4.5 Article

A new Hoxb8FlpO mouse line for intersectional approaches to dissect developmentally defined adult sensorimotor circuits

Related references

Note: Only part of the references are listed.
Article Neurosciences

g-Protocadherins control synapse formation and peripheral branching of touch sensory neurons

Shan Meltzer et al.

Summary: Light touch sensation begins with the activation of low-threshold mechanoreceptor (LTMR) endings and the transmission of their signals in the spinal cord and brainstem. The Pcdhg gene locus, encoding 22 cell-surface homophilic binding proteins, is crucial for normal behavioral reactivity to tactile stimuli in somatosensory neurons. Developmentally, different Pcdhg isoforms play roles in synapse formation and axonal branching of LTMR through neuron-neuron and neuron-glia interactions. Disruption of Pcdhg isoforms leads to fewer corticospinal synapses in the dorsal horn, highlighting their importance in the assembly of central mechanosensory circuitry.

NEURON (2023)

Article Anesthesiology

Conditional knockout of CRMP2 in neurons, but not astrocytes, disrupts spinal nociceptive neurotransmission to control the initiation and maintenance of chronic neuropathic pain

Lisa Boinon et al.

Summary: CRMP2 is a key regulator of synaptic transmission and contributes to the transition of physiological pain into pathological pain.
Article Biology

Control of spinal motor neuron terminal differentiation through sustained Hoxc8 gene activity

Catarina Catela et al.

Summary: This study identified the transcriptome of spinal motor neurons (MNs) in mice during embryonic and postnatal stages and discovered novel genes and transcription factors related to terminal differentiation. It was found that homeodomain transcription factors, including Hoxc8, played a crucial role in maintaining the expression of terminal differentiation markers in MNs. These findings provide insights into the evolutionary role of Hox in neuronal terminal differentiation.

ELIFE (2022)

Article Neurosciences

Chemogenetic modulation of sensory afferents induces locomotor changes and plasticity after spinal cord injury

Jaclyn T. Eisdorfer et al.

Summary: Activating lumbar large diameter peripheral afferents using DREADDs, similar to EES, induced plasticity and observed locomotor changes, providing new insights into spinal cord injury rehabilitation.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2022)

Article Biochemistry & Molecular Biology

Mechanoreceptor signal convergence and transformation in the dorsal horn flexibly shape a diversity of outputs to the brain

Anda M. Chirila et al.

Summary: This study reveals how touch is encoded in the spinal cord dorsal horn and its influence on tactile representations in the brain. Neurons in the dorsal horn receive inputs from different types of mechanoreceptors and exhibit various mechanical response profiles. Genetic manipulations uncover an interconnected network in the dorsal horn that regulates the activity of dorsal column output neurons and influences how neurons in the primary somatosensory cortex respond to touch.
Article Neurosciences

Mechanical Allodynia Circuitry in the Dorsal Horn Is Defined by the Nature of the Injury

Cedric Peirs et al.

Summary: Mechanical allodynia in the spinal dorsal horn is conveyed by different neural circuits depending on the nature of the injury, such as inflammatory or neuropathic. Calretinin neurons and protein kinase C gamma neurons play distinct roles in conveying mechanical allodynia in different locations within the dorsal horn. Cholecystokinin neurons located deeper in the dorsal horn are important for both types of injuries.

NEURON (2021)

Article Neurosciences

Long-range GABAergic projections from the nucleus of the solitary tract

Mei-Yu Shi et al.

Summary: The GAD2 inhibitory neurons in the NTS have both local and short-range projections, as well as previously unknown long-range projections targeting forebrain regions. These findings provide new insights into the role of NTS in physiological and emotional modulation.

MOLECULAR BRAIN (2021)

Article Biology

A spinoparabrachial circuit defined by Tacr1 expression drives pain

Arnab Barik et al.

Summary: The pathway from spinal cord to brain for ongoing pain involves activation of spinal neurons expressing Tacr1, leading to pain-related behaviors. PBN-SLTacr1 neurons respond to sustained stimuli, enhancing nocifensive behaviors and suppressing itch, while their silencing causes mice to ignore long-lasting noxious stimuli. This spinoparabrachial pathway plays a key role in the sensation of ongoing pain.

ELIFE (2021)

Review Multidisciplinary Sciences

Central circuit mechanisms of itch

Xiao-Jun Chen et al.

NATURE COMMUNICATIONS (2020)

Article Cell Biology

Spinal Inhibitory Ptf1a-Derived Neurons Prevent Self-Generated Itch

Augusto Escalante et al.

CELL REPORTS (2020)

Article Multidisciplinary Sciences

Parallel ascending spinal pathways for affective touch and pain

Seungwon Choi et al.

NATURE (2020)

Review Biochemistry & Molecular Biology

Chronic Pain: Structural and Functional Changes in Brain Structures and Associated Negative Affective States

Seoyon Yang et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemical Research Methods

Using DeepLabCut for 3D markerless pose estimation across species and behaviors

Tanmay Nath et al.

NATURE PROTOCOLS (2019)

Article Biochemistry & Molecular Biology

Targeting Peripheral Somatosensory Neurons to Improve Tactile-Related Phenotypes in ASD Models

Lauren L. Orefice et al.

Article Neurosciences

Pou2f2 Regulates the Distribution of Dorsal Interneurons in the Mouse Developing Spinal Cord

Gauhar Masgutova et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2019)

Article Multidisciplinary Sciences

Identifying the pathways required for coping behaviours associated with sustained pain

Tianwen Huang et al.

NATURE (2019)

Article Neurosciences

Brainstem Pain-Control Circuitry Connectivity in Chronic Neuropathic Pain

Emily P. Mills et al.

JOURNAL OF NEUROSCIENCE (2018)

Article Biochemistry & Molecular Biology

Corticostriatal circuit defects in Hoxb8 mutant mice

N. Nagarajan et al.

MOLECULAR PSYCHIATRY (2018)

Review Physiology

Spinal Circuits for Touch, Pain, and Itch

Stephanie C. Koch et al.

ANNUAL REVIEW OF PHYSIOLOGY, VOL 80 (2018)

Article Developmental Biology

Two distinct ontogenies confer heterogeneity to mouse brain microglia

Shrutokirti De et al.

DEVELOPMENT (2018)

Article Multidisciplinary Sciences

Conditional knockout of NaV1.6 in adult mice ameliorates neuropathic pain

Lubin Chen et al.

SCIENTIFIC REPORTS (2018)

Review Physiology

Spinal Control of Locomotion: Individual Neurons, Their Circuits and Functions

Marie-Pascale Cote et al.

FRONTIERS IN PHYSIOLOGY (2018)

Article Neurosciences

DeepLabCut: markerless pose estimation of user-defined body parts with deep learning

Alexander Mathis et al.

NATURE NEUROSCIENCE (2018)

Article Biochemistry & Molecular Biology

Nervous System Regionalization Entails Axial Allocation before Neural Differentiation

Vicki Metzis et al.

Article Multidisciplinary Sciences

Sagittal Plane Kinematic Gait Analysis in C57BL/6 Mice Subjected to MOG35-55 Induced Experimental Autoimmune Encephalomyelitis

Maximillian D. J. Fiander et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2017)

Article Biochemistry & Molecular Biology

The Cellular and Synaptic Architecture of the Mechanosensory Dorsal Horn

Victoria E. Abraira et al.

Review Developmental Biology

Making sense out of spinal cord somatosensory development

Helen C. Lai et al.

DEVELOPMENT (2016)

Review Neurosciences

DREADDs for Neuroscientists

Bryan L. Roth

NEURON (2016)

Article Cell Biology

Identification of Serotonergic Neuronal Modules that Affect Aggressive Behavior

Vera Niederkofler et al.

CELL REPORTS (2016)

Article Biochemistry & Molecular Biology

Identification of a Spinal Circuit for Light Touch and Fine Motor Control

Steeve Bourane et al.

Article Developmental Biology

Expanding the power of recombinase-based labeling to uncover cellular diversity

Nicholas W. Plummer et al.

DEVELOPMENT (2015)

Review Developmental Biology

From classical to current: Analyzing peripheral nervous system and spinal cord lineage and fate

Samantha J. Butler et al.

DEVELOPMENTAL BIOLOGY (2015)

Article Neurosciences

Dual-Channel Circuit Mapping Reveals Sensorimotor Convergence in the Primary Motor Cortex

Bryan M. Hooks et al.

JOURNAL OF NEUROSCIENCE (2015)

Article Neurosciences

Cell type-specific manipulation with GFP-dependent Cre recombinase

Jonathan C. Y. Tang et al.

NATURE NEUROSCIENCE (2015)

Article Neurosciences

Dorsal Horn Circuits for Persistent Mechanical Pain

Cedric Peirs et al.

NEURON (2015)

Article Neurosciences

Mapping Sub-Second Structure in Mouse Behavior

Alexander B. Wiltschko et al.

NEURON (2015)

Article Multidisciplinary Sciences

Gate control of mechanical itch by a subpopulation of spinal cord interneurons

Steeve Bourane et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

2A self-cleaving peptide-based multi-gene expression system in the silkworm Bombyx mori

Yuancheng Wang et al.

SCIENTIFIC REPORTS (2015)

Review Neurosciences

Molecular and cellular development of spinal cord locomotor circuitry

Daniel C. Lu et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2015)

Review Genetics & Heredity

A Mouse Geneticist's Practical Guide to CRISPR Applications

Priti Singh et al.

GENETICS (2015)

Article Biochemistry & Molecular Biology

Identification of Spinal Circuits Transmitting and Gating Mechanical Pain

Bo Duan et al.

Article Multidisciplinary Sciences

Global Nav1.7 Knockout Mice Recapitulate the Phenotype of Human Congenital Indifference to Pain

Jacinthe Gingras et al.

PLOS ONE (2014)

Article Neurosciences

Anatomical characterization of Cre driver mice for neural circuit mapping and manipulation

Julie A. Harris et al.

FRONTIERS IN NEURAL CIRCUITS (2014)

Article Neurosciences

Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals

Esteban O. Mazzoni et al.

NATURE NEUROSCIENCE (2013)

Review Neurosciences

The Sensory Neurons of Touch

Victoria E. Abraira et al.

NEURON (2013)

Article Neurosciences

Projections and interconnections of genetically defined serotonin neurons in mice

Sun Jung Bang et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2012)

Article Biochemistry & Molecular Biology

Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice

Shau-Kwaun Chen et al.

Article Developmental Biology

Hoxb8-Cre Mice: A Tool for Brain-Sparing Conditional Gene Deletion

Robert Witschi et al.

GENESIS (2010)

Review Medicine, Research & Experimental

Nociceptors: the sensors of the pain pathway

Adrienne E. Dubin et al.

JOURNAL OF CLINICAL INVESTIGATION (2010)

Review Neurosciences

Neuronal circuitry for pain processing in the dorsal horn

Andrew J. Todd

NATURE REVIEWS NEUROSCIENCE (2010)

Article Neurosciences

Characterization of Nkx6-2-Derived Neocortical Interneuron Lineages

Vitor H. Sousa et al.

CEREBRAL CORTEX (2009)

Article Developmental Biology

A Multifunctional Reporter Mouse Line for Cre- and FLP-Dependent Lineage Analysis

Masakazu Yamamoto et al.

GENESIS (2009)

Article Multidisciplinary Sciences

Loss of Hoxb8 alters spinal dorsal laminae and sensory responses in mice

Jan C. Holstege et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Review Neurosciences

Genetically manipulated mice: a powerful tool with unsuspected caveats

Klaus I. Matthaei

JOURNAL OF PHYSIOLOGY-LONDON (2007)

Article Multidisciplinary Sciences

High-Efficiency FLP and ΦC31 Site-Specific Recombination in Mammalian Cells

Christopher S. Raymond et al.

PLOS ONE (2007)

Article Neurosciences

Gene expression nervous system atlas (GENSAT)

N Heintz

NATURE NEUROSCIENCE (2004)

Article Biochemistry & Molecular Biology

Flp recombinase transgenic mice of C57BL/6 strain for conditional gene targeting

T Takeuchi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)

Article Neurosciences

Hoxb8 is required for normal grooming behavior in mice

JM Greer et al.

NEURON (2002)

Review Genetics & Heredity

Neuronal specification in the spinal cord: Inductive signals and transcriptional codes

TM Jessell

NATURE REVIEWS GENETICS (2000)