Journal
NANOSCALE RESEARCH LETTERS
Volume 11, Issue -, Pages -Publisher
SPRINGEROPEN
DOI: 10.1186/s11671-016-1288-x
Keywords
Reduced nano-graphene oxide; Indocyanine green; Photoacoustic/fluorescence dual-modality imaging; Molecular imaging
Funding
- International Science and Technology Cooperation Program of China (MOST) [2014DFG32800]
- National Natural Science Foundation of China (NSFC) [61205203, 81427804]
- National Key Basic Research (973) Program of China [2014CB744503]
- Shenzhen Science and Technology Innovation grants [JCYJ-2014-0416122811-974, ZDSY-2013-0401165820-357, KQCX-2012-0816155844-962, JCYJ-2012-0615125857-842]
- NSFC [61405234, 81430038, 61475182]
- 973 program [2015CB755500]
- China-ROK Research Program [NRF-2013K1A3A1A20046921]
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Multimodality imaging based on multifunctional nanocomposites holds great promise to fundamentally augment the capability of biomedical imaging. Specifically, photoacoustic and fluorescence dual-modality imaging is gaining much interest because of their non-invasiveness and the complementary nature of the two modalities in terms of imaging resolution, depth, sensitivity, and speed. Herein, using a green and facile method, we synthesize indocyanine green (ICG) loaded, polyethylene glycol (PEG) ylated, reduced nano-graphene oxide nanocomposite (rNGO-PEG/ICG) as a new type of fluorescence and photoacoustic dual-modality imaging contrast. The nanocomposite is shown to have minimal toxicity and excellent photoacoustic/fluorescence signals both in vitro and in vivo. Compared with free ICG, the nanocomposite is demonstrated to possess greater stability, longer blood circulation time, and superior passive tumor targeting capability. In vivo study shows that the circulation time of rNGO-PEG/ICG in the mouse body can sustain up to 6 h upon intravenous injection; while after 1 day, no obvious accumulation of rNGO-PEG/ICG is found in any major organs except the tumor regions. The demonstrated high fluorescence/photoacoustic dual contrasts, together with its low toxicity and excellent circulation life time, suggest that the synthesized rNGO-PEG/ICG can be a promising candidate for further translational studies on both the early diagnosis and image-guided therapy/surgery of cancer.
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