☆ 4.5 Article

Human blood-labyrinth barrier model to study the effects of cytokines and inflammation

FRONTIERS IN MOLECULAR NEUROSCIENCE (2023)

Related references

Note: Only part of the references are listed.

Review Pharmacology & Pharmacy

An overview of in vitro 3D models of the blood-brain barrier as a tool to predict the in vivo permeability of nanomedicines

Alexandre Perez-Lopez et al.

Summary: The blood-brain barrier (BBB) poses challenges for drug delivery to the central nervous system, resulting in unmet medical needs for brain diseases. Research on the three-dimensional structure of the BBB provides insights into its pathology and aids in the development of novel brain disease therapies. Various 3D models, including hydrogel, spheroid, organoid-based static models, and microfluidic-based BBB-on-a-chip models, have been developed to mimic the human neurovascular unit. This review discusses the development and application of these BBB models for permeability testing of nanomedicines, as well as their advantages and disadvantages, and the validation of their results with in vivo preclinical data.

ADVANCED DRUG DELIVERY REVIEWS (2023)

Add to Collection

Article Immunology

Single-cell immune profiling of Meniere Disease patients

Marisa Flook et al.

Summary: This study performed mass cytometry and ELISA on peripheral blood samples from Meniere Disease (MD) patients and controls, and found that MD patients can be divided into two clusters based on their cytokine profiles, IgE levels and immune cell populations. The results suggest the existence of an allergic phenotype in some MD patients, which may benefit from personalized IL-4 blockers.

CLINICAL IMMUNOLOGY (2023)

Add to Collection

Article Otorhinolaryngology

Cytokines and Inflammation in Meniere Disease

Lidia Frejo et al.

Summary: Meniere disease is a rare condition characterized by the accumulation of endolymph in the inner ear and abnormal immune response. Its core symptoms include hearing loss, vertigo, and tinnitus. Genetic factors and innate immune response play significant roles in its development. Autoimmune Meniere disease refers to the condition where patients fulfill the diagnostic criteria for Meniere disease and also have autoimmune disorders. By studying evidence related to genetic variations, inflammation, and cytokines, we can better understand the mechanisms of this disease and potentially find new treatment options.

CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY (2022)

Add to Collection

Article Immunology

Bidirectional Transport of IgE by CD23 in the Inner Ear of Patients with Meniere's Disease

Na Zhang et al.

Summary: This study found that IgE levels are elevated in Meniere's disease and positively correlated with clinical symptoms. Additionally, CD23-mediated IgE transcytosis plays a critical role in initiating inflammation in the inner ear. Therefore, reducing IgE levels may be a potentially effective approach for treating Meniere's disease.

JOURNAL OF IMMUNOLOGY (2022)

Add to Collection

Article Clinical Neurology

Up-Regulated Expression of Interferon-Gamma, Interleukin-6 and Tumor Necrosis Factor-Alpha in the Endolymphatic Sac of Meniere's Disease Suggesting the Local Inflammatory Response Underlies the Mechanism of This Disease

Chao Huang et al.

Summary: This study explored differentially expressed cytokines in the endolymphatic sac (ES) luminal fluid of patients with Meniere's disease (MD) and found up-regulated expression of TNF-alpha, IL-6 and IFN-gamma in the ES, suggesting a potential role of local inflammatory response in the pathology of MD.

FRONTIERS IN NEUROLOGY (2022)

Add to Collection

Article Neurosciences

Lack of NHE6 and Inhibition of NKCC1 Associated With Increased Permeability in Blood Labyrinth Barrier-Derived Endothelial Cell Layer

Marijana Sekulic-Jablanovic et al.

Summary: This study found that the lack or inhibition of NHE6 or NKCC1 affects the permeability of endothelial BLB-derived cells. These findings suggest that NHE6 and NKCC1 could serve as potential targets to modify BLB permeability for drug delivery to the cochlea or to protect the cochlea from ototoxic insults.

FRONTIERS IN CELLULAR NEUROSCIENCE (2022)

Add to Collection

Article Biochemical Research Methods

Developing a transwell millifluidic device for studying blood-brain barrier endothelium

Ian C. Harding et al.

Summary: The function of blood-brain barrier endothelial cells is influenced by flow conditions and supportive cells, necessitating the use of physiologically relevant multicellular models to investigate and understand their role.

LAB ON A CHIP (2022)

Add to Collection

Review Genetics & Heredity

A Systematic Review of Extreme Phenotype Strategies to Search for Rare Variants in Genetic Studies of Complex Disorders

Sana Amanat et al.

GENES (2020)

Add to Collection

Review Audiology & Speech-Language Pathology

The aging cochlea: Towards unraveling the functional contributions of strial dysfunction and synaptopathy

Amarins N. Heeringa et al.

HEARING RESEARCH (2019)

Add to Collection

Article Multidisciplinary Sciences

Proinflammatory cytokines and response to molds in mononuclear cells of patients with Meniere disease

Lidia Frejo et al.

SCIENTIFIC REPORTS (2018)

Add to Collection

Article Multidisciplinary Sciences

The blood labyrinthine barrier in the human normal and Meniere's disease macula utricle

Gail Ishiyama et al.

SCIENTIFIC REPORTS (2017)

Add to Collection

Article Clinical Neurology

Blood-Labyrinth Barrier Permeability in Meniere Disease and Idiopathic Sudden Sensorineural Hearing Loss: Findings on Delayed Postcontrast 3D-FLAIR MRI

M. N. Pakdaman et al.

AMERICAN JOURNAL OF NEURORADIOLOGY (2016)

Add to Collection

Article Radiology, Nuclear Medicine & Medical Imaging

Delayed intravenous contrast-enhanced 3D FLAIR MRI in Meniere's disease: correlation of quantitative measures of endolymphatic hydrops with hearing

Ali R. Sepandari et al.

CLINICAL IMAGING (2015)

Add to Collection

Review Otorhinolaryngology

Current understanding of the pathogenesis of autoimmune inner ear disease: a review

A. F. Goodall et al.

CLINICAL OTOLARYNGOLOGY (2015)

Add to Collection

Article Cell Biology

Endotoxemia-mediated inflammation potentiates aminoglycoside-induced ototoxicity

Ja-Won Koo et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Add to Collection

Article Multidisciplinary Sciences

Intronic Variants in the NFKB1 Gene May Influence Hearing Forecast in Patients with Unilateral Sensorineural Hearing Loss in Meniere's Disease

Sonia Cabrera et al.

PLOS ONE (2014)

Add to Collection

Article Genetics & Heredity

Allelic variants in TLR10 gene may influence bilateral affectation and clinical course of Meniere's disease

Teresa Requena et al.

IMMUNOGENETICS (2013)

Add to Collection

Article Neurosciences

Endothelial Cell, Pericyte, and Perivascular Resident Macrophage-Type Melanocyte Interactions Regulate Cochlear Intrastrial Fluid-Blood Barrier Permeability

Lingling Neng et al.

JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY (2013)

Add to Collection

Article Neurosciences

Characterization and Inflammatory Response of Perivascular-Resident Macrophage-Like Melanocytes in the Vestibular System

Fei Zhang et al.

JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY (2013)

Add to Collection

Article Biochemical Research Methods

Isolation and culture of endothelial cells, pericytes and perivascular resident macrophage-like melanocytes from the young mouse ear

Lingling Neng et al.

NATURE PROTOCOLS (2013)

Add to Collection

Article Clinical Neurology

Endolymphatic Hydrops in Ménière’s Disease

Carol A. Foster et al.

OTOLOGY & NEUROTOLOGY (2013)

Add to Collection

Article Multidisciplinary Sciences

Perivascular-resident macrophage-like melanocytes in the inner ear are essential for the integrity of the intrastrial fluid-blood barrier

Wenjing Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Add to Collection

Review Audiology & Speech-Language Pathology

Physiopathology of the cochlear microcirculation

Xiaorui Shi

HEARING RESEARCH (2011)

Add to Collection

Article Pathology

Cochlear Pericyte Responses to Acoustic Trauma and the Involvement of Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor

Xiaorui Shi

AMERICAN JOURNAL OF PATHOLOGY (2009)

Add to Collection

Review Oncology

TNF-mediated inflammatory disease

J. R. Bradley

JOURNAL OF PATHOLOGY (2008)

Add to Collection

Article Neurosciences

Proinflammatory cytokines expression in noise-induced damaged cochlea

M Fujioka et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2006)

Add to Collection

Article Clinical Neurology

Pathophysiology of Meniere's syndrome: Are symptoms caused by endolymphatic hydrops?

SN Merchant et al.

OTOLOGY & NEUROTOLOGY (2005)

Add to Collection

Article Medicine, General & Internal

Loss of KCNJ10 protein expression abolishes endocochlear potential and causes deafness in Pendred syndrome mouse model

Philine Wangemann et al.

BMC MEDICINE (2004)

Add to Collection

Article Neurosciences

Proinflammatory cytokine expression in the endolymphatic sac during inner ear inflammation

H Satoh et al.

JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY (2003)

Add to Collection

Article Medicine, Research & Experimental

Aldosterone (mineralocorticoid) equivalent to prednisolone (glucocorticoid) in reversing hearing loss in MRL/MpJ-Fas1pr autoimmune mice

DR Trune et al.

LARYNGOSCOPE (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.