Mitochondria Dictate Function and Fate of HSCs and T Cells

Article Cell Biology

Induction of mitochondrial recycling reverts age-associated decline of the hematopoietic and immune systems

Mukul Girotra et al.

Summary: Aging impairs hematopoietic and immune system functions, but restoring mitochondrial function can reverse aging in hematopoietic stem cells and improve immune system function.

NATURE AGING (2023)

Add to Collection

Article Hematology

PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity

Christopher Ronald Funk et al.

BLOOD (2022)

Add to Collection

Article Multidisciplinary Sciences

Decade-long leukaemia remissions with persistence of CD4(+) CAR T cells

J. Joseph Melenhorst et al.

Summary: CAR T cells redirected to target CD19 demonstrated long-lasting potential and clonal stability in two patients with chronic lymphocytic leukaemia. Highly activated CD4(+) cells emerged and dominated the CAR T cell population at later time points. These unexpected CAR T cell populations provide novel insights into anti-cancer response and long-term remission in leukaemia.

NATURE (2022)

Add to Collection

Article Oncology

Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors

Yosuke Dotsu et al.

Summary: PQDN, a small molecule, has been identified to enhance CD8 T cell activation by activating mitochondrial ETC, even in the presence of weak antigen stimulation. Intratumoral administration of PQDN improves therapeutic efficacy by enhancing antitumor immune responses and retarding tumor growth.

JOURNAL FOR IMMUNOTHERAPY OF CANCER (2022)

Add to Collection

Article Hematology

Asymmetric organelle inheritance predicts human blood stem cell fate

Dirk Loeffler et al.

Summary: This study reveals the presence of asymmetric cell division in human blood stem cells, showing that lysosomes and active mitochondria are asymmetrically inherited and their inheritance is coordinated. There are also other organelles that show preferential asymmetric segregation with lysosomes. The asymmetric inheritance of lysosomes predicts the future fate of daughter cells, while the asymmetric inheritance of active mitochondria correlates with daughter metabolic activity.

BLOOD (2022)

Add to Collection

Article Cell Biology

The mitochondrial pyruvate carrier regulates memory T cell differentiation and antitumor function

Mathias Wenes et al.

Summary: Mitochondrial pyruvate uptake instructs metabolic flexibility for guiding T cell differentiation and antitumor responses.

CELL METABOLISM (2022)

Add to Collection

Article Cell Biology

A genome-scale gain-of-function CRISPR screen in CD8 T cells identifies proline metabolism as a means to enhance CAR-T therapy

Lupeng Ye et al.

Summary: This study developed a dgRNA-based CRISPR activation screen to identify gain-of-function (GOF) targets for CAR-T engineering. Enhancing PRODH2 expression improved the killing ability and in vivo efficacy of CAR-T cells against cancer. Metabolic and immunological analyses showed that PRODH2 engineering enhances the metabolic and immune functions of CAR-T cells.

CELL METABOLISM (2022)

Add to Collection

Article Oncology

PD-1-induced T cell exhaustion is controlled by a Drp1-dependent mechanism

Luca Simula et al.

Summary: The PD-1 signaling pathway downregulates T-cell response by inhibiting Drp1 activity, leading to reduced motility and proliferation of tumor-infiltrating T cells. This highlights the potential of targeting Drp1 activity as a valuable strategy to enhance anticancer immune response in future immunotherapy approaches.

MOLECULAR ONCOLOGY (2022)

Add to Collection

Article Oncology

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

Julia A. Belk et al.

Summary: This study demonstrates that modulation of chromatin remodeling complexes improves the persistence of T cells in tumors and enhances antitumor immunity, providing important insights into the genetic regulators of T cell exhaustion.

CANCER CELL (2022)

Add to Collection

Review Medicine, Research & Experimental

Targeting memory T cell metabolism to improve immunity

Mauro Corrado et al.

Summary: Vaccination activates specific immune cells to provide protection and promote the development of immune memory against specific pathogens. Recent research has made progress in defining the metabolism of memory T cells and discussed the impact of metabolic abnormalities on infections and vaccine efficacy.

JOURNAL OF CLINICAL INVESTIGATION (2022)

Add to Collection

Article Immunology

Enforced PGC-1α expression promotes CD8 T cell fitness, memory formation and antitumor immunity

Nina Dumauthioz et al.

Summary: The overexpression of PGC-1 alpha favors central memory formation of CD8 T cells and enhances antitumor immunity. CD8 T cells with enhanced PGC-1 alpha expression show stronger antitumor immunity in a melanoma model.

CELLULAR & MOLECULAR IMMUNOLOGY (2021)

Add to Collection

Article Cell & Tissue Engineering

Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function

Els Mansell et al.

Summary: This study demonstrates that mitochondrial membrane potential (MMP) plays a crucial role in old hematopoietic stem cells (HSCs) and its pharmacological manipulation can alter transcriptional programs with beneficial consequences for function. Enhancing MMP in old HSCs can increase engraftment potential upon transplantation and reverse myeloid-biased peripheral blood output.

CELL STEM CELL (2021)

Add to Collection

Article Medicine, Research & Experimental

Mitigating oxygen stress enhances aged mouse hematopoietic stem cell numbers and function

Maegan L. Capitano et al.

Summary: Research indicates that collecting and processing old bone marrow cells under hypoxic conditions enhances their engraftment capability and functionality, reducing stress associated with ambient air collection and suggesting that aged bone marrow can be more efficiently used for hematopoietic cell transplantation.

JOURNAL OF CLINICAL INVESTIGATION (2021)

Add to Collection

Article Immunology

Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion

Nicole E. Scharping et al.

Summary: Continuous TCR signaling and hypoxia increase Blimp-1, suppressing mitochondrial reprogramming and generating reactive oxygen species, leading to T cell exhaustion. Mitigating T cell-intrinsic ROS and reducing tumor hypoxia can limit T cell exhaustion, synergizing with immunotherapy.

NATURE IMMUNOLOGY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Mitochondrial Contributions to Hematopoietic Stem Cell Aging

Claudia Morganti et al.

Summary: Mitochondrial dysfunction and stem cell exhaustion are characteristic features of aging, particularly in the hematopoietic system. Understanding the key mechanisms of HSC aging, including mitochondrial ROS production and alterations in metabolism, could lead to the identification of new therapeutic targets to prevent, delay, or reverse aspects of the aging process.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Hematology

TWIST1 preserves hematopoietic stem cell function via the CACNA1B/Ca2+/mitochondria axis

Nan Wang et al.

Summary: The transcription factor TWIST1 is identified as a critical regulator of HSC maintenance by modulating mitochondrial function. Deletion of Twist1 leads to decreased HSC frequency, impaired self-renewal capacity, skewed myeloid differentiation, and compromised stress tolerance. The mechanism involves activation of voltage-gated calcium channel Cacna1b, resulting in increased mitochondrial calcium levels, metabolic activity, and reactive oxygen species production, which can be rescued by calcium channel blocker under stress conditions.

BLOOD (2021)

Add to Collection

Article Immunology

Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T cells during the primary immune response

Lauren S. Levine et al.

Summary: Memory T cells rely on oxidative phosphorylation, while short-lived effector T cells rely on glycolysis. The study revealed a distinct metabolic state in early-activated T cells characterized by maximal expression of glycolytic and oxidative metabolic proteins, which rapidly decreased after 5 days post-infection. This transient state was also observed in chimeric antigen receptor (CAR) T cells in lymphoma patients.

IMMUNITY (2021)

Add to Collection

Article Hematology

Using mitochondrial activity to select for potent human hematopoietic stem cells

Jiajing Qiu et al.

Summary: Research has found that human HSCs show variations in mitochondrial activity, with the most potent HSCs exhibiting the lowest mitochondrial activity in the population. HSCs with low MMP have a higher frequency of long-term culture initiating cells and greater long-term repopulating capacity after transplantation in immunodeficient mice compared to HSCs with high MMP.

BLOOD ADVANCES (2021)

Add to Collection

Article Cell & Tissue Engineering

Decline in IGF1 in the bone marrow microenvironment initiates hematopoietic stem cell aging

Kira Young et al.

Summary: As individuals age, the function of hematopoietic stem cells (HSCs) declines, leading to limited health span of the blood and immune systems. Research indicates that the hallmarks of aging in HSCs and hematopoiesis start accumulating by middle age, with decreased levels of the longevity-associated molecule IGF1 in the bone marrow microenvironment playing a key role in causing HSC aging. By directly stimulating middle-aged HSCs with IGF1, molecular and functional hallmarks of aging can be rescued, highlighting the complex relationship between IGF1 levels, longevity, and HSC function.

CELL STEM CELL (2021)

Add to Collection

Review Oncology

Fueling T-cell Antitumor Immunity: Amino Acid Metabolism Revisited

Chenfeng Han et al.

Summary: T cells play a crucial role in eliminating malignant tumors and their activation and differentiation are tightly controlled at multiple levels. Amino acids are essential for T cell antitumor immunity, but their deprivation or accumulation within the tumor microenvironment can diminish T cell functionality. Modulating amino acid metabolism in T cells may be a potential strategy to enhance the efficacy of immunotherapy.

CANCER IMMUNOLOGY RESEARCH (2021)

Add to Collection

Article Multidisciplinary Sciences

Mitochondrial C1qbp promotes differentiation of effector CD8+ T cells via metabolic-epigenetic reprogramming

Xingyuan Zhai et al.

Summary: C1qbp plays a crucial role in the differentiation of effector CD8(+) T cells by regulating mitochondrial oxidative phosphorylation, affecting levels of acetyl-coenzyme A and fumarate, influencing the methylation status of H3K27, and impacting the transcriptional levels of effector genes.

SCIENCE ADVANCES (2021)

Add to Collection

Article Cell Biology

'Off-the-Shelf' Immunotherapy: Manufacture of CD8+ T Cells Derived from Hematopoietic Stem Cells

Nicholas Boyd et al.

Summary: This study demonstrates an in vitro method for differentiating T cells from umbilical cord blood hematopoietic stem cells, which can potentially increase T cell yields, simplify manufacturing, and reduce costs.

CELLS (2021)

Add to Collection

Article Multidisciplinary Sciences

Distinct fission signatures predict mitochondrial degradation or biogenesis

Tatjana Kleele et al.

Summary: Mitochondrial fission is a highly regulated process that can impact cell function and health. Depending on the location and manner of division, mitochondria can be divided into two types, one for clearing damaged material and undergoing mitophagy, and the other for mitochondrial proliferation.

NATURE (2021)

Add to Collection

Article Multidisciplinary Sciences

Mutant ASXL1 induces age-related expansion of phenotypic hematopoietic stem cells through activation of Akt/mTOR pathway

Takeshi Fujino et al.

Summary: ASXL1 mutations are frequently detected in age-related clonal hematopoiesis (CH), but their mechanism in driving CH remains unclear. The study demonstrates that expression of C-terminal truncated ASXL1 in hematopoietic stem cells leads to Akt de-ubiquitination, activated Akt/mTOR signaling, and aberrant HSC proliferation.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Cell & Tissue Engineering

TFEB-mediated endolysosomal activity controls human hematopoietic stem cell fate

Laura Garcia-Prat et al.

Summary: This study reveals that transcription factor EB-mediated control of lysosomal activity plays a central role in regulating the fate determination of stem cells. TFEB induces the endolysosomal pathway to limit LT-HSC activation, promoting quiescence and self-renewal, while MYC engages biosynthetic processes to drive stem cell activation.

CELL STEM CELL (2021)

Add to Collection

Review Hematology

The Akt-mTOR network at the interface of hematopoietic stem cell homeostasis

Feng Wu et al.

Summary: Hematopoietic stem cells require homeostasis for their potential and lifelong hematopoiesis, with the Akt-mTOR network playing a central role in regulating HSC homeostasis and affecting various cellular processes.

EXPERIMENTAL HEMATOLOGY (2021)

Add to Collection

Article Immunology

Epigenetic scars of CD8+ T cell exhaustion persist after cure of chronic infection in humans

Kathleen B. Yates et al.

Summary: Exhausted CD8(+) T cells exhibit a stable core epigenetic exhaustion signature that is largely irreversible even after the resolution of chronic infection. The epigenetic state of exhaustion persists independent of chronic antigen stimulation and inflammation, suggesting that therapeutic efforts to reverse T cell exhaustion may require increasing the epigenetic plasticity of exhausted T cells.

NATURE IMMUNOLOGY (2021)

Add to Collection

Article Immunology

Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity

Yugang Guo et al.

Summary: The study demonstrates that a half-life-extended IL-10-Fc fusion protein can enhance the function of terminally exhausted CD8(+) tumor-infiltrating lymphocytes by promoting oxidative phosphorylation, leading to improved response to cancer immunotherapy.

NATURE IMMUNOLOGY (2021)

Add to Collection

Article Multidisciplinary Sciences

Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development

Jianli He et al.

Summary: Research findings indicate that SUMO protease SENP1 promotes T cell memory development through Sirt3 deSUMOylation and enhances mitochondrial fusion and OXPHOS. Additionally, the glycolytic intermediate fructose-1,6-bisphosphate (FBP) acts as a negative regulator that suppresses AMPK-mediated activation of the SENP1-Sirt3 axis, thereby decreasing T cell memory development. Glucose limitation activates AMPK and subsequent SENP1-Sirt3 signaling to promote T cell memory development. Memory T cells heavily rely on fatty acid oxidation, which is controlled by AMPK sensing of glucose scarcity triggering SENP1-Sirt3 signaling for mitochondrial fusion and memory differentiation.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Multidisciplinary Sciences

Single-cell transcriptome of early hematopoiesis guides arterial endothelial-enhanced functional T cell generation from human PSCs

Jun Shen et al.

Summary: This study used single-cell transcriptomic analysis to explore hematopoietic differentiation of human pluripotent stem cells and found that hypoxic conditions during differentiation promoted the generation of functional T cells, which inhibited tumor growth in vitro and in vivo. This represents a significant advancement in guiding the generation of functional T cells for clinical applications.

SCIENCE ADVANCES (2021)

Add to Collection

Article Cell Biology

Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy

Yan-Ruid Li et al.

Summary: Through hematopoietic stem cell gene engineering and in vitro differentiation, human allogeneic iNKT cells can be produced at high yield and purity, effectively targeting tumor cells with low immunogenicity. These cells can be further engineered to enhance tumor targeting or reduce immunogenicity for potential cancer therapy.

CELL REPORTS MEDICINE (2021)

Add to Collection

Article Cell & Tissue Engineering

Mitochondria Transfer in Bone Marrow Hematopoietic Activity

Abhishek K. Singh et al.

Summary: Recent research has shown that the interaction between hematopoietic stem cells (HSC) and the bone marrow (BM) microenvironment is crucial for maintaining homeostasis and hematopoietic regeneration during blood formation emergencies. Mitochondria have been identified as potential regulators of HSC fate, with mitochondria transfer playing a key role in maintaining HSC activity and supporting stem cell transplantation and regenerative medicine. Additionally, the transfer of healthy mitochondria from BM stromal cells to HSC has been found to promote HSC bioenergetics shift and stimulate leukocyte expansion, highlighting the importance of mitochondrial dynamics in hematopoietic and BM regeneration.

CURRENT STEM CELL REPORTS (2021)

Add to Collection

Article Cell & Tissue Engineering

Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency

Raymond Liang et al.

CELL STEM CELL (2020)

Add to Collection

Article Cell & Tissue Engineering

Asymmetrically Segregated Mitochondria Provide Cellular Memory of Hematopoietic Stem Cell Replicative History and Drive HSC Attrition

Ashwini Hinge et al.

CELL STEM CELL (2020)

Add to Collection

Article Multidisciplinary Sciences

T cells with dysfunctional mitochondria induce multimorbidity and premature senescence

Gabriela Desdin-Mico et al.

SCIENCE (2020)

Add to Collection

Review Cell Biology

Hematopoietic Stem Cell Metabolism during Development and Aging

Ayako Nakamura-Ishizu et al.

DEVELOPMENTAL CELL (2020)

Add to Collection

Article Cell Biology

Sirt2 Inhibition Enhances Metabolic Fitness and Effector Functions of Tumor-Reactive T Cells

Imene Hamaidi et al.

CELL METABOLISM (2020)

Add to Collection

Article Hematology

Bone marrow regeneration requires mitochondrial transfer from donor Cx43-expressing hematopoietic progenitors to stroma

Karin Golan et al.

BLOOD (2020)

Add to Collection

Article Immunology

Impaired mitochondrial oxidative phosphorylation limits the self-renewal of T cells exposed to persistent antigen

Santosha A. Vardhana et al.

NATURE IMMUNOLOGY (2020)

Add to Collection

Article Immunology

Disturbed mitochondrial dynamics in CD8+TILs reinforce T cell exhaustion

Yi-Ru Yu et al.

NATURE IMMUNOLOGY (2020)

Add to Collection

Article Cell & Tissue Engineering

The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance

Nicola Vannini et al.

CELL STEM CELL (2019)

Add to Collection

Article Immunology

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

Brian C. Miller et al.

NATURE IMMUNOLOGY (2019)

Add to Collection

Article Cell Biology

Mitochondrial Stress-Initiated Aberrant Activation of the NLRP3 Inflammasome Regulates the Functional Deterioration of Hematopoietic Stem Cell Aging

Hanzhi Luo et al.

CELL REPORTS (2019)

Add to Collection

Article Immunology

The Transcription Factor Bhlhe40 Programs Mitochondria! Regulation of Resident CD8+ T Cell Fitness and Functionality

Chaofan Li et al.

IMMUNITY (2019)

Add to Collection

Correction Multidisciplinary Sciences

Asymmetric lysosome inheritance predicts activation of haematopoietic stem cells (vol 573, pg 426, 2019)

Dirk Loeffler et al.

NATURE (2019)

Add to Collection

Article Immunology

Metabolic Profiling Using Stable Isotope Tracing Reveals Distinct Patterns of Glucose Utilization by Physiologically Activated CD8+ T Cells

Eric H. Ma et al.

IMMUNITY (2019)

Add to Collection

Article Cell Biology

NIX-Mediated Mitophagy Promotes Effector Memory Formation in Antigen-Specific CD8+ T Cells

Shubhranshu S. Gupta et al.

CELL REPORTS (2019)

Add to Collection

Article Multidisciplinary Sciences

Targeting REGNASE-1 programs long-lived effector T cells for cancer therapy

Jun Wei et al.

NATURE (2019)

Add to Collection

Article Immunology

Metabolic reprogramming of human CD8+ memory T cells through loss of SIRT1

Mark Y. Jeng et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Add to Collection

Article Cell Biology

The mitochondrial unfolded protein response is activated upon hematopoietic stem cell exit from quiescence

Mary Mohrin et al.

AGING CELL (2018)

Add to Collection

Article Hematology

SRC-3 is involved in maintaining hematopoietic stem cell quiescence by regulation of mitochondrial metabolism in mice

Mengjia Hu et al.

BLOOD (2018)

Add to Collection

Article Immunology

Early effector maturation of naive human CD8+ Tcells requires mitochondrial biogenesis

Marco Fischer et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2018)

Add to Collection

Article Immunology

Mitochondria-Endoplasmic Reticulum Contact Sites Function as Immunometabolic Hubs that Orchestrate the Rapid Recall Response of Memory CD8(+) T Cells

Glenn R. Bantug et al.

IMMUNITY (2018)

Add to Collection

Review Cell Biology

Mitochondrial activity in T cells

Gabriela Desdin-Mico et al.

MITOCHONDRION (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

Joseph A. Fraietta et al.

NATURE MEDICINE (2018)

Add to Collection

Article Hematology

Membrane-potential compensation reveals mitochondrial volume expansion during HSC commitment

Massimo Bonora et al.

EXPERIMENTAL HEMATOLOGY (2018)

Add to Collection

Article Cell Biology

Drp1 Controls Effective T Cell Immune-Surveillance by Regulating T Cell Migration, Proliferation, and cMyc-Dependent Metabolic Reprogramming

Luca Simula et al.

CELL REPORTS (2018)

Add to Collection

Article Immunology

Atad3a suppresses Pink1-dependent mitophagy to maintain homeostasis of hematopoietic progenitor cells

Guoxiang Jin et al.

NATURE IMMUNOLOGY (2018)

Add to Collection

Article Endocrinology & Metabolism

FoxO1 Promotes Mitophagy in the Podocytes of Diabetic Male Mice via the PINK1/Parkin Pathway

Wen Li et al.

ENDOCRINOLOGY (2017)

Add to Collection

Article Immunology

Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation

Haiyan Tan et al.

IMMUNITY (2017)

Add to Collection

Article Multidisciplinary Sciences

Autophagy maintains the metabolism and function of young and old stem cells

Theodore T. Ho et al.

NATURE (2017)

Add to Collection

Article Cell & Tissue Engineering

Dye-Independent Methods Reveal Elevated Mitochondrial Mass in Hematopoietic Stem Cells

Mariana Justino de Almeida et al.

CELL STEM CELL (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Mitochondrial Priming by CD28

Ramon I. Klein Geltink et al.

CELL (2017)

Add to Collection

Review Cell Biology

Metabolic Regulation of T Cell Longevity and Function in Tumor Immunotherapy

Rigel J. Kishton et al.

CELL METABOLISM (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming

Michael D. Buck et al.

CELL (2016)

Add to Collection

Article Cell Biology

Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation

Noga Ron-Harel et al.

CELL METABOLISM (2016)

Add to Collection

Editorial Material Cell & Tissue Engineering

HSC Fate Is Tethered to Mitochondria

Lauren P. Diebold et al.

CELL STEM CELL (2016)

Add to Collection

Article Cell & Tissue Engineering

The Dlk1-Gtl2 Locus Preserves LT-HSC Function by Inhibiting the PI3K-mTOR Pathway to Restrict Mitochondrial Metabolism

Pengxu Qian et al.

CELL STEM CELL (2016)

Add to Collection

Article Geriatrics & Gerontology

Myelodysplastic Syndromes and Acute Myeloid Leukemia in the Elderly

Heidi D. Klepin

CLINICS IN GERIATRIC MEDICINE (2016)

Add to Collection

Article Multidisciplinary Sciences

Mitofusin 2 maintains haematopoietic stem cells with extensive lymphoid potential

Larry L. Luchsinger et al.

NATURE (2016)

Add to Collection

Article Multidisciplinary Sciences

Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells

Lenka V. Hurton et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Add to Collection

Article Multidisciplinary Sciences

Self-renewal of a purified Tie2+ hematopoietic stem cell population relies on mitochondrial clearance

Kyoko Ito et al.

SCIENCE (2016)

Add to Collection

Article Multidisciplinary Sciences

Specification of haematopoietic stem cell fate via modulation of mitochondrial activity

Nicola Vannini et al.

NATURE COMMUNICATIONS (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Enhancing Hematopoietic Stem Cell Transplantation Efficacy by Mitigating Oxygen Shock

Charlie R. Mantel et al.

CELL (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Mitochondrial metabolism in hematopoietic stem cells requires functional FOXO3

Pauline Rimmele et al.

EMBO REPORTS (2015)

Add to Collection

Article Immunology

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8+ T Cells

Gustavo J. Martinez et al.

IMMUNITY (2015)

Add to Collection

Article Medicine, Research & Experimental

mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

Kristen N. Pollizzi et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Add to Collection

Article Multidisciplinary Sciences

Deep imaging of bone marrow shows non-dividing stem cells are mainly perisinusoidal

Melih Acar et al.

NATURE (2015)

Add to Collection

Article Multidisciplinary Sciences

A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging

Mary Mohrin et al.

SCIENCE (2015)

Add to Collection

Article Biochemistry & Molecular Biology

Notch controls the survival of memory CD4(+) T cells by regulating glucose uptake

Yoichi Maekawa et al.

NATURE MEDICINE (2015)

Add to Collection

Article Cell Biology

Proteolytic Cleavage of Opa1 Stimulates Mitochondrial Inner Membrane Fusion and Couples Fusion to Oxidative Phosphorylation

Prashant Mishra et al.

CELL METABOLISM (2014)

Add to Collection

Article Cell & Tissue Engineering

Quiescent Hematopoietic Stem Cells Accumulate DNA Damage during Aging that Is Repaired upon Entry into Cell Cycle

Isabel Beerman et al.

CELL STEM CELL (2014)

Add to Collection

Article Biochemistry & Molecular Biology

OPA1-dependent cristae modulation is essential for cellular adaptation to metabolic demand

David A. Patten et al.

EMBO JOURNAL (2014)

Add to Collection

Article Multidisciplinary Sciences

Direct measurement of local oxygen concentration in the bone marrow of live animals

Joel A. Spencer et al.

NATURE (2014)

Add to Collection

Article Multidisciplinary Sciences

Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells

Johanna Flach et al.

NATURE (2014)

Add to Collection

Article Cell & Tissue Engineering

Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells

Pauline Rimmele et al.

STEM CELL REPORTS (2014)

Add to Collection

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

CELL (2013)

Add to Collection

Article Cell & Tissue Engineering

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

Keiyo Takubo et al.

CELL STEM CELL (2013)

Add to Collection

Article Cell & Tissue Engineering

Metabolic Regulation by the Mitochondrial Phosphatase PTPMT1 Is Required for Hematopoietic Stem Cell Differentiation

Wen-Mei Yu et al.

CELL STEM CELL (2013)

Add to Collection

Article Immunology

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

Laura A. Sena et al.

IMMUNITY (2013)

Add to Collection

Article Immunology

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

Gerritje J. W. van der Windt et al.

IMMUNITY (2012)

Add to Collection

Article Biochemistry & Molecular Biology

A PML-PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

Keisuke Ito et al.

NATURE MEDICINE (2012)

Add to Collection

Article Multidisciplinary Sciences

Basic leucine zipper transcription factor, ATF-like (BATF) regulates epigenetically and energetically effector CD8 T-cell differentiation via Sirt1 expression

Shoko Kuroda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Add to Collection

Article Cell Biology

Upregulation of nascent mitochondrial biogenesis in mouse hematopoietic stem cells parallels upregulation of CD34 and loss of pluripotency A potential strategy for reducing oxidative risk in stem cells

Charlie Mantel et al.

CELL CYCLE (2010)

Add to Collection

Article Cell & Tissue Engineering

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

Tugba Simsek et al.

CELL STEM CELL (2010)

Add to Collection

Article Cell & Tissue Engineering

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

Keiyo Takubo et al.

CELL STEM CELL (2010)

Add to Collection

Review Endocrinology & Metabolism

The Secret Life of NAD+: An Old Metabolite Controlling New Metabolic Signaling Pathways

Riekelt H. Houtkooper et al.

ENDOCRINE REVIEWS (2010)

Add to Collection

Article Multidisciplinary Sciences

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

Daisuke Nakada et al.

NATURE (2010)

Add to Collection

Article Multidisciplinary Sciences

The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

Sushma Gurumurthy et al.

NATURE (2010)

Add to Collection

Article Multidisciplinary Sciences

Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells

Boyi Gan et al.

NATURE (2010)

Add to Collection

Article Multidisciplinary Sciences

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

Isabel Beerman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Add to Collection

Article Cell Biology

Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1

Sarah Ehses et al.

JOURNAL OF CELL BIOLOGY (2009)

Add to Collection

Article Multidisciplinary Sciences

Enhancing CD8 T-cell memory by modulating fatty acid metabolism

Erika L. Pearce et al.

NATURE (2009)

Add to Collection

Article Biochemistry & Molecular Biology

mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells

Chong Chen et al.

SCIENCE SIGNALING (2009)

Add to Collection

Article Biochemistry & Molecular Biology

Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self-Renewal during Homeostasis and Repair

Anne Wilson et al.

CELL (2008)

Add to Collection

Article Biochemistry & Molecular Biology

Control Over the Contribution of the Mitochondrial Membrane Potential (Δψ) and Proton Gradient (ΔpH) to the Protonmotive Force (Δp) IN SILICO STUDIES

Jaroslaw Dzbek et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Add to Collection

Article Immunology

TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species

Chong Chen et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

Add to Collection

Article Multidisciplinary Sciences

Distribution of hematopoietic stem cells in the bone marrow according to regional hypoxia

Kalindi Parmar et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Add to Collection

Article Biochemistry & Molecular Biology

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

K Ito et al.

NATURE MEDICINE (2006)

Add to Collection

Article Biochemistry & Molecular Biology

SLAM family receptors distinguish hematopoietic stem and progenitor cells and reveal endothelial niches for stem cells

MJ Kiel et al.

CELL (2005)

Add to Collection

Article Multidisciplinary Sciences

Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

K Ito et al.

NATURE (2004)

Add to Collection

Article Immunology

Age-associated characteristics of murine hematopoietic stem cells

K Sudo et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2000)

Add to Collection

Article Biochemistry & Molecular Biology

The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes

RB Vega et al.

MOLECULAR AND CELLULAR BIOLOGY (2000)

Add to Collection

Mitochondria Dictate Function and Fate of HSCs and T Cells

Related references

Export Citation

Share Paper