Enhanced monitoring and detection of recent genotype 3 hepatitis E virus infection through urine antigen testing

Article Gastroenterology & Hepatology

Urine is a viral antigen reservoir in hepatitis E virus infection

Dong Ying et al.

Summary: This study revealed the origin and diagnostic value of urine Ag in HEV infection, demonstrating that urine Ag has higher diagnostic sensitivity than serum, appears earlier and lasts longer, and shows good concordance with fecal RNA.

HEPATOLOGY (2023)

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Article Immunology

Profile of clinical characteristics and serologic markers of sporadic hepatitis E in a community cohort study

Zi-Min Tang et al.

Summary: This community-based study provides evidence that Hepatitis E virus (HEV) is a globally significant pathogen. The high prevalence of HEV infection in hepatitis E cases suggests the importance of including HEV testing in the diagnosis of hepatitis E.

EMERGING MICROBES & INFECTIONS (2023)

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Article Gastroenterology & Hepatology

A small animal model of chronic hepatitis E infection using immunocompromised rats

Siddharth Sridhar et al.

Summary: By suppressing the immune responses of rats with drugs commonly taken by organ transplant recipients, we have successfully developed a rat model that closely mimics chronic hepatitis E infection, providing a reliable tool for studying this infection in transplant recipients.

JHEP REPORTS (2022)

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Article Microbiology

Dynamics of Hepatitis E Virus (HEV) Antibodies and Development of a Multifactorial Model To Improve the Diagnosis of HEV Infection in Resource-Limited Settings

Jie Lu et al.

Summary: Serological markers play a crucial role in diagnosing hepatitis E virus infection. This study established a multifactorial model to improve the accuracy of HEV infection diagnosis when HEV RNA detection is not available.

JOURNAL OF CLINICAL MICROBIOLOGY (2021)

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Editorial Material Gastroenterology & Hepatology