4.6 Article

Rare FGFR fusion genes in cervical cancer and transcriptome-based subgrouping of patients with a poor prognosis

Related references

Note: Only part of the references are listed.
Article Oncology

Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer: a randomized, non-inferiority, multicenter trial

Danhui Weng et al.

Summary: This study assessed the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy as an alternative strategy for patients with early-stage cervical cancer. The results showed that adjuvant chemotherapy alone had similar efficacy in terms of prognosis, adverse effects, and quality of life compared to adjuvant concurrent chemoradiotherapy.

FRONTIERS OF MEDICINE (2023)

Article Immunology

Stemness Refines the Classification of Colorectal Cancer With Stratified Prognosis, Multi-Omics Landscape, Potential Mechanisms, and Treatment Options

Zaoqu Liu et al.

Summary: This study deciphers two stemness clusters in colorectal cancer (CRC), which have stratified prognosis, multi-omics landscape, potential mechanisms, and treatment options. It provides new insights into the heterogeneity of cancer stemness and sheds light on optimizing decision-making in immunotherapy and chemotherapy.

FRONTIERS IN IMMUNOLOGY (2022)

Article Oncology

C-CAT: The National Datacenter for Cancer Genomic Medicine in Japan

Takashi Kohno et al.

Summary: Since June 2019, Japan has implemented cancer genomic medicine under the national health insurance system. With the establishment of a network of CGM hospitals and a national datacenter, clinical and genomic data from comprehensive genomic profiling tests are securely transferred and aggregated. The data are used to generate reports containing clinical annotation and information on matched clinical trials, which are now open for sharing with CGM hospitals, academic institutions, and industries.

CANCER DISCOVERY (2022)

Article Oncology

Distribution and prognostic impact of M1 macrophage on esophageal squamous cell carcinoma

Chen Hao Jiang et al.

Summary: M1 macrophages play an important role in esophageal squamous cell carcinoma, correlating with tumor staging, lymph node metastasis, and clinical stage. They inhibit the migration and invasion abilities of cancer cells, serving as a potential prognostic factor for patients with ESCC.

CARCINOGENESIS (2021)

Article Immunology

Macrophages in tumor: An inflammatory perspective

Kuntal Kanti Goswami et al.

CLINICAL IMMUNOLOGY (2021)

Article Oncology

Comparative Analysis of Genetic Alterations, HPV-Status, and PD-L1 Expression in Neuroendocrine Carcinomas of the Cervix

Daisuke Takayanagi et al.

Summary: NECC is a rare and aggressive cancer with limited treatment options. This study identified specific genetic alterations in NECC and potential therapeutic targets. Some NECC cases showed actionable mutations for targeted therapies and increased expression of PD-L1, suggesting the potential for more effective treatments in the future.

CANCERS (2021)

Article Multidisciplinary Sciences

TP53 mutants and non-HPV16/18 genotypes are poor prognostic factors for concurrent chemoradiotherapy in locally advanced cervical cancer

Ikumi Kuno et al.

Summary: In locally advanced cervical cancer, TP53 mutation, large tumor diameter, and non-HPV16/18 genotype were independently correlated with poor progression-free survival, despite receiving concurrent chemoradiotherapy.

SCIENTIFIC REPORTS (2021)

Article Genetics & Heredity

Genomic alterations associated with mutational signatures, DNA damage repair and chromatin remodeling pathways in cervical carcinoma

Mari K. Halle et al.

Summary: This study identified previously unreported significantly mutated genes, amplifications, and deletions in cervical cancer, providing potential targets and prognostic markers for clinical applications. Distinctive copy number alterations related to specific mutations were observed, with unique amplifications within certain tumor types. Aberrations within DNA damage repair and chromatin remodeling genes were also detected at a high frequency.

NPJ GENOMIC MEDICINE (2021)

Article Multidisciplinary Sciences

Distribution of genetic alterations in high-risk early-stage cervical cancer patients treated with postoperative radiation therapy

Naoya Murakami et al.

Summary: In this study, somatic genetic alterations were analyzed in high-risk early-stage uterine cervical cancer patients who underwent post-operative radiation therapy, identifying actionable mutations in approximately one-third of patients. The 5-year relapse-free survival rate was 72.6%, and the overall survival rate was 85.9%, demonstrating the potential of precision medicine in treating high-risk uterine cervical cancer patients in the future.

SCIENTIFIC REPORTS (2021)

Article Obstetrics & Gynecology

The baseline recurrence risk of patients with intermediate-risk cervical cancer

Yutaka Yoneoka et al.

Summary: The study found that patients with intermediate-risk cervical cancer, specifically those with squamous cell carcinoma, had good prognosis without adjuvant therapy. On the other hand, patients with endocervical adenocarcinoma, usual type, or adenosquamous carcinoma had a poorer prognosis without adjuvant therapy. Therefore, adjuvant therapy may be omitted for the former group while it should be considered for the latter group.

OBSTETRICS & GYNECOLOGY SCIENCE (2021)

Article Oncology

Cervical Cancer, Version 1.2020 Featured Updates to the NCCN Guidelines

Nadeem R. Abu-Rustum et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2020)

Article Ethnic Studies

Racial/ethnic variation in the prevalence of vaccine-related human papillomavirus genotypes

Jane R. Montealegre et al.

ETHNICITY & HEALTH (2019)

Article Biotechnology & Applied Microbiology

Determining cell type abundance and expression from bulk tissues with digital cytometry

Aaron M. Newman et al.

NATURE BIOTECHNOLOGY (2019)

Article Clinical Neurology

GOPC-ROS1 Fusion Due to Microdeletion at 6q22 Is an Oncogenic Driver in a Subset of Pediatric Gliomas and Glioneuronal Tumors

Timothy E. Richardson et al.

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2019)

Article Oncology

Japan Society of Gynecologic Oncology guidelines 2017 for the treatment of uterine cervical cancer

Yasuhiko Ebina et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2019)

Article Biochemistry & Molecular Biology

GENCODE reference annotation for the human and mouse genomes

Adam Frankish et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Obstetrics & Gynecology

Cancer of the cervix uteri

Neerja Bhatla et al.

INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS (2018)

Review Biochemistry & Molecular Biology

Role of Extracellular Matrix in Development and Cancer Progression

Cameron Walker et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Article Multidisciplinary Sciences

Integrative clinical genomics of metastatic cancer

Dan R. Robinson et al.

NATURE (2017)

Article Multidisciplinary Sciences

Integrated genomic and molecular characterization of cervical cancer

Robert D. Burk et al.

NATURE (2017)

Article Biochemistry & Molecular Biology

Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Ahmet Zehir et al.

NATURE MEDICINE (2017)

Article Biochemistry & Molecular Biology

The Reactome pathway Knowledgebase

Antonio Fabregat et al.

NUCLEIC ACIDS RESEARCH (2016)

Review Biochemistry & Molecular Biology

Functions of Fibroblast Growth Factor Receptors in cancer defined by novel translocations and mutations

Leandro H. Gallo et al.

CYTOKINE & GROWTH FACTOR REVIEWS (2015)

Article Oncology

Japan Society of Gynecologic Oncology guidelines 2011 for the treatment of uterine cervical cancer

Yasuhiko Ebina et al.

INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY (2015)

Article Biochemistry & Molecular Biology

Coiled-coil Coactivators Play a Structural Role Mediating Interactions in Hypoxia-inducible Factor Heterodimerization

Yirui Guo et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Biotechnology & Applied Microbiology

StringTie enables improved reconstruction of a transcriptome from RNA-seq reads

Mihaela Pertea et al.

NATURE BIOTECHNOLOGY (2015)

Article Genetics & Heredity

Aurora-A-Dependent Control of TACC3 Influences the Rate of Mitotic Spindle Assembly

Selena G. Burgess et al.

PLOS GENETICS (2015)

Article Biochemistry & Molecular Biology

The landscape and therapeutic relevance of cancer-associated transcript fusions

K. Yoshihara et al.

ONCOGENE (2015)

Article Multidisciplinary Sciences

Landscape of genomic alterations in cervical carcinomas

Akinyemi I. Ojesina et al.

NATURE (2014)

Article Multidisciplinary Sciences

The landscape of kinase fusions in cancer

Nicolas Stransky et al.

NATURE COMMUNICATIONS (2014)

Article Biochemistry & Molecular Biology

Functional roles of fibroblast growth factor receptors (FGFRs) signaling in human cancers

Kai Hung Tiong et al.

APOPTOSIS (2013)

Article Biochemical Research Methods

STAR: ultrafast universal RNA-seq aligner

Alexander Dobin et al.

BIOINFORMATICS (2013)

Article Medicine, General & Internal

Human papillomavirus and cervical cancer

Emma J. Crosbie et al.

LANCET (2013)

Article Multidisciplinary Sciences

Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma

Devendra Singh et al.

SCIENCE (2012)

Review Immunology

Alternative Activation of Macrophages: Mechanism and Functions

Siamon Gordon et al.

IMMUNITY (2010)

Review Genetics & Heredity

Evolution of the Fgf and Fgfr gene families

N Itoh et al.

TRENDS IN GENETICS (2004)

Article Multidisciplinary Sciences

The TACC domain identifies a family of centrosomal proteins that can interact with microtubules

F Gergely et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)