4.5 Article

Acute effects of single and repeated mild traumatic brain injury on levels of neurometabolites, lipids, and mitochondrial function in male rats

Related references

Note: Only part of the references are listed.
Article Critical Care Medicine

Serum Acylcarnitine and Long-Term Functional Prognosis after Traumatic Brain Injury with Intracranial Injury: A Multi-Center Prospective Study

Stephen Gyung Won Lee et al.

Summary: This study evaluates the association between serum acylcarnitine levels and functional outcomes at 1 month/6 months after traumatic brain injury. The study finds that higher serum acylcarnitine levels are associated with poor functional outcomes for TBI patients with intracranial injury.

JOURNAL OF NEUROTRAUMA (2023)

Article Medicine, Research & Experimental

Association between blood glucose levels and Glasgow Outcome Score in patients with traumatic brain injury: secondary analysis of a randomized trial

Tao Yuan et al.

Summary: This study demonstrates the relationship between blood glucose levels and the Glasgow Outcome Score (GOS) in traumatic brain injury (TBI) patients. Blood glucose levels that are too high or too low are associated with a poor prognosis.

TRIALS (2022)

Review Pharmacology & Pharmacy

Revisiting Excitotoxicity in Traumatic Brain Injury: From Bench to Bedside

Daniela Baracaldo-Santamaria et al.

Summary: Traumatic brain injury (TBI) is a major cause of increased morbidity and mortality, with consequences ranging from mild cognitive impairment to death. This review provides a comprehensive understanding of the various pathways involved in tissue damage following TBI. It summarizes the preclinical evidence of potential therapeutic interventions and describes the available clinical evaluation of novel drug targets.

PHARMACEUTICS (2022)

Review Neurosciences

Traumatic Brain Injury and Risk of Neurodegenerative Disorder

Benjamin L. Brett et al.

Summary: This article reviews the evidence for traumatic brain injury (TBI) as a risk factor for neurodegenerative disorders, including Alzheimer's dementia and Parkinson's disease, in clinical and neuropathological studies. It also describes the dynamic interactions between acute response to injury and chronic processes that may be involved in TBI-related pathogenesis and progression of neurodegeneration.

BIOLOGICAL PSYCHIATRY (2022)

Article Multidisciplinary Sciences

Serum metabolome associated with severity of acute traumatic brain injury

Ilias Thomas et al.

Summary: Acute traumatic brain injury is associated with distinctive serum metabolic patterns, particularly involving compounds related to lipid metabolism, which may indicate protective changes aiming to maintain lipid homeostasis in the brain.

NATURE COMMUNICATIONS (2022)

Article Biochemistry & Molecular Biology

Plasma Lipid Profiles Change with Increasing Numbers of Mild Traumatic Brain Injuries in Rats

Chidozie C. Anyaegbu et al.

Summary: Mild traumatic brain injury (mTBI) can cause structural, cellular, and biochemical changes in the brain that are difficult to detect and may persist chronically. Lipidomic analysis of blood samples, which can easily cross the blood-brain barrier, may provide valuable insights into the neuropathological state. This study used liquid chromatography-mass spectrometry (LC-MS) to analyze plasma lipid concentrations after 11 days of sham, one (1 x), or two (2 x) mTBI in rats. They identified 18 lipid species that distinguished between different injury conditions and found that the changes in lipid concentrations varied depending on the number of mTBI, suggesting a balance of damage and reparative responses.

METABOLITES (2022)

Article Biochemistry & Molecular Biology

Phosphatidylethanolamine Deficiency and Triglyceride Overload in Perilesional Cortex Contribute to Non-Goal-Directed Hyperactivity after Traumatic Brain Injury in Mice

Lisa Hahnefeld et al.

Summary: Traumatic brain injury (TBI) often results in long-lasting disabilities such as headache, fatigue, insomnia, hyperactivity, and cognitive deficits. A study conducted in mice found that persistent non-goal-directed hyperactivity is a characteristic behavior after TBI and is associated with low levels of endocannabinoids in the perilesional cortex. In a new analysis, lipidome patterns in the brain and plasma of TBI mice were compared to sham mice, revealing an increase in neutral lipids in the perilesional cortex. This lipid accumulation, along with a reduction in hexosylceramides and phosphatidylethanolamines, may contribute to the behavioral dimensions of post-TBI psychopathology.

BIOMEDICINES (2022)

Article Sport Sciences

Sub-acute Changes on MRI Measures of Cerebral Blood Flow and Venous Oxygen Saturation in Concussed Australian Rules Footballers

David K. Wright et al.

Summary: This study used magnetic resonance imaging to measure cerebral venous oxygen saturation (SvO(2)) and cerebral blood flow (CBF) in concussed Australian football athletes during recovery. The results showed evidence of increased susceptibility in the global white matter and reduced relative CBF compared to the control group. There was also an interaction between sex and injury in straight sinus susceptibility values. The findings suggest the need to reassess return-to-play guidelines for concussed athletes.

SPORTS MEDICINE-OPEN (2022)

Article Medicine, Research & Experimental

The oncogenic lysophosphatidylinositol (LPI)/GPR55 signaling

Argelia Calvillo-Robledo et al.

Summary: GPR55 is an orphan receptor that has been found to play a crucial role in various pathophysiological processes. This receptor can be modulated by cannabinoids and is proposed to be a part of the endocannabinoid system. The LPI/GPR55 axis is involved in cell survival and tumor progression, and has potential as a biomarker for cancer diagnosis.

LIFE SCIENCES (2022)

Review Multidisciplinary Sciences

Brain lipidomics: From functional landscape to clinical significance

Jong Hyuk Yoon et al.

Summary: This review highlights the importance of lipidomics in diagnosing and treating brain diseases, and explores lipid alterations associated with brain diseases, the functions of brain lipids, and the latest analytical techniques and potential applications.

SCIENCE ADVANCES (2022)

Article Cell Biology

Melatonin Provides Neuroprotection Following Traumatic Brain Injury-Promoted Mitochondrial Perturbation in Wistar Rat

Mohd Salman et al.

Summary: The study demonstrated the neuroprotective effects of melatonin against TBI-induced oxidative damage and mitochondrial dysfunction in rats. Melatonin treatment attenuated brain edema, oxidative damage, mitochondrial fission, and promoted mitochondrial fusion, while also restoring mitochondrial membrane potential and oxidative phosphorylation. Furthermore, melatonin inhibited the translocation of certain proteins to mitochondria, suggesting a potential therapeutic role in mitochondrial-mediated neuroprotection in brain trauma.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2021)

Article Neurosciences

Behavioral, axonal, and proteomic alterations following repeated mild traumatic brain injury: Novel insights using a clinically relevant rat model

Louise Pham et al.

Summary: This study using a rat model found that repeated mTBI can cause acute cognitive deficits and prolonged sensorimotor impairments, with elevated serum NfL levels correlating with sensorimotor deficits at 7 days post injury. Furthermore, several hippocampal proteins were altered by repeated mTBI and diffusion MRI analysis at 3.5 months revealed widespread reductions in white matter integrity.

NEUROBIOLOGY OF DISEASE (2021)

Article Biochemistry & Molecular Biology

Glutamine restores mitochondrial respiration in bleomycin-injured epithelial cells

Hoora Shaghaghi et al.

Summary: Research has shown that mitochondrial respiratory dysfunction in lung epithelial cells during pulmonary fibrosis modeling experiments is influenced by different metabolic fuels. Results indicate a significant reduction in mitochondrial respiration when glucose is the primary fuel, while the addition of glutamine can protect mitochondrial respiration in lung epithelial cells, reducing DNA damage and cell death.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Article Multidisciplinary Sciences

Deletion of Trim28 in committed adipocytes promotes obesity but preserves glucose tolerance

Simon T. Bond et al.

Summary: This study reveals Trim28 as a sex-specific regulator of post-developmental adiposity and white adipose tissue function, impacting lipolysis and triglyceride metabolism. The loss of Trim28 in committed adipocytes leads to sex-specific differences in obesity development, potentially through alterations in Klf14 expression, known to modulate adipocyte size and body composition in a sex-specific manner.

NATURE COMMUNICATIONS (2021)

Review Neurosciences

The Complexity of Secondary Cascade Consequent to Traumatic Brain Injury: Pathobiology and Potential Treatments

Nidhi Khatri et al.

Summary: Traumatic brain injury is a major cause of death and disability, with patients facing issues like mood changes, impulsivity, social judgment problems, and memory deficits. The consequences of TBI differ between open and closed head injuries. Despite significant research, many individuals may still suffer from lifelong disability.

CURRENT NEUROPHARMACOLOGY (2021)

Article Neurosciences

Temporal profile and utility of serum neurofilament light in a rat model of mild traumatic brain injury

William T. O'Brien et al.

Summary: The study demonstrates that serum NfL levels significantly increase following mTBI in rats, with a peak at 1 day post-injury and sustained elevation at 14 days. Repeat mTBI further elevates NfL levels, which are correlated with the severity of sensorimotor impairment. These findings highlight the potential utility of NfL as a blood biomarker for assessing the severity of mTBI.

EXPERIMENTAL NEUROLOGY (2021)

Article Neurosciences

Diffusion Imaging Reveals Sex Differences in the White Matter Following Sports-Related Concussion

David K. Wright et al.

Summary: The preliminary study showed that male athletes with SRC reported more severe symptoms compared to female athletes. dMRI revealed white matter differences between SRC athletes and non-concussed athletes at 48 hours post-injury, which persisted at 2 weeks post-injury. Furthermore, male SRC athletes exhibited significantly greater white matter disruption than female SRC athletes. These findings have implications for concussion management, including return-to-play decisions, and enhance our understanding of the role of sex in SRC outcomes.

CEREBRAL CORTEX (2021)

Article Psychiatry

Adverse clinical outcomes in people at clinical high-risk for psychosis related to altered interactions between hippocampal activity and glutamatergic function

Paul Allen et al.

Summary: The study suggests that alterations in hippocampal activity and glutamatergic function are associated with the onset of psychosis and adverse clinical outcomes in individuals at clinical high-risk for psychosis, supporting the role of the hippocampus in the pathogenesis of psychosis.

TRANSLATIONAL PSYCHIATRY (2021)

Review Neurosciences

Sex Differences in Mitochondrial Function Following a Controlled Cortical Impact Traumatic Brain Injury in Rodents

Olivia J. Kalimon et al.

Summary: TBI is a complex disease with multifactorial injury cascades. Mitochondria play important roles in cellular energy generation, cell death regulation, and intracellular calcium modulation, making them susceptible to TBI.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2021)

Review Cell Biology

Reviving mitochondrial bioenergetics: A relevant approach in epilepsy

Shareen Singh et al.

Summary: Epileptogenesis is closely linked to neurodegeneration and bioenergetic defects, primarily due to mitochondrial dysfunction leading to neuronal death. Mitochondria play a crucial role in neuronal cells, and dysfunction can disrupt calcium homeostasis, leading to abnormal neuronal excitation and death in epilepsy.

MITOCHONDRION (2021)

Article Multidisciplinary Sciences

Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease

K. Watt et al.

Summary: Reduced levels of Yap in muscle contribute to the development of obesity and metabolic disease, while increasing Yap abundance in skeletal muscle enhances energy expenditure and reduces adiposity in obese mice.

NATURE COMMUNICATIONS (2021)

Review Neurosciences

Identifying degenerative effects of repetitive head trauma with neuroimaging: a clinically-oriented review

Breton M. Asken et al.

Summary: Varying severities and frequencies of head trauma can lead to dynamic acute and chronic pathophysiologic responses in the brain, attracting more attention. Studying neuroimaging data from repetitive head trauma cohorts can help improve the diagnosis of chronic traumatic encephalopathy. Structural MRI and PET imaging may be helpful in differential diagnosis, but there is currently no clear metabolic or molecular pattern associated with repetitive head trauma.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2021)

Review Biochemistry & Molecular Biology

Traumatic Brain Injury: Oxidative Stress and Novel Anti-Oxidants Such as Mitoquinone and Edaravone

Helene Ismail et al.

ANTIOXIDANTS (2020)

Review Biochemistry & Molecular Biology

The Emerging and Diverse Roles of Bis(monoacylglycero) Phosphate Lipids in Cellular Physiology and Disease

Megan R. Showalter et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Clinical Neurology

Estimating the global incidence of traumatic brain injury

Michael C. Dewan et al.

JOURNAL OF NEUROSURGERY (2019)

Article Sport Sciences

International consensus definitions of video signs of concussion in professional sports

Gavin A. Davis et al.

BRITISH JOURNAL OF SPORTS MEDICINE (2019)

Article Neurosciences

Consolidated Biochemical Profile of Subacute Stage Traumatic Brain Injury in Early Development

Jyothsna Chitturi et al.

FRONTIERS IN NEUROSCIENCE (2019)

Review Clinical Neurology

Understanding neurodegeneration after traumatic brain injury: from mechanisms to clinical trials in dementia

Neil S. N. Graham et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

Review Neurosciences

Traumatic Brain Injuries: Pathophysiology and Potential Therapeutic Targets

Si Yun Ng et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2019)

Article Sport Sciences

Functional balance assessment in recreational college-aged individuals with a concussion history

Robert C. Lynall et al.

JOURNAL OF SCIENCE AND MEDICINE IN SPORT (2019)

Article Biochemistry & Molecular Biology

Mitochondria-Targeted Antioxidants as Potential Therapy for the Treatment of Traumatic Brain Injury

Elena Stelmashook et al.

ANTIOXIDANTS (2019)

Article Orthopedics

Concussion Pathophysiology and Injury Biomechanics

Rafael Romeu-Mejia et al.

CURRENT REVIEWS IN MUSCULOSKELETAL MEDICINE (2019)

Article Neuroimaging

Mild traumatic brain injury: The effect of age at trauma onset on brain structure integrity

Sebastien Tremblay et al.

NEUROIMAGE-CLINICAL (2019)

Review Endocrinology & Metabolism

An energetic view of stress: Focus on mitochondria

Martin Picard et al.

FRONTIERS IN NEUROENDOCRINOLOGY (2018)

Article Critical Care Medicine

A Mild Traumatic Brain Injury in Mice Produces Lasting Deficits in Brain Metabolism

Danielle N. Lyons et al.

JOURNAL OF NEUROTRAUMA (2018)

Article Biochemical Research Methods

Discovery of Lipidome Alterations Following Traumatic Brain Injury via High-Resolution Metabolomics

Scott R. Hogan et al.

JOURNAL OF PROTEOME RESEARCH (2018)

Review Neurosciences

Recent Advances in Pathophysiology of Traumatic Brain Injury

Parmeet Kaur et al.

CURRENT NEUROPHARMACOLOGY (2018)

Review Critical Care Medicine

Glutamate Neurotransmission in Rodent Models of Traumatic Brain Injury

Christopher R. Dorsett et al.

JOURNAL OF NEUROTRAUMA (2017)

Article Sport Sciences

Single-task and dual-task tandem gait test performance after concussion

David R. Howell et al.

JOURNAL OF SCIENCE AND MEDICINE IN SPORT (2017)

Review Behavioral Sciences

The potential for animal models to provide insight into mild traumatic brain injury: Translational challenges and strategies

Sandy R. Shultz et al.

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS (2017)

Review Emergency Medicine

Pediatric Mild Traumatic Brain Injury in the Acute Setting

Daniel J. Corwin et al.

PEDIATRIC EMERGENCY CARE (2017)

Article Clinical Neurology

Sex matters: repetitive mild traumatic brain injury in adolescent rats

David K. Wright et al.

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY (2017)

Review Biochemistry & Molecular Biology

Engulfment signals and the phagocytic machinery for apoptotic cell clearance

Seung-Yoon Park et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2017)

Article Multidisciplinary Sciences

Mass spectrometry imaging of biomarker lipids for phagocytosis and signalling during focal cerebral ischaemia

Mette M. B. Nielsen et al.

SCIENTIFIC REPORTS (2016)

Article Medicine, General & Internal

Isoflurane Provides Neuroprotection in Neonatal Hypoxic Ischemic Brain Injury

Sherrefa R. Burchell et al.

JOURNAL OF INVESTIGATIVE MEDICINE (2016)

Article Multidisciplinary Sciences

Behavioral, blood, and magnetic resonance imaging biomarkers of experimental mild traumatic brain injury

David K. Wright et al.

SCIENTIFIC REPORTS (2016)

Review Clinical Neurology

Glutamate and GABA Imbalance Following Traumatic Brain Injury

Rejean M. Guerriero et al.

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2015)

Article Biochemistry & Molecular Biology

An Efficient Single Phase Method for the Extraction of Plasma Lipids

Zahir H. Alshehry et al.

METABOLITES (2015)

Article Endocrinology & Metabolism

Acylcarnitines activate proinflammatory signaling pathways

Jennifer M. Rutkowsky et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2014)

Article Biochemistry & Molecular Biology

Lipidomic analyses identify injury-specific phospholipid changes 3 mo after traumatic brain injury

Laila Abdullah et al.

FASEB JOURNAL (2014)

Article Clinical Neurology

Regional Neurodegeneration and Gliosis Are Amplified by Mild Traumatic Brain Injury Repeated at 24-Hour Intervals

Amanda N. Bolton et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2014)

Review Critical Care Medicine

A Systematic Review of Proton Magnetic Resonance Spectroscopy Findings in Sport-Related Concussion

Andrew Gardner et al.

JOURNAL OF NEUROTRAUMA (2014)

Article Critical Care Medicine

Impaired Neurovascular Unit Function Contributes to Persistent Symptoms after Concussion: A Pilot Study

Brenda L. Bartnik-Olson et al.

JOURNAL OF NEUROTRAUMA (2014)

Article Clinical Neurology

The New Neurometabolic Cascade of Concussion

Christopher C. Giza et al.

NEUROSURGERY (2014)

Article Gastroenterology & Hepatology

Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease

Giuseppe Paradies et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

Review Chemistry, Multidisciplinary

The neuroprotective effects of progesterone on traumatic brain injury: current status and future prospects

Jing Wei et al.

ACTA PHARMACOLOGICA SINICA (2013)

Review Biophysics

Glutamate and glutamine: a review of in vivo MRS in the human brain

Saadallah Ramadan et al.

NMR IN BIOMEDICINE (2013)

Article Biochemistry & Molecular Biology

The creatine kinase system and pleiotropic effects of creatine

Theo Wallimann et al.

AMINO ACIDS (2011)

Review Biochemistry & Molecular Biology

Assessing mitochondrial dysfunction in cells

Martin D. Brand et al.

BIOCHEMICAL JOURNAL (2011)

Article Critical Care Medicine

A Longitudinal Proton Magnetic Resonance Spectroscopy Study of Mild Traumatic Brain Injury

Ronald A. Yeo et al.

JOURNAL OF NEUROTRAUMA (2011)

Article Nursing

Differences in CSF Phospholipid Concentration by Traumatic Brain Injury Outcome

Alice E. Pasvogel et al.

BIOLOGICAL RESEARCH FOR NURSING (2010)

Article Critical Care Medicine

Age-Related Mitochondrial Changes after Traumatic Brain Injury

Lesley K. Gilmer et al.

JOURNAL OF NEUROTRAUMA (2010)

Article Nursing

Cerebrospinal fluid phospholipid changes following traumatic brain injury

Alice E. Pasvogel et al.

BIOLOGICAL RESEARCH FOR NURSING (2008)

Article Psychology, Experimental

Football increases the risk for Lou Gehrig's disease, amyotrophic lateral sclerosis

Ernest L. Abel

PERCEPTUAL AND MOTOR SKILLS (2007)

Article Critical Care Medicine

Proteomic identification of oxidized mitochondrial proteins following experimental traumatic brain injury

Wycliffe O. Opii et al.

JOURNAL OF NEUROTRAUMA (2007)

Article Endocrinology & Metabolism

Cytochrome c, a biomarker of apoptosis, is increased in cerebrospinal fluid from infants with inflicted brain injury from child abuse

MA Satchell et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2005)

Article Endocrinology & Metabolism

A potent protective role of lysophospholipids against global cerebral ischemia and glutamate excitotoxicity in neuronal cultures

N Blondeau et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2002)