Journal
CHEMICAL ENGINEERING SCIENCE
Volume 125, Issue -, Pages 20-24Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.ces.2014.10.022
Keywords
Non-spherical particles; Particle fabrication; Drug loading; Release rate; Targeting efficiency
Categories
Funding
- National Institutes of Health [1R01 HL109192, R25 CA154015A]
- Center for Advanced Study at the University of Illinois
- Korean Institute of Industrial Technology
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Nano- and microparticles loaded with various bioimaging contrast agents or therapeutic molecules have been increasingly used for the diagnosis and treatment of diseases and tissue defects. These particles, often a filled or hollow sphere, can extend the lifetime of encapsulated biomedical modalities in circulation and in target tissue. However, there is a great need to improve the drug loading and targeting efficiency of these particles. Recently, several simulations and in vitro experimental studies reported that particle shape plays a pivotal role in the targeted delivery of molecules. To better understand these findings and subsequently expedite the use of particles in biomedical applications, this review paper summarizes the methods to prepare non-spherical nano- and micro-scaled particles. In addition, this review covers studies reporting the effects of particle shape on the loading, delivery, and release of encapsulated bioactive cargos. Finally, it discusses future directions to further improve the properties of non-spherical particles. (C) 2014 Elsevier Ltd. All rights reserved.
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