Journal
NANOSCALE
Volume 8, Issue 27, Pages 13223-13227Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6nr03317b
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Funding
- National Natural Science Foundation of China [81361140345, 21535001, 41130526, 41371471, U1401234, 21575032]
- Chinese Academy of Sciences [XDA09030305]
- Shenzhen Science Plan [JSGG20130411160504896, JCYJ20130408173226864, CYJ20-140418182819179]
- Basic research project of knowledge innovation program in Shenzhen [JCYJ20150330-102720122]
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We demonstrate that N-heterocyclic molecule-capped gold nanoparticles (Au NPs) have broad-spectrum antibacterial activity. Optimized antibacterial activity can be achieved by using different initial molar ratios (1 : 1 and 10 : 1) of N-heterocyclic prodrugs and the precursor of Au NPs (HAuCl4). This work opens up new avenues for antibiotics based on Au NPs.
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