Journal
CHEMICAL ENGINEERING SCIENCE
Volume 125, Issue -, Pages 75-84Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ces.2014.08.046
Keywords
Nanocarriers; Controlled release; Drug delivery; Drug release kinetics; Drug release mechanisms
Categories
Funding
- NSF [DMR-1056997]
- NIH [R01 EB017791]
- Lilly Endowment, Inc
- Intramural Research Program (Global RNAi Carrier Initiative) of the Korea Institute of Science and Technology
- Division Of Materials Research
- Direct For Mathematical & Physical Scien [1056997] Funding Source: National Science Foundation
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Nanocarriers providing spatiotemporal control of drug release contribute to reducing toxicity and improving therapeutic efficacy of a drug. On the other hand, nanocarriers face unique challenges in controlling drug release kinetics, due to the large surface area per volume ratio and the short diffusion distance. To develop nanocarriers with desirable release kinetics for target applications, it is important to understand the mechanisms by which a carrier retains and releases a drug, the effects of composition and morphology of he carrier on the drug release kinetics, and current techniques for preparation and modification of nanocarriers. This review provides an overview of drug release mechanisms and various nanocarriers with a specific emphasis on approaches to control the drug release kinetics. (C) 2014 Elsevier Ltd. All rights reserved.
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