELL STEM CELL (2021)

Article Developmental Biology

Hes1 oscillation frequency correlates with activation of neural stem cells

Takashi Kaise et al.

Summary: The active form of Notch1 can significantly activate neural stem cells, and its levels are proportional to NSC activation. The frequency of Hes1 oscillations rather than the peak levels correlates with the efficiency of NSC activation, suggesting that burst Hes1 oscillations may increase the chance of Ascl1 oscillations in quiescent NSCs.

GENE EXPRESSION PATTERNS (2021)

Article Neurosciences

Proneural genes define ground-state rules to regulate neurogenic patterning and cortical folding

Sisu Han et al.

Summary: The research reveals that Neurog2 and Ascl1 genes sustain neurogenic continuity and lissencephaly, while double+ NPCs show unique features of multipotency and play a key role in neurogenic symmetry and cortical folding.

NEURON (2021)

Article Cell Biology

The transcription factor ZEB1 regulates stem cell self-renewal and cell fate in the adult hippocampus

Bhavana Gupta et al.

Summary: The study reveals that the transcription factor ZEB1 plays a crucial role in the self-renewal of active RGL cells in the adult mammalian hippocampus, with its deletion leading to a shift towards symmetric cell division and an increase in newborn neurons while decreasing newly generated astrocytes. ZEB1 is identified as a positive regulator of the ets-domain transcription factor ETV5, which is essential for asymmetric division.

CELL REPORTS (2021)

Article Cell & Tissue Engineering

Kappa opioid receptor controls neural stem cell differentiation via a miR-7a/Pax6 dependent pathway

Chi Xu et al.

Summary: This study reveals that OPRK1 agonists inhibit adult neurogenesis in the mouse hippocampus by upregulating the expression of miR-7a, which in turn downregulates Pax6/Neurog2/NeuroD1 activities and hinders neuronal differentiation of neural stem cells.

STEM CELLS (2021)

Article Cell Biology

Foxp1 Regulates Neural Stem Cell Self-Renewal and Bias Toward Deep Layer Cortical Fates

Caroline Alayne Pearson et al.

CELL REPORTS (2020)

Article Multidisciplinary Sciences

Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function

Svetlana O. Dodonova et al.

NATURE (2020)

Article Biochemistry & Molecular Biology

Genome-wide cooperation of EMT transcription factor ZEB1 with YAP and AP-1 in breast cancer

Nora Feldker et al.

EMBO JOURNAL (2020)

Review Neurosciences

Beyond the Hippocampus and the SVZ: Adult Neurogenesis Throughout the Brain

Michal P. Jurkowski et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2020)

Review Biochemistry & Molecular Biology

More than just Stem Cells: Functional Roles of the Transcription Factor Sox2 in Differentiated Glia and Neurons

Sara Mercurio et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Multidisciplinary Sciences

Live imaging of neurogenesis in the adult mouse hippocampus

Gregor-Alexander Pilz et al.

SCIENCE (2018)

Article Biochemistry & Molecular Biology

Zinc finger E-box-binding homeobox 1 (ZEB1) is required for neural differentiation of human embryonic stem cells

Yuan Jiang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis

Xuekun Li et al.

NATURE COMMUNICATIONS (2017)

Article Cell & Tissue Engineering

FOXP1 Promotes Embryonic Neural Stem Cell Differentiation by Repressing Jagged1 Expression

Luca Braccioli et al.

STEM CELL REPORTS (2017)

Review Biochemistry & Molecular Biology

Hes1: the maestro in neurogenesis

Sivadasan Bindu Dhanesh et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2016)

Article Cell Biology

Phosphorylation Regulates Functions of ZEB1 Transcription Factor

M. Candelaria Llorens et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2016)

Review Neurosciences

Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor

Martine N. Manuel et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Review Neurosciences

Transcriptional control of vertebrate neurogenesis by the proneural factor Ascl1

Francisca F. Vasconcelos et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2014)

Review Biochemistry & Molecular Biology

FoxOs in neural stem cell fate decision

Seung-Hyun Ro et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2013)

Article Neurosciences

FoxP2 Regulates Neurogenesis during Embryonic Cortical Development

David Tsui et al.

JOURNAL OF NEUROSCIENCE (2013)

Article Neurosciences

Foxg1 Has an Essential Role in Postnatal Development of the Dentate Gyrus

Chuanxi Tian et al.

JOURNAL OF NEUROSCIENCE (2012)

Article Cell Biology

Molecular Control of Neurogenesis: A View from the Mammalian Cerebral Cortex

Ben Martynoga et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

Review Neurosciences

Dynamic expression of Notch signaling genes in neural stem/progenitor cells

Hiromi Shimojo et al.

FRONTIERS IN NEUROSCIENCE (2011)

Review Biochemistry & Molecular Biology

All purpose Sox: The many roles of Sox proteins in gene expression

Michael Wegner

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Sox2 roles in neural stem cells

Larysa H. Pevny et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2010)

Article Cell & Tissue Engineering

FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis

Ji-hye Paik et al.

CELL STEM CELL (2009)

Article Cell & Tissue Engineering

FoxO3 Regulates Neural Stem Cell Homeostasis

Valerie M. Renault et al.

CELL STEM CELL (2009)

Review Biochemistry & Molecular Biology

The role of the ZEB family of transcription factors in development and disease

C. Vandewalle et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2009)

Article Cell Biology

Bmi-1 cooperates with Foxg1 to maintain neural stem cell self-renewal in the forebrain

Christopher A. Fasano et al.

GENES & DEVELOPMENT (2009)

Review Genetics & Heredity

The evolution of Fox genes and their role in development and disease

Sridhar Hannenhalli et al.

NATURE REVIEWS GENETICS (2009)

Article Developmental Biology

Zeb1 links epithelial-mesenchymal transition and cellular senescence

Yongqing Liu et al.

DEVELOPMENT (2008)

Article Developmental Biology

Impaired generation of mature neurons by neural stem cells from hypomorphic Sox2 mutants

Maurizio Cavallaro et al.

DEVELOPMENT (2008)

Article Biochemistry & Molecular Biology

Consequence of the loss of Sox2 in the developing brain of the mouse

Satoru Miyagi et al.

FEBS LETTERS (2008)

Article Biochemistry & Molecular Biology

Basic helix-loop-helix transcription factors cooperate to specify a cortical projection neuron identity

Pierre Mattar et al.

MOLECULAR AND CELLULAR BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors

Ulrich Schueller et al.

MOLECULAR AND CELLULAR BIOLOGY (2007)

Article Biology

Classification and nomenclature of all human homeobox genes

Peter W. H. Holland et al.

BMC BIOLOGY (2007)

Article Developmental Biology

The Hes gene family: repressors and oscillators that orchestrate embryogenesis

Ryoichiro Kageyama et al.

DEVELOPMENT (2007)

Article Multidisciplinary Sciences

Bone morphogenetic protein signaling regulates the size of hair follicles and modulates the expression of cell cycle-associated genes

Andrey A. Sharov et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Article Neurosciences

A role for proneural genes in the maturation of cortical progenitor cells

Olivier Britz et al.

CEREBRAL CORTEX (2006)

Review Neurosciences

From stem cells to neurons and glia: a Soxist's view of neural development

M Wegner et al.

TRENDS IN NEUROSCIENCES (2005)

Article Neurosciences

Neuronal fate determinants of adult olfactory bulb neurogenesis

MA Hack et al.

NATURE NEUROSCIENCE (2005)

Article Biochemistry & Molecular Biology

Hes1 directly controls cell proliferation through the transcriptional repression of p27Kip1

K Murata et al.

MOLECULAR AND CELLULAR BIOLOGY (2005)

Review Biotechnology & Applied Microbiology

An overview of the basic helix-loop-helix proteins

S Jones

GENOME BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Accumulation of p27KIP1 is associated with BMP2-induced growth arrest and neuronal differentiation of human neuroblastoma-derived cell lines

Y Nakamura et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2003)

Article Cell Biology

Multipotent cell lineages in early mouse development depend on SOX2 function

AA Avilion et al.

GENES & DEVELOPMENT (2003)

Article Biochemistry & Molecular Biology

The winged-helix protein brain factor 1 interacts with Groucho and Hes proteins to repress transcription

J Yao et al.

MOLECULAR AND CELLULAR BIOLOGY (2001)

Article Biochemistry & Molecular Biology

BF-1 interferes with transforming growth factor β signaling by associating with Smad partners

CL Dou et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)

Article Neurosciences

The bHLH gene Hes1 as a repressor of the neuronal commitment of CNS stem cells

Y Nakamura et al.

JOURNAL OF NEUROSCIENCE (2000)