4.8 Article

Stem cell secretome-rich nanoclay hydrogel: a dual action therapy for cardiovascular regeneration

Journal

NANOSCALE
Volume 8, Issue 14, Pages 7371-7376

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c5nr07806g

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Funding

  1. NIH- Biotechnology Predoctoral Research Training Program [T32-GM008359]
  2. University of Kansas New Faculty General Research Fund
  3. Institutional Development Award (IDeA) from the National Institute of General Medical Sciences (NIGMS) of the NIH [P20GM103638-04]
  4. NIH [R01HL106190, R01HL087288]
  5. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL106190, R01HL087288] Funding Source: NIH RePORTER
  6. NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [T32GM008359, P20GM103638] Funding Source: NIH RePORTER

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A nanocomposite hydrogel with photocrosslinkable micro-porous networks and a nanoclay component was successfully prepared to control the release of growth factor-rich stem cell secretome. The proven pro-angiogenic and cardioprotective potential of this new bioactive system provides a valuable therapeutic platform for cardiac tissue repair and regeneration.

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