Body composition is associated with disease aetiology and prognosis in patients undergoing resection of intrahepatic cholangiocarcinoma

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LIVER CANCER (2022)

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Prognostic and Predictive Molecular Markers in Cholangiocarcinoma

Sandra Pavicevic et al.

Summary: Cholangiocarcinoma is a rapidly increasing global malignancy of the biliary tract, often presenting with advanced or unresectable disease. Biomarkers obtained from patients' serum or tumor tissue could help guide therapy and identify those at higher risk of recurrence. Genetic aberrations in cholangiocarcinoma have also been linked with improved response to targeted therapies. This review provides an overview of prognostic and predictive biomarkers in cholangiocarcinoma.

CANCERS (2022)

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Impact of sarcopenia on outcomes of patients undergoing liver resection for hepatocellular carcinoma

Jinhuan Yang et al.

Summary: This study found that sarcopenia is associated with adverse outcomes after liver resection for HCC, with higher rates of major complications, blood transfusion, hospitalization expenses, and longer hospital stay. Evaluating sarcopenia upon admission can help classify high-risk patients and reduce the risk of major complications.

JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2022)

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Article Gastroenterology & Hepatology

The prognostic impact of preoperative body composition in perihilar and intrahepatic cholangiocarcinoma

Isabella Lurje et al.

Summary: This study investigated the prevalence of body composition (BC) alterations and their prognostic role for surgical patients with cholangiocarcinoma (CCA). The study found that sarcopenic obesity may affect long-term survival, indicating that imaging-based analysis of BC could aid preoperative patient selection.

HEPATOLOGY COMMUNICATIONS (2022)

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Body fat composition determines outcomes before and after liver transplantation in patients with cirrhosis

Cornelius Engelmann et al.

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HEPATOLOGY COMMUNICATIONS (2022)

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Dietary cholesterol drives fatty liver-associated liver cancer by modulating gut microbiota and metabolites

Xiang Zhang et al.

Summary: High dietary cholesterol leads to sequential progression of steatosis, steatohepatitis, fibrosis and eventually HCC in mice, concomitant with insulin resistance. Cholesterol-induced NAFLD-HCC formation is associated with gut microbiota dysbiosis, with specific bacterial composition changes between stages of liver disease. Alterations in gut bacterial metabolites were also observed with dietary cholesterol intake. Therapies targeting cholesterol and gut microbiota may be effective for preventing NAFLD-HCC.

GUT (2021)

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Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention

Daniel Q. Huang et al.

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NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

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Obesity is a risk factor for intrahepatic cholangiocarcinoma progression associated with alterations of metabolic activity and immune status

Kyohei Yugawa et al.

Summary: This study investigated the relationship between BMI and the long-term outcomes of patients with intrahepatic cholangiocarcinoma (ICC). The results showed that patients in the obesity group had significantly worse prognoses, and BMI displayed a positive correlation with F-18-FDG uptake. Obesity was associated with larger tumor size and higher intrahepatic metastasis rate in ICC patients.

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Zoltan Czigany et al.

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JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE (2021)

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Article Multidisciplinary Sciences

Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

Michael Dudek et al.

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NATURE (2021)

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Metabolic dysfunction-associated fatty liver disease is associated with increased all-cause mortality in the United States

Donghee Kim et al.

Summary: This study demonstrated that metabolic dysfunction-associated fatty liver disease (MAFLD) was associated with an increased risk of all-cause mortality in US adults, while non-alcoholic fatty liver disease (NAFLD) showed no association with all-cause mortality after adjusting for metabolic risk factors. Individuals who met the criteria for MAFLD but not NAFLD had a higher risk of all-cause mortality.

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Association of Body Composition and Sarcopenia with NASH in Obese Patients

Sophia Marie-Therese Schmitz et al.

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Article Medicine, General & Internal

Sarcopenia and Myosteatosis as Prognostic Markers in Patients with Advanced Cholangiocarcinoma Undergoing Palliative Treatment

Markus S. Jordens et al.

Summary: This study assessed the prognostic significance of sarcopenia and myosteatosis using routine abdominal CT scans in advanced stage CCA patients undergoing palliative treatment. The results showed that L3SMI, L3PMI, and MMA are negative prognostic factors associated with reduced overall survival in these patients.

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Myosteatosis to predict inferior perioperative outcome in patients undergoing orthotopic liver transplantation

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Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: A systematic review and meta-analysis

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Adipose Tissue-Liver Cross Talk in the Control of Whole-Body Metabolism: Implications in Nonalcoholic Fatty Liver Disease

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Cholangiocarcinoma 2020: the next horizon in mechanisms and management

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Prognostic Nomogram for Intrahepatic Cholangiocarcinoma After Partial Hepatectomy

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Body composition is associated with disease aetiology and prognosis in patients undergoing resection of intrahepatic cholangiocarcinoma

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