Journal
BIOLOGY OPEN
Volume 12, Issue 8, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/bio.059980
Keywords
Extracellular matrix; Laminin; Collagen; Nidogen; Perlecan
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The basement membrane (BM) is a planar-organized extracellular matrix that plays important roles in tissue structure, organ shape, cell polarity, migration, and signaling. Different organization of BM leads to various physical features and can be regulated through deposition or degradation to enable tissue sculpting.
The basement membrane (BM) is a thin, planar-organized extracellular matrix that underlies epithelia and surrounds most organs. During development, the BM is highly dynamic and simultaneously provides mechanical properties that stabilize tissue structure and shape organs. Moreover, it is important for cell polarity, cell migration, and cell signaling. Thereby BM diverges regarding molecular composition, structure, and modes of assembly. Different BM organization leads to various physical features. The mechanisms that regulate BM composition and structure and how this affects mechanical properties are not fully understood. Recent studies show that precise control of BM deposition or degradation can result in BMs with locally different protein densities, compositions, thicknesses, or polarization. Such heterogeneous matrices can induce temporospatial force anisotropy and enable tissue sculpting. In this Review, I address recent findings that provide new perspectives on the role of the BM in morphogenesis.
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