4.6 Article

Determining patients with spinal metastases suitable for surgical intervention: A cost-effective analysis

Related references

Note: Only part of the references are listed.
Article Clinical Neurology

30 Gy in 4 Stereotactic Body Radiotherapy Fractions for Complex Spinal Metastases: Mature Outcomes Supporting This Novel Regimen

Daniel Moore-Palhares et al.

Summary: This study reports the outcomes of a novel fractionation scheme, 30 Gy in 4 fractions, for the treatment of spinal metastases. The results show that this approach is safe and effective, especially for patients with a clinical target volume (CTV) volume of ≥72 cc.

NEUROSURGERY (2023)

Article Clinical Neurology

Body composition predictors of mortality on computed tomography in patients with spinal metastases undergoing surgical treatment

Michiel E. R. Bongers et al.

Summary: This study aimed to predict the 90-day and 1-year mortality in patients with spinal metastases undergoing surgery using body composition measures obtained on opportunistic abdomen CTs. The study found that sarcopenia was associated with an increased risk of 1-year mortality, even after controlling for other clinical factors.

SPINE JOURNAL (2022)

Article Economics

Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) Statement: Updated Reporting Guidance for Health Economic Evaluations

Don Husereau et al.

Summary: The Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement was created to ensure health economic evaluations are identifiable, interpretable, and useful for decision making. The new CHEERS 2022 statement replaces previous guidance and reflects the need for guidance that can be applied to all types of health economic evaluation and includes stakeholder involvement.

VALUE IN HEALTH (2022)

Article Oncology

Mature Local Control and Reirradiation Rates Comparing Spine Stereotactic Body Radiation Therapy With Conventional Palliative External Beam Radiation Therapy

K. Liang Zeng et al.

Summary: Stereotactic body radiation therapy (SBRT) improves complete pain response for painful spinal metastases compared with conventional external beam radiation therapy (cEBRT). This study analyzed a large cohort of patients to compare local control and reirradiation rates between SBRT and cEBRT. The findings suggest that SBRT has a lower risk of local failure and reirradiation compared to cEBRT for spinal metastases.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2022)

Article Oncology

Prognostic significance of lab data and performance comparison by validating survival prediction models for patients with spinal metastases after radiotherapy

Hung-Kuan Yen et al.

Summary: This retrospective study investigates the prognostic impacts of laboratory data and compares the performances of different prediction models for spinal metastases (SM). The results show that laboratory data are of prognostic significance, and the machine learning-based SORG-MLA model outperforms other models in survival predictions.

RADIOTHERAPY AND ONCOLOGY (2022)

Article Clinical Neurology

Prospective validation of a clinical prediction score for survival in patients with spinal metastases: the New England Spinal Metastasis Score

Andrew J. Schoenfeld et al.

Summary: The study successfully validates the utility of NESMS in predicting survival for patients with spinal metastatic disease, regardless of treatment strategy. It is the first prospective validation study for prognostic utility in patients with spinal metastases. NESMS can be directly applied to patient care, hospital-based practice, and healthcare policy.

SPINE JOURNAL (2021)

Article Clinical Neurology

Health related quality of life outcomes following surgery and/or radiation for patients with potentially unstable spinal metastases

Annemarie L. Versteeg et al.

Summary: Surgery in patients with potentially unstable spinal metastases showed significant and sustained improvements in pain and HRQOL up to 1-year post-surgery, while treatment with radiotherapy alone resulted in short-term pain relief but no significant changes in HRQOL. Different clinical profiles were observed in patients treated with surgery or radiotherapy alone within the SINS potentially unstable group.

SPINE JOURNAL (2021)

Editorial Material Orthopedics

CORR Insights®: What Is the Value of Undergoing Surgery for Spinal Metastases at Dedicated Cancer Centers?

Stein J. Janssen

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2021)

Review Clinical Neurology

Utility of prediction model score: a proposed tool to standardize the performance and generalizability of clinical predictive models based on systematic review

Jeff Ehresman et al.

Summary: This study evaluated current prediction models in spine metastasis and degenerative spine disease to create a scoring system. Only a few models were rated as excellent, most fell under good, fair, or poor. The performance and characteristics of prediction models impact their reliability and usability in clinical settings.

JOURNAL OF NEUROSURGERY-SPINE (2021)

Article Clinical Neurology

International external validation of the SORG machine learning algorithms for predicting 90-day and one-year survival of patients with spine metastases using a Taiwanese cohort

Jiun-Jen Yang et al.

Summary: The study validated the SORG machine-learning algorithms for predicting 90-day and one-year mortality in Taiwanese patients with spinal metastatic disease. The algorithms showed good discriminative ability, overall performance, and positive net benefit. However, 90-day mortality was underestimated in this group possibly due to differences in primary tumor characteristics, body mass index, selection bias, or other factors. Further validation with international and diverse populations may help clarify these inconsistencies.

SPINE JOURNAL (2021)

Review Orthopedics

Availability and reporting quality of external validations of machine-learning prediction models with orthopedic surgical outcomes: a systematic review

Olivier Q. Groot et al.

Summary: External validation of machine learning prediction models in orthopedic surgery is essential but currently lacking. Most existing models have not been externally validated, and the available validation studies demonstrate incomplete reporting of performance measures. Further research is needed for transparent evaluation and clinical implementation of these predictive models.

ACTA ORTHOPAEDICA (2021)

Article Clinical Neurology

Updated external validation of the SORG machine learning algorithms for prediction of ninety-day and one-year mortality after surgery for spinal metastasis

Akash A. Shah et al.

Summary: This study validated the SORG machine learning algorithms for predicting 90-day and 1-year mortality after surgery for spinal metastasis. The algorithms demonstrated excellent discrimination for 90-day mortality and good calibration for 1-year mortality. The externally validated algorithms may inform shared decision-making with patients in managing spinal metastatic disease.

SPINE JOURNAL (2021)

Article Orthopedics

Estimating survival and choosing treatment for spinal metastases: Do spine surgeons agree with each other?

Quirina C. B. S. Thio et al.

Summary: The study found significant variability in survival estimates among spine surgeons, with survival generally being overestimated and longer estimated survival leading to more invasive procedures. Prognostic models to estimate survival may help surgeons treating patients with spinal metastases.

JOURNAL OF ORTHOPAEDICS (2021)

Review Orthopedics

Wide range of applications for machine-learning prediction models in orthopedic surgical outcome: a systematic review

Paul T. Ogink et al.

Summary: The study evaluated the development of clinical prediction models based on machine learning in orthopedic surgery, finding that medical management is the most commonly studied topic and neural networks are the most frequently employed algorithm. However, calibration and decision-curve analysis were generally poorly reported in these studies.

ACTA ORTHOPAEDICA (2021)

Article Oncology

Stereotactic body radiotherapy versus conventional external beam radiotherapy in patients with painful spinal metastases: an open-label, multicentre, randomised, controlled, phase 2/3 trial

Arjun Sahgal et al.

Summary: Stereotactic body radiotherapy at a dose of 24 Gy in two daily fractions was found to be superior to conventional external beam radiotherapy at a dose of 20 Gy in five daily fractions in improving the complete response rate for pain in patients with painful spinal metastasis. This suggests that conformal, image-guided, dose-escalated radiotherapy is appropriate for symptom control in selected patients with painful spinal metastases, highlighting the importance of specialized and multidisciplinary care in end-of-life treatment.

LANCET ONCOLOGY (2021)

Review Clinical Neurology

Design of the prospective observational study of spinal metastasis treatment (POST)

Andrew J. Schoenfeld et al.

SPINE JOURNAL (2020)

Article Clinical Neurology

Complications and reoperations after surgery for 647 patients with spine metastatic disease

Nuno Rui Paulino Pereira et al.

SPINE JOURNAL (2019)

Editorial Material Clinical Neurology

The next generation in surgical research for patients with spinal metastases

Andrew J. Schoenfeld et al.

SPINE JOURNAL (2018)

Article Clinical Neurology

Modeling 1-year survival after surgery on the metastatic spine

Ahmer K. Ghori et al.

SPINE JOURNAL (2015)

Article Oncology

New prognostic factors and scoring system for patients with skeletal metastasis

Hirohisa Katagiri et al.

CANCER MEDICINE (2014)

Article Orthopedics

Is Surgery for Spine Metastasis Reasonable in Patients Older Than 60 Years?

Tangzhao Liang et al.

CLINICAL ORTHOPAEDICS AND RELATED RESEARCH (2013)

Review Orthopedics

Metastatic Disease in the Thoracic and Lumbar Spine: Evaluation and Management

Peter S. Rose et al.

JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS (2011)

Article Social Sciences, Mathematical Methods

eq5d: A command to calculate index values for the EQ-5D quality-of-life instrument

Juan Manuel Ramos-Goni et al.

STATA JOURNAL (2011)